WIN 55,212-2 – a synthetic cannabinoid, CB1 agonist

 

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. (full – 1992)                                          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525583/

 

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.                                                              (full – 1993)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1

 

(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.                                                              (abst – 1994)      http://www.ncbi.nlm.nih.gov/pubmed/7698178

 

Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity            (full – 1998)                                   http://molpharm.aspetjournals.org/content/54/3/459.full

 

Loss of Cannabinoid Receptor Binding and Messenger Rna Levels and Cannabinoid Agonist-stimulated [35s]guanylyl-5’o-(Thio)-triphosphate Binding in the Basal Ganglia of Aged Rats.           (abst – 1998)                                         http://www.ncbi.nlm.nih.gov/pubmed/9578396?dopt=Abstract

 

Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures       (full – 1999)  http://www.jneurosci.org/cgi/content/full/19/8/2987?maxtoshow=&hits=80&RESULTFORMAT=&fulltext

=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype

=HWCIT

 

The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats (abst – 1999)                                           http://www.ncbi.nlm.nih.gov/pubmed/10611417

 

Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2    (full – 2000)                                 http://jpet.aspetjournals.org/content/292/1/136.long

 

Cannabinoids might reduce spasticity in multiple sclerosis                      (full – 2000)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117698/?tool=pmcentrez

 

Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human                                                              (full – 2000)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez

 

Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil                                              (full – 2000)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572019&tool=pmcentrez

 

Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea-pig ileum (full – 2000)                                 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1571902&tool=pmcentrez

 

Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.                                                     (full – 2000)  http://depts.washington.edu/stellalb/images/Nature2000.pdf

 

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.                                                   (full – 2001)  http://www.nature.com/npp/journal/v24/n2/full/1395605a.html

 

The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain                                                         (full – 2001)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572814&tool=pmcentrez

 

The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. (link to PDF – 2001)

http://journals.lww.com/anesthesiology/Fulltext/2001/05000/The_Cannabinoid_Agonist_WIN55,212_2_Su  ppresses.29.aspx

 

The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2                                                     (abst – 2001)  http://www.ncbi.nlm.nih.gov/pubmed/11120402

 

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)

http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte   xt=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetyp   e=HWCIT

 

Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus. (full – 2002)                                  http://www.jneurosci.org/content/22/16/7147.long

 

CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5- Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H- pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia       (full – 2002)  http://jpet.aspetjournals.org/content/301/3/963.full

 

A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding       (full – 2002)

http://www.jneurosci.org/cgi/content/abstract/22/21/9612?ijkey=328b5e83d7be9297b9483d22e0d6319fa0a862e8&keytype2=tf_ipsecsha

 

Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats                                                       (full – 2002)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573379/?tool=pmcentrez

 

The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. (full – 2002)  http://jpet.aspetjournals.org/content/300/1/34.long

 

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)

http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte   xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top

 

Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesia.                                                               (abst – 2002)  http://www.ncbi.nlm.nih.gov/pubmed/12421641

 

Inhibition of tumor angiogenesis by cannabinoids               (full – 2003)  http://www.fasebj.org/cgi/reprint/02-  0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear  chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT

 

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy                                                        (full – 2003)  http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

 

Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212           (full – 2003)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152941/?tool=pmcentrez

 

Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon         (full – 2003)  http://ajpgi.physiology.org/content/286/1/G110.full?sid=fc6948f0-78cf-405c-981b-afaa05ee417c

 

Effect of WIN 55212-2, a Cannabinoid Receptor Agonist, on Aqueous Humor Dynamics in Monkeys    (link to PDF – 2003)

http://archopht.ama-  assn.org/cgi/content/full/121/1/87?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana&sear  chid=1&FIRSTINDEX=640&resourcetype=HWCIT

 

The cannabinoid agonist WIN 55, 212-2 increases nociception threshold in cholestatic rats: implications for the treatment of the pruritus of cholestasis.                                                      (abst – 2003)  http://www.ncbi.nlm.nih.gov/pubmed/13679241

 

Cannabinoids: Defending the Epileptic Brain            (full – 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez

 

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats. (abst – 2004)                                    http://www.ncbi.nlm.nih.gov/pubmed/15519750

 

Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain         (news – 2004)

http://www.eurekalert.org/pub_releases/2004-10/sfn-mcm102604.php

 

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full – 2005)                                   http://www.nature.com/npp/journal/v30/n3/full/1300655a.html

 

Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. (full – 2005)                                   https://www.jstage.jst.go.jp/article/jnms/72/1/72_1_43/_pdf

 

Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression.                                                   (full – 2005)  http://onlinelibrary.wiley.com/doi/10.1111/j.1462-5822.2005.00577.x/pdf

 

The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues.       (full – 2005)                            https://www.jstage.jst.go.jp/article/jphs/98/1/98_1_77/_pdf

 

Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex         (abst – 2005)                          http://www.ncbi.nlm.nih.gov/pubmed/15927549

 

Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma         (full – 2006)                                        http://molpharm.aspetjournals.org/content/70/5/1612.full

 

Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice                                                          (full – 2006)        http://www.fasebj.org/cgi/content/full/20/7/1003

 

Activation of G-proteins in brain by endogenous and exogenous cannabinoids. (full – 2006)                                     http://www.ncbi.nlm.nih.gov/pubmed/16584117

 

Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain         (full – 2006)                                http://jn.physiology.org/cgi/content/full/96/6/2984

 

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus (full – 2006)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/?tool=pmcentrez

 

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury     (full – 2006)                        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

 

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus        (full – 2006)

http://jpet.aspetjournals.org/content/317/3/1072.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext

=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#ref-list-1

 

Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest  (full – 2006)                       http://www.jbc.org/content/281/51/39480.full

 

Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. (abst – 2006)                                        http://www.ncbi.nlm.nih.gov/pubmed/16956707

 

Cannabinoid receptors as a target for therapy of ovarian cancer                  (abst – 2006)  http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084?maxtoshow=&hits=80&RESULTF  ORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT

 

Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.                                                       (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16536902

 

The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.         (abst – 2006)                            http://www.ncbi.nlm.nih.gov/pubmed/16458258

 

Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats.                                                (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16864698

 

Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.    (abst – 2006)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=17369898&dopt=abstrac tplus

 

Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect (news – 2006)                                       http://www.norml.org/index.cfm?Group_ID=6819

 

Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity                                                            (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013951/?tool=pmcentrez

 

The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum       (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438968/

 

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury     (full – 2007)                       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

 

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.                                       (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190028/?tool=pubmed

 

Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior.                                                           (full – 2007)  http://www.nature.com/npp/journal/v32/n11/abs/1301365a.html

 

Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.                                                                 (full – 2007)  http://www.jneurosci.org/cgi/content/full/27/43/11700

 

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation                                           (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852513/?tool=pmcentrez

 

Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test                                                     (full – 2007)

http://www.anesthesia- analgesia.org/content/104/3/719.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&  searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

 

Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full – 2007)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190006/?tool=pmcentrez

 

Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia                                                   (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771679/?tool=pubmed

 

CANNABINOID-INDUCED HYPERPHAGIA: CORRELATION WITH INHIBITION OF PROOPIOMELANOCORTIN NEURONS?                    (full – 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720321/?tool=pmcentrez

 

Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB1 and TRPV1 receptors                                                (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128772/?tool=pmcentrez

 

Cannabinoid self-administration in rats: sex differences and the influence of ovarian function      (full – 2007)                           http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190022/

 

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus                                                              (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094113/?tool=pmcentrez

 

Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.  (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189718/?tool=pubmed

 

Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation                                        (full – 2007)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1852513&tool=pmcentrez

 

The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.                                                           (abst – 2007)       http://www.ncbi.nlm.nih.gov/pubmed/17572451

 

Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice       (abst – 2007)  http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/2195?maxtosh  ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcety  pe=HWCIT

 

Additive Effects of Timolol and Cannabinoids on Intraocular Pressure in a Rat Glaucoma Model            (abst – 2007)  http://abstracts.iovs.org/cgi/content/abstract/48/5/4807?maxtoshow=&hits=80&RESULTFORMAT=&fullt  ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT

 

Synthetic form of THC is an effective anti-depressant at low doses               (news – 2007)

http://www.news-medical.net/news/2007/10/24/31666.aspx?page=2

 

Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses (news – 2007)                                      http://www.sciencedaily.com/releases/2007/10/071023183937.htm

 

Chronic cannabinoid administration in vivo compromises extinction of fear memory. (full – 2008)                                 http://learnmem.cshlp.org/content/15/12/876.long

 

Topical WIN55212-2 Alleviates Intraocular Hypertension in Rats Through a CB1 Receptor-Mediated Mechanism of Action                                                                  (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637200/?tool=pmcentrez

 

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                   (full – 2008)  http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

 

Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice (full – 2008)                                 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771220/

 

Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages         (full – 2008)  http://cardiovascres.oxfordjournals.org/content/81/4/805.full?sid=7d2438c4-a727-410f-870d-  4a971695b4fb

 

Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats    (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez

 

The influence of mast cell mediators on migration of SW756 cervical carcinoma cells. (full – 2008)                                  https://www.jstage.jst.go.jp/article/jphs/106/2/106_FP0070736/_pdf

 

Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.                                                      (full – 2008)  http://www.nature.com/cgt/journal/v15/n2/full/7701101a.html

 

Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.

(abst – 2008)                 http://www.ncbi.nlm.nih.gov/pubmed/18611408

 

Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer (abst – 2008)

http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/4081?maxtosh ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=480&resourcety  pe=HWCIT

 

Scientists are High on Idea that Cannabis Reduces Memory Impairment             (news – 2008)

http://www.physorg.com/news146320102.html

 

Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain?     (news – 2008)                        http://www.sciencedaily.com/releases/2008/11/081119120141.htm

 

WIN55,212-2, a Cannabinoid Receptor Agonist, Protects Against Nigrostriatal Cell Loss in the MPTP Mouse Model of Parkinson’s Disease                                                (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755595/?tool=pmcentrez

 

Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain                                        (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743245/?tool=pmcentrez

 

Cannabinoid-1 (CB1) receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon                                                            (full – 2009)  http://ajpgi.physiology.org/cgi/content/full/296/1/G119?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

 

Cannabinoid Receptor Activation in the Basolateral Amygdala Blocks the Effects of Stress on the Conditioning and Extinction of Inhibitory Avoidance                                                       (full –  2009)  http://www.jneurosci.org/cgi/content/full/29/36/11078?maxtoshow=&hits=10&RESULTFORMAT=&fullt   ext=Dr.+Irit+Akirav+&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

 

Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats.                                                       (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915592/?tool=pubmed

 

The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi’s sarcoma cells in vitro            (full – 2009)  http://science.iowamedicalmarijuana.org/pdfs/cancer/Luca%20et%20al%202009%2019539619.pdf

 

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory                                                   (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660732/?tool=pmcentrez

 

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer      (full – 2009)                         http://mct.aacrjournals.org/content/8/11/3117.full

 

Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts              (full – 2009)

http://rheumatology.oxfordjournals.org/content/48/9/1050.full

 

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.       (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed

 

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain (full – 2009)                                      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011092/?tool=pubmed

 

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. (abst – 2009)                                    http://www.ncbi.nlm.nih.gov/pubmed/19385063

 

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                                             (full – 2010)  http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html

 

Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.                                                         (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed

 

Cannabinoids excite circadian clock neurons.               (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927117/?tool=pubmed

 

A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats            (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981070/?tool=pubmed

 

The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis.   (full – 2010)                                                                        http://molpharm.aspetjournals.org/content/77/5/854.long

 

Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)

http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17

 

Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior.                                                                               (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996668/?tool=pubmed

 

The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor

 

Interaction                   (full – 2010)

http://celljournal.org/library/upload/article/af_4334422Hashemi.pdf

 

The effect of the activation of cannabinoid receptor on the proliferation and apoptosis of hepatoma HepG2 cells                                                   (abst – 2010)          http://www.ncbi.nlm.nih.gov/pubmed/20368112

 

WIN55212-2 ameliorates atherosclerosis associated with suppression of pro- inflammatory responses in ApoE-knockout mice.                                                                     (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20868672

 

The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways.                                                          (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20150748

 

Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.                                                                 (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/20375197/abstract/Rimonabant_induced_Delta9_te trahydrocannabinol_withdrawal_in_rhesus_monkeys:_discriminative_stimulus_effects_and_other_withdra wal_signs_

 

The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. (abst – 2010)                                    http://www.ncbi.nlm.nih.gov/pubmed/21115947

 

The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model.         (abst – 2010)                         http://www.ncbi.nlm.nih.gov/pubmed/21177293

 

Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212- 2 after cardiopulmonary resuscitation                                                       (abst – 2010)  http://journals.lww.com/ccmjournal/Abstract/2010/12000/Pharmacologically_induced_hypothermia_with.2

.aspx

 

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala                                                                     (abst – 2010)  http://www.nature.com/npp/journal/v35/n9/abs/npp201070a.html

 

Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats.       (abst – 2010)                     http://www.ncbi.nlm.nih.gov/pubmed/19854030

 

Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis. (abst – 2010)                                    http://www.ncbi.nlm.nih.gov/pubmed/21057002

 

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells.            (abst – 2010)                          http://www.ncbi.nlm.nih.gov/pubmed/20336665

 

Cannabinoid Receptor Agonist WIN-55,212-2 Protects Differentiated PC12 Cells From Organophosphorus- Induced Apoptosis                                                  (abst – 2010)  http://ijt.sagepub.com/content/29/2/201.abstract

 

Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.                                                       (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20920894

 

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells. (full – 2011)                                  http://www.nature.com/cddis/journal/v2/n11/full/cddis2011106a.html

 

Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases.                                                       (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172222/?tool=pubmed

 

Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis.         (full – 2011)                         https://www.jstage.jst.go.jp/article/bpb/34/7/34_7_1090/_pdf

 

Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.  (full – 2011)  http://www.nature.com/npp/journal/v37/n2/full/npp2011204a.html

 

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease                                                        (full – 2011)  http://molpharm.aspetjournals.org/content/early/2011/02/24/mol.111.071290.long

 

A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats                                                     (full – 2011)  http://www.hindawi.com/journals/sd/2011/178469/

 

Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness (full – 2011)                                  http://www.biomedcentral.com/1471-2202/12/3

 

The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia.                                                     (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/21909954

 

Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy                                                       (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21469332/abstract/%5BProtective_effects_of_CB1

_receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lob       e_epilepsy%5D_

 

Cannabinoid applications in glaucoma.              (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21414525/abstract/Cannabinoid_applications_in_g  laucoma_

 

Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: Potential in glaucoma therapy.                                               (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21989812/abstract/Effect_of_ion_pairing_on_in_vi

 

tro_transcorneal_permeability_of_a_%CE%94_9 a_therapy_


tetrahydrocannabinol_prodrug:_Potential_in_glaucom

 

Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression.                                                       (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21309057

 

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.                                                                              (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21245146

 

Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells.   (abst – 2011)                                     http://www.ncbi.nlm.nih.gov/pubmed/21312237

 

Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.  (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21238473/abstract/Synthetic_cannabinoid_WIN_5  5212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maxima  l_electroshock_induced_seizures_in_mice_

 

The Effect of Hypoxia on G Protein Coupled (CB1) Receptor Gene Expression in Cortical B50 Neurons in Culture                                                                       (abst – 2011)  http://www.maxwellsci.com/jp/abstract.php?jid=BJPT&no=92&abs=05

 

The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft.                                                                   (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21807457

 

Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro.             (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21921665

 

Cannabinoids Prevent the Development of Behavioral and Endocrine Alterations in a Rat Model of Intense Stress.                                                      (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/21918506

 

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.      (abst – 2011)                       http://www.ncbi.nlm.nih.gov/pubmed/22110202

 

Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner                                                                    (abst – 2011)

 

 

 

 

Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and

cross-tolerance among cannabinoids.         (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21091643/abstract/Chronic_%CE%94%E2%81%B 9_tetrahydrocannabinol_treatment_in_rhesus_monkeys:_differential_tolerance_and_cross_tolerance_amon g_cannabinoids_

 

Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington’s disease.                                                          (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/22207189

 

Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.                                                           (full – 2012)  http://www.sciencedirect.com/science/article/pii/S0028390812000470

 

The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                                      http://www.jneuroinflammation.com/content/9/1/79

 

Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta- amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice.

(full – 2012)                  http://www.jneuroinflammation.com/content/pdf/1742-2094-9-8.pdf

 

Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. (full – 2012)  http://www.if-pan.krakow.pl/pjp/pdf/2012/3_723.pdf

 

Antiproliferative Effects of Cannabinoid Agonists on Deep Infiltrating Endometriosis (full – 2012)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993285/?tool=pubmed

 

Cannabinoids Facilitate the Swallowing Reflex Elicited by the Superior Laryngeal Nerve Stimulation in Rats     (full – 2012)                                http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507745/

 

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α                                                       (full – 2012)  http://www.jbc.org/content/early/2012/05/31/jbc.M112.371757.full.pdf+html

 

Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.                                                                 (full – 2012)  http://www.jbc.org/content/early/2012/07/11/jbc.M112.346296.full.pdf+html

 

Cannabinoid receptor activation correlates with the pro-apoptotic action of the β2- adrenergic agonist, (R,R’)-4-methoxy-1-naphthylfenoterol, in HepG2 hepatocarcinoma cells.    (full – 2012)                    http://jpet.aspetjournals.org/content/early/2012/07/09/jpet.112.195206.long

 

Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences                                                        (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152481&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=3&uiLanguage=en

 

Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

(link to PDF – 2012)                     http://www.hindawi.com/isrn/pharmacology/2012/276902/

 

Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior

 

(abst – 2012)  http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_differen t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_

 

Review article: The endocannabinoid system in normal and pathological brain ageing (abst – 2012)                                       http://www.ncbi.nlm.nih.gov/pubmed/23108550

 

Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.                                                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22019959

 

The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia.                                                     (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/21909954

 

Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/21701813

 

Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/22354705

 

Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects. (abst – 2012)   http://www.ncbi.nlm.nih.gov/pubmed/22342378

 

Cannabinoid 1 (CB1) receptor mediates WIN55, 212-2 induced hypothermia and improved survival in a rat post-cardiac arrest model.                                                                  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22289684

 

Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22285599

 

Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke.                                              (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22285309

 

The cannabinoid agonist WIN55212-2 decreases l-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats.                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22192465

 

Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.                                                               (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22374260

 

Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.  (abst – 2012)                                         http://www.ncbi.nlm.nih.gov/pubmed/22388975

 

Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior.                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22405775

 

WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway.                                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22634229

 

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22654113

 

Analgesic effects of cannabinoids on central pain syndrome               (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22359935

 

Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes.                                             (abst – 2012)           http://www.ncbi.nlm.nih.gov/pubmed/22609797

 

Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice. (abst – 2012)  http://www.springerlink.com/content/ur5784gm34782505/

 

Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: potential in glaucoma therapy.                                                (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/21989812

 

Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells.                                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22842590

 

Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats.                                                    (abst – 2012)      http://www.ncbi.nlm.nih.gov/pubmed/22903392

 

The molecular connections between the cannabinoid system and endometriosis (abst – 2012)                                   http://www.ncbi.nlm.nih.gov/pubmed/22923487

 

Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression.   (abst – 2012)                      http://www.ncbi.nlm.nih.gov/pubmed/22971846

 

Diuretic effects of cannabinoids.  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23019138

 

The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23063785

 

Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.                                                                   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23183218

 

Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult                                                  (abst – 2012)  http://www.safetylit.org/citations/index.php?fuseaction=citations.viewdetails&citationIds[]=citjournalarticl e_374483_1

 

Endocannabinoid modulation of jejunal afferent responses to LPS                     (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2012.01961.x/abstract

 

Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.                                                                               (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22697514?dopt=Abstract

 

WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats.                                                                (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23202804

 

WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.                                                                                            (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23148948

 

Effects of glucagon-like peptide-1 receptor stimulation and blockade on food consumption and body weight in rats treated with a cannabinoid CB1 receptor agonist WIN 55,212-2.   (abst – 2013)                                                               http://www.ncbi.nlm.nih.gov/pubmed/23291632

 

Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats                                                             (abst – 2013)

http://link.springer.com/article/10.1007/s00213-012-2839-1

 

Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.  (abst – 2013)                                    http://www.ncbi.nlm.nih.gov/pubmed/23386808

 

Novelty-Induced Emotional Arousal Modulates Cannabinoid Effects on Recognition Memory and Adrenocortical Activity                                                                  (abst – 2013)  http://www.nature.com/npp/journal/vaop/naam/pdf/npp201326a.pdf

 

Share a link for