WIN 55,212-2 – a synthetic cannabinoid, CB1 agonist


Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. (full – 1992)                                


Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.                                                              (full – 1993)


(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.                                                              (abst – 1994)


Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity            (full – 1998)                         


Loss of Cannabinoid Receptor Binding and Messenger Rna Levels and Cannabinoid Agonist-stimulated [35s]guanylyl-5’o-(Thio)-triphosphate Binding in the Basal Ganglia of Aged Rats.           (abst – 1998)                               


Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures       (full – 1999)




The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats (abst – 1999)                                 


Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2    (full – 2000)                       


Cannabinoids might reduce spasticity in multiple sclerosis                      (full – 2000)


Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human                                                              (full – 2000)


Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil                                              (full – 2000)


Modulation of peristalsis by cannabinoid CB1 ligands in the isolated guinea-pig ileum (full – 2000)                       


Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.                                                     (full – 2000)


Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.                                                   (full – 2001)


The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain                                                         (full – 2001)


The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. (link to PDF – 2001),212_2_Su  ppresses.29.aspx


The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2                                                     (abst – 2001)


Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)   xt=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetyp   e=HWCIT


Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus. (full – 2002)                        


CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5- Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H- pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia       (full – 2002)


A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding       (full – 2002)


Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats                                                       (full – 2002)


The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids. (full – 2002)


Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)   xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top


Effects of pharmacological manipulations of cannabinoid receptors on severity of dystonia in a genetic model of paroxysmal dyskinesia.                                                               (abst – 2002)


Inhibition of tumor angiogenesis by cannabinoids               (full – 2003)  0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear  chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT


The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy                                                        (full – 2003)  cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212           (full – 2003)


Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon         (full – 2003)


Effect of WIN 55212-2, a Cannabinoid Receptor Agonist, on Aqueous Humor Dynamics in Monkeys    (link to PDF – 2003)

http://archopht.ama-  chid=1&FIRSTINDEX=640&resourcetype=HWCIT


The cannabinoid agonist WIN 55, 212-2 increases nociception threshold in cholestatic rats: implications for the treatment of the pruritus of cholestasis.                                                      (abst – 2003)


Cannabinoids: Defending the Epileptic Brain            (full – 2004)


The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats. (abst – 2004)                          


Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain         (news – 2004)


Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full – 2005)                         


Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. (full – 2005)                         


Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression.                                                   (full – 2005)


The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues.       (full – 2005)                  


Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex         (abst – 2005)                


Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma         (full – 2006)                              


Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice                                                          (full – 2006)


Activation of G-proteins in brain by endogenous and exogenous cannabinoids. (full – 2006)                           


Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain         (full – 2006)                      


The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus (full – 2006)                        


Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury     (full – 2006)              


Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus        (full – 2006)



Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest  (full – 2006)             


Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. (abst – 2006)                              


Cannabinoid receptors as a target for therapy of ovarian cancer                  (abst – 2006)  ORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT


Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.                                                       (abst – 2006)


The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.         (abst – 2006)                  


Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats.                                                (abst – 2006)


Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.    (abst – 2006) tplus


Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect (news – 2006)                             


Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity                                                            (full – 2007)


The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum       (full – 2007)


Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury     (full – 2007)             


Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.                                       (full – 2007)


Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior.                                                           (full – 2007)


Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.                                                                 (full – 2007)


Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation                                           (full – 2007)


Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test                                                     (full – 2007)

http://www.anesthesia-  searchid=1&FIRSTINDEX=320&resourcetype=HWCIT


Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full – 2007)                          


Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia                                                   (full – 2007)




Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB1 and TRPV1 receptors                                                (full – 2007)


Cannabinoid self-administration in rats: sex differences and the influence of ovarian function      (full – 2007)                 


Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus                                                              (full – 2007)


Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.  (full – 2007)


Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation                                        (full – 2007)


The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.                                                           (abst – 2007)


Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22R{nu}1 xenograft in athymic nude mice       (abst – 2007)  ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcety  pe=HWCIT


Additive Effects of Timolol and Cannabinoids on Intraocular Pressure in a Rat Glaucoma Model            (abst – 2007)  ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT


Synthetic form of THC is an effective anti-depressant at low doses               (news – 2007)


Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses (news – 2007)                            


Chronic cannabinoid administration in vivo compromises extinction of fear memory. (full – 2008)                       


Topical WIN55212-2 Alleviates Intraocular Hypertension in Rats Through a CB1 Receptor-Mediated Mechanism of Action                                                                  (full – 2008)


Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                   (full – 2008) ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block


Peripheral Cannabinoids Attenuate Carcinoma Induced Nociception in Mice (full – 2008)                       


Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages         (full – 2008)  4a971695b4fb


Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats    (full – 2008)


The influence of mast cell mediators on migration of SW756 cervical carcinoma cells. (full – 2008)                        


Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.                                                      (full – 2008)


Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain.

(abst – 2008)       


Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer (abst – 2008) ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=480&resourcety  pe=HWCIT


Scientists are High on Idea that Cannabis Reduces Memory Impairment             (news – 2008)


Could Marijuana Substance Help Prevent Or Delay Memory Impairment In The Aging Brain?     (news – 2008)              


WIN55,212-2, a Cannabinoid Receptor Agonist, Protects Against Nigrostriatal Cell Loss in the MPTP Mouse Model of Parkinson’s Disease                                                (full – 2009)


Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain                                        (full – 2009)


Cannabinoid-1 (CB1) receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon                                                            (full – 2009) text=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


Cannabinoid Receptor Activation in the Basolateral Amygdala Blocks the Effects of Stress on the Conditioning and Extinction of Inhibitory Avoidance                                                       (full –  2009)   ext=Dr.+Irit+Akirav+&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT


Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in rats.                                                       (full – 2009)


The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi’s sarcoma cells in vitro            (full – 2009)


Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory                                                   (full – 2009)


Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer      (full – 2009)               


Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts              (full – 2009)


Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.       (full – 2009)


Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain (full – 2009)                            


Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. (abst – 2009)                          


International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                                             (full – 2010)


Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.                                                         (full – 2010)


Cannabinoids excite circadian clock neurons.               (full – 2010)


A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats            (full – 2010)


The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis.   (full – 2010)                                                              


Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)


Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior.                                                                               (full – 2010)


The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor


Interaction                   (full – 2010)


The effect of the activation of cannabinoid receptor on the proliferation and apoptosis of hepatoma HepG2 cells                                                   (abst – 2010)


WIN55212-2 ameliorates atherosclerosis associated with suppression of pro- inflammatory responses in ApoE-knockout mice.                                                                     (abst – 2010)


The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways.                                                          (abst – 2010)


Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.                                                                 (abst – 2010) trahydrocannabinol_withdrawal_in_rhesus_monkeys:_discriminative_stimulus_effects_and_other_withdra wal_signs_


The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. (abst – 2010)                          


The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model.         (abst – 2010)               


Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212- 2 after cardiopulmonary resuscitation                                                       (abst – 2010)



The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala                                                                     (abst – 2010)


Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats.       (abst – 2010)           


Antiproliferative effects of cannabinoid agonists on deep infiltrating endometriosis. (abst – 2010)                          


Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells.            (abst – 2010)                


Cannabinoid Receptor Agonist WIN-55,212-2 Protects Differentiated PC12 Cells From Organophosphorus- Induced Apoptosis                                                  (abst – 2010)


Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.                                                       (abst – 2010)


WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells. (full – 2011)                        


Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases.                                                       (full – 2011)


Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis.         (full – 2011)               


Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.  (full – 2011)


Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease                                                        (full – 2011)


A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats                                                     (full – 2011)


Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness (full – 2011)                        


The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia.                                                     (abst – 2011)


Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy                                                       (abst – 2011)

_receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lob       e_epilepsy%5D_


Cannabinoid applications in glaucoma.              (abst – 2011)  laucoma_


Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: Potential in glaucoma therapy.                                               (abst – 2011)


tro_transcorneal_permeability_of_a_%CE%94_9 a_therapy_



Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression.                                                       (abst – 2011)


Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.                                                                              (abst – 2011)


Antiproliferative mechanism of a cannabinoid agonist by cell cycle arrest in human gastric cancer cells.   (abst – 2011)                           


Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.  (abst – 2011)  5212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maxima  l_electroshock_induced_seizures_in_mice_


The Effect of Hypoxia on G Protein Coupled (CB1) Receptor Gene Expression in Cortical B50 Neurons in Culture                                                                       (abst – 2011)


The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft.                                                                   (abst – 2011)


Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro.             (abst – 2011)


Cannabinoids Prevent the Development of Behavioral and Endocrine Alterations in a Rat Model of Intense Stress.                                                      (abst – 2011)


Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.      (abst – 2011)             


Δ(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner                                                                    (abst – 2011)





Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and

cross-tolerance among cannabinoids.         (abst – 2011) 9_tetrahydrocannabinol_treatment_in_rhesus_monkeys:_differential_tolerance_and_cross_tolerance_amon g_cannabinoids_


Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington’s disease.                                                          (abst – 2011)


Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.                                                           (full – 2012)


The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                            


Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta- amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice.

(full – 2012)        


Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. (full – 2012)


Antiproliferative Effects of Cannabinoid Agonists on Deep Infiltrating Endometriosis (full – 2012)                          


Cannabinoids Facilitate the Swallowing Reflex Elicited by the Superior Laryngeal Nerve Stimulation in Rats     (full – 2012)                      


The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α                                                       (full – 2012)


Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.                                                                 (full – 2012)


Cannabinoid receptor activation correlates with the pro-apoptotic action of the β2- adrenergic agonist, (R,R’)-4-methoxy-1-naphthylfenoterol, in HepG2 hepatocarcinoma cells.    (full – 2012)          


Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences                                                        (link to PDF – 2012) cNo=3&uiLanguage=en


Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

(link to PDF – 2012)           


Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior


(abst – 2012) t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_


Review article: The endocannabinoid system in normal and pathological brain ageing (abst – 2012)                             


Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.                                                              (abst – 2012)


The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia.                                                     (abst – 2012)


Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. (abst – 2012)                            


Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                            


Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects. (abst – 2012)


Cannabinoid 1 (CB1) receptor mediates WIN55, 212-2 induced hypothermia and improved survival in a rat post-cardiac arrest model.                                                                  (abst – 2012)


Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.                                                       (abst – 2012)


Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke.                                              (abst – 2012)


The cannabinoid agonist WIN55212-2 decreases l-DOPA-induced PKA activation and dyskinetic behavior in 6-OHDA-treated rats.                                                      (abst – 2012)


Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.                                                               (abst – 2012)


Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.  (abst – 2012)                               


Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior.                                                         (abst – 2012)


WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway.                                                     (abst – 2012)


The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α                                                         (abst – 2012)


Analgesic effects of cannabinoids on central pain syndrome               (abst – 2012)


Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes.                                             (abst – 2012) 


Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice. (abst – 2012)


Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: potential in glaucoma therapy.                                                (abst – 2012)


Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells.                                              (abst – 2012)


Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats.                                                    (abst – 2012)


The molecular connections between the cannabinoid system and endometriosis (abst – 2012)                         


Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression.   (abst – 2012)            


Diuretic effects of cannabinoids.  (abst – 2012)


The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)


Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.                                                                   (abst – 2012)


Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult                                                  (abst – 2012)[]=citjournalarticl e_374483_1


Endocannabinoid modulation of jejunal afferent responses to LPS                     (abst – 2012)


Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.                                                                               (abst – 2012)


WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats.                                                                (abst – 2012)


WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.                                                                                            (abst – 2013)


Effects of glucagon-like peptide-1 receptor stimulation and blockade on food consumption and body weight in rats treated with a cannabinoid CB1 receptor agonist WIN 55,212-2.   (abst – 2013)                                                     


Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats                                                             (abst – 2013)


Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.  (abst – 2013)                          


Novelty-Induced Emotional Arousal Modulates Cannabinoid Effects on Recognition Memory and Adrenocortical Activity                                                                  (abst – 2013)


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