THCV/ TETRAHYDROCANNABIVARIN phytocannabinoid, CB1 & CB2 antagonist

 

Phytocannabinoids                    (news – undated)

http://www.news-medical.net/health/Phytocannabinoids.aspx

 

Cannabivarin and Tetrahydrocannabivarin, Two New Constituents of Hashish (abst – 1971)                                                       http://www.nature.com/nature/journal/v232/n5312/abs/232579a0.html

 

Delta9-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study                                                              (abst – 2001)  http://www.unboundmedicine.com/medline/ebm/record/11599601/abstract/

 

Plant cannabinoids: a neglected pharmacological treasure trove                    (full – 2005)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1751232&tool=pmcentrez

 

Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist                                                           (full – 2005)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751228/?tool=pubmed

 

The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.                                                       (full – 2007)

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189766/?tool=pubmed

 

The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum       (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438968/

 

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9- tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/

 

Non-psychotropic plant cannabinoids:new therapeutic opportunities from an ancient herb (full – 2009 )

http://cannabisinternational.org/info/Non-Psychoactive-Cannabinoids.pdf

 

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice                                                          (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed

 

Delta9-tetrahydrocannabivarin testing may not have the sensitivity to detect marijuana use among individuals ingesting dronabinol.                                                     (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815025/?tool=pubmed

 

The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.                                                         (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931567/?tool=pubmed

 

Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.   (abst – 2010)                                      http://www.ncbi.nlm.nih.gov/pubmed/20196794

 

Anticonvulsant effects of GWP42006 in vitro and in vivo in rat               (abst – 2010)

http://www.physoc.org/proceedings/abstract/Proc%20Physiol%20Soc%2019C117

 

Symptom-relieving and neuroprotective effects of the phytocannabinoid D(9) -THCV in animal models of Parkinson’s disease                                                (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21323909/abstract/Symptom_relieving_and_neuro

 

 

 

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ(9)-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive- compulsive behaviour.          (abst – 2011)                                                 http://www.ncbi.nlm.nih.gov/pubmed/21796370

 

Δ(8) -Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response involving CB(2) receptors. (abst – 2011)

 

 

 

 

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.                                                          (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21175579/abstract/Effects_of_cannabinoids_and_c annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_

 

CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant). (abst – 2011)                                           http://www.ncbi.nlm.nih.gov/pubmed/21740450

 

Cannabis could help treat epilepsy                        (news – 2011)

http://www.newkerala.com/news/world/fullnews-186693.html

 

Cannabis could be used to treat epilepsy                      (news – 2011)

http://www.telegraph.co.uk/science/science-news/8440303/Cannabis-could-be-used-to-treat-epilepsy.html

 

New research provides hope for those with epilepsy                   (news – 2011)

http://medicalxpress.com/news/2011-04-epilepsy.html

 

The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (full – 2012)                                       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349875/

 

Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy: Patent Application 20120004251                                                                 (full – 2012)

http://www.freshpatents.com/-dt20120105ptan20120004251.php

 

Δ(8) -Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB(2) receptors.        (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/21470208

 

Phytocannabinoids as novel therapeutic agents in CNS disorders                     (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/21924288

 

How marijuana could help cure obesity-related diseases                    (news – 2012)

http://news.yahoo.com/marijuana-could-help-cure-obesity-related-diseases-175900182.html

 

Cannabis can help treat obesity                   (news – 2012)

http://in.news.yahoo.com/cannabis-help-treat-obesity-121931025.html

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