THCV/ TETRAHYDROCANNABIVARIN phytocannabinoid, CB1 & CB2 antagonist


Phytocannabinoids                    (news – undated)


Cannabivarin and Tetrahydrocannabivarin, Two New Constituents of Hashish (abst – 1971)                                             


Delta9-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study                                                              (abst – 2001)


Plant cannabinoids: a neglected pharmacological treasure trove                    (full – 2005)


Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist                                                           (full – 2005)


The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.                                                       (full – 2007)


The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum       (full – 2007)


The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9- tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin (full – 2008)


Non-psychotropic plant cannabinoids:new therapeutic opportunities from an ancient herb (full – 2009 )


Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice                                                          (full – 2009)


Delta9-tetrahydrocannabivarin testing may not have the sensitivity to detect marijuana use among individuals ingesting dronabinol.                                                     (full – 2010)


The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.                                                         (full – 2010)


Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.   (abst – 2010)                            


Anticonvulsant effects of GWP42006 in vitro and in vivo in rat               (abst – 2010)


Symptom-relieving and neuroprotective effects of the phytocannabinoid D(9) -THCV in animal models of Parkinson’s disease                                                (abst – 2011)




Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ(9)-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive- compulsive behaviour.          (abst – 2011)                                       


Δ(8) -Tetrahydrocannabivarin protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress and inflammatory response involving CB(2) receptors. (abst – 2011)





Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.                                                          (abst – 2011) annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_


CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant). (abst – 2011)                                 


Cannabis could help treat epilepsy                        (news – 2011)


Cannabis could be used to treat epilepsy                      (news – 2011)


New research provides hope for those with epilepsy                   (news – 2011)


The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications (full – 2012)                             


Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy: Patent Application 20120004251                                                                 (full – 2012)


Δ(8) -Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB(2) receptors.        (abst – 2012)                            


Phytocannabinoids as novel therapeutic agents in CNS disorders                     (abst – 2012)


How marijuana could help cure obesity-related diseases                    (news – 2012)


Cannabis can help treat obesity                   (news – 2012)

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