THC/ TETRAHYDROCANNABINOL CB1 & 2 agonist

 

Phytocannabinoids                        (news – undated)

http://www.news-medical.net/health/Phytocannabinoids.aspx

 

Tetrahydrocannabinol- an interview with Akshat Rathi                   (transcript – undated)

http://www.rsc.org/chemistryworld/podcast/CIIEcompounds/transcripts/THC.asp

 

STUDIES ON THE PHARMACOLOGY AND ACUTE TOXICITY OF COMPOUNDS WITH MARIHUANA ACTIVITY                                                         (abst – 1946)

http://jpet.aspetjournals.org/content/88/2/154.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=marihuana&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

 

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish (1st page – 1964)                                                 http://pubs.acs.org/doi/abs/10.1021/ja01062a046

 

Chemical basis of hashish activity.                   (abst – 1970)

http://www.ncbi.nlm.nih.gov/pubmed/4987683

 

Some actions of delta-1 tetrahydrocannabinol and cannabidiol at cholinergic junctions. (full – 1971)                                      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1703324/pdf/brjpharm00552-0217.pdf

 

Activity of Dgr8-and Dgr9-Tetrahydrocannabinol and Related Compounds in the Mouse (abst – 1971)  http://www.sciencemag.org/cgi/content/abstract/172/3979/165?maxtoshow=&hits=80&RESULTFORMAT

=&fulltext=marihuana&searchid=1&FIRSTINDEX=2240&resourcetype=HWCIT

 

A metabolic interaction in vivo between cannabidiol and DELTA1-tetrahydrocannabinol (full – 1972)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1666148/?tool=pubmed

 

The Report of the National Commission on Marihuana and Drug Abuse Acute Effects of Marihuana       (full – 1972)  http://www.druglibrary.org/schaffer/library/studies/nc/nc1e.htm

 

Water-soluble derivatives of 1 -tetrahydrocannabinol.               (abst- 1972)

http://www.ncbi.nlm.nih.gov/pubmed/5043146

 

Effect of Biogenic Amines and Cannabinoids on Bacterial Chemotaxis               (full – 1973)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC246374/?page=1

 

Effects of marihuana in laboratory animals and in man                 (full – 1974)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1776629&tool=pmcentrez

 

A pilot study of orally administered DELTA1-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus                                               (full – 1974)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402430/?tool=pmcentrez&page=1

 

Smoked marijuana and oral delta-9-THC on specific airway conductance in asthmatic subjects     (full – 1974)                         http://www.ukcia.org/research/SmokedAndOralInAsthmatic.php

 

Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects.                                                       (abst – 1974)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=67

 

Intravenous delta9-Tetrahydrocannabinol: Effects of ventilatory control and cardiovascular dynamics.   (full – 1975)  http://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=1975&issue=06000&article=00008

&type=abstract

 

Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol. (abst – 1975)                                            http://www.ncbi.nlm.nih.gov/pubmed/1097148

 

Effects of smoked marijuana in experimentally induced asthma.               (abst – 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=57

 

The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption.                                                (abst – 1975)       http://www.ncbi.nlm.nih.gov/pubmed/1197914

 

Analgesic effect of delta-9-tetrahydrocannabinol.                (abst – 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=16

 

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.              (abst – 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=17

 

Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9- tetrahydrocannabinol.  (abst – 1975)                                         http://www.ncbi.nlm.nih.gov/pubmed/1222370

 

Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.        (abst – 1975)                      http://www.ncbi.nlm.nih.gov/pubmed/1183427

 

Absence of interaction between delta9-tetrahydrocannabinol (delta-THC) and cannabidiol (CBD) in aggression, muscle control and body temperature experiments in mice.

(abst – 1975)                http://www.ncbi.nlm.nih.gov/pubmed/1171491

 

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients.       (full – 1976)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470501/?tool=pubmed

 

Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs. (abst – 1976)                                      http://www.ncbi.nlm.nih.gov/pubmed/1253828

 

Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol.               (abst – 1976)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=1085130&dopt=abstract plus

 

In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.           (abst  – 1977)                                   http://www.ncbi.nlm.nih.gov/pubmed/616322

 

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects. (abst – 1977)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=109

 

Delta-9-Tetrahydrocannibinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate   (full – 1979)                           http://www.ukcia.org/research/AntiemeticForMethotrexate.php

 

The effect of cannabichromene on mean blood pressure, heart rate, and respiration rate responses to tetrahydrocannabinol in the anesthetized rat                                       (abst – 1979)  http://www.sciencedirect.com/science/article/pii/0041008X79902503

 

Plasma delta-9-tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking                                                             (abst – 1980)  http://www.nature.com/clpt/journal/v28/n3/abs/clpt1980181a.html

 

Marihuana as a therapeutic agent for muscle spasm or spasticity.                 (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=53

 

Sedative activity of cannabis in relation to its delta’-trans-tetrahydrocannabinol and cannabidiol content.            (full -1981)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071638/?tool=pmcentrez

 

Activity of cannabis in relation to its delta’-trans-tetrahydro-cannabinol content.

(full – 1981)              http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071597/?tool=pmcentrez&page=1

 

The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.                         (full – 1981)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401962/?tool=pubmed

 

The cardiovascular and autonomic effects of repeated administration of delta-9- tetrahydrocannabinol to rhesus monkeys.                                                                 (abst – 1981)  http://www.ncbi.nlm.nih.gov/pubmed/6257883

 

Comparison of effects of marihuana cigarettes of three different potencies             (full – 1982)

http://www.nature.com/clpt/journal/v31/n5/pdf/clpt198286a.pdf

 

Ocular  Effects  of  Topical  Administration  of  {Delta}9-Tetrahydrocannabinol  in  Man (link to PDF – 1982)

http://archopht.ama-  assn.org/cgi/reprint/100/2/265?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searc hid=1&FIRSTINDEX=2960&resourcetype=HWCIT

 

Multiple-Drop Study of Topically Applied 1% {Delta}9-Tetrahydrocannabinol in Human Eyes   (link to PDF – 1983)

http://archopht.ama-  assn.org/cgi/reprint/101/4/591?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabis&searchid=   1&FIRSTINDEX=2800&resourcetype=HWCIT

 

Neurobehavioral actions of cannabichromene and interactions with delta 9- tetrahydrocannabinol.           (abst – 1983)                                       http://www.ncbi.nlm.nih.gov/pubmed/6301931

 

Respiratory and cardiovascular depressant effects of nabilone, N-methyllevonantradol and delta 9-tetrahydrocannabinol in anesthetized cats.                                  (abst – 1983)  http://jpet.aspetjournals.org/content/227/2/508.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt  ext=marihuana&searchid=1&FIRSTINDEX=1920&resourcetype=HWCIT

 

Allergenic properties of naturally occurring cannabinoids.                (abst – 1983)

http://www.ncbi.nlm.nih.gov/pubmed/6620158

 

Acute Effects of Natural and Synthetic Cannabis Compounds on Prolactin Levels in Human Males.        (abst – 1984)                            http://www.ncbi.nlm.nih.gov/pubmed/6320226

 

Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta 9- tetrahydrocannabinol or cannabichromene.                                                      (abst – 1984)  http://www.ncbi.nlm.nih.gov/pubmed/6323206

 

Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol.                                          (abst – 1984)       http://www.ncbi.nlm.nih.gov/pubmed/6098513

 

Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds (abst – 1984)                                    http://www.ncbi.nlm.nih.gov/pubmed/6090851

 

The quasi-morphine withdrawal syndrome: effect of cannabinol, cannabidiol and tetrahydrocannabinol.  (abst – 1985)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=2994117&dopt=abstract  plus

 

Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting.                                                                (abst – 1985)  http://www.ncbi.nlm.nih.gov/pubmed/2981616

 

The effect of delta-9-THC on human spasticity.             (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=154

 

UV-B RADIATION EFFECTS ON PHOTOSYNTHESIS, GROWTH and CANNABINOID PRODUCTION OF TWO Cannabis sativa CHEMOTYPES

(abst – 1987)

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-  1097.1987.tb04757.x/abstract;jsessionid=E27DFF97974EDECC7DCDFFD1EED18D17.d03t03

 

Oral vs. Inhaled Cannabinoids for Nausea/Vomiting from Cancer Chemotherapy (full – 1988)                                    http://www.druglibrary.org/schaffer/hemp/medical/pierson.html

 

The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation.                                                           (abst – 1989)  http://www.ncbi.nlm.nih.gov/pubmed/2575149

 

Marijuana Smoking: Factors That Influence the Bioavailability of Tetrahydrocannabinol (full – 1990)                                    http://www.ukcia.org/research/FactorsThatInfluenceBioavailability.pdf

 

A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol.            (abst – 1990)                          http://www.ncbi.nlm.nih.gov/pubmed/1965836

 

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. (abst – 1990)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=10

 

Chronic Exposure to Delta 9-tetrahydrocannabinol Fails to Irreversibly Alter Brain Cannabinoid Receptors.                                                     (abst – 1991)      http://www.ncbi.nlm.nih.gov/pubmed/1649662

 

Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism.                                                       (full – 1992)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907498/?tool=pmcentrez&page=1

 

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.                                                         (full – 1993)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1

 

Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking.       (full – 1994)                       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334408/?tool=pubmed

 

Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice. (abst – 1994)

http://jpet.aspetjournals.org/content/268/3/1381.abstract?maxtoshow=&hits=80&RESULTFORMAT=&ful ltext=marihuana&searchid=1&FIRSTINDEX=1840&resourcetype=HWCIT

 

Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin (abst – 1995)  http://ajpheart.physiology.org/cgi/content/abstract/269/6/H1859?maxtoshow=&hits=80&RESULTFORMA  T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=2320&resourcetype=HWCIT

 

Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.     (abst – 1995)                            http://www.ncbi.nlm.nih.gov/pubmed/7498260

 

AM630, a competitive cannabinoid receptor antagonist.              (abst – 1995)

http://www.ncbi.nlm.nih.gov/pubmed/7776818

 

Cannabinoids enhance human B-cell growth at low nanomolar concentrations. (abst – 1995)                                      http://www.ncbi.nlm.nih.gov/pubmed/7544292

 

NTP Technical Report on the Toxicology and Carcinogenesis Studies of 1-Trans-Delta9- Tetrahyrdocannabinol (CAS No. 1972-08-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)           (full – 1996)                             http://www.druglibrary.org/Schaffer/hemp/Trans-Delta%20Report.pdf

 

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity : a pilot study with 2 patients.                                              (abst – 1996)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=12

 

Toxicity and Carcinogenicity of {Delta}9-Tetrahydrocannabinol in Fischer Rats and B6C3F1 Mice         (abst – 1996)  http://toxsci.oxfordjournals.org/cgi/content/abstract/30/1/109?maxtoshow=&hits=80&RESULTFORMAT=

&fulltext=marihuana&searchid=1&FIRSTINDEX=240&resourcetype=HWCIT

 

Genetic differences in delta 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains.      (abst – 1996)  http://www.ncbi.nlm.nih.gov/pubmed/8649214

 

Immunochemical localization of tetrahydrocannabinol (THC) in cryofixed glandular trichomes of Cannabis (Cannabaceae)                                                      (full – 1997)  http://www.amjbot.org/content/84/3/336.full.pdf+html

 

The perceived effects of smoked cannabis on patients with multiple sclerosis. (abst – 1997)           http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=13

 

Study: THC Not Cancer-Causing           (news – 1997)    http://www.ukcia.org/research/cancer.php

 

Cannabidiol and (−)DELTA9-tetrahydrocannabinol are neuroprotective antioxidants (full – 1998)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20965&tool=pmcentrez

 

Cerebellar activity and disturbed time sense after THC.           (abst – 1998)

http://www.ncbi.nlm.nih.gov/pubmed/9666122

 

Treatment of Tourette’s Syndrome With Delta-9-Tetrahydrocannabinol            (letter – 1999)

http://ajp.psychiatryonline.org/cgi/content/full/156/3/495

 

Cannabis and cannabinoids: pharmacology and rationale for clinical use                (abst – 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10575283

 

Cannabis: Discrimination of “Internal Bliss”?              (abst – 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10515300

 

Advantages of polypharmaceutical herbal cannabis compared to single ingredient, synthetic tetrahydrocannabinol                                                                 (full – 2000)  http://cannabismovement.org/docs/cannabis%20terpenes.pdf

 

Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.                                                   (full – 2000)  http://depts.washington.edu/stellalb/images/Nature2000.pdf

 

Cannabinoids might reduce spasticity in multiple sclerosis              (full – 2000)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117698/?tool=pmcentrez

 

Variations of D9-THC content in single plants of hemp varieties            (full – 2000)

http://www.ukcia.org/research/VariationOfTHCContent.pdf

 

GC-MS analysis of the total delta9-THC content of both drug- and fiber-type cannabis seeds.     (abst – 2000)                      http://www.ncbi.nlm.nih.gov/pubmed/11110027

 

Endogenous cannabinoids and appetite.                (abst – 2000)

http://www.ncbi.nlm.nih.gov/pubmed/19087417

 

Cannabinoids in clinical practice.              (abst – 2000)

http://www.ncbi.nlm.nih.gov/pubmed/11152013

 

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.                                                   (full – 2001)  http://www.nature.com/npp/journal/v24/n2/full/1395605a.html

 

Tetrahydrocannabinol for treatment of chronic pain               (abst – 2001)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=147

 

Neuroprotection by Delta 9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity                                                             (abst – 2001)  http://www.jneurosci.org/cgi/content/abstract/21/17/6475?maxtoshow=&hits=10&RESULTFORMAT=&f  ulltext=cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=70&sortspec=relevance&resourcet  ype=HWCIT

 

Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients.                                                   (abst – 2001)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=102

 

Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease            (full – 2002)  http://bloodjournal.hematologylibrary.org/cgi/content/full/100/2/627?ijkey=eb71d6d7a06f311440761cfac6  a7d081bcc2771d

 

The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.                                                     (full – 2002)  http://jpet.aspetjournals.org/content/300/1/34.long

 

Cannabinoids and multiple sclerosis.                 (abst – 2002)

http://www.ncbi.nlm.nih.gov/pubmed/12182963

 

Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. (abst – 2002)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=12137404&dopt=abstrac  tplus

 

Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN                                                     (full – 2003)  http://www.jleukbio.org/cgi/content/full/75/3/453?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

 

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy                                                         (full – 2003)  http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

 

Inhibition of tumor angiogenesis by cannabinoids                 (full – 2003)  http://www.fasebj.org/cgi/reprint/02-  0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT

 

Effects of THC on Behavioral Measures of Impulsivity in Humans             (full – 2003)

http://www.nature.com/npp/journal/v28/n7/full/1300176a.html

 

Cannabis and the brain.            (full – 2003)  http://brain.oxfordjournals.org/cgi/content/full/126/6/1252

 

Treatment of Tourette Syndrome with Delta-9-Tetrahydrocannabinol (Delta9-THC): No Influence on Neuropsychological Performance                                       (full – 2003)

http://www.nature.com/npp/journal/v28/n2/abs/1300047a.html

 

Cannabinoids: Potential Anticancer Agents             (full – 2003)

http://americanmarijuana.org/Guzman-Cancer.pdf

 

Cannabis use for chronic non-cancer pain: results of a prospective survey.              (abst – 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=91

 

The treatment of spasticity with D9-THC) in patients with spinal cord injury (abst – 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=79

 

Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. (abst – 2003)                                   http://www.ncbi.nlm.nih.gov/pubmed/12447606

 

Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial.                                                 (abst – 2003)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=146#1

 

Cannabis can help MS sufferers              (news – 2003)  (may need registration)

http://www.newscientist.com/article/dn4356-cannabis-can-help-ms-sufferers.html

 

Differential Effects of  THC or CBD-rich Cannabis Extracts on  Working Memory in Rats          (full – 2004)                     http://www.ukcia.org/research/THCCBDWorkingMemory.pdf

 

Cannabinoids: Defending the Epileptic Brain                (full – 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez

 

Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies            (full – 2004)                          http://www.ukcia.org/research/InitialExperiencesChronicPain.pdf

 

The good and the bad effects of (−) trans-delta-9-tetrahydrocannabinol (DELTA9-THC) on humans     (abst – 2004)  http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCS-4CSG2C4-

2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlV  ersion=0&_userid=10&md5=99df29b0ce94c395c01f5aad8825d28b

 

Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss.                                                          (abst – 2004)      http://www.ncbi.nlm.nih.gov/pubmed/15099912

 

Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early- morning behavior in young adults.                                                           (abst – 2004)  http://www.ncbi.nlm.nih.gov/pubmed/15118485?dopt=Abstract

 

[123I]AM281 single-photon emission computed tomography imaging of central cannabinoid CB1 receptors before and after Delta9-tetrahydrocannabinol therapy and whole-body scanning for assessment of radiation dose in tourette patients.

(abst – 2004)               http://www.ncbi.nlm.nih.gov/pubmed/15110734

 

THC in marijuana may block the spread of forms of cancer causing herpes viruses (news – 2004)  http://www.news-medical.net/news/2004/09/22/4990.aspx

 

Cannabis truly helps multiple sclerosis sufferers                 (news – 2004) (may need registration)

http://www.newscientist.com/article/dn6387-cannabis-truly-helps-multiple-sclerosis-sufferers.html

 

Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain         (news – 2004)

http://www.eurekalert.org/pub_releases/2004-10/sfn-mcm102604.php

 

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice (full – 2005)                                 http://www.nature.com/nature/journal/v434/n7034/full/nature03389.html

 

Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala                                                        (full – 2005)  http://www.nature.com/npp/journal/v30/n3/full/1300535a.html

 

Protective effects of DELTA9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death      (full – 2005)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824211/?tool=pmcentrez

 

The effects of DELTA9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide                                                         (full – 2005)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576168/?tool=pmcentrez

 

Pharmacokinetics and metabolism of the plant cannabinoids, delta9- tetrahydrocannabinol, cannabidiol and cannabinol.                                                                                 (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/16596792

 

Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N- arachidonoyldopamine (NADA) in the rat isolated aorta. (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/15659311

 

Cannabis may help keep arteries clear                 (news – 2005)  (may need registration)

http://www.newscientist.com/article/mg18624956.000

 

Medical marijuana: study shows that THC slows atherosclerosis               (news – 2005)

http://thenexthurrah.typepad.com/the_next_hurrah/2005/04/medical_marijua.html

 

Science: THC slows development of atherosclerosis in animal study              (news – 2005)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=190#1

 

Cannabis Spray for Bipolar             (news – 2005)

http://www.prohealth.com/me-cfs/blog/boardDetail.cfm?id=565511

 

Chemicals in Cannabis may help mentally ill               (news – 2005)

http://www.news-medical.net/news/2005/06/06/10716.aspx

 

THC effective in appetite and weight loss in severe lung disease (COPD)           (news – 2005)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=191#2

 

New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery , Phase I Study (news – 2005)                                       http://www.medicalnewstoday.com/articles/22937.php

 

A tale of two cannabinoids:The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.         (full – 2006)  http://mcforadhd.free.fr/Russo_Tale_of_Two_Cannabinoids_Med_Hypoth_2006.pdf

 

Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In- Cachexia-Study-Group  (full – 2006)     http://jco.ascopubs.org/content/24/21/3394.long

 

A Molecular Link between the Active Component of  Marijuana and Alzheimer’s Disease Pathology      (full – 2006)  http://www.ukcia.org/research/AlzheimersDiseasePathology.pdf

 

{Delta}9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer Cells through Cdc2 Regulation                                                 (full – 2006)  http://cancerres.aacrjournals.org/cgi/content/full/66/13/6615

 

DELTA9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria                                                       (full – 2006)  http://mcr.aacrjournals.org/content/4/8/549.full

 

Further Characterization of the Time-Dependent Vascular Effects of DELTA9- Tetrahydrocannabinol  (full – 2006)                                                  http://jpet.aspetjournals.org/content/317/1/428.full

 

Cannabinoids and the Endocannabinoid System             (full – 2006)

http://www.cannabis-med.org/english/journal/en_2006_01_2.pdf

 

The Cannabinoid Cb1 Receptor Antagonist Rimonabant Attenuates the Hypotensive Effect of Smoked Marijuana in Male Smokers.                                                             (full – 2006)  http://www.ahjonline.com/article/S0002-8703%2805%2901013-6/fulltext

 

Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia. (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16997463?dopt=Abstract

 

Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief                                                           (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16834825

 

A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.                                                      (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=193

 

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity (abst – 2006)

http://www.unboundmedicine.com/medline/ebm/record/17140550/abstract/Delta_9  l_protects_hippocampal_neurons_from_excitotoxicity

Tetrahydrocannabino


The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.         (abst – 2006)                          http://www.ncbi.nlm.nih.gov/pubmed/16458258

 

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury.           (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=166

 

An Experimental Study of Catechol-O-Methyltransferase Val(158)Met Moderation of Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition

(abst – 2006)  http://www.unboundmedicine.com/medline/ebm/record/16936704/abstract/An_Experimental_Study_of_Ca  techol_O_Methyltransferase_Val_158_Met_Moderation_of_Delta_9_Tetrahydrocannabinol_Induced_Effe  cts_on_Psychosis_and_Cognition

 

Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.        (abst – 2006)                             http://www.ncbi.nlm.nih.gov/pubmed/16506408

 

Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma.                                                (abst – 2006)      http://www.ncbi.nlm.nih.gov/pubmed/16314952

 

THC and prochlorperazine effective in reducing vomiting in women following breast surgery      (news – 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=219#1

 

Marijuana’s Active Ingredient Shown to Inhibit Primary Marker of Alzheimer’s Disease (news – 2006)                                       http://www.scripps.edu/newsandviews/e_20060828/news.html

 

THC inhibits primary marker of Alzheimer’s disease                (news – 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=225#3

 

Cannabis destroys cancer cells                     (news – 2006)

http://www.news-medical.net/news/2006/03/01/16340.aspx

 

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: DELTA9- tetrahydrocannabinol, cannabidiol and DELTA9-tetrahydrocannabivarin                                                      (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/?tool=pubmed&itool=EntrezSystem2.PEntrez.Pub   med.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_DiscoveryDbLinks&ordinalpos=1

 

Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia                                                   (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771679/?tool=pubmed

 

Opioid Antagonism of Cannabinoid Effects: Differences between Marijuana Smokers and Nonmarijuana Smokers                                                            (full – 2007)  http://www.nature.com/npp/journal/v32/n6/full/1301243a.html

 

The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.                                              (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189766/?tool=pubmed

 

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.     (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083705/?tool=pubmed

 

CB2 receptors in the brain: role in central immune function                (full – 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219530/?tool=pmcentrez

 

DELTA9-Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors                                                             (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189998/?tool=pmcentrez

 

Low dose combination of morphine and DELTA9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors                                                                (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040345/

 

On the pharmacological properties of Delta9-tetrahydrocannabinol (THC). (abst – 2007)                                      http://www.ncbi.nlm.nih.gov/pubmed/17712813

 

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat involves the CB(2) cannabinoid receptor.                                               (abst – 2007)  http://www.unboundmedicine.com/medline/ebm/record/17588560/abstract/The_antinociceptive_effect_of_

Delta9_tetrahydrocannabinol_in_the_arthritic_rat_involves_the_CB_2

cannabinoid_receptor


THC improves appetite and reverses weight loss in AIDS patients                 (abst – 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=189

 

Repeated Treatment with Cannabidiol but Not Delta9-tetrahydrocannabinol Has a Neuroprotective Effect Without the Development of Tolerance                                                                    (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17320118

 

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat (abst – 2007) http://www.unboundmedicine.com/medline/ebm/record/17498686/abstract/Synergy_between_Delta_9 rahydrocannabinol_and_morphine_in_the_arthritic_rat

tet

 

 

The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. (abst – 2007)   http://www.ncbi.nlm.nih.gov/pubmed/17583570

 

Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.                                                           (abst – 2007)

http://www.unboundmedicine.com/medline/ebm/record/17289082/abstract/Delta_9

tetrahydrocannabinol

Delta_9

THC

prevents_cerebral_infarction_via_hypothalamic_independent_hypothermia

 

Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances. (abst – 2007)                                       http://www.ncbi.nlm.nih.gov/pubmed/17868014

 

Medicinal chemistry endeavors around the phytocannabinoids.              (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17712816

 

Effects of a Selective Cannabinoid Agonist and Antagonist on Body Temperature in Rats (abst – 2007)  http://www.fasebj.org/cgi/content/meeting_abstract/21/5/A409?maxtoshow=&hits=80&RESULTFORMA T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=800&resourcetype=HWCIT

 

Pot’s Active Ingredient Halts Lung Cancer Growth, Study Says            (news – 2007)

http://www.illinoisnorml.org/content/view/529/27/

 

Cannabis can reduce Allergic Skin Reactions, latest research shows (news – 2007)  http://www.healthjockey.com/2007/06/08/cannabis-can-reduce-allergic-skin-reactions-latest-research-  shows/

 

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: DELTA9- tetrahydrocannabinol, cannabidiol and DELTA9-tetrahydrocannabivarin                                                  (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/

 

DELTA9-Tetrahydrocannabinol Content of Commercially Available Hemp Products

(full – 2008)            https://secure.manitobaharvest.com/images/uploads/pages/File/thc_study_jat_2008.pdf

 

Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of DELTA9-tetrahydrocannabinol                                       (full – 2008)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2279017

 

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                   (full – 2008)  http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

 

Cannabinoids in the management of difficult to treat pain              (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/?tool=pmcentrez

 

Cannabinoid receptors in acute and chronic complications of atherosclerosis (full – 2008)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219535/?tool=pmcentrez

 

Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.   (full – 2008)  http://www.scribd.com/doc/7718968/Antibacterial-Cannabinoids-From-Cannabis-Sativa-A-  StructureActivity-Study

 

The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.                                                                 (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677557/

 

Delta-9-tetrahydrocannabinol pharmacokinetics               (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18847571

 

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. (abst – 2008)                                    http://www.ncbi.nlm.nih.gov/pubmed/18615640

 

Effect of intrapulmonary tetrahydrocannabinol administration in humans.             (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18515447

 

Science: THC reduces reflux of acid from the stomach                (news – 2008)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=285

 

CSI: fingerprinting and drug detection in one              (news – 2008)

http://arstechnica.com/science/2008/12/csi-fingerprinting-and-drug-detection-in-one/

 

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice                                                      (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed

 

Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. (full – 2009)                                  http://www.nature.com/npp/journal/v34/n3/full/npp2008138a.html

 

Cannabinoids DELTA9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells        (full – 2009)  http://www.jbc.org/content/285/3/1616.full?sid=43211ca4-a4aa-4182-a554-d15e2835e288

 

Hydroxylation and Further Oxidation of DELTA9-Tetrahydrocannabinol by Alkane-Degrading Bacteria          (full – 2009)                 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786519/?tool=pmcentrez

 

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation (full – 2009)                                 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pubmed

 

Cannabinoid Receptor 1 Binding Activity and Quantitative Analysis of Cannabis sativa

L. Smoke and Vapor           (full – 2009)    https://www.jstage.jst.go.jp/article/cpb/58/2/58_2_201/_pdf

 

Evaluation of Prevalent Phytocannabinoids in the Acetic Acid Model of Visceral Nociception     (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765124/?tool=pubmed

 

Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey                                                          (full – 2009)  http://www.hindawi.com/journals/arp/2009/827290.html

 

Actions of delta-9-tetrahydrocannabinol in cannabis             (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731700/?tool=pmcentrez

 

Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma       (full – 2009)                                  http://mct.aacrjournals.org/content/8/7/1838.full

 

TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.             (full – 2009)

http://www.landesbioscience.com/journals/autophagy/SalazarAUTO5-7.pdf

 

Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells.                                                              (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19425170/abstract/

 

Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)- tetrahydrocannabinol in rats.                                                     (abst – 2009)      http://www.ncbi.nlm.nih.gov/pubmed/19393686

 

Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users.        (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/18719045?ordinalpos=44&itool=EntrezSystem2.PEntrez.Pubmed.Pu   bmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

Modulation of effective connectivity during emotional processing by Delta9- tetrahydrocannabinol and cannabidiol.                                                                            (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19775500?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pub   med_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.                                   (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19924114/full_citation/Opposite_Effects_of_Delta

_9_Tetrahydrocannabinol_and_Cannabidiol_on_Human_Brain_Function_and_Psychopathology_

 

Active cannabis chemicals halt prostate cancer cell growth                  (news – 2009)  http://www.news-medical.net/news/20090908/Active-cannabis-chemicals-halt-prostate-cancer-cell-  growth.aspx

 

Marijuana Chemicals Ease MS Symptoms, Review Confirms                (news – 2009)

http://www.drugfree.org/uncategorized/marijuana-chemicals-ease-ms

 

THC initiates brain cancer cells to destroy themselves                 (news – 2009)

http://www.worldhealth.net/news/thc_initiates_brain_cancer_cells_to_dest/

 

Active Component Of Marijuana Has Anti-Cancer Effects, Study Suggests (news – 2009)                                       http://www.sciencedaily.com/releases/2009/04/090401181217.htm

 

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition (full – 2010)                                 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917429/?tool=pmcentrez

 

Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)

http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17

 

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis                                                                (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898685/?tool=pmcentrez

 

Therapeutical use of the cannabinoids in psychiatry               (full – 2010)  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-  44462010000500009&lng=en&nrm=iso&tlng=en

 

Effect of (-)-Delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. (full – 2010)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-  879X2010007500015&lng=en&nrm=iso&tlng=en

 

The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.                                                          (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/?tool=pubmed

 

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial (full – 2010)                                 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/?tool=pmcentrez

 

Antidepressant-like effect of Delta(9)-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.                                                                (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/?tool=pubmed

 

Cannabinoid Administration Attenuates the Progression of Simian Immunodeficiency Virus       (full – 2010)                        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131805/

 

Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells              (full – 2010)

http://content.karger.com/produktedb/produkte.asp?DOI=000312686&typ=pdf

 

Disposition of Cannabichromene, Cannabidiol, and DELTA9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High- Performance Liquid Chromatography-Tandem Mass Spectrometry                                                                                                     (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023979/

 

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                                             (full – 2010)  http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html

 

Modulation of Adipocyte Biology by DELTA9-Tetrahydrocannabinol               (full – 2010)

http://onlinelibrary.wiley.com/doi/10.1038/oby.2010.100/full

 

Anti-tumoural effects of cannabinoid combinations  – Patent  TW201002315  (A) ― 2010-01-16            (full – 2010)

http://worldwide.espacenet.com/publicationDetails/description?CC=TW&NR=201002315A&KC=A&FT=  D&ND=3&date=20100116&DB=EPODOC&locale=en_EP

 

Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting                                                                      (link to PDF – 2010)  http://www.mdpi.com/1424-8247/3/9/2930

 

Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus.                                       (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/20417220/abstract/Delta9_tetrahydro       cannabinol_is

_a_full_agonist_at_CB1_receptors_on_GABA_neuron_axon_terminals_in_the_hippocampus_

 

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.           (abst – 2010)                                                     http://www.ncbi.nlm.nih.gov/pubmed/19896326

 

The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti- invasion activity at low concentration and apoptosis induction at high concentration. (abst – 2010)                                     http://www.ncbi.nlm.nih.gov/pubmed/19916793

 

Chronic cannabinoid administration lowers viral replication in lymph nodes of SIV infected Rhesus macaques                                                           (abst – 2010)  http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/752.6?maxtoshow=&hits=80&   RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=720&resourcetype=HWCIT

 

Exposure to a high-fat diet decreases sensitivity to DELTA9-tetrahydrocannabinol-induced motor effects in female rats                                                          (abst – 2010)     http://www.ncbi.nlm.nih.gov/pubmed/20850461

 

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study.                                                        (abst – 2010)         http://www.ncbi.nlm.nih.gov/pubmed/20884951

 

THC Prevents MDMA Neurotoxicity in Mice.             (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20174577

 

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform- selective and potent inhibitors of human CYP1 enzymes.                                                   (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20117100

 

Opposite Effects of DELTA-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology                                                                  (abst – 2010)  http://www.nature.com/npp/journal/v35/n3/full/npp2009184a.html

 

A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice.                                                                (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/19785914/abstract/A_behavioural_comparison_of_  acute_and_chronic_Delta9_tetrahydrocannabinol_and_cannabidiol_in_C57BL/6JArc_mice_

 

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study.                                                         (abst – 2010)      http://www.ncbi.nlm.nih.gov/pubmed/20884951

 

Oral Delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report.                                            (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20520294

 

Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by DELTA9-tetrahydrocannabinol                                                                                 (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20619971

 

Regulation of nausea and vomiting by cannabinoids                (abst – 2010)  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-  5381.2010.01176.x/abstract;jsessionid=56CED9CE51B025C161AA2E821BEC94ED.d01t01

 

Tocolytic Effect of DELTA9-Tetrahydrocannabinol in Mice Model of Lipopolysaccharide— Induced Preterm Delivery: Role of Nitric Oxide                                                           (abst – 2010)  http://rsx.sagepub.com/content/17/4/391.abstract

 

Key ingredient staves off marijuana memory loss                  (news – 2010)

http://www.nature.com/news/2010/101001/full/news.2010.508.html?s=news_rss

 

Marijuana May Extend Life Expectancy Of Lou Gehrig’s Disease Patients, Study Says (news – 2010)                                       http://www.norml.org/index.cfm?Group_ID=8191

 

Science: Cannabidiol enhances the anti-cancer effects of THC on human brain cancer cells           (news – 2010)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=313#3

 

Science: Cannabis effective in the treatment of TOURETTE Syndrome and attention deficit hyperactivity disorder (ADHD)                                                              (news – 2010)

http://www.cannabis-  med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=323&search_pattern=tourette#2

 

A New Use for Medical Marijuana?                   (news – 2010)

http://consults.blogs.nytimes.com/2010/03/31/a-new-use-for-medical-marijuana/

 

Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: Evidence from an experimental murine model.                                                            (full – 2011)  http://jpet.aspetjournals.org/content/early/2011/06/14/jpet.111.182717.long

 

Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa (full – 2011)  https://www.jstage.jst.go.jp/article/bpb/34/5/34_5_774/_pdf

 

Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial

(full – 2011)               http://annonc.oxfordjournals.org/content/early/2011/02/11/annonc.mdq727.full

 

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.      (full – 2011)                          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

 

Prospects for cannabinoid therapies in basal ganglia disorders.              (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165947/

 

Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study.                                                                   (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096803/

 

US Patent Application 20110257256 – CANNABINOIDS FOR USE IN TREATING OR PREVENTING COGNITIVE IMPAIRMENT AND DEMENTIA                                       (full – 2011)

http://www.patentstorm.us/applications/20110257256/fulltext.html

 

Influence of agroclimatic conditions on content of main cannabinoids in industrial hemp (Cannabis sativa L.)                                                 (full– 2011)

http://www.doiserbia.nb.rs/img/doi/0534-0012/2011/0534-00121103449S.pdf

 

Cannabinoid Neuroimmune Modulation of SIV Disease.            (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208744/

 

Tolerance to chronic delta-9-tetrahydrocannabinol (DELTA⁹-THC) in rhesus macaques infected

with simian immunodeficiency virus.                  (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21463073/abstract/Tolerance_to_chronic_delta_9_

tetrahydrocannabinol__%CE%94%E2%81%B9_THC  nodeficiency_virus_

in_rhesus_macaques_infected_with_simian_immu

 

Cannabidiol potentiates DELTA(9)-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.

(abst – 2011)                 http://www.ncbi.nlm.nih.gov/pubmed/21667074

 

Combined effects of THC and caffeine on working memory in rats.               (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21699509

 

Behavioral alterations in cystic fibrosis mice are prevented by cannabinoid treatment in infancy   (abst – 2011)

http://www.degruyter.com/abstract/j/jbcpp.2011.22.issue-1-  2/jbcpp.2011.005/jbcpp.2011.005.xml?rskey=wRYgJd&result=2&q=cannabinoid

 

DELTA(9)-THC and WIN55,212-2 affect brain tissue levels of excitatory amino acids in a phenotype-, compound-, dose-, and region-specific manner                                                                     (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21645556/abstract/%CE%94_9

THC_and_WIN5

5212_2_affect_brain_tissue_levels_of_excitatory_amino_acids_in_a_phenotype__compound

_region_specific_manner_

dose__and

 

The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.      (abst – 2011)

 

http://www.unboundmedicine.com/medline/ebm/record/21449917/abstract/The_fatty_acid_amide_hydrolas e_inhibitor_URB_597:_interactions_with_anandamide_in_rhesus_monkeys_

 

Effects of synthetic cannabinoids on electroencephalogram power spectra in rats. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabino  ids_on_electroencephalogram_power_spectra_in_rats_

 

THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis.                                                     (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21456949/abstract/THC_and_CBD_oromucosal_s

pray

Sativex%C2%AE

in_the_management_of_spasticity_associated_with_multiple_sclerosis_

 

Plasma cannabinoid pharmacokinetics following controlled oral delta9- tetrahydrocannabinol and oromucosal cannabis extract administration                                                                              (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21078841/abstract/Plasma_cannabinoid_pharmaco  kinetics_following_controlled_oral_delta9_tetrahydrocannabinol_and_oromucosal_cannabis_extract_admi  nistration_

 

Pharmacokinetics of a combination of DELTA9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock.                                                                 (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21341278/abstract/Pharmacokinetics_of_a_combin  ation_of_%CE%949_tetrahydro_cannabinol_and_celecoxib_in_a_porcine_model_of_hemor       rhagic_shock_

 

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and DELTA(9) -tetrahydrocannabinol in BV-2 microglial cells                                   (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21542829/abstract/Differential_transcriptional_pro

files_mediated_by_exposure_to_the_cannabinoids_cannabidiol_and_%CE%94_9

_in_BV_2_microglial_cells_

tetrahydrocannabinol

 

Pre- and post-conditioning treatment with an ultra-low dose of DELTA9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage.

(abst – 2011)                  http://www.ncbi.nlm.nih.gov/pubmed/21315768

 

Heterogeneity in the composition of marijuana seized in California.                (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21288662/abstract/Heterogeneity_in_the_composit  ion_of_marijuana_seized_in_California_

 

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.                                                   (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21175579/abstract/Effects_of_cannabinoids_and_c annabinoid_enriched_Cannabis_extracts_on_TRP_channels_and_endocannabinoid_metabolic_enzymes_

 

Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by DELTA9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2011)

http://jpet.aspetjournals.org/content/340/3/787.abstract?sid=2ef42c80-59ad-4b4e-8eed-d5b9d556b866

 

Ingredient in cannabis restores taste for cancer patients                (news – 2011)

http://phys.org/news/2011-02-ingredient-cannabis-cancer-patients.html

 

Marijuana Compound Treats Multiple Health Issues               (news – 2011)

http://www.foxnews.com/health/2010/03/10/cannabis-deficient/

 

Another Study Confirms Anti-Cancer Effects of THC and CBD               (news – 2011)  http://www.examiner.com/medical-marijuana-in-philadelphia/another-study-confirms-anti-cancer-effects-  of-thc-and-cbd-1

 

Synaptic Targets of DELTA9-Tetrahydrocannabinol in the Central Nervous System. (full – 2012)  http://perspectivesinmedicine.cshlp.org/content/early/2012/12/03/cshperspect.a012237.long

 

The cannabinoid receptor agonist THC attenuates weight loss in a rodent model of activity-based anorexia.        (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096804/?tool=pubmed

 

Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report. (full – 2012)                                    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2012.01365.x/full

 

GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                                   http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full

 

Towards the use of non-psychoactive cannabinoids for prostate cancer.               (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02121.x/pdf

 

So what do we call GPR18 now?               (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01731.x/full

 

DELTA9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells                                                           (full – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01497.x/full

 

NANOENCAPSULATED DELTA-9-TETRAHYDROCANNABINOL   – Patent US2012052119  (A1) ― 2012-03-01                                                                     (full – 2012)

http://worldwide.espacenet.com/publicationDetails/description?CC=US&NR=2012052119A1&KC=A1&F   T=D&ND=3&date=20120301&DB=EPODOC&locale=en_EP

 

Review article: The endocannabinoid system in normal and pathological brain ageing (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/23108550

 

DELTA(9) -THC exerts a direct neuroprotective effect in a human cell culture model of Parkinson’s disease.     (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/22236282

 

Effect of delta-9-tetrahydrocannabinol on behavioral despair and on presynaptic and postsynaptic serotonergic transmission.                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22386778

 

Heat Exposure of Cannabis sativa Extracts Affects the Pharmacokinetic and Metabolic Profile in Healthy Male Subjects.                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22411724

 

Rimonabant eliminates responsiveness to workload changes in a time-constrained food- reinforced progressive ratio procedure in rats.                                                               (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22425597

 

A critical review of the antipsychotic effects of Cannabidiol: 30 years of a translational investigation.     (abst – 2012)                             http://www.ncbi.nlm.nih.gov/pubmed/22716160

 

Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22623656

 

Cannabinoid Receptor Activity In The Tumour Necrosis Factor (tnf)−α-Induced Increased Contractility Of The Guinea-Pig Isolated Trachea                                                                   (abst – 2012)  http://ajrccm.atsjournals.org/cgi/reprint/185/1_MeetingAbstracts/A2154?maxtoshow=&hits=25&RESULT   FORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCI   T

 

Effects of cannabinoids DELTA(9)-tetrahydrocannabinol, DELTA(9)-tetrahydrocannabinolic acid and cannabidiol in MPP(+) affected murine mesencephalic cultures.                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22571976

 

Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers.                                                        (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22716148

 

Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by DELTA9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2012)

http://jpet.aspetjournals.org/content/340/3/787.abstract?sid=ae58f15a-06bb-4a81-b850-61bb89fd59f5

 

Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.               (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22791906

 

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.                                                                                                (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23180178

 

Effect of ion pairing on in vitro transcorneal permeability of a DELTA(9) -tetrahydrocannabinol prodrug: potential in glaucoma therapy.                                                   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/21989812

 

Single-dose Pharmacokinetics and Tolerability of Oral Delta-9-Tetrahydrocannabinol in Patients with Amyotrophic Lateral Sclerosis.                                                          (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22594565

 

Cannabinoid facilitation of fear extinction memory recall in humans.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22796109

 

Manipulating brain connectivity with Delta(9)-tetrahydrocannabinol: A pharmacological resting state FMRI study.                                                       (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22885247

 

Brain regional differences in CB1 receptor adaptation and regulation of transcription. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22940268

 

Cannabinoid CB(1) receptor in the modulation of stress coping behaviour in mice: the role of serotonin and different forebrain neuronal subpopulations.                                                   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23000076

 

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.                                              (abst – 2012)          http://www.ncbi.nlm.nih.gov/pubmed/23042808

 

Diuretic effects of cannabinoids.  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23019138

 

The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23063785

 

DELTA9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice.                 (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23075707

 

△9-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection:

Role of Antigen Presenting Cells and the Cannabinoid Receptors 1 and 2.            (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23152191

 

Acute effects of THC on time perception in frequent and infrequent cannabis users (abst – 2012)                                       http://link.springer.com/article/10.1007%2Fs00213-012-2915-6

 

Treatment of Tourette syndrome with cannabinoids.               (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23187140

 

Magnitude of stimulation dictates the cannabinoid-mediated differential T cell response to HIVgp120.  (abst – 2012)                           http://www.ncbi.nlm.nih.gov/pubmed/22899554?dopt=Abstract

 

What place for cannabis extract in MS?            (abst – 2012)

http://dtb.bmj.com/content/50/12/141.abstract

 

Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR.                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23280038

 

Pharmacological modulation of the endocannabinoid signalling alters binge-type eating behaviour in female rats                                                        (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/bph.12014/abstract

 

Researchers study neuroprotective properties in cannabis              (news – 2012)

http://www.foxnews.com/health/2012/03/20/researchers-study-neuroprotective-properties-in-cannabis/

 

Simple Method: Isolating & Extracting INDIVIDUAL Cannabinoids… from BadKittySmiles     (forum post – 2012)

http://forum.grasscity.com/incredible-edible-herb/1051569-simple-method-isolating-extracting-individual-  cannabinoids-badkittysmiles.html

 

Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)

http://www.nature.com/npp/journal/vaop/naam/pdf/npp201331a.pdf

 

Towards the use of non-psychoactive cannabinoids for prostate cancer               (full – 2013)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02121.x/abstract

 

Amygdala activity contributes to the dissociative effect of cannabis on pain perception. (abst – 2013)                                   http://www.ncbi.nlm.nih.gov/pubmed/23273106

 

Differential Expression of Intracellular and Extracellular CB(2) Cannabinoid Receptor Protein by Human Peripheral Blood Leukocytes.                                                                (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23299999

 

Surinabant, a selective CB(1) antagonist, inhibits THC-induced central nervous system and heart rate effects in humans.                                                       (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23278647

 

Prior Exposure to THC Increases the Addictive Effects of Nicotine in Rats. (abst – 2013)                                   http://www.ncbi.nlm.nih.gov/pubmed/23314220

 

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme.                                                  (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23349970

 

DELTA9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2.                                                             (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23152191

 

Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.          (abst – 2013)                          http://www.ncbi.nlm.nih.gov/pubmed/23369054

 

A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany.                                                          (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23369055

 

Cannabis and DELTA(9)-tetrahydrocannabinol (THC) for weight loss?                   (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23410498

 

Science/Human: THC reduces sleep apnoea in small clinical study                     (news – 2013)  http://www.cannabis-  med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=392&search_pattern=2013#2

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