The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation.                                                                (abst – 1989)


HU-211, a Novel Noncompetitive N-Methyl-D-Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat           (full – 1995)                                           


Marijuana chemical tapped to fight strokes ?                     (news – 1998)


Dope hope for stroke victims                        (news – 1998)


Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures       (full – 1999)




Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. (abst – 1999)                                  


Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)  xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top


Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. (full – 2003)                                      


US Patent 6630507 – Cannabinoids as antioxidants and neuroprotectants                     (full – 2003)


Post-ischemic Treatment with Cannabidiol Prevents Electroencephalographic Flattening, Hyperlocomotion and Neuronal Injury in Gerbils.                                                          (abst – 2003)


Therapeutic potential of cannabinoids in CNS disease.                      (abst – 2003)


Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. (abst – 2004)                                 


Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine1A Receptor–Dependent Mechanism                                                   (full – 2005)


Medical marijuana: study shows that THC slows atherosclerosis                 (news – 2005)


Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats. (abst – 2006)


The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis                                                                 (full – 2007)


Cannabinoid CB2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model (full – 2007)


Δ9-Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors                                                              (full – 2007)


Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.                                                    (full – 2007)


Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.                                                           (abst – 2007)





The endocannabinoid system and neurogenesis in health and disease.                (abst – 2007)


Role of cannabinoids and endocannabinoids in cerebral ischemia             (full – 2008)


Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury                                         (full – 2008)


Cannabinoid receptors in acute and chronic complications of atherosclerosis (full – 2008)                       


Endocannabinoids and cannabinoid receptors in ischaemia–reperfusion injury and preconditioning          (full – 2008)


Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism.                                                        (abst – 2008)


Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia. (abst – 2008)                                  


Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke.            (full – 2009)    


Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high- mobility group box1-inhibiting mechanism.                                                 (full – 2009)


Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death.  (abst – 2009)             


CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.   (abst – 2009)                                                             


Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.     (full – 2010)                             


Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke (link to PDF – 2010)                                       


The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.           (abst – 2010)                                       


The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. (abst – 2010)                          


The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic- ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. (abst – 2010)   cannabidiol_in_an_in_vitro_model_of_newborn_hypoxic_ischemic_brain_damage_in_mice_is_mediated_




Targeting the Endocannabinod System to Limit Myocardial and Cerebral Ischemic and Reperfusion Injury.                                             (abst – 2011)



Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia- ischemia in newborn pigs.                                                       (abst – 2011)


Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.                                                          (abst – 2011)


Contribution of Hypothermia and CB(1) Receptor Activation to Protective Effects of TAK-937, a Cannabinoid Receptor Agonist, in Rat Transient MCAO Model.

(full– 2012)      


Update on the role of cannabinoid receptors after ischemic stroke.             (full – 2012)


Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model     (full – 2012)


Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates.                                                         (abst – 2012)


Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection. (abst – 2012)                            


The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia.                                                      (abst – 2012)


Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke.                                                 (abst – 2012)


The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.                                                                      (abst – 2012)


Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor α.                                                                  (abst – 2012)


Cannabinoid Receptor Subtypes 1 and 2 Mediate Long-Lasting Neuroprotection and Improve Motor Behaviour Deficits After Transient Focal Cerebral Ischemia.

(abst – 2012)     


WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats.                                                          (abst – 2012)


WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.                                                                                      (abst – 2012)


Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats                                                                    (abst – 2012)


“A Marijuana Bud a Day Keeps the Stroke Away”                    (news – 2012)


WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.                                                                                              (abst – 2013)


Is the cardiovascular system a therapeutic target for cannabidiol?                     (abst – 2013)

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