STROKE– also see PERINATAL HYPOXIC-ISCHEMIC INJURY

 

The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation.                                                                (abst – 1989)  http://www.ncbi.nlm.nih.gov/pubmed/2575149

 

HU-211, a Novel Noncompetitive N-Methyl-D-Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat           (full – 1995)                                                     http://stroke.ahajournals.org/cgi/content/full/26/12/2313

 

Marijuana chemical tapped to fight strokes ?                     (news – 1998)

http://www.sciencenews.org/pages/sn_arc98/7_11_98/fob2.htm

 

Dope hope for stroke victims                        (news – 1998)

http://news.bbc.co.uk/2/hi/science/nature/126181.stm

 

Cannabinoids and Neuroprotection in Global and Focal Cerebral Ischemia and in Neuronal Cultures       (full – 1999)  http://www.jneurosci.org/cgi/content/full/19/8/2987?maxtoshow=&hits=80&RESULTFORMAT=&fulltext

=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype

=HWCIT

 

Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. (abst – 1999)                                            http://www.ncbi.nlm.nih.gov/pubmed/10202976

 

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)

http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top

 

Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. (full – 2003)                                                http://stroke.ahajournals.org/cgi/reprint/34/8/2000

 

US Patent 6630507 – Cannabinoids as antioxidants and neuroprotectants                     (full – 2003)

http://www.patentstorm.us/patents/6630507/fulltext.html

 

Post-ischemic Treatment with Cannabidiol Prevents Electroencephalographic Flattening, Hyperlocomotion and Neuronal Injury in Gerbils.                                                          (abst – 2003)  http://www.sciencedirect.com/science/article/pii/S030439400300569X

 

Therapeutic potential of cannabinoids in CNS disease.                      (abst – 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

 

Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. (abst – 2004)                                           http://www.ncbi.nlm.nih.gov/pubmed/15640760

 

Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine1A Receptor–Dependent Mechanism                                                   (full – 2005)  http://stroke.ahajournals.org/cgi/content/full/36/5/1071

 

Medical marijuana: study shows that THC slows atherosclerosis                 (news – 2005)

http://thenexthurrah.typepad.com/the_next_hurrah/2005/04/medical_marijua.html

 

Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats. (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16864698

 

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis                                                                 (full – 2007)     http://www.jbc.org/content/282/33/23892.full

 

Cannabinoid CB2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637559/?tool=pmcentrez

 

Δ9-Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors                                                              (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189998/?tool=pmcentrez

 

Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.                                                    (full – 2007)   http://www3.interscience.wiley.com/cgi-bin/fulltext/118484119/HTMLSTART

 

Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent hypothermia.                                                           (abst – 2007)

 

 

 

 

The endocannabinoid system and neurogenesis in health and disease.                (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17404371

 

Role of cannabinoids and endocannabinoids in cerebral ischemia             (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581413/?tool=pmcentrez

 

Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury                                         (full – 2008)  http://science.iowamedicalmarijuana.org/pdfs/neuro/Zhang%202008.pdf

 

Cannabinoid receptors in acute and chronic complications of atherosclerosis (full – 2008)                                 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219535/?tool=pmcentrez

 

Endocannabinoids and cannabinoid receptors in ischaemia–reperfusion injury and preconditioning          (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219536/?tool=pmcentrez

 

Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism.                                                        (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18634812

 

Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia. (abst – 2008)                                            http://www.ncbi.nlm.nih.gov/pubmed/18823959.

 

Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke.            (full – 2009)              http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855650/?tool=pubmed

 

Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high- mobility group box1-inhibiting mechanism.                                                 (full – 2009)  https://www.jstage.jst.go.jp/article/bpb/32/9/32_9_1538/_pdf

 

Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death.  (abst – 2009)                       http://www.ncbi.nlm.nih.gov/pubmed/19087195

 

CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.   (abst – 2009)                                                                       http://www.ncbi.nlm.nih.gov/pubmed/19332079

 

Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.     (full – 2010)                                       http://www.fasebj.org/content/24/3/788.long

 

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke (link to PDF – 2010)                                                 http://www.mdpi.com/1424-8247/3/7/2197

 

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.           (abst – 2010)                                                 http://www.ncbi.nlm.nih.gov/pubmed/20875047

 

The cannabinoid WIN55212-2 promotes neural repair after neonatal hypoxia-ischemia. (abst – 2010)                                    http://www.ncbi.nlm.nih.gov/pubmed/21115947

 

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic- ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/19900555/abstract/The_neuroprotective_effect_of_   cannabidiol_in_an_in_vitro_model_of_newborn_hypoxic_ischemic_brain_damage_in_mice_is_mediated_

 

 

 

Targeting the Endocannabinod System to Limit Myocardial and Cerebral Ischemic and Reperfusion Injury.                                             (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21470162/abstract/Targeting_the_Endocannabinod

_System_to_Limit_Myocardial_and_Cerebral_Ischemic_and_Reperfusion_Injury_

 

Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia- ischemia in newborn pigs.                                                       (abst – 2011)         http://www.ncbi.nlm.nih.gov/pubmed/21654550

 

Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.                                                          (abst – 2011)      http://www.ncbi.nlm.nih.gov/pubmed/21145311

 

Contribution of Hypothermia and CB(1) Receptor Activation to Protective Effects of TAK-937, a Cannabinoid Receptor Agonist, in Rat Transient MCAO Model.

(full– 2012)                http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397930/?tool=pubmed

 

Update on the role of cannabinoid receptors after ischemic stroke.             (full – 2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337695/?tool=pubmed

 

Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model     (full – 2012)  http://link.springer.com/article/10.1007/s00259-012-2209-6/fulltext.html

 

Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates.                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22119394

 

Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/22020035

 

The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia.                                                      (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/21909954

 

Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke.                                                 (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22285309

 

The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.                                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22420307

 

Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor α.                                                                  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22480617

 

Cannabinoid Receptor Subtypes 1 and 2 Mediate Long-Lasting Neuroprotection and Improve Motor Behaviour Deficits After Transient Focal Cerebral Ischemia.

(abst – 2012)               http://www.ncbi.nlm.nih.gov/pubmed/23069763

 

WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats.                                                          (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23202804

 

WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.                                                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23202804

 

Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats                                                                    (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23192660

 

“A Marijuana Bud a Day Keeps the Stroke Away”                    (news – 2012)

http://www.tokeofthetown.com/2012/04/a_marijuana_bud_a_day_keeps_the_stroke_away.php

 

WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination.                                                                                              (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23148948

 

Is the cardiovascular system a therapeutic target for cannabidiol?                     (abst – 2013)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04351.x/abstract

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