SPICE – various synthetic cannabinoid mixtures – also see the HU, JWH, and CP series

 

Withdrawal Phenomena and Dependence Syndrome After the Consumption of “Spice Gold”       (full – 2009)                            http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719097/?tool=pmcentrez

 

Spice: a never ending story?                   (abst – 2009)     http://www.ncbi.nlm.nih.gov/pubmed/19589652

 

Synthetic cannabis mimic found in herbal incense                (news – 2009)

http://www.rsc.org/chemistryworld/News/2009/January/15010901.asp

 

Pharmacological properties and dependence liabilities of synthetic cannabinoids (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/20681249/abstract/%5BPharmacological_propertie  s_and_dependence_liabilities_of_synthetic_cannabinoids%5D_

 

Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. (abst – 2010)                                  http://www.ncbi.nlm.nih.gov/pubmed/20117892

 

Spice drugs as a new trend: mode of action, identification and legislation.           (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20566335

 

Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds.                                                       (abst – 2010)       http://www.ncbi.nlm.nih.gov/pubmed/20857386

 

Inhaled Incense “K2” May Cause Heart Damage              (news – 2010)

http://drwes.blogspot.com/2010/08/inhaled-incense-k2-may-cause-heart.html

 

The New Cannabinoids            (news – 2010)

http://www.wellsphere.com/drug-addiction-article/the-new-cannabinoids/1247426

 

Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full – 2011)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed

 

Beyond THC: The New Generation of Cannabinoid Designer Drugs.            (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed

 

Investigating a not-so-natural high.               (full – 2011)

http://pubs.acs.org/doi/full/10.1021/ac900564u

 

Convulsions Associated with the Use of a Synthetic Cannabinoid Product.           (full – 2011)

http://www.springerlink.com/content/9651q2672027n38g/fulltext.html

 

Psychosis Associated With Synthetic Cannabinoid Agonists: A Case Series (letter – 2011)                                    http://ajp.psychiatryonline.org/cgi/content/full/168/10/1119

 

The “new” marijuana.             (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/21325097

 

Liquid chromatography-tandem mass spectrometry analysis of urine specimens for K2 (JWH-018) metabolites.                                                     (abst– 2011)      http://www.ncbi.nlm.nih.gov/pubmed/21871158

 

The impact of changes in UK classification of the synthetic cannabinoid receptor agonists in ‘Spice’.       (abst – 2011)                     http://www.ncbi.nlm.nih.gov/pubmed/21482092

 

Synthetic cannabinoid use in New Zealand: a brief evaluation of inquiries to the New Zealand National Poisons Centre                                                            (abst – 2011)  http://journal.nzma.org.nz/journal/124-1347/5004/

 

 Severe toxicity following synthetic cannabinoid ingestion.               (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21970775

 

The emergence and analysis of synthetic cannabinoids.                (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21337724

 

Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in “herbal high” products.                                                                  (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/20529459

 

“Spice” girls: synthetic cannabinoid intoxication.             (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21167669

 

Three cases of “spice” exposure.               (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21740143

 

“Legal highs” – new players in the old drama.             (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21711229

 

Comparison of “herbal highs” composition.              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21318244

 

Synthetic cannabinoid use: a case series of adolescents.              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21939863

 

Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K2. (abst – 2011)                                     http://www.ncbi.nlm.nih.gov/pubmed/22065271

 

Cytotoxicity of synthetic cannabinoids found in “Spice” products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line.                                                        (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21907772/abstract/Cytotoxicity_of_synthetic_cann abinoids_found_in_%22Spice%22_products:_the_role_of_cannabinoid_receptors_and_the_caspase_cascad e_in_the_NG_108_15_cell_line_

 

High-performance sport, marijuana, and cannabimimetics.              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22080902

 

Effects of synthetic cannabinoids on electroencephalogram power spectra in rats. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabino   ids_on_electroencephalogram_power_spectra_in_rats_

 

Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21441120/abstract/Marijuana_based_drugs:_innov ative_therapeutics_or_designer_drugs_of_abuse

 

Detection of synthetic cannabinoids in herbal incense products.              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21741374

 

Synthetic cannabinoids–the new “legal high” drugs              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/22352277

 

1 in 9 high school seniors using synthetic marijuana                 (news – 2011)

http://thechart.blogs.cnn.com/2011/12/14/1-in-9-high-school-seniors-using-synthetic-marijuana/

 

‘Fake Marijuana’ May Trigger Heart Trouble in Teens                (news – 2011)

http://health.yahoo.net/news/s/hsn/fakemarijuanamaytriggerhearttroubleinteens

 

Texas teens had heart attacks after smoking K2                (news – 2011)

http://www.reuters.com/article/2011/11/07/us-teens-heart-attacks-smoking-idUSTRE7A66TN20111107

 

Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation            (news – 2011)                       http://www.justice.gov/dea/pubs/pressrel/pr030111.html

 

A Characterization of Synthetic Cannabinoid Exposures Reported to the National Poison Data System in 2010  (full – 2012)  http://www.annemergmed.com/webfiles/images/journals/ymem/FA-cohoyte.pdf

 

Acute mental disturbance caused by synthetic cannabinoid: a potential emerging substance of abuse in Hong Kong.                                                                       (full – 2012)  http://easap.asia/journal_file/1201_V22N1_p31.pdf

 

Characterization of In Vitro Metabolites of CP 47,497, a Synthetic Cannabinoid, in Human Liver Microsomes by LC-MS/MS.                                                                (full – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1556-4029.2012.02261.x/full

 

Using dopamine research to generate rational cannabinoid drug policy.             (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1002/dta.1410/full

 

Synthetic legal intoxicating drugs: The emerging ‘incense’ and ‘bath salt’ phenomenon (full – 2012)  http://www.ccjm.org/content/79/4/258.abstract?ijkey=5c626a27db768c92b048d2d30e94a1a6421fe767&ke  ytype2=tf_ipsecsha

 

Acute Intoxication Caused by a Synthetic Cannabinoid in Two Adolescents (full – 2012)                                     http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470439/

 

A survey study to characterize use of Spice products (synthetic cannabinoids). (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/21835562

 

Identification and structural characterization of the synthetic cannabinoid 3-(1- adamantoyl)-1-pentylindole as an additive in ‘herbal incense’. (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22359329

 

Headache after substance abuse: A diagnostic dilemma.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22245279

 

Synthetic cannabinoid use: recognition and management.               (abst – 2012)

 

http://www.ncbi.nlm.nih.gov/pubmed/22418399

 

Detection and disposition of JWH-018 and JWH-073 in mice after exposure to “Magic Gold” smoke.      (abst – 2012)                           http://www.ncbi.nlm.nih.gov/pubmed/22405481

 

Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids.                                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22561602

 

“Spice” and “k2” herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans.                                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22691010

 

Detection and quantification of new designer drugs in human blood: part 1 – synthetic cannabinoids.       (abst – 2012)                           http://www.ncbi.nlm.nih.gov/pubmed/22593567

 

Spice: a new “legal” herbal mixture abused by young active duty military personnel. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22489593

 

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.          (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22266354

 

Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction                                                       (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1002/jms.3020/abstract

 

Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples.     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22576873

 

Risky Recreation: Synthetic Cannabinoids Have Dangerous Effects.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22801822

 

The spice in France: mixed herbs containing synthetic cannabinoids.                (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22796613

 

Internet Highs-Seizures After Consumption of Synthetic Cannabinoids Purchased Online. (abst – 2012)                                   http://www.ncbi.nlm.nih.gov/pubmed/22824736

 

Prevalence of Synthetic Cannabinoids in U.S. Athletes: Initial Findings. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22872465

 

Synthetic cannabinoid and marijuana exposures reported to poison centers.   (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22859662

 

Ultra high performance liquid chromatography-electrospray ionization-tandem mass spectrometry screening method for direct analysis of designer drugs, “spice” and stimulants in oral fluid.    (abst – 2012)                                                      http://www.ncbi.nlm.nih.gov/pubmed/22939380

 

First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.                                                  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22936123

 

Synthetic Cannabinoid Intoxication: A Case Series and Review.               (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22989695

 

Synthetic Cannabinoid and Cathinone Use Among US Soldiers.             (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23007932

 

Adolescent Synthetic Cannabinoid Exposures Reported to Texas Poison Centers. (abst – 2012)                                        http://www.ncbi.nlm.nih.gov/pubmed/23023462

 

URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products.       (abst – 2012)                    http://www.ncbi.nlm.nih.gov/pubmed/23063179

 

DNA sequence analyses of blended herbal products including synthetic cannabinoids as designer drugs.                                       (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/23092848

 

Identification, extraction and quantification of the synthetic cannabinoid JWH-018 from commercially available herbal marijuana alternatives.                                                        (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23092847

 

Inhalation exposure to smoke from synthetic “marijuana” produces potent cannabimimetic effects in mice.                                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22776442

 

Determination of 22 synthetic cannabinoids in human hair by liquid chromatography- tandem mass spectrometry.                                                         (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22835826

 

Synthetic cannabinoids in “spice-like” herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market.                                                           (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22748479

 

Patterns of synthetic cannabinoid use in Australia                  (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1465-3362.2012.00519.x/abstract

 

Determination of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in mouse blood and tissue after inhalation exposure to ‘buzz’ smoke by HPLC/MS/MS

(abst – 2012)               http://onlinelibrary.wiley.com/doi/10.1002/bmc.2710/abstract

 

 

Synthetic cannabis and respiratory depression.                 (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23234589

 

AKI Associated with Synthetic Cannabinoids: A Case Series.                (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23243266

 

‘Hammer Head’ ‘incense’ blamed for seizure of youth in Le Roy             (news – 2012)

http://thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983

 

Synthetic marijuana was created strictly for research at Clemson (news – 2012)  http://www.timesnews.net/article/9042095/synthetic-marijuana-was-created-strictly-for-research-at-  clemson

 

Outbreak of kidney failure in Wyoming linked to “Spice”                 (news – 2012)

http://www.reuters.com/article/2012/03/03/us-spice-illness-wyoming-idUSTRE82204T20120303

 

‘Spice’-y Party Drugs Can Lead to the ED               (news – 2012)

http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/32690

 

Wyoming kidney failure outbreak linked to designer ‘blueberry spice’ drug, aka ‘legal marijuana’  (news – 2012)  http://www.naturalnews.com/035181_spice_recreational_drugs_kidney_failure.html

 

Blueberry “spice” in Wyoming linked to cases of renal failure                  (news – 2012)

http://www.thepoisonreview.com/2012/03/03/blueberry-spice-in-wyoming-linked-to-cases-of-renal-failure/

 

New health concerns about ‘fake pot’ in US              (news – 2012)

http://medicalxpress.com/news/2012-03-health-fake-pot.html

 

Tachycardia followed by bradycardia after smoking the synthetic cannabinoid “K9″ (news – 2012)                                       http://www.thepoisonreview.com/2012/05/22/tachycardia-followed-by-  bradycardia-after-smoking-the-synthetic-cannabinoid-k9/

 

Synthetic marijuana sent more than 11,400 people to ER in 2010                 (news – 2012)  http://www.cbsnews.com/8301-204_162-57557080/synthetic-marijuana-sent-more-than-11400-people-to-  er-in-2010/

 

Acute Kidney Injury Associated with Synthetic Cannabinoid Use — Multiple States, 2012          (report – 2013)                        http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6206a1.htm

 

Suicidal ideation and self-harm following K2 use.               (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23304900

 

Synthetic cannabis: A comparison of patterns of use and effect profile with natural cannabis in a large global sample.                                                         (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23291209

 

Prevalence of new designer drugs and their legal status in Japan.               (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23292017

 

Synthetic Cannabinoid Overdose in a 20-Year-Old Male US Soldier.            (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23327506

 

Kronic hysteria: Exploring the intersection between Australian synthetic cannabis legislation, the media, and drug-related harm.                                                                           (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23333135

 

Identification and Structural Elucidation of Four Cannabimimetic Compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in Seized Products.                                                               (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23339188

 

Symptoms, toxicities, and analytical results for a patient after smoking herbs containing the novel synthetic cannabinoid MAM-2201                                                    (abst – 2013)  http://link.springer.com/article/10.1007/s11419-012-0166-1

 

Synthetic Marijuana Dangerous for Kidneys                   (news – 2013)

http://www.sciencedaily.com/releases/2013/02/130208124553.htm

 

Study: Consumers Prefer Natural Cannabis Over Synthetic ‘Marijuana’ Herbal Products (news – 2013)

http://norml.org/news/2013/01/10/study-consumers-prefer-natural-cannabis-over-synthetic-marijuana-  herbal-products

 

Synthetic Marijuana Harms Kidneys of 16 Users, CDC Reports                      (news – 2013)

http://news.yahoo.com/synthetic-marijuana-harms-kidneys-16-users-cdc-reports-170208780.html

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