SEPTIC SHOCK

 

Protection Against Septic Shock and Suppression of Tumor Necrosis Factor α and Nitric Oxide Production by Dexanabinol (HU-211), a Nonpsychotropic Cannabinoid

(full – 1997)                     http://jpet.aspetjournals.org/content/283/2/918.full

 

Cardiovascular actions of cannabinoids and their generation during shock.                  (abst – 1998)

http://www.ncbi.nlm.nih.gov/pubmed/9846953

 

Endocannabinoid Degradation, Endotoxic Shock and Inflammation (link to PDF – 2002)                                                      http://www.eurekaselect.com/91915/article

 

Presynaptic cannabinoid CB1 receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats                                                                      (full – 2004)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575049/?tool=pmcentrez

 

Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats                                                                       (full – 2005)  http://bja.oxfordjournals.org/content/94/5/563.full

 

Effects of AM281, a cannabinoid antagonist, on circulatory deterioration and cytokine production in an endotoxin shock model: comparison with norepinephrine.

(abst – 2006)                           http://www.ncbi.nlm.nih.gov/pubmed/17072693

 

The cannabinoid receptor 2 is critical for the host response to sepsis.                      (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763235/?tool=pubmed

 

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full – 2010)                                         http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?tool=pubmed

 

 

 

 

 

 

 

 

Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture.                                                      (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20561509

 

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study                                                     (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034694/?tool=pmcentrez

 

The endocannabinoid system in sepsis – a potential target to improve microcirculation? (full – 2011)

http://www.signavitae.com/articles/review-articles/161-the-endocannabinoid-system-in-sepsis-a-potential-  target-to-improve-microcirculation

 

Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis                                                            (full – 2012)  http://ccforum.com/content/16/2/R47

 

Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.       (abst – 2012)                                           http://www.ncbi.nlm.nih.gov/pubmed/22504215

 

Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut.                                                                               (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23382309

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