R(+)-METHANANANDAMIDE– synthetic, anandamide analog


(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability         (abst – 1994)                                          http://www.ncbi.nlm.nih.gov/pubmed/8021930


Cannabinoids might reduce spasticity in multiple sclerosis                       (full – 2000)



Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.                                                               (abst – 2002)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=12428277&dopt=abstrac tplus


Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors                                                                             (abst – 2002)  http://www.ncbi.nlm.nih.gov/pubmed/12227101





Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells                                                                  (full – 2004)  http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz%202004.pdf


Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma         (full – 2006)                                                http://molpharm.aspetjournals.org/content/70/5/1612.full


R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase- 2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells.









(full – 2006)               http://jpet.aspetjournals.org/content/316/3/1219.long


Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.                                                            (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769340/?tool=pubmed


R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells.                                                                (abst – 2006)  http://www.springerlink.com/content/l403431l1728x733/


Loss of cannabinoid receptor 1 accelerates intestinal tumor growth                  (full – 2008)



Cannabinoids enhance gastric X/A-like cells activity.                 (full – 2008)



Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation.                                                                (full – 2008)  http://onlinelibrary.wiley.com/doi/10.1002/ijc.23584/full


Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)- Methanandamide and JWH-015: Involvement of CB2                                                                     (full – 2009)  http://www.nature.com/bjc/journal/v101/n6/full/6605248a.html


Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.                                                         (full – 2009)  http://mcr.aacrjournals.org/content/7/7/1086.long


Cannabinoid Receptor Activation Protects Coronary Endothelium Against Reperfusion Induced Intercellular Gap Formation in a Cellular Model of Ischemia and Reperfusion (abst – 2009)  http://circ.ahajournals.org/cgi/content/meeting_abstract/120/18_MeetingAbstracts/S1072-

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The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.          (abst – 2009)                       http://www.ncbi.nlm.nih.gov/pubmed/19908944


R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway.                                              (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19015962


Energetic Metabolism and Human Sperm Motility: Impact of CB1 Receptor Activation (full – 2010)                                    http://endo.endojournals.org/content/151/12/5882.full


Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. (full – 2011)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037938/?tool=pubmed









Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus.                                                           (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21767554


Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.          (abst – 2011)                              http://www.ncbi.nlm.nih.gov/pubmed/22198381


Effects of Cannabinoid Agonists on Sheep Sphincter of Oddi in vitro.                     (abst – 2011)



Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines.           (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281848/?tool=pubmed


Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB(1) Receptor Agonist Methanandamide in Adult Rats.                                                                    (full – 2012)  http://www.springerlink.com/content/d44543844w814p33/fulltext.html


GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                                          http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full


Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst – 2012)  http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_differen  t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_


Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats. (abst – 2012)                                           http://www.ncbi.nlm.nih.gov/pubmed/22581275


Diuretic effects of cannabinoids.                      (abst – 2012)



Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos            (abst – 2012)                          http://molehr.oxfordjournals.org/content/19/2/93.abstract


Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst – 2013)                                             http://www.ncbi.nlm.nih.gov/pubmed/23394450

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