PEA– PALMITOYLETHANOLAMIDE – endocannabinoid , CB 2, GPR55 & GPR119 agonist

 

The palmitoylethanolamide and oleamide enigmas : are these two fatty acid amides cannabimimetic?      (abst – 1999)                                       http://lib.bioinfo.pl/pmid:10469890

 

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase

and enhances the anti-proliferative effect of anandamide in human breast cancer cells (full – 2001)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222054/pdf/11485574.pdf/?tool=pmcentrez

 

 

 

 

 

 

 

 

Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated With Inflammation of the Urinary Bladder                                                 (full – 2001)  http://journals.lww.com/anesthesiology/Fulltext/2001/03000/Administration_of_Endocannabinoids_Preven  ts_a.23.aspx

 

Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.           (abst – 2001)                          http://www.ncbi.nlm.nih.gov/pubmed/11442148

 

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat                                                         (full – 2002)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1573125&tool=pmcentrez

 

Endocannabinoids and related fatty acid derivatives in pain modulation.              (abst – 2002)

http://www.ncbi.nlm.nih.gov/pubmed/12505698

 

The search for the palmitoylethanolamide receptor.              (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/15963531

 

Finding of endocannabinoids in human eye tissues: implications for glaucoma. (abst – 2005)                                     http://www.ncbi.nlm.nih.gov/pubmed/15823551

 

Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid. (abst – 2005)                                      http://www.ncbi.nlm.nih.gov/pubmed/15461672

 

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.                                                          (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/17011761

 

Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury.    (full – 2008)                                  http://jpet.aspetjournals.org/content/326/1/12.long

 

Endocannabinoids and nutrition.                (full – 2008)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2008.01687.x/full

 

‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.                                                                         (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597234/?tool=pubmed

 

Adjuvant treatment of atopic eczema: assessment of an emollient containing N- palmitoylethanolamine (ATOPA study).                                                                     (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18181976

 

Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. (abst – 2008)                                   http://www.ncbi.nlm.nih.gov/pubmed/18535023

 

Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.                                                    (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716432/?tool=pubmed

 

 

 

 

 

 

 

 

 

Receptors for acylethanolamides-GPR55 and GPR119.              (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751869/?tool=pubmed

 

Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain                                                                         (full – 2009)  http://www.molecularpain.com/content/5/1/35

 

Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. (abst – 2009)                                    http://www.ncbi.nlm.nih.gov/pubmed/19131941

 

Plasma endocannabinoid levels in multiple sclerosis.               (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19695579

 

N-acylethanolamines, anandamide and food intake.             (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19413995

 

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.                                                   (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868848/?tool=pubmed

 

Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls (full – 2010)                                     http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00787.x/full

 

Endocannabinoids and Human Sperm Cells              (link to PDF – 2010)

http://www.mdpi.com/1424-8247/3/10/3200

 

Protective role of palmitoylethanolamide in contact allergic dermatitis.              (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/19909294

 

Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.     (abst – 2010)                        http://www.ncbi.nlm.nih.gov/pubmed/20353771

 

Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats.                                                      (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/19931394

 

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis.                                                  (abst – 2010)         http://www.ncbi.nlm.nih.gov/pubmed/19840245

 

Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations.                                                 (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20176435

 

Protective role of palmitoylethanolamide in contact allergic dermatitis.               (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/19909294

 

 

 

 

 

 

 

 

Misdiag nosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide.                                                    (abst – 2010)        http://www.ncbi.nlm.nih.gov/pubmed/20345619

 

Chocolate: The Good, the Bad and the Angry               (news – 2010)

http://www.psychologytoday.com/blog/your-brain-food/201011/chocolate-the-good-the-bad-and-the-angry

 

Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism.                                                             (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203169/?tool=pubmed

 

Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.                                                               (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136458/?tool=pubmed

 

Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats     (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034677/?tool=pubmed

 

Ocular Hypotensive Effect of Oral Palmitoyl-ethanolamide: A Clinical Trial

(full – 2011)  http://www.iovs.org/content/52/9/6096.full?sid=b5ebf404-f190-49ee-9076-758ee6c9190d

 

Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice                                                           (full – 2011)  http://www.nutritionandmetabolism.com/content/8/1/51

 

Palmitoylethanolamide counteracts reactive astrogliosis induced by beta-amyloid peptide. (abst – 2011)                                       http://www.ncbi.nlm.nih.gov/pubmed/21255263

 

Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist. (abst – 2011)                                        http://www.ncbi.nlm.nih.gov/pubmed/21483401

 

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury.                                                         (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21354467

 

Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?                                        (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21664223

 

Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs.                                                                     (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21601500

 

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.

(full – 2012)                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315437/?tool=pubmed

 

 

 

 

 

 

 

 

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action                                                           (full – 2012)  http://www.biomedcentral.com/1471-2407/12/92

 

The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                                    http://www.jneuroinflammation.com/content/9/1/79

 

Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409167/?tool=pubmed

 

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series                                                      (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/

 

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

(full – 2012)                http://www.jneuroinflammation.com/content/9/1/49

 

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action                                                              (full – 2012)  http://www.biomedcentral.com/1471-2407/12/92

 

Endocannabinoids in stressed humans                (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152482&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=2&uiLanguage=en

 

Effects of Palmitoylethanolamide on Aqueous Humor Outflow.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22589443

 

The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.      (abst – 2012)                                                            http://www.ncbi.nlm.nih.gov/pubmed/22201038

 

Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice                                                                (abst – 2012)  http://www.jleukbio.org/content/91/6/911.abstract?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

 

Review article: Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23108549

 

Inhibition Of Fatty Acid Amide Hydrolase Produces Anti-Tussive Effects In Guinea- Pigs: Evidence For Elevated Fatty Acid Amides Acting Via Cannabinoid Receptors On Airway Sensory Nerves          (abst – 2012)  http://ajrccm.atsjournals.org/cgi/reprint/185/1_MeetingAbstracts/A2149?maxtoshow=&hits=25&RESULT   FORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCI  T

 

 

 

 

 

 

 

 

 

THE CO-EXPRESSION OF THE ENDOCANNABINOID SYSTEM AND THE RANK/RANKL SIGNALLING PATHWAY IN HUMAN BONE AND OSTEOCLAST CULTURE      (abst – 2012)

http://www.bjjprocs.boneandjoint.org.uk/content/94-  B/SUPP_XVIII/7.abstract?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid= 1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCIT

 

The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (abst – 2012)

http://jpet.aspetjournals.org/content/342/1/188.abstract?sid=ae58f15a-06bb-4a81-b850-61bb89fd59f5

 

Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22442280

 

Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.                                                     (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22697514

 

Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.

(abst – 2012)                 http://www.ncbi.nlm.nih.gov/pubmed/21952131

 

Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry.

(abst – 2012)               http://www.ncbi.nlm.nih.gov/pubmed/22946841

 

Optimized synthesis and characterization of N-acylethanolamines and O- acylethanolamines, important family of lipid-signalling molecules.                                                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22850591?dopt=Abstract

 

Temporal changes in N-acylethanolamine content and metabolism throughout the peri- adolescent period                                         (abst – 2012)     http://onlinelibrary.wiley.com/doi/10.1002/syn.21609/abstract

 

Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans     (abst – 2012)                               http://www.ncbi.nlm.nih.gov/pubmed/22763622

 

Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.                                                                    (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22697514?dopt=Abstract

 

β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors    (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.01889.x/abstract

 

 

 

 

 

 

 

 

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone ( abst – 2012)                                           http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01478.x/abstract

 

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.                                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23206503

 

Metabolisms of endocannabinoids and related N-acylethanolamines: Canonical and alternate pathways  (full – 2013)                                         http://onlinelibrary.wiley.com/doi/10.1111/febs.12152/pdf

 

CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                                               (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23302980

 

Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity.    (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23372171

 

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.                                                                       (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23373571

 

Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice.                                                               (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23394524

 

Measurement of Palmitoylethanolamide and Other N-acylethanolamines During Physiological and Pathological Conditions.                                                                         (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23394528

 

Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain.                       (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23394527

 

New Insights in Mast Cell Modulation by Palmitoylethanolamide.                      (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23394523

 

Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.                                                    (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23398921

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