PEA– PALMITOYLETHANOLAMIDE – endocannabinoid , CB 2, GPR55 & GPR119 agonist


The palmitoylethanolamide and oleamide enigmas : are these two fatty acid amides cannabimimetic?      (abst – 1999)                             


Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase

and enhances the anti-proliferative effect of anandamide in human breast cancer cells (full – 2001)









Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated With Inflammation of the Urinary Bladder                                                 (full – 2001)  ts_a.23.aspx


Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.           (abst – 2001)                


Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat                                                         (full – 2002)


Endocannabinoids and related fatty acid derivatives in pain modulation.              (abst – 2002)


The search for the palmitoylethanolamide receptor.              (abst – 2005)


Finding of endocannabinoids in human eye tissues: implications for glaucoma. (abst – 2005)                           


Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid. (abst – 2005)                            


Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.                                                          (abst – 2006)


Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury.    (full – 2008)                        


Endocannabinoids and nutrition.                (full – 2008)


‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.                                                                         (full – 2008)


Adjuvant treatment of atopic eczema: assessment of an emollient containing N- palmitoylethanolamine (ATOPA study).                                                                     (abst – 2008)


Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. (abst – 2008)                         


Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.                                                    (full – 2009)










Receptors for acylethanolamides-GPR55 and GPR119.              (full – 2009)


Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain                                                                         (full – 2009)


Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. (abst – 2009)                          


Plasma endocannabinoid levels in multiple sclerosis.               (abst – 2009)


N-acylethanolamines, anandamide and food intake.             (abst – 2009)


Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.                                                   (full – 2010)


Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls (full – 2010)                           


Endocannabinoids and Human Sperm Cells              (link to PDF – 2010)


Protective role of palmitoylethanolamide in contact allergic dermatitis.              (abst – 2010)


Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.     (abst – 2010)              


Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats.                                                      (abst – 2010)


Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis.                                                  (abst – 2010)


Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations.                                                 (abst – 2010)


Protective role of palmitoylethanolamide in contact allergic dermatitis.               (abst – 2010)









Misdiag nosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide.                                                    (abst – 2010)


Chocolate: The Good, the Bad and the Angry               (news – 2010)


Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism.                                                             (full – 2011)


Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.                                                               (full – 2011)


Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats     (full – 2011)


Ocular Hypotensive Effect of Oral Palmitoyl-ethanolamide: A Clinical Trial

(full – 2011)


Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice                                                           (full – 2011)


Palmitoylethanolamide counteracts reactive astrogliosis induced by beta-amyloid peptide. (abst – 2011)                             


Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist. (abst – 2011)                              


Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury.                                                         (abst – 2011)


Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?                                        (abst – 2011)


Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs.                                                                     (abst – 2011)


Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.

(full – 2012)        









The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action                                                           (full – 2012)


The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                          


Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012)                          


Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series                                                      (full – 2012)


Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

(full – 2012)      


The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action                                                              (full – 2012)


Endocannabinoids in stressed humans                (link to PDF – 2012) cNo=2&uiLanguage=en


Effects of Palmitoylethanolamide on Aqueous Humor Outflow.              (abst – 2012)


The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.      (abst – 2012)                                                  


Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice                                                                (abst – 2012)  cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT


Review article: Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide                                                      (abst – 2012)


Inhibition Of Fatty Acid Amide Hydrolase Produces Anti-Tussive Effects In Guinea- Pigs: Evidence For Elevated Fatty Acid Amides Acting Via Cannabinoid Receptors On Airway Sensory Nerves          (abst – 2012)   FORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCI  T












The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (abst – 2012)


Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. (abst – 2012)


Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.                                                     (abst – 2012)


Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.

(abst – 2012)       


Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry.

(abst – 2012)     


Optimized synthesis and characterization of N-acylethanolamines and O- acylethanolamines, important family of lipid-signalling molecules.                                                                                 (abst – 2012)


Temporal changes in N-acylethanolamine content and metabolism throughout the peri- adolescent period                                         (abst – 2012)


Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans     (abst – 2012)                     


Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma.                                                                    (abst – 2012)


β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors    (abst – 2012)









The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone ( abst – 2012)                                 


Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.                                                                      (abst – 2012)


Metabolisms of endocannabinoids and related N-acylethanolamines: Canonical and alternate pathways  (full – 2013)                               


CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                                               (abst – 2013)


Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity.    (abst – 2013)


The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.                                                                       (abst – 2013)


Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice.                                                               (abst – 2013)


Measurement of Palmitoylethanolamide and Other N-acylethanolamines During Physiological and Pathological Conditions.                                                                         (abst – 2013)


Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain.                       (abst – 2013)


New Insights in Mast Cell Modulation by Palmitoylethanolamide.                      (abst – 2013)


Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.                                                    (abst – 2013)

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