PAIN

 

ANTI-EDEMA AND ANALGESIC PROPERTIES OF Δ9- TETRAHYDROCANNABINOL (THC)  (abst- 1973)

http://jpet.aspetjournals.org/content/186/3/646.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=marihuana&searchid=1&FIRSTINDEX=2160&resourcetype=HWCIT

 

Analgesic effect of delta-9-tetrahydrocannabinol.                   (abst – 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=16

 

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.                    (abst – 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=17

 

Marihuana as a therapeutic agent for muscle spasm or spasticity.                      (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=53

 

ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L.                                                             (full – 1988)

http://www.ukcia.org/research/AnalgesicAndAntiInflammatoryActivityofConstituents.html

 

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.                                               (abst – 1996)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=12

 

The perceived effects of smoked cannabis on patients with multiple sclerosis. (abst – 1997)           http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=13

 

Pain relief with oral cannabinoids in familial Mediterranean fever                (abst – 1997)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=18

 

Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia       (full – 1998)                                    http://www.jneurosci.org/content/18/1/451.long

 

Doped skin               (news – 1998) (may need registration)

http://www.newscientist.com/article/mg15921434.700-doped-skin.html

 

Pain modulation by release of the endogenous cannabinoid anandamide              (full – 1999)

http://www.pnas.org/content/96/21/12198.full

 

Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.          (abst – 1999)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=203

 

Brain Releases Marijuana-Like Substance In Response To Pain, Study Finds (news – 1999)                                          http://www.sciencedaily.com/releases/1999/10/991013074947.htm

 

Most pain patients gain benefit from cannabis in a British study                (news – 2000)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=84#1

 

Therapeutic aspects of cannabis and cannabinoids.              (full – 2001)

http://bjp.rcpsych.org/cgi/content/full/178/2/107

 

Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review                                                   (full – 2001)  http://www.ukcia.org/research/EffectiveTreatmentOptionForPain.pdf

 

Therapeutic Aspects of Cannabis and Cannabinoids             (full – 2001)

http://bjp.rcpsych.org/cgi/reprint/178/2/107.pdf

 

Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated With Inflammation of the Urinary Bladder                                                  (full – 2001)  http://journals.lww.com/anesthesiology/Fulltext/2001/03000/Administration_of_Endocannabinoids_Preven ts_a.23.aspx

 

Tetrahydrocannabinol for treatment of chronic pain               (abst – 2001)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=147

 

The Role of Cannabis and Cannabinoids in Pain Management              (full – 2002)

http://www.humanhemphealth.ca/Russo-AAPM_chapter.pdf

 

 A Dramatic Response to Inhaled Cannabis in a Woman with Central Thalamic Pain and Dystonia            (full – 2002)                     http://www.jpsmjournal.com/article/PIIS0885392402004268/fulltext

 

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? (abst – 2002)                                        http://www.ncbi.nlm.nih.gov/pubmed/12550743

 

The Pharmacology of Cannabinoid Derivatives: Are There Applications to Treatment of Pain?     (abst – 2002)                          http://www.ncbi.nlm.nih.gov/pubmed/12134594

 

Endocannabinoids and related fatty acid derivatives in pain modulation.              (abst – 2002)

http://www.ncbi.nlm.nih.gov/pubmed/12505698

 

A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms                                               (full – 2003)  http://www.ukcia.org/research/WholePlantExtractsImproveNeurogenicSymptoms.pdf

 

Cannabis reduces opioid dose in the treatment of chronic non-cancer pain.             (full – 2003)

http://www.jpsmjournal.com/article/S0885-3924(03)00142-8/fulltext

 

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors          (full – 2003)  http://journals.lww.com/anesthesiology/Fulltext/2003/10000/Inhibition_of_Inflammatory_Hyperalgesia_by

.31.aspx

 

Cannabis and Pain Management               (article – 2003)

http://www.letfreedomgrow.com/articles/can030828.htm

 

Topical cannabinoid enhances topical morphine antinociception.                (abst – 2003)

http://www.ncbi.nlm.nih.gov/pubmed/14499448

 

Cannabis use for chronic non-cancer pain: results of a prospective survey.              (abst – 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=91

 

Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review                                                                         (abst – 2003)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=61

 

Cannabis Use in HIV for Pain and Other Medical Symptoms              (full – 2004)

http://www.jpsmjournal.com/article/S0885-3924(05)00063-1/fulltext

 

3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid Cb1/Cb2 receptor partial agonist with antihyperalgesic and antiallodynic effects.      (full – 2004)                                                     http://jpet.aspetjournals.org/content/310/2/620.long

 

Are oral cannabinoids safe and effective in refractory neuropathic pain?

(abst – 2004)              http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=143

 

Ajulemic acid:  A novel cannabinoid produces analgesia without a “high” (abst – 2004)                                         http://www.ncbi.nlm.nih.gov/pubmed/15240185

 

Cannabinoids called equivalent to codeine for killing pain                 (news – 2004)  http://www.thefreelibrary.com/Cannabinoids+called+equivalent+to+codeine+for+killing+pain.-  a0120185689

 

High hopes for cannabinoid analgesia                (news – 2004)

http://www.bmj.com/cgi/content/full/329/7460/257?maxtoshow=&hits=80&RESULTFORMAT=&fulltext

=cannabis&searchid=1&FIRSTINDEX=2880&resourcetype=HWCIT

 

Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain         (news – 2004)

http://www.eurekalert.org/pub_releases/2004-10/sfn-mcm102604.php

 

Chronic Pain and Cannabinoids                  (full – 2005)

http://www.drkoprp.com/pdfs/fibromyalgia/CannabinoidsPPM.pdf

 

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids                                                    (full – 2005)     http://www.pnas.org/content/102/8/3093.full

 

Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials (full – 2005)                                              http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751505/?tool=pubmed

 

Analgesia through endogenous cannabinoids               (analysis – 2005)  http://www.cmaj.ca/cgi/content/full/173/4/357?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=end  ocannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HW CIT

 

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors            (abst – 2005)                    http://www.sciencedirect.com/science/article/pii/S0014299905013178

 

Targeted lipidomics: fatty acid amides and pain modulation.                (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/16099389

 

Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal delta9-tetrahydrocannabinol.                          (abst – 2005)     http://www.ncbi.nlm.nih.gov/pubmed/16288738

 

Cannabis: Use in HIV for Pain and Other Medical Symptoms             (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/15857739

 

Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat                                                             (abst – 2005)  http://www.sciencedirect.com/science/article/pii/S0014299905003870

 

Body’s Pot-Like Chemicals May Help Curb Pain                (news – 2005)

http://www.webmd.com/pain-management/news/20050622/bodys-pot-like-chemicals-may-help-curb-pain

 

Depression: URB597 increases endocannabinoids in brain                 (news – 2005)

http://www.xagena.it/news/medicinenews_net_news/158388770a41292b277c199ca8d95ccf.html

 

A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management.                                                                      (full – 2006)  http://journals.lww.com/anesthesiology/Fulltext/2006/05000/A_Multicenter_Dose_escalation_Study_of_th  e.21.aspx

 

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models    (full – 2006)                          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751298/?tool=pmcentrez

 

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes                                                          (full – 2006)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2430692&tool=pmcentrez

 

Cannabinoids In Medicine: A Review Of Their Therapeutic Potential                  (full – 2006)

http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/CannabinoidsMedMetaAnalysis06.pdf

 

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

 

Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.    (abst – 2006)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=17369898&dopt=abstrac tplus

 

Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain.      (abst – 2006)                     http://www.ncbi.nlm.nih.gov/pubmed/16449552

 

Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

(abst – 2006)                    http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=200

 

Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief                                                             (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16834825

 

Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain – a randomized controlled trial.                                                 (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=197

 

Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.  (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=178

 

Cannabinoid–improgan cross-tolerance: Improgan is a cannabinomimetic analgesic lacking affinity at the cannabinoid CB1 receptor                                                   (abst – 2006)  http://www.sciencedirect.com/science/article/pii/S0014299906008855

 

Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain                                                                           (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16480822

 

Cannabinoids Enhance Analgesic Effects Of Anti-Inflammatory Drugs, Study Says (news – 2006)                                       http://www.norml.org/index.cfm?Group_ID=6819

 

In MedPanel Summit, Leading Pain Experts Name Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain, Assert That Sociopolitical Climate Will Hamper Drug Approvals          (news – 2006)  http://www.redorbit.com/news/health/545812/in_medpanel_summit_leading_pain_experts_name_cannabin  oids_among_most/index.html?source=r_health

 

Cannabis effective at relieving pain after major surgery                (news – 2006)

http://www.news-medical.net/?id=17995

 

Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia                                                  (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771679/?tool=pubmed

 

Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors                                                             (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040345/

 

Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test                                                      (full – 2007)

http://www.anesthesia- analgesia.org/content/104/3/719.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&  searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

 

Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.  (full – 2007)  http://journals.lww.com/anesthesiology/Fulltext/2007/11000/Dose_dependent_Effects_of_Smoked_Cannab  is_on.16.aspx

 

Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain   (full – 2007)                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190014/?tool=pubmed

 

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors           (full – 2007)                         http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234438/

 

Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity                                                           (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013951/?tool=pmcentrez

 

Cannabinoids for postoperative pain.              (letter – 2007)  http://journals.lww.com/anesthesiology/Fulltext/2007/02000/Cannabinoids_for_Postoperative_Pain.29.asp x

 

A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.                                         (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/12749972

 

Cannabis, pain, and sleep: lessons from trials of Sativex, a cannabis-based medicine. (abst – 2007)                                     http://marijuana.researchtoday.net/archive/4/8/1384.htm

 

Pain relief from cannabis depends on how much you smoke              (news – 2007)

http://www.news-medical.net/news/2007/11/26/32855.aspx

 

Therapeutic potential of cannabis in pain medicine              (full – 2008)

http://bja.oxfordjournals.org/cgi/reprint/101/1/59

 

Cannabinoids in the management of difficult to treat pain             (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/?tool=pmcentrez

 

Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception                               (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743428/?tool=pmcentrez

 

Cannabinoids in chronic pain and palliative care.              (full – 2008)  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-  70942008000300010&lng=en&nrm=iso&tlng=en

 

NOVEL SYNERGISTIC OPIOID-CANNABINOID CODRUG FOR PAIN

MANAGEMENT              (full – 2008)     http://www.freepatentsonline.com/y2008/0176885.html

 

Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation (full – 2008)                                   http://jn.physiology.org/cgi/reprint/100/5/2794

 

Cannabinoids in chronic pain and palliative care.              (full – 2008)

(First in Spanish, then English)                  http://www.rbaonline.com.br/files/rba/mai08267.pdf

 

A Randomized, Placebo Controlled Cross-Over Trial of Cannabis Cigarettes in Neuropathic Pain            (full – 2008)                                http://cmcr.ucsd.edu/images/pdfs/Wilsey_2008.pdf

 

Nabilone for the treatment of pain in fibromyalgia.               (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/17974490

 

Pain relief with cannabinoids– the importance of endocannabinoids and cannabinoids for pain therapy   (abst – 2008)                           http://www.ncbi.nlm.nih.gov/pubmed/18671173

 

Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo   (abst – 2008)                            http://www.sciencedirect.com/science/article/pii/S0014299908002719

 

Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests

(news – 2008)                  http://www.sciencedaily.com/releases/2008/02/080217214547.htm

 

Scientist Discovers New Molecule to Treat Chronic Pain              (news – 2008)

http://www.physorg.com/news137778721.html

 

New Cannabis-Like Drugs Could Block Pain Without Affecting Brain, Says Study (news – 2008)                                       http://www.sciencedaily.com/releases/2008/09/080912091728.htm

 

Cannabislike Drugs May Hold Key to Treating Pain While Bypassing the Brain (news – 2008)                                     http://jama.jamanetwork.com/article.aspx?articleid=182826

 

Cannabis suggests treatment for chronic pain               (news – 2008)

http://arstechnica.com/science/news/2008/09/cannabis-suggests-treatment-for-chronic-pain.ars

 

Dynamic regulation of the endocannabinoid system: implications for analgesia (full – 2009)                                    http://www.molecularpain.com/content/5/1/59

 

The endocannabinoid system and pain.              (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834283/?tool=pmcentrez

 

Cannabinoids: An emerging role in pain management?                 (full – 2009)

http://www.nursingcenter.com/library/JournalArticle.asp?Article_ID=863277

 

Standardized natural product cannabis in pain management and observations at a Canadian compassion society: a case report                                                                   (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740265/?tool=pmcentrez

 

Systematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain. (abst – 2009)                                    http://www.ncbi.nlm.nih.gov/pubmed/19732371

 

Interaction of the cannabinoid and opioid systems in the modulation of nociception. (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19367508?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa  nel.Pubmed_RVDocSum&ordinalpos=34

 

The analgesic potential of cannabinoids.                 (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/20073408

 

Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State.                                            (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19947069/full_citation/Characteristics_of_patients

_with_chronic_pain_accessing_treatment_with_medical_cannabis_in_Washington_State_

 

Endocannabinoids, Closely Related To Active Ingredients In Cannabis Plant, Can Promote Pain (news – 2009)  http://www.sciencedaily.com/releases/2009/09/090911212404.htm

 

Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain                                                               (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878341/?tool=pmcentrez

 

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism (full – 2010)                                     http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260554/?tool=pubmed

 

Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia.      (abst – 2010)                               http://www.ncbi.nlm.nih.gov/pubmed/19744255

 

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. (abst – 2010)                                     http://www.ncbi.nlm.nih.gov/pubmed/20176037

 

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.           (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/19896326

 

Pain target enzyme’s working made crystal clear                (news – 2010)

http://www.rsc.org/chemistryworld/News/2010/May/26051001.asp

 

Chronic Pain Improved by Cannabis Smoking                (news – 2010)

http://news.softpedia.com/news/Chronic-Pain-Improved-by-Cannabis-Smoking-154254.shtml

 

Study: Smoking pot may ease chronic pain                 (news – 2010)

http://www.cnn.com/2010/HEALTH/08/30/health.pot.reduce.pain/

 

Marijuana better than pharmaceuticals at treating chronic pain, improving mood (news – 2010)                                     http://www.naturalnews.com/029662_marijuana_chronic_pain.html

 

Painkilling System in Brain: Too Much of a Good Thing?               (news – 2010)

http://www.sciencedaily.com/releases/2010/08/100824151036.htm

 

Smoking cannabis relieves chronic pain                 (news – 2010)  http://www.independent.co.uk/life-style/health-and-families/smoking-cannabis-relieves-chronic-pain-  2067287.html

 

A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245783/

 

Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats     (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034677/?tool=pubmed

 

Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture                                      (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281798/

 

Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/


The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief                                                                          (full – 2011)  
http://www.hindawi.com/isrn/anesthesiology/2011/593894/

 

Pharmacological characterization of AM1710, a putative cannabinoid CB(2) agonist from the cannabilactone class: Antinociception without central nervous system side-effects. (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21382397/abstract/Pharmacological_characterizati

 

on_of_AM1710_a_putative_cannabinoid_CB_2 n_without_central_nervous_system_side_effects_


agonist_from_the_cannabilactone_class:_Antinociceptio

 

 

Treating pain in multiple sclerosis.                (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21916786

 

Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2011)

http://jpet.aspetjournals.org/content/340/3/787.abstract?sid=2ef42c80-59ad-4b4e-8eed-d5b9d556b866

 

Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity           (abst – 2011)  http://ajh.sagepub.com/content/early/2011/04/07/1049909111402318.abstract?maxtoshow=&h       its=80&RES   ULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=H WCIT

 

Cannabinoid-opioid interaction in chronic pain.                (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/22048225/abstract/Cannabinoid_opioid_interaction

_in_chronic_pain_

 

Antinociception and sedation following intracerebroventricular administration of Δ⁹-

tetrahydrocannabinol in female vs. male rats.                (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/20692296/abstract/Antinociception_and_sedation_ following_intracerebroventricular_administration_of_%CE%94%E2%81%B9_tetrahydrocannabinol_in_fe

 

 

 

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action                                                               (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/20942863/abstract/Non_psychoactive_cannabinoid  s_modulate_the_descending_pathway_of_antinociception_in_anaesthetized_rats_through_several_mechani  sms_of_action_

 

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.                                                               (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21740924

 

Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.   (abst – 2011)                                    http://www.ncbi.nlm.nih.gov/pubmed/21426373

 

Marijuana, Narcotics Help Patients Reduce Chronic Pain, Study Finds              (news – 2011)

 

http://www.huffingtonpost.com/2011/12/08/marijuana-narcotics-help-patients-reduce-  pain_n_1137416.html

 

New Way to Boost Potency of Natural Pain Relief Chemical in Body              (news – 2011)

http://www.sciencedaily.com/releases/2011/11/111121142501.htm

 

Part of placebo effect ascribed to cannabinoids              (news – 2011)

http://arstechnica.com/science/2011/10/is-the-placebo-effect-partially-caused-by-cannabinoids/

 

Marijuana component could ease pain from chemotherapy drugs                (news – 2011)

http://medicalxpress.com/news/2011-10-marijuana-component-ease-pain-chemotherapy.html

 

The Positive Uses of Marijuana for Cancer Patients             (news – 2011)

http://www.livestrong.com/article/94355-positive-uses-marijuana-cancer-patients/#ixzz21Ib5ILhj

 

Cannabis brings relief to women suffering from PMS and PMDD symptoms (news – 2011)

http://www.examiner.com/cannabis-revolution-in-las-vegas/cannabis-brings-relief-to-women-suffering- from-pms-and-pmdd-symptoms

 

Father: Medical marijuana eased pain of my cancer-battling son             (anecdotal – 2011)

http://www.komonews.com/news/local/120941429.html

 

Medical Marijuana: Clearing Away the Smoke               (full – 2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358713/

 

Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat        (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02179.x/full

 

Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. (full – 2012)  http://www.if-pan.krakow.pl/pjp/pdf/2012/3_723.pdf

 

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain         (full – 2012)                                                      http://jpet.aspetjournals.org/content/338/1/114.full

 

Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB(1) Receptor Agonist Methanandamide in Adult Rats.                                                              (full – 2012)  http://www.springerlink.com/content/d44543844w814p33/fulltext.html

 

Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. (full – 2012)                                        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366638/

 

The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy                      (full – 2012)

http://www.molecularpain.com/content/8/1/71

 

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series                                                              (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/

 

Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier

(full – 2012)                       http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02098.x/full

 

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(full – 2012)                         http://link.springer.com/article/10.1007/s12035-012-8299-0/fulltext.html

 

Behavioral effects of pulp exposure in mice lacking cannabinoid receptor 2. (abst – 2012)                                              http://www.ncbi.nlm.nih.gov/pubmed/22152627

 

Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                                           http://www.ncbi.nlm.nih.gov/pubmed/22354705

 

Cannabinergic Pain Medicine: A Concise Clinical Primer and Survey of Randomized- controlled Trial Results.                                                           (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22367503

 

Review article: Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23108549

 

Dynamic changes to the endocannabinoid system in models of chronic pain (abst – 2012)                                        http://www.ncbi.nlm.nih.gov/pubmed/23108548

 

The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.                                                                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22420307

 

Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels.                                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22425445

 

Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level. (abst – 2012)                                          http://www.ncbi.nlm.nih.gov/pubmed/22451592

 

Role of cannabinoid 2 receptor in the development of bone cancer pain (abst – 2012)                                            http://www.ncbi.nlm.nih.gov/pubmed/22490961

 

Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial.                                                           (abst – 2012)

`                 http://www.sciencedirect.com/science/article/pii/S1526590012000193

 

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.       (abst – 2012)                            http://www.ncbi.nlm.nih.gov/pubmed/22585736

 

The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.      (abst – 2012)                                                            http://www.ncbi.nlm.nih.gov/pubmed/22201038

 

Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment    (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2012.02170.x/abstract

 

Monoacylglycerol lipase – a target for drug development?               (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.01950.x/abstract

 

Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22787031

 

Therapeutic modulation of cannabinoid lipid signaling: Metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist.                                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22749867

 

Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2012)

http://jpet.aspetjournals.org/content/340/3/787.abstract?sid=ae58f15a-06bb-4a81-b850-61bb89fd59f5

 

Analgesic effects of cannabinoids on central pain syndrome               (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22359935

 

Cannabis as an adjunct to or substitute for opiates in the treatment of chronic pain. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/22880540

 

“Redundancy” of endocannabinoid inactivation: new challenges and opportunities for pain control.        (abst – 2012)                         http://www.ncbi.nlm.nih.gov/pubmed/22860203

 

Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis.     (abst – 2012)                             http://www.ncbi.nlm.nih.gov/pubmed/22954177

 

The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23063785

 

Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals          (abst – 2012)                          http://onlinelibrary.wiley.com/doi/10.1002/syn.21586/abstract

 

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.                                        (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/23138934

 

Endocannabinoid modulation of jejunal afferent responses to LPS               (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2012.01961.x/abstract

 

Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment.   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22670561?dopt=Abstract

 

Neuromodulators for pain management in rheumatoid arthritis               (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008921.pub2/abstract

 

Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.                                                                  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22940464

 

Cannabinoid therapy helps provide effective analgesia for cancer patients with pain (news – 2012)

http://www.news-medical.net/news/20120605/Cannabinoid-therapy-helps-provide-effective-analgesia-for-  cancer-patients-with-pain.aspx

 

Reefer tokin’ seniors in South Florida see pain go up in smoke              (news – 2012)

http://articles.sun-sentinel.com/2012-07-23/news/fl-toking-oldsters-20120723_1_reefer-pain-seniors

 

Cannabinoid Shown Effective as Adjuvant Analgesic for Cancer Pain             (news – 2012)

http://www.sciencedaily.com/releases/2012/06/120604142426.htm

 

Cannabinoid formulation benefits opioid-refractory pain                 (news – 2012)

http://medicalxpress.com/news/2012-06-cannabinoid-benefits-opioid-refractory-pain.html

 

Cannabis as Painkiller                  (news – 2012)

http://www.sciencedaily.com/releases/2012/08/120807101232.htm

 

Cannabis can make pain less bothering                (news – 2012)

http://in.news.yahoo.com/cannabis-pain-less-bothering-065147441.html

 

Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)

http://www.nature.com/npp/journal/vaop/naam/pdf/npp201331a.pdf

 

The role of endocannabinoids in pain modulation.               (full – 2013)

http://onlinelibrary.wiley.com/doi/10.1111/fcp.12008/pdf

 

Amygdala activity contributes to the dissociative effect of cannabis on pain perception. (abst – 2013)                                     http://www.ncbi.nlm.nih.gov/pubmed/23273106

 

CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                                          (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23302980

 

Repeated Low Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains CB1 Receptor Mediated Antinociceptive and Gastroprotective Effects.

(abst – 2013)                      http://www.ncbi.nlm.nih.gov/pubmed/23412396

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