Analgesic effect of delta-9-tetrahydrocannabinol.                   (abst – 1975)


The analgesic properties of delta-9-tetrahydrocannabinol and codeine.                    (abst – 1975)


Marihuana as a therapeutic agent for muscle spasm or spasticity.                      (abst – 1980)


ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CONSTITUENTS OF CANNABIS SATIVA L.                                                             (full – 1988)


The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.                                               (abst – 1996)


The perceived effects of smoked cannabis on patients with multiple sclerosis. (abst – 1997) 


Pain relief with oral cannabinoids in familial Mediterranean fever                (abst – 1997)


Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia       (full – 1998)                          


Doped skin               (news – 1998) (may need registration)


Pain modulation by release of the endogenous cannabinoid anandamide              (full – 1999)


Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.          (abst – 1999)


Brain Releases Marijuana-Like Substance In Response To Pain, Study Finds (news – 1999)                                


Most pain patients gain benefit from cannabis in a British study                (news – 2000)


Therapeutic aspects of cannabis and cannabinoids.              (full – 2001)


Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review                                                   (full – 2001)


Therapeutic Aspects of Cannabis and Cannabinoids             (full – 2001)


Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated With Inflammation of the Urinary Bladder                                                  (full – 2001) ts_a.23.aspx


Tetrahydrocannabinol for treatment of chronic pain               (abst – 2001)


The Role of Cannabis and Cannabinoids in Pain Management              (full – 2002)


 A Dramatic Response to Inhaled Cannabis in a Woman with Central Thalamic Pain and Dystonia            (full – 2002)           


CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? (abst – 2002)                              


The Pharmacology of Cannabinoid Derivatives: Are There Applications to Treatment of Pain?     (abst – 2002)                


Endocannabinoids and related fatty acid derivatives in pain modulation.              (abst – 2002)


A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms                                               (full – 2003)


Cannabis reduces opioid dose in the treatment of chronic non-cancer pain.             (full – 2003)


Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors          (full – 2003)



Cannabis and Pain Management               (article – 2003)


Topical cannabinoid enhances topical morphine antinociception.                (abst – 2003)


Cannabis use for chronic non-cancer pain: results of a prospective survey.              (abst – 2003)


Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review                                                                         (abst – 2003)


Cannabis Use in HIV for Pain and Other Medical Symptoms              (full – 2004)


3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid Cb1/Cb2 receptor partial agonist with antihyperalgesic and antiallodynic effects.      (full – 2004)                                           


Are oral cannabinoids safe and effective in refractory neuropathic pain?

(abst – 2004)    


Ajulemic acid:  A novel cannabinoid produces analgesia without a “high” (abst – 2004)                               


Cannabinoids called equivalent to codeine for killing pain                 (news – 2004)  a0120185689


High hopes for cannabinoid analgesia                (news – 2004)



Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson’s to pain         (news – 2004)


Chronic Pain and Cannabinoids                  (full – 2005)


CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids                                                    (full – 2005)


Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials (full – 2005)                                    


Analgesia through endogenous cannabinoids               (analysis – 2005)  ocannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HW CIT


The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors            (abst – 2005)          


Targeted lipidomics: fatty acid amides and pain modulation.                (abst – 2005)


Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal delta9-tetrahydrocannabinol.                          (abst – 2005)


Cannabis: Use in HIV for Pain and Other Medical Symptoms             (abst – 2005)


Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat                                                             (abst – 2005)


Body’s Pot-Like Chemicals May Help Curb Pain                (news – 2005)


Depression: URB597 increases endocannabinoids in brain                 (news – 2005)


A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management.                                                                      (full – 2006)  e.21.aspx


Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models    (full – 2006)                


Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes                                                          (full – 2006)


Cannabinoids In Medicine: A Review Of Their Therapeutic Potential                  (full – 2006)


The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)


Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.    (abst – 2006) tplus


Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain.      (abst – 2006)           


Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

(abst – 2006)          


Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief                                                             (abst – 2006)


Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain – a randomized controlled trial.                                                 (abst – 2006)


Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.  (abst – 2006)


Cannabinoid–improgan cross-tolerance: Improgan is a cannabinomimetic analgesic lacking affinity at the cannabinoid CB1 receptor                                                   (abst – 2006)


Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain                                                                           (abst – 2006)


Cannabinoids Enhance Analgesic Effects Of Anti-Inflammatory Drugs, Study Says (news – 2006)                             


In MedPanel Summit, Leading Pain Experts Name Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain, Assert That Sociopolitical Climate Will Hamper Drug Approvals          (news – 2006)  oids_among_most/index.html?source=r_health


Cannabis effective at relieving pain after major surgery                (news – 2006)


Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia                                                  (full – 2007)


Low dose combination of morphine and Δ9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors                                                             (full – 2007)


Antinociceptive Synergy Between the Cannabinoid Receptor Agonist WIN 55,212-2 and Bupivacaine in the Rat Formalin Test                                                      (full – 2007)

http://www.anesthesia-  searchid=1&FIRSTINDEX=320&resourcetype=HWCIT


Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.  (full – 2007)  is_on.16.aspx


Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain   (full – 2007)          


Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors           (full – 2007)               


Continuous infusion of the cannabinoid WIN 55,212–2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity                                                           (full – 2007)


Cannabinoids for postoperative pain.              (letter – 2007) x


A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.                                         (abst – 2007)


Cannabis, pain, and sleep: lessons from trials of Sativex, a cannabis-based medicine. (abst – 2007)                           


Pain relief from cannabis depends on how much you smoke              (news – 2007)


Therapeutic potential of cannabis in pain medicine              (full – 2008)


Cannabinoids in the management of difficult to treat pain             (full – 2008)


Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception                               (full – 2008)


Cannabinoids in chronic pain and palliative care.              (full – 2008)  70942008000300010&lng=en&nrm=iso&tlng=en



MANAGEMENT              (full – 2008)


Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation (full – 2008)                         


Cannabinoids in chronic pain and palliative care.              (full – 2008)

(First in Spanish, then English)        


A Randomized, Placebo Controlled Cross-Over Trial of Cannabis Cigarettes in Neuropathic Pain            (full – 2008)                      


Nabilone for the treatment of pain in fibromyalgia.               (abst – 2008)


Pain relief with cannabinoids– the importance of endocannabinoids and cannabinoids for pain therapy   (abst – 2008)                 


Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo   (abst – 2008)                  


Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests

(news – 2008)        


Scientist Discovers New Molecule to Treat Chronic Pain              (news – 2008)


New Cannabis-Like Drugs Could Block Pain Without Affecting Brain, Says Study (news – 2008)                             


Cannabislike Drugs May Hold Key to Treating Pain While Bypassing the Brain (news – 2008)                           


Cannabis suggests treatment for chronic pain               (news – 2008)


Dynamic regulation of the endocannabinoid system: implications for analgesia (full – 2009)                          


The endocannabinoid system and pain.              (full – 2009)


Cannabinoids: An emerging role in pain management?                 (full – 2009)


Standardized natural product cannabis in pain management and observations at a Canadian compassion society: a case report                                                                   (full – 2009)


Systematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain. (abst – 2009)                          


Interaction of the cannabinoid and opioid systems in the modulation of nociception. (abst – 2009)  nel.Pubmed_RVDocSum&ordinalpos=34


The analgesic potential of cannabinoids.                 (abst – 2009)


Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State.                                            (abst – 2009)



Endocannabinoids, Closely Related To Active Ingredients In Cannabis Plant, Can Promote Pain (news – 2009)


Evidence for a Role of Endocannabinoids, Astrocytes and p38 Phosphorylation in the Resolution of Postoperative Pain                                                               (full – 2010)


Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism (full – 2010)                           


Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia.      (abst – 2010)                     


A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss. (abst – 2010)                           


Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.           (abst – 2010)


Pain target enzyme’s working made crystal clear                (news – 2010)


Chronic Pain Improved by Cannabis Smoking                (news – 2010)


Study: Smoking pot may ease chronic pain                 (news – 2010)


Marijuana better than pharmaceuticals at treating chronic pain, improving mood (news – 2010)                           


Painkilling System in Brain: Too Much of a Good Thing?               (news – 2010)


Smoking cannabis relieves chronic pain                 (news – 2010)  2067287.html


A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011)                         


Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats     (full – 2011)


Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by Electroacupuncture                                      (full – 2011)


Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)                        

The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief                                                                          (full – 2011)


Pharmacological characterization of AM1710, a putative cannabinoid CB(2) agonist from the cannabilactone class: Antinociception without central nervous system side-effects. (abst – 2011)


on_of_AM1710_a_putative_cannabinoid_CB_2 n_without_central_nervous_system_side_effects_




Treating pain in multiple sclerosis.                (abst – 2011)


Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2011)


Cannabis in Palliative Medicine: Improving Care and Reducing Opioid-Related Morbidity           (abst – 2011)       its=80&RES   ULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=H WCIT


Cannabinoid-opioid interaction in chronic pain.                (abst – 2011)



Antinociception and sedation following intracerebroventricular administration of Δ⁹-

tetrahydrocannabinol in female vs. male rats.                (abst – 2011) following_intracerebroventricular_administration_of_%CE%94%E2%81%B9_tetrahydrocannabinol_in_fe




Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action                                                               (abst – 2011)  s_modulate_the_descending_pathway_of_antinociception_in_anaesthetized_rats_through_several_mechani  sms_of_action_


Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.                                                               (abst – 2011)


Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials.   (abst – 2011)                          


Marijuana, Narcotics Help Patients Reduce Chronic Pain, Study Finds              (news – 2011)  pain_n_1137416.html


New Way to Boost Potency of Natural Pain Relief Chemical in Body              (news – 2011)


Part of placebo effect ascribed to cannabinoids              (news – 2011)


Marijuana component could ease pain from chemotherapy drugs                (news – 2011)


The Positive Uses of Marijuana for Cancer Patients             (news – 2011)


Cannabis brings relief to women suffering from PMS and PMDD symptoms (news – 2011) from-pms-and-pmdd-symptoms


Father: Medical marijuana eased pain of my cancer-battling son             (anecdotal – 2011)


Medical Marijuana: Clearing Away the Smoke               (full – 2012)


Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat        (full – 2012)


Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. (full – 2012)


Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain         (full – 2012)                                            


Neonatal DSP-4 Treatment Modifies Antinociceptive Effects of the CB(1) Receptor Agonist Methanandamide in Adult Rats.                                                              (full – 2012)


Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. (full – 2012)                              


The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy                      (full – 2012)


Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series                                                              (full – 2012)


Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier

(full – 2012)             


Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(full – 2012)               


Behavioral effects of pulp exposure in mice lacking cannabinoid receptor 2. (abst – 2012)                                    


Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                                 


Cannabinergic Pain Medicine: A Concise Clinical Primer and Survey of Randomized- controlled Trial Results.                                                           (abst – 2012)


Review article: Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide                                                            (abst – 2012)


Dynamic changes to the endocannabinoid system in models of chronic pain (abst – 2012)                              


The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.                                                                              (abst – 2012)


Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels.                                                                         (abst – 2012)


Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level. (abst – 2012)                                


Role of cannabinoid 2 receptor in the development of bone cancer pain (abst – 2012)                                  


Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial.                                                           (abst – 2012)



Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.       (abst – 2012)                  


The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.      (abst – 2012)                                                  


Acute Reduction of Anandamide-Hydrolase (FAAH) Activity is Coupled With a Reduction of Nociceptive Pathways Facilitation in Medication-Overuse Headache Subjects After Withdrawal Treatment    (abst – 2012)


Monoacylglycerol lipase – a target for drug development?               (abst – 2012)


Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia. (abst – 2012)                           


Therapeutic modulation of cannabinoid lipid signaling: Metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist.                                                                 (abst – 2012)


Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2012)


Analgesic effects of cannabinoids on central pain syndrome               (abst – 2012)


Cannabis as an adjunct to or substitute for opiates in the treatment of chronic pain. (abst – 2012)                            


“Redundancy” of endocannabinoid inactivation: new challenges and opportunities for pain control.        (abst – 2012)               


Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis.     (abst – 2012)                   


The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)


Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals          (abst – 2012)                


Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.                                        (abst – 2012)


Endocannabinoid modulation of jejunal afferent responses to LPS               (abst – 2012)


Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment.   (abst – 2012)


Neuromodulators for pain management in rheumatoid arthritis               (abst – 2012)


Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.                                                                  (abst – 2012)


Cannabinoid therapy helps provide effective analgesia for cancer patients with pain (news – 2012)  cancer-patients-with-pain.aspx


Reefer tokin’ seniors in South Florida see pain go up in smoke              (news – 2012)


Cannabinoid Shown Effective as Adjuvant Analgesic for Cancer Pain             (news – 2012)


Cannabinoid formulation benefits opioid-refractory pain                 (news – 2012)


Cannabis as Painkiller                  (news – 2012)


Cannabis can make pain less bothering                (news – 2012)


Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)


The role of endocannabinoids in pain modulation.               (full – 2013)


Amygdala activity contributes to the dissociative effect of cannabis on pain perception. (abst – 2013)                           


CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                                          (abst – 2013)


Repeated Low Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains CB1 Receptor Mediated Antinociceptive and Gastroprotective Effects.

(abst – 2013)            

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