OLEOYLETHANOLAMIDE/ OEA – endocannabinoid, an anandamide analog, GPR 119 agonist


‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.                                                                                (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597234/?tool=pubmed


Endocannabinoids and nutrition.               (full – 2008)



Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats.                                                                (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494809/?tool=pubmed


The lipid messenger OEA links dietary fat intake to satiety.               (full – 2008)



Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells.                                                            (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528830/?tool=pubmed


Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. (abst – 2008)                                      http://www.ncbi.nlm.nih.gov/pubmed/18535023


Biological functions and metabolism of oleoylethanolamide.               (abst – 2008)



Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice.                                                   (abst – 2008)      http://www.ncbi.nlm.nih.gov/pubmed/18278475


Fat-induced satiety factor oleoylethanolamide enhances memory consolidation (full – 2009)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683095/?tool=pubmed


GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell.                                                 (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671052/?tool=pubmed


Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. (full – 2009)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757605/?tool=pubmed


Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.                                                   (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716432/?tool=pubmed


Receptors for acylethanolamides-GPR55 and GPR119.              (full – 2009)



Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons.                                            (abst – 2009)         http://www.ncbi.nlm.nih.gov/pubmed/19070629


Plasma endocannabinoid levels in multiple sclerosis.                 (abst – 2009)



N-acylethanolamines, anandamide and food intake.               (abst – 2009)


The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin.          (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900249/?tool=pubmed


Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls (full – 2010)                                     http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00787.x/full


Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.                                                  (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868848/?tool=pubmed


Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women     (full – 2010)                           http://www.nutritionandmetabolism.com/content/7/1/49


CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free- feeding mice.            (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846762/?tool=pubmed


Endocannabinoids and Human Sperm Cells              (link to PDF – 2010)



Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.     (abst – 2010)                        http://www.ncbi.nlm.nih.gov/pubmed/20353771


Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice.                                                                                         (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/19954948


Oleoylethanolamide affects food intake and sleep-waking cycle through a hypothalamic modulation.      (abst – 2010)                         http://www.ncbi.nlm.nih.gov/pubmed/20100574


Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea– specific role of oleoylethanolamide.                                          (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20429051


Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.                                                               (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136458/?tool=pubmed


Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. (full – 2011)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084524/?tool=pubmed


Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice   (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111743/?tool=pubmed


Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice                                                           (full – 2011)  http://www.nutritionandmetabolism.com/content/8/1/51


The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.                                                  (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/22029844


Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?                                        (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21664223


Gut fat sensing in the negative feedback control of energy balance–recent advances. (abst – 2011)                                      http://www.ncbi.nlm.nih.gov/pubmed/21557957


The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                                     http://www.jneuroinflammation.com/content/9/1/79


The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.                                                    (full – 2012)



Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409167/?tool=pubmed


Plasma Endocannabinoid Alterations in Individuals with Substance Use Disorder are Dependent on the “Mirror Effect” of Schizophrenia.                                                            (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457074/


Endocannabinoids in stressed humans                (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152482&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=2&uiLanguage=en


Synthesis of oleoylethanolamide using lipase.               (abst – 2012)



Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor α. (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22480617


Stimulating beta cell replication and improving islet graft function by GPR119 agonists. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/21902730


Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22442280


The Volitional Nature of Nicotine Exposure Alters Anandamide and Oleoylethanolamide Levels in the Ventral Tegmental Area.                                                             (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23169348


Optimized synthesis and characterization of N-acylethanolamines and O- acylethanolamines, important family of lipid-signalling molecules.                                                                                           (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22850591?dopt=Abstract


Temporal changes in N-acylethanolamine content and metabolism throughout the peri- adolescent period                                                         (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1002/syn.21609/abstract


Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans     (abst – 2012)                                         http://www.ncbi.nlm.nih.gov/pubmed/22763622


β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors    (abst – 2012)



The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone (abst – 2012)                                          http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01478.x/abstract


Mechanisms of vasorelaxation induced by oleoylethanolamide in the rat small mesenteric artery.  (abst – 2013)                                 http://www.ncbi.nlm.nih.gov/pubmed/23340219


Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity.    (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23372171


The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.                                                                       (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23373571


Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain.                       (abst – 2013)



Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.                                                    (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23398921


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