NAUSEAalso see MORNING SICKNESS, MOTION SICKNESS, RADIATION-INDUCED NAUSEA

 

Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.      (full – 1975)                                           http://www.ukcia.org/research/antiemetic.php

 

Delta-9-Tetrahydrocannibinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate   (full – 1979)                                 http://www.ukcia.org/research/AntiemeticForMethotrexate.php

 

Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo                                                                       (abst – 1979)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=27

 

 

 

 

 

 

 

 

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9- tetrahydrocannabinol.    (abst – 1979)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=107

 

Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.                                                    (abst – 1979)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=126

 

Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.                                                                       (abst – 1979)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=5

 

Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.                                                      (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=131

 

Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis                                            (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=6

 

The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy.                                                                              (abst – 1980)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=24

 

Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine.                           (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=3

 

Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics.          (abst – 1981)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=30

 

Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.       (abst – 1981)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=88

 

Clinical experience with levonantradol hydrochloride in the prevention of cancer chemotherapy-induced nausea and vomiting.                                                                      (abst – 1981)  http://www.ncbi.nlm.nih.gov/pubmed/7298877

 

Comparative trial of the antiemetic effects of THC and haloperidol             (abst – 1981)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=64

 

A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.                                              (abst – 1982)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=146

 

 

 

 

 

 

 

 

Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine.       (abst – 1982)                                          http://www.ncbi.nlm.nih.gov/pubmed/6284334

 

A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.                                                 (abst – 1982)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=156

 

Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.       (full -1983)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011510/?tool=pmcentrez&page=1

 

Levonantradol: a synthetic cannabinoid in the treatment of severe chemotherapy-induced nausea and vomiting resistant to conventional anti-emetic therapy.                                                 (abst – 1983)  http://www.ncbi.nlm.nih.gov/pubmed/6309451

 

THC or Compazine for the cancer chemotherapy patient–the UCLA study. Part II: Patient drug preference.                                                     (abst – 1985)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=34

 

A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. (abst – 1985)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=128

 

Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting.                                                                 (abst – 1985)  http://www.ncbi.nlm.nih.gov/pubmed/2981616

 

Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.                                                                    (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=121

 

Nabilone: an alternative antiemetic for cancer chemotherapy.                (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=123

 

Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.                                                      (abst – 1986)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=127

 

Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.                                                                  (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=129

 

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.                                                      (abst – 1987)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=120

 

A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.                                                     (abst – 1987)

 

 

 

 

 

 

 

 

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=130

 

Oral vs. Inhaled Cannabinoids for Nausea/Vomiting from Cancer Chemotherapy (full – 1988)                                    http://www.druglibrary.org/schaffer/hemp/medical/pierson.html

 

Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy (abst – 1988)                                    http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=31

 

A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.                                                                                            (abst – 1988)  http://www.ncbi.nlm.nih.gov/pubmed/2838294

 

Marijuana as antiemetic medicine: a survey of oncologists’ experiences and attitudes. (abst – 1991)                                             http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=134

 

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy. (abst – 1994)        http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=137

 

Effect of nabilone on nausea and vomiting              (letter – 1995)  http://bja.oxfordjournals.org/cgi/reprint/74/1/111?maxtoshow=&hits=80&RESULTFORMAT=1&andorex  acttitle=and&andorexacttitleabs=and&fulltext=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTI NDEX=0&sortspec=relevance&resourcetype=HWCIT

 

An efficient new cannabinoid antiemetic in pediatric oncology.             (abst – 1995)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=7

 

Patent 5605928 – Antiemetic compositions                (full – 1997)

http://www.patentstorm.us/patents/5605928/fulltext.html

 

Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol).                                                   (abst – 1997)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=35

 

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review            (full – 2001)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC34325/?tool=pmcentrez

 

Therapeutic Aspects of Cannabis and Cannabinoids              (full – 2001)

http://bjp.rcpsych.org/cgi/reprint/178/2/107.pdf

 

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.                                                   (full – 2001)  http://www.nature.com/npp/journal/v24/n2/full/1395605a.html

 

The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. (full – 2001)

http://journals.lww.com/anesthesiology/Fulltext/2001/05000/The_Cannabinoid_Agonist_WIN55,212_2_Su  ppresses.29.aspx

 

 

 

 

 

 

 

 

 

The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. (abst – 2001)                                    http://www.ncbi.nlm.nih.gov/pubmed/11854768?dopt=Abstract

 

The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2                                                     (abst – 2001)  http://www.ncbi.nlm.nih.gov/pubmed/11120402

 

Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac                                                           (abst – 2001)  http://www.ncbi.nlm.nih.gov/pubmed/11509190?dopt=Abstract

 

Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat? (abst – 2002)                                    http://haworthpress.com/store/ArticleAbstract.asp?ID=18139

 

Delta9-tetrahydrocannabinol selectively acts on CB1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets.                                                                  (full – 2003)  http://ajpgi.physiology.org/content/285/3/G566.long

 

Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve       (full – 2004)                        http://jp.physoc.org/content/559/3/923.full#sec-19

 

A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew).

(abst – 2004)                http://www.ncbi.nlm.nih.gov/pubmed/14740147

 

US Patent Application 20050165088 – Compositions comprising cannabinoids for treatment of nausea, vomiting, emesis, motion sickness or like conditions

(full – 2005)                http://www.patentstorm.us/applications/20050165088/fulltext.html

 

Cannabinoids In Medicine: A Review Of Their Therapeutic Potential                  (full – 2006)

http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/CannabinoidsMedMetaAnalysis06.pdf

 

Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting.                                                                                                 (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16197970

 

Prevention of nausea and vomiting following breast surgery.             (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16720146

 

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

 

Experience with the Synthetic Cannabinoid Nabilone in Chronic Noncancer Pain (abst – 2006)

 

 

 

 

 

 

 

 

http://onlinelibrary.wiley.com/doi/10.1111/j.1526-  4637.2006.00085.x/abstract;jsessionid=E64762ABC5DA541547D051CCC8EE2DFC.d03t01

 

Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.         (abst – 2006)                               http://www.ncbi.nlm.nih.gov/pubmed/16506408

 

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.       (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=180

 

US Patent Application 20070049645 – Anti-nausea and anti-vomiting activity of cannabidiol compounds           (full – 2007)  http://www.patentstorm.us/applications/20070049645/fulltext.html

 

THC improves appetite and reverses weight loss in AIDS patients              (abst – 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=189

 

Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.                                                        (abst – 2007)     http://www.ncbi.nlm.nih.gov/pubmed/17566383

 

Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.                                            (abst – 2007)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=191

 

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.    (abst – 2007)                      http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=190

 

Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.                                                          (abst – 2007)  http://www.unboundmedicine.com/medline/ebm/record/17362921/abstract/Receptor_mechanism_and_anti   emetic_activity_of_structurally_diverse_cannabinoids_against_radiation_induced_emesis_in_the_least_shr  ew

 

Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.                                                    (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17459108

 

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects      (abst – 2008)                           http://gut.bmj.com/content/57/8/1140.abstract

 

Medical marijuana: a surprising solution to severe morning sickness                  (news – 2008)  http://current.com/items/89174292_medical-marijuana-a-surprising-solution-to-severe-morning-  sickness.htm

 

Medical Marijuana and Severe Nausea              (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/99?ailment=severe-nausea

 

Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting                                                                  (full – 2010)

 

 

 

 

 

 

 

 

http://www.unboundmedicine.com/medline/ebm/record/21039759/abstract/Preliminary_efficacy_and_safet y_of_an_oromucosal_standardized_cannabis_extract_in_chemotherapy_induced_nausea_and_vomiting_

 

Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting                                                                       (link to PDF– 2010)  http://www.mdpi.com/1424-8247/3/9/2930

 

The abuse potential of the synthetic cannabinoid nabilone.               (abst – 2010)

http://www.ncbi.nlm.nih.gov/pubmed/20402993

 

Regulation of nausea and vomiting by cannabinoids                (abst – 2010)  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-  5381.2010.01176.x/abstract;jsessionid=56CED9CE51B025C161AA2E821BEC94ED.d01t01

 

Motion Sickness, Stress and the Endocannabinoid System                (abst – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873996/?tool=pmcentrez

 

Medical Marijuana: Can Pot Help Pregnant Women With Vomiting and Nausea? (article – 2011)

http://patients4medicalmarijuana.wordpress.com/2011/01/13/pregnancy-and-medical-marijuana-can-pot-  help-pregnant-women-with-vomiting-and-nausea/

 

Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. (abst – 2011)                                           http://www.ncbi.nlm.nih.gov/pubmed/21243485

 

Cannabidiol, a Non-Psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.     (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21827451

 

Regulation of nausea and vomiting by cannabinoids.                (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21175589/abstract/Regulation_of_nausea_and_vo miting_by_cannabinoids_

 

How Does Marijuana Help Cancer Patients?               (news – 2011)

http://www.livestrong.com/article/219707-how-does-marijuana-help-cancer-patients/

 

The Positive Uses of Marijuana for Cancer Patients                (news – 2011)

http://www.livestrong.com/article/94355-positive-uses-marijuana-cancer-patients/#ixzz21Ib5ILhj

 

Medical Marijuana: Clearing Away the Smoke               (full – 2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358713/

 

Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22491047

 

Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids.   (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22496569

 

 

 

 

 

 

 

 

 

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?                                                    (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22625422

 

The therapeutic potential of cannabis and cannabinoids.                    (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23008748

 

Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. (abst – 2012)                                            http://www.ncbi.nlm.nih.gov/pubmed/23023882

 

Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals          (abst – 2012)                                http://onlinelibrary.wiley.com/doi/10.1002/syn.21586/abstract

 

The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex.            (abst – 2012)                      http://www.ncbi.nlm.nih.gov/pubmed/22671779

 

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation.                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23121618

 

Cannabis as Painkiller                         (news – 2012)

http://www.sciencedaily.com/releases/2012/08/120807101232.htm

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