NABILONE/ CESAMET – a synthetic THC, CB 1 & CB 2 agonist

 

GENERIC NAME: NABILONE – ORAL (NAB-ih-lone)

Brand Names : Cesamet                     (monograph – undated)

http://www.medicinenet.com/nabilone-oral/article.htm

 

Microbiological transformations of nabilone, a synthetic cannabinoid.                     (full – 1979)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC243333/?tool=pmcentrez&page=1

 

Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.                                                        (abst – 1979)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=126

 

Cannabinoids. II. Cardiovascular Effects                    (full – 1980)  http://jpet.aspetjournals.org/content/214/1/131.full.pdf+html?ijkey=e751d405c4b7e494c235b602119e4f9b  8c62c04d&keytype2=tf_ipsecsha

 

Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.                                                            (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=131

 

 

 

 

 

 

 

 

 

The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety (abst – 1981)  http://jcp.sagepub.com/cgi/content/abstract/21/8_suppl/377S?maxtoshow=&hits=80&RESULTFORMAT=

&fulltext=marihuana&searchid=1&FIRSTINDEX=240&resourcetype=HWCIT

 

A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.                                             (abst – 1982)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=146

 

A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.                                                (abst – 1982)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=156

 

Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.       (full – 1983)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011510/?tool=pmcentrez&page=1

 

Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects.    (abst – 1983)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=43

 

Respiratory and cardiovascular depressant effects of nabilone, N-methyllevonantradol and delta 9-tetrahydrocannabinol in anesthetized cats.                                  (abst – 1983)  http://jpet.aspetjournals.org/content/227/2/508.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=marihuana&searchid=1&FIRSTINDEX=1920&resourcetype=HWCIT

 

Acute Effects of Natural and Synthetic Cannabis Compounds on Prolactin Levels in Human Males.        (abst – 1984)                             http://www.ncbi.nlm.nih.gov/pubmed/6320226

 

A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. (abst – 1985)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=128

 

Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.                                                                     (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=121

 

Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.                                                     (abst – 1986)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=127

 

Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.                                                                 (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=129

 

Nabilone: an alternative antiemetic for cancer chemotherapy.               (abst – 1986)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=123

 

 

 

 

 

 

 

 

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.                                                      (abst – 1987)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=120

 

A species comparison of the toxicity of nabilone, a new synthetic cannabinoid. (abst – 1987)                                   http://www.ncbi.nlm.nih.gov/pubmed/2888699

 

Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes.    (abst – 1987)                               http://www.ncbi.nlm.nih.gov/pubmed/3037806

 

A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.                                                    (abst – 1987)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=130

 

A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.                                                                                             (abst – 1988)  http://www.ncbi.nlm.nih.gov/pubmed/2838294

 

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy (abst – 1994)         http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=137

 

Effect of nabilone on nausea and vomiting                (letter – 1995)  http://bja.oxfordjournals.org/cgi/reprint/74/1/111?maxtoshow=&hits=80&RESULTFORMAT=1&andorex  acttitle=and&andorexacttitleabs=and&fulltext=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTI  NDEX=0&sortspec=relevance&resourcetype=HWCIT

 

Nabilone in the treatment of multiple sclerosis.               (abst – 1995)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=11

 

The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson’s disease (PD).                                                          (abst – 1998)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=153

 

Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.          (excerpt – 1999)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=203

 

Cannabis and cannabinoids: pharmacology and rationale for clinical use                (abst – 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10575283

 

Different effects of nabilone and cannabidiol on binocular depth inversion in Man. (abst – 2000)                                     http://www.ncbi.nlm.nih.gov/pubmed/10837858

 

Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.                                                    (full – 2001)  http://www.nature.com/npp/journal/v24/n2/full/1395605a.html

 

 

 

 

 

 

 

 

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: a pilot study. (abst – 2001)                                   http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=54

 

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat                                                          (full – 2002)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1573125&tool=pmcentrez

 

Cannabinoids and multiple sclerosis.                (abst – 2002)

http://www.ncbi.nlm.nih.gov/pubmed/12182963

 

Cannabinoid rotation in a young woman with chronic cystitis                 (abst – 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=115

 

Therapeutic potential of cannabinoids in CNS disease.              (abst – 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

 

Nabilone Could Treat Chorea and Irritability in Huntington’s Disease              (letter – 2006)

http://neuro.psychiatryonline.org/article.aspx?articleid=102920

 

Nabilone significantly reduces spasticity-related pain                 (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=200

 

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)                        http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

 

Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.   (abst – 2006)   http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=200

 

Synthetic cannabinomimetic nabilone on patients with chronic pain               (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=197

 

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

 

Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

(abst – 2006)                  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=200

 

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

 

Nabilone improves pain and symptom management in cancer patients

(abst – 2006)             http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=177

 

Synthetic cannabinomimetic nabilone on patients with chronic pain             (abst – 2006)

 

 

 

 

 

 

 

 

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=197

 

A Look At FDA-OK’d ‘Marijuana’ Drug             (news – 2006)

http://www.cbsnews.com/stories/2006/05/18/health/webmd/main1632561.shtml

 

2nd synthetic marijuana drug OK’d for chemo effects                (news – 2006)

http://www.usatoday.com/news/health/2006-05-16-marijuana-drug_x.htm

 

Cesamet (nabilone)  capsule                    (info page – 2007)

http://dailymed.nlm.nih.gov/dailymed/mobile/drugInfo.cfm?id=4474

 

Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.                                                         (abst – 2007)        http://www.ncbi.nlm.nih.gov/pubmed/17566383

 

Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances. (abst – 2007)                                  http://www.ncbi.nlm.nih.gov/pubmed/17868014

 

Synthetic Cannabis for Fibromyalgia Pain?                (news – 2007)

http://www.healthcentral.com/chronic-pain/c/5949/16104/fm-pain

 

Nabilone relieves many advanced Ca symptoms                  (news – 2007)

http://www.highbeam.com/doc/1G1-178441488.html

 

Cannabinoids in the management of difficult to treat pain             (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/?tool=pmcentrez

 

Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.                                                   (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213874/?tool=pubmed

 

Nabilone for the treatment of pain in fibromyalgia.              (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/17974490

 

Nabilone for the treatment of paraneoplastic night sweats: a report of four cases (abst – 2008)                                     http://www.ncbi.nlm.nih.gov/pubmed/18715188

 

Science: Nabilone effective in the treatment of night sweats of four patients with advanced cancer          (news – 2008)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=277#1

 

Marijuana Derivative Called Effective in Fibromyalgia                (news – 2008)

http://www.medpagetoday.com/Rheumatology/Fibromyalgia/8377

 

Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests                (news – 2008)

http://www.sciencedaily.com/releases/2008/02/080217214547.htm

 

Two New Approaches for Fibromyalgia                (news – 2008)

http://www.health-and-age.org/health-topics/2008/2/27/two-new-approaches-for-fibromyalgia.html

 

 

 

 

 

 

 

 

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

(full – 2009)                http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/?tool=pmcentrez

 

The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial.      (full – 2009)                       http://www.anesthesia-analgesia.org/content/110/2/604.long

 

Emerging strategies for exploiting cannabinoid receptor agonists as medicines. (full – 2009)                                    http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2008.00048.x/full

 

Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. (full – 2009)                                        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755639/

 

A pilot study using nabilone for symptomatic treatment in Huntington’s disease. (abst – 2009)

http://www.unboundmedicine.com/medline/ebm/record/19845035/abstract/A_pilot_study_using_nabilone_  for_symptomatic_treatment_in_Huntington%27s_disease_

 

The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD).                                                    (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19228182?dopt=Abstract

 

CESAMET® CII (nabilone) Capsules For Oral Administration (Archived drug label – 2010)  http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=16800

 

A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury.                                                         (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20434606

 

An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.          (abst – 2010)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=311

 

What Are Prescription Drugs That Are a Substitute for Marijuana?               (news – 2011)  http://www.livestrong.com/article/137065-what-are-prescription-drugs-that-are-substitute-  marijuana/#ixzz21Ia1dVQG

 

CADTH Rapid Response Report: Cannabinoids for the treatment of post-traumatic stress disorder         (full – 2012)

http://www.cadth.ca/media/pdf/htis/july-2012/RC0368%20Cannabinoids%20Final.pdf

 

Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.                                               (abst – 2012)          http://www.ncbi.nlm.nih.gov/pubmed/22260337

 

Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting. (abst – 2012)                                       http://www.ncbi.nlm.nih.gov/pubmed/22491047

 

 

 

 

 

 

 

 

A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003)           (abst – 2012)

http://www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/S38.003?maxtosho w=&hit   s=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=180&sortspec=date&reso  urcetype=HWCIT

 

An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo- controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain.                                                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22921260

 

Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients   (news – 2012)

http://norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-well-  tolerated-in-patients

 

New drug offers novel pain management therapy for diabetics.                        (news – 2012)  http://www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+diabetics.-  a0306899453

 

Synthetic cannabinoid could treat pain in diabetes patients                     (news – 2012)  http://www.medwirenews.com/57/102248/Diabetes/Synthetic_cannabinoid_could_treat_pain_in_diabetes_  patients_.html

 

Drug offers new pain management therapy for diabetics                     (news – 2012)

http://medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html

 

The pharmacologic and clinical effects of medical cannabis.                       (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23386598

Share a link for