NABILONE/ CESAMET – a synthetic THC, CB 1 & CB 2 agonist



Brand Names : Cesamet                     (monograph – undated)


Microbiological transformations of nabilone, a synthetic cannabinoid.                     (full – 1979)


Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.                                                        (abst – 1979)


Cannabinoids. II. Cardiovascular Effects                    (full – 1980)  8c62c04d&keytype2=tf_ipsecsha


Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.                                                            (abst – 1980)










The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety (abst – 1981)



A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.                                             (abst – 1982)


A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.                                                (abst – 1982)


Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.       (full – 1983)


Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects.    (abst – 1983)


Respiratory and cardiovascular depressant effects of nabilone, N-methyllevonantradol and delta 9-tetrahydrocannabinol in anesthetized cats.                                  (abst – 1983) ext=marihuana&searchid=1&FIRSTINDEX=1920&resourcetype=HWCIT


Acute Effects of Natural and Synthetic Cannabis Compounds on Prolactin Levels in Human Males.        (abst – 1984)                   


A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. (abst – 1985)


Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.                                                                     (abst – 1986)


Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.                                                     (abst – 1986)


Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.                                                                 (abst – 1986)


Nabilone: an alternative antiemetic for cancer chemotherapy.               (abst – 1986)









Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.                                                      (abst – 1987)


A species comparison of the toxicity of nabilone, a new synthetic cannabinoid. (abst – 1987)                         


Species specificity in the metabolism of nabilone. Relationship between toxicity and metabolic routes.    (abst – 1987)                     


A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.                                                    (abst – 1987)


A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.                                                                                             (abst – 1988)


Effect of nabilone on nausea and vomiting after total abdominal hysterectomy (abst – 1994)


Effect of nabilone on nausea and vomiting                (letter – 1995)  acttitle=and&andorexacttitleabs=and&fulltext=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTI  NDEX=0&sortspec=relevance&resourcetype=HWCIT


Nabilone in the treatment of multiple sclerosis.               (abst – 1995)


The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson’s disease (PD).                                                          (abst – 1998)


Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.          (excerpt – 1999)


Cannabis and cannabinoids: pharmacology and rationale for clinical use                (abst – 1999)


Different effects of nabilone and cannabidiol on binocular depth inversion in Man. (abst – 2000)                           


Delta(9)-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB(1) receptor antagonist/inverse agonist SR 141716A.                                                    (full – 2001)









Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: a pilot study. (abst – 2001)                         


Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat                                                          (full – 2002)


Cannabinoids and multiple sclerosis.                (abst – 2002)


Cannabinoid rotation in a young woman with chronic cystitis                 (abst – 2003)


Therapeutic potential of cannabinoids in CNS disease.              (abst – 2003)


Nabilone Could Treat Chorea and Irritability in Huntington’s Disease              (letter – 2006)


Nabilone significantly reduces spasticity-related pain                 (abst – 2006)


The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)              


Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.   (abst – 2006)


Synthetic cannabinomimetic nabilone on patients with chronic pain               (abst – 2006)


The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)


Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

(abst – 2006)        


The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients  (abst – 2006)


Nabilone improves pain and symptom management in cancer patients

(abst – 2006)   


Synthetic cannabinomimetic nabilone on patients with chronic pain             (abst – 2006)







A Look At FDA-OK’d ‘Marijuana’ Drug             (news – 2006)


2nd synthetic marijuana drug OK’d for chemo effects                (news – 2006)


Cesamet (nabilone)  capsule                    (info page – 2007)


Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting: beyond prevention of acute emesis.                                                         (abst – 2007)


Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances. (abst – 2007)                        


Synthetic Cannabis for Fibromyalgia Pain?                (news – 2007)


Nabilone relieves many advanced Ca symptoms                  (news – 2007)


Cannabinoids in the management of difficult to treat pain             (full – 2008)


Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.                                                   (full – 2008)


Nabilone for the treatment of pain in fibromyalgia.              (abst – 2008)


Nabilone for the treatment of paraneoplastic night sweats: a report of four cases (abst – 2008)                           


Science: Nabilone effective in the treatment of night sweats of four patients with advanced cancer          (news – 2008)


Marijuana Derivative Called Effective in Fibromyalgia                (news – 2008)


Marijuana-Based Drug Reduces Fibromyalgia Pain, Study Suggests                (news – 2008)


Two New Approaches for Fibromyalgia                (news – 2008)









Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

(full – 2009)      


The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial.      (full – 2009)             


Emerging strategies for exploiting cannabinoid receptor agonists as medicines. (full – 2009)                          


Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. (full – 2009)                              


A pilot study using nabilone for symptomatic treatment in Huntington’s disease. (abst – 2009)  for_symptomatic_treatment_in_Huntington%27s_disease_


The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD).                                                    (abst – 2009)


CESAMET® CII (nabilone) Capsules For Oral Administration (Archived drug label – 2010)


A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury.                                                         (abst – 2010)


An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.          (abst – 2010)


What Are Prescription Drugs That Are a Substitute for Marijuana?               (news – 2011)  marijuana/#ixzz21Ia1dVQG


CADTH Rapid Response Report: Cannabinoids for the treatment of post-traumatic stress disorder         (full – 2012)


Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.                                               (abst – 2012)


Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting. (abst – 2012)                             









A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003)           (abst – 2012) w=&hit   s=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=180&sortspec=date&reso  urcetype=HWCIT


An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo- controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain.                                                                                 (abst – 2012)


Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients   (news – 2012)  tolerated-in-patients


New drug offers novel pain management therapy for diabetics.                        (news – 2012)  a0306899453


Synthetic cannabinoid could treat pain in diabetes patients                     (news – 2012)  patients_.html


Drug offers new pain management therapy for diabetics                     (news – 2012)


The pharmacologic and clinical effects of medical cannabis.                       (abst – 2013)

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