MULTIPLE SCLEROSIS/ MS

 

The use of cannabinoids in MS: is it evidence based?                      (abst – undated)

http://www.ukcia.org/research/UseOfCannabinoidsInMSEvidenceBased.pdf                        

 

Marihuana as a therapeutic agent for muscle spasm or spasticity                      (abst – 1980)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=53

 

Tetrahydrocannabinol for tremor in multiple sclerosis.                      (abst – 1983)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=9

 

Delta-9-THC in the treatment of spasticity associated with retinopathy.                    (abst – 1987)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=1

 

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.                   (abst – 1989)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=2

 

Nabilone in the treatment of multiple sclerosis                     (abst – 1995)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=11

 

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.                                                      (abst – 1996)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=12

 

The perceived effects of smoked cannabis on patients with multiple sclerosis. (abst – 1997)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=13

 

Cannabis and cannabinoids: pharmacology and rationale for clinical use                      (abst – 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10575283

 

Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.          (abst – 1999)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=203

 

Endocannabinoids control spasticity in a multiple sclerosis model                      (full – 2000)  http://www.fasebj.org/cgi/reprint/00-  0399fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear  chid=1&FIRSTINDEX=10&sortspec=relevance&resourcetype=HWCIT

 

 

 

 

 

 

 

 

 

Cannabinoids might reduce spasticity in multiple sclerosis                 (full – 2000)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1117698/?tool=pmcentrez

 

Cannabinoids control spasticity and tremor in a multiple sclerosis model                 (full – 2000)

http://www.ukcia.org/research/CannabinoidsControlSpasticityAndTremorInAMultipleSclerosisModel.php

 

Cannabinoids reduce tremor in animal model of multiple sclerosis               (news – 2000)  http://www.cannabis-  med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=12&search_pattern=Cannabinoids,reduce,tre mor,in,animal,model,of,multiple,sclerosis#2

 

Therapeutic aspects of cannabis and cannabinoids.               (full – 2001)

http://bjp.rcpsych.org/cgi/content/full/178/2/107

 

Acute and chronic effects of cannabis based medicinal extract on refractory lower urinary tract dysfunction in patients with advanced multiple sclerosis – early results

(abst – 2001)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=103

 

The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. (abst – 2001)                                      http://www.ncbi.nlm.nih.gov/pubmed/11854768?dopt=Abstract

 

Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis (full – 2002)    http://proxy.baremetal.com/cannabiscoalition.ca/chronic.pdf

 

Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. (abst – 2002)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=12137404&dopt=abstrac tplus

 

Cannabinoids and multiple sclerosis.              (abst – 2002)

http://www.ncbi.nlm.nih.gov/pubmed/12182963

 

Marijuana Helps MS Patients Alleviate Pain, Spasms               (news – 2002)

http://www.mult-sclerosis.org/news/Sep2002/MedMJForMSSpasmsAndPain.html

 

MS SUFFERER DEFENDS DRUG; CANNABIS HELPED ME WALK.

(news – 2002)  http://www.thefreelibrary.com/MS+SUFFERER+DEFENDS+DRUG%3b+CANNABIS+HELPED+ME+  WALK.-a082609025

 

Cannabis Use As Described by People with Multiple Sclerosis.              (full – 2003)

http://cjns.metapress.com/content/5mw9rpyxvtpjrwf1/fulltext.pdf

 

Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis (full – 2003)

 

 

 

 

 

 

 

 

http://www.jneurosci.org/cgi/content/full/23/7/2511?maxtoshow=&hits=10&RESULTFORMAT=&fulltext

=cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=H  WCIT

 

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis                (full – 2003)  http://brain.oxfordjournals.org/cgi/content/full/126/10/2191?ijkey=c7c6bfd158b85c98cb1a190d5ca261455  2989ba0

 

Whether whole plant Cannabis extracts can improve intractable neurogenic symptoms? (full – 2003)                                   http://www.ukcia.org/research/WholePlantExtractsImproveNeurogenicSymptoms.pdf

 

Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212           (full – 2003)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152941/?tool=pmcentrez

 

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis                (full – 2003)

http://brain.oxfordjournals.org/cgi/content/full/126/10/2191

 

Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.                                                       (abst – 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=82

 

Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial.                                         (abst – 2003)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=108

 

Therapeutic potential of cannabinoids in CNS disease.                (abst – 2003)

http://www.ncbi.nlm.nih.gov/pubmed/12617697

 

‘How cannabis helped me’                (news/anecdotal – 2003)

http://news.bbc.co.uk/2/hi/health/3248701.stm

 

Cannabis helps symptoms of multiple sclerosis: study               (news – 2003)

http://www.cbc.ca/health/story/2003/11/07/ms_cannabis031107.html

 

Cannabis May Help Multiple Sclerosis               (news – 2003)

http://www.webmd.com/multiple-sclerosis/news/20031106/cannabis-may-help-multiple-sclerosis

 

Cannabis can help MS sufferers                (news – 2003)  (may need registration)

http://www.newscientist.com/article/dn4356-cannabis-can-help-ms-sufferers.html

 

Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies            (full – 2004)                          http://www.ukcia.org/research/InitialExperiencesChronicPain.pdf

 

Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial                                                 (full – 2004)  http://www.bmj.com/cgi/content/full/329/7460/253

 

Cannabinoids and neuroinflammation               (full – 2004)

 

 

 

 

 

 

 

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574256/?tool=pmcentrez

 

Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients.         (full – 2004)

http://www.ukcia.org/research/GenOrSpecEffectsOnMSSymptoms.pdf

 

Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.  (full – 2004)  http://www.ukcia.org/research/EfficacySafetyTolerabilityInMSSpasticityTreatment.pdf

 

An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.      (full – 2004)  http://www.ukcia.org/research/CBEForMSBladderDysfunction.pdf

 

Multiple Sclerosis Following Treatment with a Cannabinoid Receptor-1 Antagonist. (abst – 2004)                                   http://www.ncbi.nlm.nih.gov/pubmed/15222701

 

Are oral cannabinoids safe and effective in refractory neuropathic pain?             (abst – 2004)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=143

 

Cannabis study encouraging for MS               (news – 2004)

http://news.bbc.co.uk/2/hi/science/nature/3644628.stm

 

Cannabis Relieves Multiple Sclerosis Pain                (news – 2004)

http://www.webmd.com/multiple-sclerosis/news/20040715/cannabis-relieves-multiple-sclerosis-pain

 

Cannabis truly helps multiple sclerosis sufferers               (news – 2004) (may need registration)

http://www.newscientist.com/article/dn6387-cannabis-truly-helps-multiple-sclerosis-sufferers.html

 

Therapy Insight: Bladder Dysfunction Associated With Multiple Sclerosis             (full – 2005)

http://www.nature.com/nrurol/journal/v2/n10/full/ncpuro0323.html

 

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation (full – 2005)                                 http://www.jneuroinflammation.com/content/2/1/29

 

Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up       (full – 2005)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739436/pdf/v076p01664.pdf

 

Emerging properties of cannabinoid medicines in the management of multiple sclerosis (full – 2005)                                   http://www.ukcia.org/research/ManagementOfMultipleSclerosis.pdf

 

The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner. (full – 2005)      http://www.jbc.org/content/280/43/35797.long

 

 

 

 

 

 

 

 

 

Sativex: Fact Sheet             (full – 2005)        http://www.bayer.ca/files/sativex_fs_fd_091289_e.pdf

 

Sativex: Health Care Professional letter              (letter – 2005)

http://www.bayer.ca/files/sativex_dhcpl_lapds_091289_e.pdf

 

Cannabinoids in multiple sclerosis — therapeutically reasonable?               (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/16052440

 

Cannabinoid control of motor function at the basal ganglia.              (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/16596785

 

Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.

(abst – 2005)                http://www.ncbi.nlm.nih.gov/pubmed/16242629

 

Cannabis-based medicine in central pain in multiple sclerosis               (abst – 2005)

http://www.neurology.org/cgi/content/abstract/65/6/812?etoc

 

Cannabinoids and neuroprotection in CNS inflammatory disease.           (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/15894331

 

Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite (abst – 2005)                                    http://www.ncbi.nlm.nih.gov/pubmed/16473327

 

Cannabis-based medicinal extract (Sativex) produced significant improvements in a subjective measure of spasticity which were maintained on long-term treatment with no evidence of tolerance.       (abst – 2005)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=170

 

Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.       (abst – 2005)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=175

 

Marijuana derivatives may provide MS treatment               (news – 2005)

http://www.health.am/ab/more/marijuana_derivatives_may_provide_ms_treatment/

 

Medicinal marijuana use Experiences of people with multiple sclerosis

(full – 2006)             http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479734/?tool=pmcentrez

 

Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection          (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458883/?tool=pmcentrez

 

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes                                                           (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/?tool=pubmed

 

 

 

 

 

 

 

 

Multiple sclerosis may disrupt endocannabinoid brain protection mechanism

(full – 2006)                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458835/?tool=pmcentrez

 

Cannabinoids In Medicine: A Review Of Their Therapeutic Potential                  (full – 2006)

http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/CannabinoidsMedMetaAnalysis06.pdf

 

US Patent Application 20060167084 – Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis                                                                (full – 2006 )  http://www.patentstorm.us/applications/20060167084/fulltext.html

 

Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis.                                                                    (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/17086911

 

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington’s disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.                                                                                           (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16006105

 

Sativex in patients with symptoms of spasticity due to multiple sclerosis

(abst – 2006)               http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=169

 

Randomised controlled study of cannabis-based medicine (Sativex®) in patients suffering from multiple sclerosis associated detrusor overactivity                                                                   (abst – 2006)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=168

 

The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).                                                                   (abst – 2006)  http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=185

 

Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.

(abst – 2006)                http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=200

 

Cuppa Gives A Better ‘ooh’             (news – 2006)

http://www.thehempire.com/index.php/cannabis/news/cuppa_gives_a_better_ooh

 

The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis                                     (full – 2007)  http://brain.oxfordjournals.org/cgi/content/full/awm160v1

 

Cannabinoid control of neuroinflammation related to multiple sclerosis

(full – 2007)             http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2190016&tool=pmcentrez

 

CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies                                                                     (full – 2007)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2219542&tool=pmcentrez

 

 

 

 

 

 

 

 

Cannabinoid CB1 and CB2 Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis                                                      (full – 2007)  http://www.jneurosci.org/cgi/content/full/27/9/2396?maxtoshow=&hits=10&RESULTFORMAT=&fulltext

=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype

=HWCIT

 

The endocannabinoid system in targeting inflammatory neurodegenerative diseases (full – 2007)

http://medicalcannabis.com/images/pdf09/indications/neurodegenerative/centonze_et_al_2007_inflammato ry_neuro.pdf

 

Control of Spasticity in a Multiple Sclerosis Model is mediated by CB1, not CB2, Cannabinoid Receptors          (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189718/?tool=pmcentrez

 

Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis           (full – 2007)  http://medicalcannabis.com/images/pdf09/indications/ms/collin_et_al_2007_sativex.pdf

 

Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.   (abst – 2007)                      http://www.ncbi.nlm.nih.gov/pubmed/17257464

 

Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

(abst – 2007)                    http://www.ncbi.nlm.nih.gov/pubmed/18035205

 

The endocannabinoid system and neurogenesis in health and disease.               (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17404371

 

The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis (abst – 2007)                                    http://www.ncbi.nlm.nih.gov/pubmed/17678961

 

Cannabinoids and neuroprotection in motor-related disorders.            (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/18220777

 

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption                                          (abst – 2007)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2228254&tool=pmcentrez

 

Cannabis-based medicine in spasticity caused by multiple sclerosis.               (abst – 2007)  http://www.unboundmedicine.com/medline/ebm/record/17355549/abstract/Randomized_controlled_trial_o  f_cannabis_based_medicine_in_spasticity_caused_by_multiple_sclerosis

 

Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.                                                                 (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17229577

 

Cannabis based treatments for neuropathic and multiple sclerosis-related pain. (abst – 2007)

 

 

 

 

 

 

 

 

http://www.unboundmedicine.com/medline/ebm/record/17257464/abstract/Meta_analysis_of_cannabis_bas ed_treatments_for_neuropathic_and_multiple_sclerosis_related_pain

 

Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances. (abst – 2007)                                    http://www.ncbi.nlm.nih.gov/pubmed/17868014

 

Cannabis’ Potential Exciting Researchers in Treatment of ALS, Parkinson’s Disease (news – 2007)                                     http://www.illinoisnorml.org/index2.php?option=com_content&do_pdf=1&id=104

 

Cannabis could hold the key to ending multiple sclerosis misery               (news – 2007)

http://www.physorg.com/news94743932.html

 

Multiple sclerosis, cannabinoids, and cognition.               (full – 2008)

http://neuro.psychiatryonline.org/cgi/content/full/20/1/36

 

Cannabinoids in the management of difficult to treat pain              (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/?tool=pmcentrez

 

CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies                                                                       (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219542/

 

The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking INVOLVEMENT IN THE PATHOGENESIS OF AN ANIMAL MODEL OF

MULTIPLE SCLEROSIS              (full – 2008)      http://www.jbc.org/content/283/19/13320.long

 

Cannabinoid CB2 receptors in human brain inflammation                  (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219537/

 

Cannabinoids in the management of spasticity associated with multiple sclerosis (full – 2008)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626929/?tool=pmcentrez

 

Current Status of Cannabis Treatment of Multiple Sclerosis with an Illustrative Case Presentation of a Patient with MS, Complex Vocal Tics, Paroxysmal Dystonia, and Marijuana Dependence Treated with Dronabinol.   (full – 2008)  http://medicalcannabis.com/images/pdf09/indications/ms/deutsch_et_al_2008.pdf

 

The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.                                                     (full – 2008)  http://www.jbc.org/content/283/19/13320.long

 

US Patent Application 20080181942 – Delta-9-THC compositions and methods for treating symptoms associated with multiple sclerosis                                                                 (full – 2008)  http://www.patentstorm.us/applications/20080181942/fulltext.html

 

The endocannabinoid system and multiple sclerosis.                (abst – 2008)

http://www.ncbi.nlm.nih.gov/pubmed/18781983

 

 

 

 

 

 

 

 

Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. (abst – 2008)                                       http://www.ncbi.nlm.nih.gov/pubmed/18535023

 

Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis                                            (abst – 2008)  http://www.sciencedirect.com/science/article/pii/S0165572807003967

 

Cannabis use in Spanish patients with multiple sclerosis                (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18691726?ordinalpos=63&itool=EntrezSystem2.PEntrez.Pubmed.Pu  bmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

Use Of Non-Psychoactive Cannabinoids In The Treatment Of Neurodegenerative Diseases.        (news – 2008)                            http://www.sciencedaily.com/releases/2008/09/080916154721.htm

 

Cannabis May Halt Progression Of Multiple Sclerosis              (news – 2008)

http://norml.org/index.cfm?Group_ID=7704

 

Can Cannabis Compounds Slow The Progression Of Multiple Sclerosis?             (news – 2008)

http://www.sciencedaily.com/releases/2008/07/080721114608.htm

 

Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects       (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768535/?tool=pmcentrez

 

Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease (full – 2009)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pmcentrez

 

Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review.      (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793241/?tool=pubmed

 

Cannabinoids as novel anti-inflammatory drugs.               (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

 

Cannabidiol: a promising drug for neurodegenerative disorders?               (full – 2009)

http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2008.00065.x/full

 

The Endocannabinoid Anandamide: From Immunomodulation to Neuroprotection. Implications for Multiple Sclerosis                                                        (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19647114

 

A review of complementary and alternative medicine (CAM) by people with multiple sclerosis.   (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19222053/abstract/A_review_of_complementary_a

 

 

 

Plasma endocannabinoid levels in multiple sclerosis.                (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19695579

 

 

 

 

 

 

 

 

Do cannabinoids reduce multiple sclerosis-related spasticity?                (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19901724/full_citation/Do_cannabinoids_reduce_ multiple_sclerosis_related_spasticity

 

Cannabinoids and neurodegenerative diseases.               (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19839933

 

Medical Marijuana and Multiple Sclerosis (MS)                 (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/80?ailment=multiple-sclerosis-ms-

 

Clinical phase III study with the cannabis extract Cannador successful in multiple sclerosis          (news – 2009)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=300

 

Marijuana Eases Spasticity in MS Patients                (news – 2009)

http://www.webmd.com/multiple-sclerosis/news/20091204/marijuana-eases-spasticity-in-ms-patients

 

Pot shows promise for reducing multiple sclerosis patients’ symptoms              (news – 2009)

http://www.scientificamerican.com/blog/post.cfm?id=pot-shows-promise-for-reducing-mult-2009-12-02

 

Study Confirms That Cannabis Is Beneficial for Multiple Sclerosis             (news – 2009)

http://www.sciencedaily.com/releases/2009/12/091203222136.htm

 

Marijuana Chemicals Ease MS Symptoms, Review Confirms               (news – 2009)

http://www.drugfree.org/uncategorized/marijuana-chemicals-ease-ms

 

14 of 15 MS patients show clinical improvement with cannabis consumption (news – 2009)

http://www.examiner.com/disability-in-dallas/14-of-15-ms-patients-show-clinical-improvement-with- cannabis-consumption

 

Cannabis can reduce spasticity in MS patients              (news – 2009)

http://www.news-medical.net/news/20091204/Cannabis-can-reduce-spasticity-in-MS-patients.aspx

 

Standardized Cannabis in Multiple Sclerosis: A Case Report              (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806860/?tool=pubmed

 

New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids        (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835560/?tool=pmcentrez

 

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full – 2010)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?tool=pubmed

 

Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. (abst – 2010)                                     http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=314

 

Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis                                                   (abst – 2010)

 

 

 

 

 

 

 

 

http://msj.sagepub.com/cgi/content/abstract/16/6/707?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabis&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HWCIT

 

The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis.                                                          (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20353778

 

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.           (abst – 2010)                                             http://www.ncbi.nlm.nih.gov/pubmed/20875047

 

Julie Falco brings hope to Multiple Sclerosis patients. Cannabinoids manage pain and promote repair!      (news – 2010)

http://www.examiner.com/x-19678-Cannabis-Revolution-Examiner~y2010m2d10-Julie-Falco-brings-hope-  to-Multiple-Sclerosis-patients-Cannabinoids-manage-pain-and-promote-repair

 

Nature’s (Legal) Cannabinoids               (news – 2010)

http://www.mapinc.org/drugnews/v10/n126/a04.html?1194

 

Marijuana and MS–an unfinished story.               (news – 2010)

http://www.thefreelibrary.com/Marijuana+and+MS–an+unfinished+story.-a0237205183

 

Weed Control Part 1: MS sufferer finds relief with medical marijuana (anecdotal/news – 2010)

http://www.theweeklyweedonline.com/weed-control-part-1-ms-sufferer-finds-relief-with-medical-  marijuana/

 

Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors.    (full – 2011)

http://www.jneuroinflammation.com/content/pdf/1742-2094-8-102.pdf

 

CANNABIDIOL INHIBITS PATHOGENIC T-CELLS, DECREASES SPINAL MICROGLIAL ACTIVATION AND AMELIORATES MULTIPLE SCLEROSIS-LIKE DISEASE IN C57BL/6 MICE.        (full – 2011)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01379.x/full

 

Gadolinium-HU-308-incorporated micelles.                (full – 2011)

http://www.ncbi.nlm.nih.gov/books/NBK54067/pdf/CB2R-Gd-Micelles.pdf

 

Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/

 

Emerging treatment options for spasticity in multiple sclerosis; clinical utility of cannabinoids      (link to PDF – 2011)  http://www.doaj.org/doaj?func=abstract&id=842067&q1=cannabinoid&f1=all&b1=or&q2=cannabis&f2=a ll&recNo=30&uiLanguage=en

 

 

 

 

 

 

 

 

Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis.                                                            (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21094240

 

Role of cannabinoids in multiple sclerosis              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21323391

 

Inhibitory Effect of Standardized Cannabis sativa Extract and Its Ingredient Cannabidiol on Rat and Human Bladder Contractility.                                             (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21310467

 

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.                                                                            (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21245146/abstract/Identification_of_the_synthetic

 

_cannabinoid_R_+_WIN55212_2_as_a_novel_regulator_of_IFN_regulatory_factor_3


IRF3


activation_

 

and_IFN_%7Bbeta%7D_expression:_relevance_to_therapeutic_effects_in_models_of_multiple_sclerosis_

 

A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.     (abst – 2011)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=322

 

Treating pain in multiple sclerosis.                (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21916786

 

THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis.                                                   (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21456949/abstract/THC_and_CBD_oromucosal_s

 

 

 

New metabolic pathway for controlling brain inflammation                 (news – 2011)  http://www.news-medical.net/news/20111021/New-metabolic-pathway-for-controlling-brain-  inflammation.aspx

 

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α                                                       (full – 2012)  http://www.jbc.org/content/early/2012/05/31/jbc.M112.371757.full.pdf+html

 

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial.          (full – 2012)                         http://www.cmaj.ca/content/184/10/1143.long

 

Cannabinoid modulation of neuroinflammatory disorders.             (full – 2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386505/

 

Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects. (abst – 2012)   http://www.ncbi.nlm.nih.gov/pubmed/22342378

 

 

 

 

 

 

 

 

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22654113

 

Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9 (abst – 2012)  http://www.jimmunol.org/cgi/content/meeting_abstract/188/1_MeetingAbstracts/173.23?maxtoshow=&hits

=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resou  rcetype=HWCIT

 

A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine.   (abst – 2012)                                        http://www.ncbi.nlm.nih.gov/pubmed/22784399

 

Potential Control of Multiple Sclerosis by Cannabis and the Endocannabinoid System. (abst – 2012)                                       http://www.ncbi.nlm.nih.gov/pubmed/22583441

 

Evaluation of the safety and tolerability profile of Sativex: is it reassuring enough? (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22509986

 

Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity.                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22509985

 

Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22791906

 

Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis.    (abst – 2012)  http://www.unboundmedicine.com/medline/ebm/record/22928118/abstract/Evaluation_of_the_Effects_of_

 

Sativex


THC_BDS:_CBD_BDS__on_Inhibition_of_Spasticity_in_a_Chronic_Relapsing_Experimental_

 

Allergic_Autoimmune_Encephalomyelitis:_A_Model_of_Multiple_Sclerosis_

 

Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis.     (abst – 2012)                              http://www.ncbi.nlm.nih.gov/pubmed/22954177

 

Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22973422

 

A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis.          (abst – 2012)                      http://www.ncbi.nlm.nih.gov/pubmed/22971837

 

The therapeutic potential of cannabis and cannabinoids.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23008748

 

Treatment of spasticity in multiple sclerosis: new perspectives regarding the use of cannabinoids  (abst – 2012)                                       http://www.ncbi.nlm.nih.gov/pubmed/23011861

 

 

 

 

 

 

 

 

Cost Effectiveness of Oromucosal Cannabis-Based Medicine (Sativex®) for Spasticity in Multiple Sclerosis.                                                     (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/23072659

 

Treatment of spasticity in multiple sclerosis: new perspectives regarding the use of cannabinoids  (abst – 2012)                                         http://www.ncbi.nlm.nih.gov/pubmed/23011861?dopt=Abstract

 

CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation                                                               (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1002/glia.22366/abstract

 

What place for cannabis extract in MS?                     (abst – 2012)

http://dtb.bmj.com/content/50/12/141.abstract

 

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.                                                                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23180178

 

Smoked Cannabis Reduces Some Symptoms of Multiple Sclerosis                    (news – 2012)  http://health.ucsd.edu/news/releases/Pages/2012-05-14-smoked-cannabis-reduces-symptoms-of-multiple-  sclerosis.aspx

 

Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.          (abst – 2013)                                http://www.ncbi.nlm.nih.gov/pubmed/23369054

 

Multiple sclerosis and the blood-central nervous system barrier.                      (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23401746

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