KNOCK-OUTMICE– examples of severely defective endocannabinoid systems.

 

Increased Mortality, Hypoactivity, and Hypoalgesia in Cannabinoid Cb1 Receptor Knockout Mice.        (full – 1999)                                     http://www.pnas.org/content/96/10/5780.long

 

Enhancement of Memory in Cannabinoid Cb1 Receptor Knock-out Mice.                   (abst – 1999)

http://www.ncbi.nlm.nih.gov/pubmed/10499380

 

Are Cannabinoid Receptor Knockout Mice Animal Models for Schizophrenia?

(abst – 2000)                    http://www.medical-hypotheses.com/article/S0306-9877%2800%2991261-1/abstract

 

The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions.  (abst – 2001)                                       http://www.ncbi.nlm.nih.gov/pubmed/11394887

 

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)

http://www.jneurosci.org/cgi/content/full/22/22/9771?maxtoshow=&hits=80&RESULTFORMAT=&fullte   xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top

 

Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.                                                     (abst – 2002)        http://www.ncbi.nlm.nih.gov/pubmed/12384171

 

Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor.                                                       (abst – 2003)      http://www.ncbi.nlm.nih.gov/pubmed/12568912

 

Cannabinoid Cb1 Receptor Knockout Mice Exhibit Markedly Reduced Voluntary Alcohol Consumption and Lack Alcohol-induced Dopamine Release in the Nucleus Accumbens.     (abst – 2003)                                           http://www.ncbi.nlm.nih.gov/pubmed/12562514

 

Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.                  (full – 2004)

http://molpharm.aspetjournals.org/content/66/2/204.long

 

 

 

 

 

 

 

 

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity                                                  (full – 2004)  http://www.nature.com/ijo/journal/v28/n4/full/0802583a.html

 

Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice                                            (abst – 2004)

http://onlinelibrary.wiley.com/doi/10.1111/j.1460-  9568.2004.03293.x/abstract;jsessionid=15C92BB3498FAF0EE40394675E8B1800.d01t01

 

Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. (abst – 2004)                                    http://www.ncbi.nlm.nih.gov/pubmed/12770700

 

Ethanol Induces Higher Bec in Cb1 Cannabinoid Receptor Knockout Mice While Decreasing Ethanol Preference.                                                                 (full – 2005)  http://alcalc.oxfordjournals.org/content/40/1/54.long

 

Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. (full – 2005)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266095/?tool=pubmed

 

Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation.       (abst – 2005)                     http://www.ncbi.nlm.nih.gov/pubmed/15953683

 

Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling          (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238031/?tool=pmcentrez

 

Loss of Cannabinoid Receptor CB1 Induces Preterm Birth               (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553193/?tool=pmcentrez

 

The peripheral cannabinoid receptor knockout mice: an update.               (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219525/?tool=pubmed

 

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain                                           (abst – 2008)  http://www.sciencedirect.com/science/article/pii/S0014299908000630

 

Turned-Off Cannabinoid Receptor Turns On Colorectal Tumor Growth             (news – 2008)

http://www.sciencedaily.com/releases/2008/08/080801074056.htm

 

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington’s disease.                                                                              (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19524019

 

Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.           (abst – 2009)                http://www.ncbi.nlm.nih.gov/pubmed/19607846

 

CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.                                                           (abst – 2009)       http://www.ncbi.nlm.nih.gov/pubmed/19332079

 

 

 

 

 

 

 

 

 

Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype.      (abst – 2010)                      http://www.ncbi.nlm.nih.gov/pubmed/20692131

 

CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis.                                                             (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20138171

 

WIN55212-2 ameliorates atherosclerosis associated with suppression of pro- inflammatory responses in ApoE-knockout mice.                                                                     (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20868672

 

Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice.    (abst – 2010)                      http://www.ncbi.nlm.nih.gov/pubmed/20189358

 

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging            (full– 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131310/?tool=pubmed

 

Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function                                                   (full – 2011)  http://www.nutritionandmetabolism.com/content/8/1/93

 

Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice.   (abst – 2011)                            http://www.ncbi.nlm.nih.gov/pubmed/20724033

 

Comparative effects of chlorpyrifos in wild type and cannabinoid Cb1 receptor knockout mice.   (abst – 2011)                       http://www.ncbi.nlm.nih.gov/pubmed/21672545

 

The role of cannabinoid receptors in bone remodeling in a CB1/2 double knockout mouse (abst – 2011)  http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/492.5?maxtoshow=&hits=80&   RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&sortspec=date&resourcety  pe=HWCIT

 

Cannabinoid-1 Receptor Protects The Brain From Aging                (news – 2011)

http://www.medicalnewstoday.com/releases/230948.php

 

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging            (full – 2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131310/?tool=pubmed

 

Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory.  (full – 2012)                           http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514639/

 

Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.                                                           (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004984/?tool=pubmed

 

 

 

 

 

 

 

 

Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.                                                  (full – 2012)  http://www.nutritionandmetabolism.com/content/pdf/1743-7075-8-93.pdf

 

Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.                                                                 (full – 2012)  http://www.jbc.org/content/early/2012/07/11/jbc.M112.346296.full.pdf+html

 

Impaired hippocampal glucoregulation in the cannabinoid CB(1) receptor knockout mice as revealed by an optimized in vitro experimental approach.                                             (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22155442

 

Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress.          (abst – 2012)                       http://www.ncbi.nlm.nih.gov/pubmed/22734681

 

Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.                                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22579951

 

Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour.                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/11982628

 

Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22778221

 

Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice.   (abst – 2012)                                                 http://www.ncbi.nlm.nih.gov/pubmed/22759743

 

Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility.                                                          (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22836266

 

The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis.                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23175820

 

Cannabinoid Modulation of Midbrain Urocortin 1 Neurones During Acute and Chronic Stress    (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2012.02355.x/abstract

 

Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.                                                       (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/23199705

 

How Weed Can Protect Us From Cancer and Alzheimer’s               (book excerpt – 2012)

http://www.alternet.org/story/156269/how_weed_can_protect_us_from_cancer_and_alzheimer%27s

 

Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)

http://www.nature.com/npp/journal/vaop/naam/pdf/npp201331a.pdf

 

Why resolutions about taking up physical activity are hard to keep.                       (news – 2013)  http://www.thefreelibrary.com/Why+resolutions+about+taking+up+physical+activity+are+hard+to+keep.       –   a0313904638

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