KNOCK-OUTMICE– examples of severely defective endocannabinoid systems.


Increased Mortality, Hypoactivity, and Hypoalgesia in Cannabinoid Cb1 Receptor Knockout Mice.        (full – 1999)                           


Enhancement of Memory in Cannabinoid Cb1 Receptor Knock-out Mice.                   (abst – 1999)


Are Cannabinoid Receptor Knockout Mice Animal Models for Schizophrenia?

(abst – 2000)          


The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions.  (abst – 2001)                             


Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice (full – 2002)   xt=cannabinoid&searchid=1&FIRSTINDEX=80&resourcetype=HWCIT#Top


Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.                                                     (abst – 2002)


Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor.                                                       (abst – 2003)


Cannabinoid Cb1 Receptor Knockout Mice Exhibit Markedly Reduced Voluntary Alcohol Consumption and Lack Alcohol-induced Dopamine Release in the Nucleus Accumbens.     (abst – 2003)                                 


Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice.                  (full – 2004)









CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity                                                  (full – 2004)


Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice                                            (abst – 2004)  9568.2004.03293.x/abstract;jsessionid=15C92BB3498FAF0EE40394675E8B1800.d01t01


Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. (abst – 2004)                          


Ethanol Induces Higher Bec in Cb1 Cannabinoid Receptor Knockout Mice While Decreasing Ethanol Preference.                                                                 (full – 2005)


Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. (full – 2005)                         


Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation.       (abst – 2005)           


Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling          (full – 2006)


Loss of Cannabinoid Receptor CB1 Induces Preterm Birth               (full – 2008)


The peripheral cannabinoid receptor knockout mice: an update.               (full – 2008)


Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain                                           (abst – 2008)


Turned-Off Cannabinoid Receptor Turns On Colorectal Tumor Growth             (news – 2008)


Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington’s disease.                                                                              (abst – 2009)


Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.           (abst – 2009)      


CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury.                                                           (abst – 2009)










Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype.      (abst – 2010)            


CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis.                                                             (abst – 2010)


WIN55212-2 ameliorates atherosclerosis associated with suppression of pro- inflammatory responses in ApoE-knockout mice.                                                                     (abst – 2010)


Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice.    (abst – 2010)            


Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging            (full– 2011)


Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function                                                   (full – 2011)


Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice.   (abst – 2011)                  


Comparative effects of chlorpyrifos in wild type and cannabinoid Cb1 receptor knockout mice.   (abst – 2011)             


The role of cannabinoid receptors in bone remodeling in a CB1/2 double knockout mouse (abst – 2011)   RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&sortspec=date&resourcety  pe=HWCIT


Cannabinoid-1 Receptor Protects The Brain From Aging                (news – 2011)


Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging            (full – 2012)


Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory.  (full – 2012)                 


Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.                                                           (full – 2012)









Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.                                                  (full – 2012)


Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.                                                                 (full – 2012)


Impaired hippocampal glucoregulation in the cannabinoid CB(1) receptor knockout mice as revealed by an optimized in vitro experimental approach.                                             (abst – 2012)


Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress.          (abst – 2012)             


Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.                                                                 (abst – 2012)


Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour.                                                       (abst – 2012)


Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice. (abst – 2012)                          


Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice.   (abst – 2012)                                       


Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility.                                                          (abst – 2012)


The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis.                                                      (abst – 2012)


Cannabinoid Modulation of Midbrain Urocortin 1 Neurones During Acute and Chronic Stress    (abst – 2012)


Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.                                                       (abst – 2012)


How Weed Can Protect Us From Cancer and Alzheimer’s               (book excerpt – 2012)


Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)


Why resolutions about taking up physical activity are hard to keep.                       (news – 2013)       –   a0313904638

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