JWH-133/3-(1_1_-dimethylbutyl)-1-deoxy-_8-THCsynthetic, CB2 agonist

 

Inhibition of tumor angiogenesis by cannabinoids                      (full – 2003)  http://www.fasebj.org/cgi/reprint/02-  0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT

 

Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea- pigs by cannabinoid (CB2) receptor activation.                                                      (full – 2003)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574031/?tool=pubmed

 

Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats                                                                      (full – 2004)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575196/?tool=pmcentrez

 

Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation (full – 2006)  http://www.fasebj.org/cgi/content/full/20/13/2405?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=  cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HW   CIT

 

Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium.                                                            (full – 2006)  http://ajpgi.physiology.org/content/291/2/G364.long

 

Signaling pathways involved in the cardioprotective effects of cannabinoids. (full – 2006)                                        https://www.jstage.jst.go.jp/article/jphs/102/2/102_2_155/_pdf

 

 

 

 

 

 

 

 

Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury (full – 2007)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228252/?tool=pmcentrez

 

Cannabinoids Induce Glioma Stem-like Cell Differentiation and Inhibit Gliomagenesis (full – 2007)                                   http://www.jbc.org/content/282/9/6854.long

 

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis                                              (full – 2007)  http://www.jleukbio.org/cgi/reprint/82/3/532?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=canna binoid&searchid=1&FIRSTINDEX=240&resourcetype=HWCIT

 

In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219539/?tool=pmcentrez

 

Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice.                                                                       (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17912054

 

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                   (full – 2008)  http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt  ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

 

Regression of Fibrosis after Chronic Stimulation of Cannabinoid CB2 Receptor in Cirrhotic Rats            (full – 2008)  http://jpet.aspetjournals.org/content/324/2/475.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

 

Additive Interaction of the Cannabinoid Receptor I Agonist Arachidonyl-2- chloroethylamide with Etomidate in a Sedation Model in Mice                                                                             (full – 2008)  http://journals.lww.com/anesthesiology/Fulltext/2008/04000/Additive_Interaction_of_the_Cannabinoid_Re ceptor_I.19.aspx

 

Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.                                                      (full – 2008)  http://www.nature.com/cgt/journal/v15/n2/full/7701101a.html

 

Cannabinoid receptor agonists inhibit growth and metastasis of breast cancer (abst – 2008)

http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2008/1_Annual_Meeting/4081?maxtosh ow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=480&resourcety  pe=HWCIT

 

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain                                           (abst – 2008)  http://www.sciencedirect.com/science/article/pii/S0014299908000630

 

Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis.

 

 

 

 

 

 

 

 

(full – 2009)                http://onlinelibrary.wiley.com/doi/10.1002/ibd.20960/full

 

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis                                                                    (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688760/?tool=pubmed

 

Cannabinoids as novel anti-inflammatory drugs.               (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

 

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer      (full – 2009)                           http://mct.aacrjournals.org/content/8/11/3117.full

 

CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion          (abst – 2009)                                        http://www.ncbi.nlm.nih.gov/pubmed/19162037                                                 

 

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition (full – 2010)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917429/?tool=pmcentrez

 

Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment.     (full – 2010)                                        http://www.fasebj.org/content/24/3/788.long

 

Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)

http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17

 

Cannabinoid (JWH-133) therapy could be effective for treatment of corneal neovascularization   (link to PDF – 2010)  http://www.doaj.org/doaj?func=abstract&id=844832&q1=cannabinoid&f1=all&b1=or&q2=cannabis&f2=a ll&recNo=68&uiLanguage=en

 

Cannabinoid (JWH-133) therapy could be effective for treatment of corneal neovascularization   (abst – 2010)  http://www.doaj.org/doaj?func=abstract&id=844832&q1=Cannabinoid%20%28JWH-  133%29%20therapy%20could%20be%20effective%20for%20treatment%20of%20corneal%20neovascular ization%20&f1=all&b1=and&q2=&f2=all&recNo=1&uiLanguage=en

 

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease                                                       (full – 2011)  http://molpharm.aspetjournals.org/content/early/2011/02/24/mol.111.071290.long

 

Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/

 

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques                                         (full – 2011)  http://eurheartj.oxfordjournals.org/content/33/7/846.full

 

Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice               (abst – 2011)

http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2874.html

 

 

 

 

 

 

 

 

 

Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo.           (abst – 2011)                http://www.ncbi.nlm.nih.gov/pubmed/21884703

 

Antinociceptive effects induced through the stimulation of spinal cannabinoid type 2 receptors in chronically inflamed mice                                                       (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21771590/abstract/Antinociceptive_effects_induce   d_through_the_stimulation_of_spinal_cannabinoid_type_2_receptors_in_chronically_inflamed_mice_

 

Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis.                                                                         (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/22119709

 

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/20597071/abstract/Beneficial_paracrine_effects_of

_cannabinoid_receptor_2_on_liver_injury_and_regeneration_

 

Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury.                                                         (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/22210507

 

Can marijuana curb cocaine addiction?                (news – 2011)

http://theweek.com/article/index/217709/can-marijuana-curb-cocaine-addiction

 

Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta- amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice.

(full – 2012)                 http://www.jneuroinflammation.com/content/pdf/1742-2094-9-8.pdf

 

Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells       (full – 2012)  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033961

 

The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                                    http://www.jneuroinflammation.com/content/9/1/79

 

GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                                   http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full

 

Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22020035

 

Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions.                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22442067

 

 

 

 

 

 

 

 

Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats.                                                               (abst – 2012)      http://www.ncbi.nlm.nih.gov/pubmed/22290687

 

Cannabinoid receptor CB2 protects against balloon-induced neointima formation. (abst – 2012)                                           http://www.ncbi.nlm.nih.gov/pubmed/22227125

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