JWH-015– synthetic, CB2 & GPR-55 agonist, mildly activates CB1 receptors


Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full – 2000)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez


Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease            (full – 2002)  http://bloodjournal.hematologylibrary.org/cgi/content/full/100/2/627?ijkey=eb71d6d7a06f311440761cfac6   a7d081bcc2771d









Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation (full – 2005)                                     http://www.jneuroinflammation.com/content/2/1/29


CB2 cannabinoid receptors in trabecular meshwork cells mediate JWH015-induced enhancement of aqueous humor outflow facility.                                                                   (full – 2005)  http://www.iovs.org/content/46/6/1988.long


Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K- dependent mechanisms: role of NF-kappaB and p53.                                                                                                  (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/17017986


Chemical modification of the naphthoyl 3-position of JWH-015: In search of a fluorescent probe to the cannabinoid CB2 receptor                                                                             (abst – 2005)  http://www.sciencedirect.com/science/article/pii/S0960894X05006803


CB2 cannabinoid receptor agonist, JWH-015 triggers apoptosis in immune cells: Potential role for CB2 selective ligands as immunosuppressive agents                                                                   (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864948/


In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219539/?tool=pmcentrez


Potential role for CB2 selective ligands as immunosuppressive agents               (full – 2007)



Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.                                                            (full – 2007)  http://jpet.aspetjournals.org/content/322/3/1144.long


Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.                                                          (full – 2007)  http://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=2007&issue=04000&article=00021



CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.                                                               (full – 2008)  http://ajpheart.physiology.org/content/294/3/H1145.long


Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.                                                 (abst – 2008)          http://www.ncbi.nlm.nih.gov/pubmed/18991890


Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells.           (full – 2009)                      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697670/?tool=pubmed









Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)- Methanandamide and JWH-015: Involvement of CB2                                                                    (full – 2009)  http://www.nature.com/bjc/journal/v101/n6/full/6605248a.html


The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages.                                                (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19505450?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPa   nel.Pubmed_RVDocSum&ordinalpos=18


Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure.                                                                (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20514518


Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2                                              (news – 2010)

http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-  Reveals-Significantly-Increased-Abuse-1356247.htm


Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB(2) in Modulating Breast Cancer Growth and Invasion.                                                         (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168464/?tool=pubmed


Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full – 2011)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed


The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids.

(full – 2011)                http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198780/?tool=pubmed


Beyond THC: The New Generation of Cannabinoid Designer Drugs.             (full – 2011)



Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.                                                                        (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168464/?tool=pubmed


Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro (abst – 2011)                                       http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01519.x/abstract


Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl- d-Aspartic Acid      (abst – 2011)

http://www.anesthesia- analgesia.org/content/early/2011/04/25/ANE.0b013e31821d1062.abstract?maxtoshow=&hits=80&RESUL  TFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWC  IT


Latest blood test detects 12 popular synthetic cannabinoids in “fake pot”.           (news – 2011)









http://www.thefreelibrary.com/Latest+blood+test+detects+12+popular+synthetic+cannabinoids+in+%22fa ke…-a0261876557


Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation            (news – 2011)                             http://www.justice.gov/dea/pubs/pressrel/pr030111.html


Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists.        (full – 2012)                                       http://onlinelibrary.wiley.com/doi/10.1002/jbmr.1732/full


GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                                          http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full


Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.                                                                 (abst – 2012)      http://www.ncbi.nlm.nih.gov/pubmed/22233683


Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                                          http://www.ncbi.nlm.nih.gov/pubmed/22354705


Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats.                                                               (abst – 2012)      http://www.ncbi.nlm.nih.gov/pubmed/22290687


Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice.                                                               (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22759743


The CB(2)-preferring agonist JWH015 also potently and efficaciously activates CB(1) in autaptic hippocampal neurons.                                                     (abst – 2012)     http://www.ncbi.nlm.nih.gov/pubmed/22921769


Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings.                                                    (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22971158


Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function.   (abst – 2012)                                   http://www.ncbi.nlm.nih.gov/pubmed/23078523

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