HUMAN ENDOCANNABINOID SYSTEM GENETICS

 

Cannabinoid receptor genes.                  (abst – 1996)     http://www.ncbi.nlm.nih.gov/pubmed/8804112

 

Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia.       (abst – 2000)                                           http://www.ncbi.nlm.nih.gov/pubmed/11204352

 

Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence.                                                      (abst – 2002)        http://www.ncbi.nlm.nih.gov/pubmed/11841893

 

Marijuana receptor gene abnormality in schizophrenia                        (news – 2002)

http://www.eurekalert.org/pub_releases/2002-07/mp-mrg061802.php

 

Human cannabinoid receptor 1: 5′ exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse.                                                                 (full – 2004)  http://www.nature.com/mp/journal/v9/n10/full/4001560a.html

 

Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes.                                                      (abst – 2004)  http://www.ncbi.nlm.nih.gov/pubmed/14755457

 

Depression in Parkinson’s disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1)                                                                              (full – 2005)  http://www.nature.com/tpj/journal/v5/n2/full/6500301a.html

 

Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders.                                                                         (full – 2005)  http://www.jleukbio.org/content/78/1/231.long

 

Cannabinoid receptor type 2 gene is associated with human osteoporosis (full – 2005)  http://hmg.oxfordjournals.org/cgi/content/full/14/22/3389?maxtoshow=&hits=80&RESULTFORMAT=&f  ulltext=cannabinoid&searchid=1&FIRSTINDEX=400&resourcetype=HWCIT

 

Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment Interaction   (full – 2006)  http://www.ukcia.org/research/COMTgene.pdf

 

(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population                                                            (abst – 2006)

 

 

 

 

 

 

 

 

http://pharmgkb.org/pmid/16314880

 

Women with a variant of the CB2 gene have a three-fold higher risk of osteoporosis (news – 2006)  http://www.xagena.it/news/medicinenews_net_news/8f1bac3967e0ff70ebc09d8ca5e08633.html

 

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation (full – 2007)  http://ajpgi.physiology.org/cgi/content/full/294/1/G13?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabinoid&searchid=1&FIRSTINDEX=1120&resourcetype=HWCIT

 

Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men.                                                           (full – 2007)  http://jcem.endojournals.org/content/92/6/2382.long

 

The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians                                                     (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17290447

 

No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.                                                           (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17292652

 

Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in Men                                                        (full – 2008)  http://jcem.endojournals.org/cgi/content/full/92/6/2382

 

Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa    (full – 2008)                                 http://www.capmh.com/content/2/1/33

 

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation.           (full – 2008)                              http://ajpgi.physiology.org/content/294/1/G13.long

 

Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder         (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685476/?tool=pubmed

 

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations                                                       (full – 2008)  http://hmg.oxfordjournals.org/content/17/13/1916.long

 

The role of fatty acid hydrolase gene variants in inflammatory bowel disease. (full – 2009)                                   http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2008.03910.x/pdf

 

Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.                                               (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19659925

 

The use and misuse of alcohol and marijuana can be traced to a common set of genes

 

 

 

 

 

 

 

 

(news – 2009)                http://www.eurekalert.org/pub_releases/2009-12/ace-tua121209.php

 

Cannabis and smoking gene links to schizophrenia ‘unfounded’               (news – 2009)

http://tribes.tribe.net/depressionhelp/thread/101509b4-228a-498e-aec6-db5e2f536398

 

A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia.                                                      (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055343/?tool=pubmed

 

A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain.                                                         (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013130/?tool=pubmed

 

The Cannabinoid 1 Receptor (CNR1) 1359 G/A Polymorphism Modulates Susceptibility to Ulcerative Colitis and the Phenotype in Crohn’s Disease                                                       (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829088/?tool=pmcentrez

 

Effects of a Commonly Occurring Genetic Polymorphism of Human CYP3A4 (I118V) on the Metabolism of Anandamide                                                     (full – 2010)  http://dmd.aspetjournals.org/content/38/11/2075.full

 

Endocannabinoids and Schizophrenia             (link to PDF – 2010)

http://www.mdpi.com/1424-8247/3/10/3101

 

G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population.                                                        (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20851297

 

A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.

(abst – 2010)                http://www.ncbi.nlm.nih.gov/pubmed/19768813

 

Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.                                              (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933347/?tool=pubmed

 

Differential signaling in human cannabinoid CB(1) receptors and their splice variants in autaptic hippocampal neurons                                                        (full – 2011)  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01744.x/pdf

 

Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise       (full – 2011)                             http://www.lipidworld.com/content/10/1/194

 

The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia.    (full – 2011)  http://www.rjme.ro/RJME/resources/files/520311791795.pdf

 

 

 

 

 

 

 

 

CNR2 functional variant (Q63R) influences childhood immune thrombocytopenic purpura.         (full – 2011)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232275/

 

Cannabis, COMT and psychotic experiences.              (full – 2011)

http://bjp.rcpsych.org/content/199/5/380.long

 

The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction

(link to PDF – 2011)               http://www.mdpi.com/1424-8247/4/8/1101

 

Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.                                                   (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21420833

 

Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21513772/abstract/Association_between_a_cannab

 

 

 

The genetic basis of the endocannabinoid system and drug addiction in humans (abst – 2011)                                     http://jop.sagepub.com/content/early/2011/09/20/0269881111416689

 

Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. (abst – 2011)                                     http://www.ncbi.nlm.nih.gov/pubmed/20506567

 

Association study of Cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia (abst – 2011)                                   http://www.ncbi.nlm.nih.gov/pubmed/21266946

 

The genetics of eating disorders.              (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21243475

 

Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor.                                                           (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21658778

 

Endocannabinoid type 1 receptor gene (CNR1) polymorphisms (rs806381, rs10485170, rs6454674, rs2023239) and cardiovascular risk factors in postmenopausal women.  (abst – 2011)          http://www.ncbi.nlm.nih.gov/pubmed/21480765

 

Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.                                                           (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21633404

 

Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?                                                    (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/20838400

 

 

 

 

 

 

 

 

 

Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene                                             (abst – 2011)  http://onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2011.00380.x/abstract

 

COMT; another “wrong” result for the reefer madness hype.               (news – 2011)

http://ukcia.org/wordpress/?p=924

 

The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription

(full – 2012)               http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02175.x/abstract

 

Alelle specific differences in the activity of a novel cannabinoid receptor 1(CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia and hippocampus.                                               (full – 2012)  http://www.jbc.org/content/early/2012/02/23/jbc.M111.336750.long

 

The Interplay between Parental Monitoring and the Dopamine D4 Receptor Gene in Adolescent Cannabis Use  (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509099/pdf/pone.0049432.pdf

 

Cannabinoid Receptor 1 (CNR1) 4895 C/T Genetic Polymorphism was Associated with Obesity in Japanese Men.                                                             (full – 2012)  https://www.jstage.jst.go.jp/article/jat/19/8/19_12732/_pdf

 

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity                                                         (full – 2012)  http://link.springer.com/article/10.1007/s00213-012-2785-y/fulltext.html

 

The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription (full – 2012)                                      http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02175.x/full

 

Endocannabinoids in stressed humans                (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152482&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=2&uiLanguage=en

 

Cannabinoid-related Agents in the Treatment of Anxiety Disorders: Current Knowledge and Future Perspectives.                                                      (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22280339

 

Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression.                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22393204

 

Genetic Epidemiology and Pharmacogenetics in Irritable Bowel Syndrome. (abst – 2012)                                         http://www.ncbi.nlm.nih.gov/pubmed/22403795

 

The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients (abst – 2012)                                        http://link.springer.com/article/10.1007%2Fs12094-010-0604-7#page-1

 

 

 

 

 

 

 

 

G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes.                                                                        (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22138970

 

Role of G1359A polymorphism of the cannabinoid receptor gene on weight loss and adipocytokines levels after two different hypocaloric diets.                                                                   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/21543209

 

Cannabinoid receptor type 2 functional variant influences liver damage in children with non-alcoholic Fatty liver disease.                                                        (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22927922

 

Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-α gene (PPARA) and schizophrenia.                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22920733

 

Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes                                                                  (abst – 2012)  http://jop.sagepub.com/content/early/2012/07/22/0269881112454229.abstract?maxtoshow=&hits=80&RES  ULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=H WCIT

 

Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/23010766

 

Childhood Obesity and the Role of Dopamine D2 Receptor and Cannabinoid Receptor-1 Gene Polymorphisms.                                                   (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/23057570

 

A genetic perspective on the proposed inclusion of cannabis withdrawal in DSM-5. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/23194657

 

Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa                                                                  (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/and.12006/abstract

 

The Cannabinoid Receptor type 2 Q63R variant increases the risk of celiac disease: Implication for a novel molecular biomarker and future therapeutic intervention. (abst – 2012)                                       http://www.sciencedirect.com/science/article/pii/S1043661812000540

 

Cannabinoid Type 1 Receptor Gene Polymorphism and Macronutrient Intake. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/23207972

 

Contribution of genetic variants to pain susceptibility in Parkinson disease

(abst – 2012)                 http://onlinelibrary.wiley.com/doi/10.1002/j.1532-2149.2012.00134.x/abstract

 

Sensation-seeking genes and physical activity in youth                  (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/gbb.12006/abstract

 

 

 

 

 

 

 

 

Smoking Cannabis Increases Risk of Depression in the Case of Genetic Vulnerability, Study Finds         (news – 2012)                              http://www.sciencedaily.com/releases/2011/10/111010074853.htm

 

Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.                                                               (full – 2013)  http://onlinelibrary.wiley.com/doi/10.1002/pro.2192/full

 

Epigenetic mechanisms and endocannabinoid signalling                       (full – 2013)

http://onlinelibrary.wiley.com/doi/10.1111/febs.12125/pdf

 

Cannabinoid Receptor 1 Gene and Irritable Bowel Syndrome: Phenotype and Quantitative Traits.           (abst – 2013)                                            http://www.ncbi.nlm.nih.gov/pubmed/23306084

 

Evidence for the involvement of cannabinoid receptors’ polymorphisms in the pathophysiology of human diseases.                                                                                 (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23293857

 

Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and their influence on anthropometric parameters and metabolic parameters under a high monounsaturated vs. high polyunsaturated fat hypocaloric diets.                                                                                               (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23337343

 

Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.                                                                                                        (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23408552

 

Cannabinoid CB2 receptor gene (CNR2) polymorphism is associated with chronic childhood immune thrombocytopenia in Egypt.                                                  (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23406660

 

Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.                                                                          (abst – 2013)  http://link.springer.com/article/10.1007%2Fs00213-013-2995-y

 

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