HU-210-  synthetic, CB 1 & CB 2 agonist


Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water- maze task. (abst – 1999)                             


Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation (full – 2000)                              


Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full – 2000)


Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.                                                                     (abst – 2000) tplus


Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour. (abst – 2000)                                 


Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease            (full – 2002)   a7d081bcc2771d


Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats                                                             (full – 2002)


Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis. (abst – 2002) tplus


Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors                                                             (abst – 2002)


The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.     (abst – 2002)                                                 


Inhibition of tumor angiogenesis by cannabinoids                   (full – 2003)





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CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full – 2003)                         


Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. (full – 2003)                       


Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.     (abst – 2003)            


The endogenous cannabinoid system protects against colonic inflammation            (full – 2004)


Cannabinoids spell relief in colon inflammation                  (news – 2004)


Direct cerebrovascular effects of CB1 receptor activation by the synthetic endocannabinoid HU-210 in vivo      (full – 2005)


Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects                                                               (full – 2005)


Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease.                                              (abst – 2005)


The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors            (abst – 2005)          


Is cannabis good for your brain?                (news – 2005)


Marijuana May Spur New Brain Cells               (news – 2005)


Study Shows Marijuana Promotes Neuron Growth              (news – 2005)


Marijuana May Grow Neurons in the Brain               (news – 2005)


Surprising Brain Effects From Pot-Like Drug                (news – 2005)










Marijuana might cause new cell growth in the brain               (news – 2005) (may need registration)


Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models    (full – 2006)                


Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.                                                    (abst – 2006)


Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis    (full – 2007)              


Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon     (full – 2007)


Cannabinoids Induce Glioma Stem-like Cell Differentiation  and Inhibit Gliomagenesis (full – 2007)                         


The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats                                                                 (full – 2007)


The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells                                         (abst – 2007)


The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.                                                           (abst – 2007)


Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.                                                                  (abst – 2007)


Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception                                (full – 2008)


Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma       (full – 2009)                      


Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum (full – 2009)                 


Spice drugs: cannabinoids as a new designer drugs.              (abst – 2009)







Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.             (full – 2010)


Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)


Regulation of nausea and vomiting by cannabinoids                (abst – 2010)  5381.2010.01176.x/abstract;jsessionid=56CED9CE51B025C161AA2E821BEC94ED.d01t01


Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2                                                    (news – 2010)  Reveals-Significantly-Increased-Abuse-1356247.htm


The potential for clinical use of cannabinoids in treatment of cardiovascular diseases. (full – 2011)                          


Beyond THC: The New Generation of Cannabinoid Designer Drugs.             (full – 2011)


Investigating a not-so-natural high.               (full – 2011)


Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.                                                                 (abst – 2011)


Regulation of nausea and vomiting by cannabinoids.                (abst – 2011) miting_by_cannabinoids_


Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation                                                         (abst – 2011)


The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.                                           (abst – 2011)  ugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesio   ned_rats_


Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDG.                                                             (abst – 2011)


Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior









(abst – 2012)  t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_


Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system.                                                       (abst – 2012)


Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples.     (abst – 2012)


The spice in France: mixed herbs containing synthetic cannabinoids.                 (abst – 2012)


Analgesic effects of cannabinoids on central pain syndrome                (abst – 2012)


Synthetic Cannabinoid and Cathinone Use Among US Soldiers.             (abst – 2012)


The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)


Activation of Cannabinoid Receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms. (abst – 2012)


The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex.            (abst – 2012)      


Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: a small animal PET imaging study with 18F-FDG.                                                            (abst – 2012)


Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis.                                     (abst – 2012)


Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system                                                         (abst – 2012)


Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. (abst – 2013)                          


Functional Residues Essential for the Activation of the CB1 Cannabinoid Receptor. (abst – 2013)

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