HU-210-  synthetic, CB 1 & CB 2 agonist

 

Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water- maze task. (abst – 1999)                                       http://www.ncbi.nlm.nih.gov/pubmed/10548271

 

Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation (full – 2000)                                        http://endo.endojournals.org/cgi/content/full/141/1/118

 

Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full – 2000)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez

 

Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.                                                                     (abst – 2000)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=11182823&dopt=abstrac tplus

 

Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour. (abst – 2000)                                           http://www.ncbi.nlm.nih.gov/pubmed/10913795

 

Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease            (full – 2002)  http://bloodjournal.hematologylibrary.org/cgi/content/full/100/2/627?ijkey=eb71d6d7a06f311440761cfac6   a7d081bcc2771d

 

Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats                                                             (full – 2002)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573379/?tool=pmcentrez

 

Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis. (abst – 2002)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=12428278&dopt=abstrac tplus

 

Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors                                                             (abst – 2002)  http://www.ncbi.nlm.nih.gov/pubmed/12136723

 

The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.     (abst – 2002)                                                           http://www.ncbi.nlm.nih.gov/pubmed/12095655

 

Inhibition of tumor angiogenesis by cannabinoids                   (full – 2003)

 

 

 

 

 

 

 

 

http://www.fasebj.org/cgi/reprint/02-  0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT

 

CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full – 2003)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573770/?tool=pmcentrez

 

Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210. (full – 2003)                                 http://stroke.ahajournals.org/cgi/reprint/34/8/2000

 

Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.     (abst – 2003)                      http://www.ncbi.nlm.nih.gov/pubmed/12835895

 

The endogenous cannabinoid system protects against colonic inflammation            (full – 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC385396/?tool=pmcentrez

 

Cannabinoids spell relief in colon inflammation                  (news – 2004)

http://www.eurekalert.org/pub_releases/2004-05/m-csr050704.php

 

Direct cerebrovascular effects of CB1 receptor activation by the synthetic endocannabinoid HU-210 in vivo      (full – 2005)  http://www.nature.com/jcbfm/journal/v25/n1s/full/9591524.0581a.html

 

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects                                                               (full – 2005)  http://www.jci.org/articles/view/25509/version/1

 

Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease.                                              (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/15837565?dopt=Abstract

 

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors            (abst – 2005)                    http://www.sciencedirect.com/science/article/pii/S0014299905013178

 

Is cannabis good for your brain?                (news – 2005)

http://arstechnica.com/science/news/2005/10/1529.ars

 

Marijuana May Spur New Brain Cells               (news – 2005)

http://www.treatingyourself.com/vbulletin/showthread.php?t=5921

 

Study Shows Marijuana Promotes Neuron Growth              (news – 2005)

http://english.ohmynews.com/articleview/article_view.asp?menu=c10400&no=253377&rel_no=1

 

Marijuana May Grow Neurons in the Brain               (news – 2005)

http://www.medpagetoday.com/Psychiatry/AnxietyStress/1934

 

Surprising Brain Effects From Pot-Like Drug                (news – 2005)

http://www.webmd.com/mental-health/news/20051013/surprising-brain-effects-from-pot-like-drug

 

 

 

 

 

 

 

 

 

Marijuana might cause new cell growth in the brain               (news – 2005) (may need registration)

http://www.newscientist.com/article/dn8155

 

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models    (full – 2006)                          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751298/?tool=pmcentrez

 

Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in-vitro.                                                    (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16536902

 

Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis    (full – 2007)                        http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2268094

 

Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon     (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755791/?tool=pmcentrez

 

Cannabinoids Induce Glioma Stem-like Cell Differentiation  and Inhibit Gliomagenesis (full – 2007)                                   http://www.jbc.org/content/282/9/6854.long

 

The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats                                                                 (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013991/

 

The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells                                         (abst – 2007)  http://lib.bioinfo.pl/pmid:17604177

 

The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.                                                           (abst – 2007)      http://www.ncbi.nlm.nih.gov/pubmed/17572451

 

Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.                                                                  (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17229577

 

Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception                                (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743428/?tool=pmcentrez

 

Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma       (full – 2009)                                http://mct.aacrjournals.org/content/8/7/1838.full

 

Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum (full – 2009)                           http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.05948.x/full

 

Spice drugs: cannabinoids as a new designer drugs.              (abst – 2009)

 

 

 

 

 

 

 

 

http://www.unboundmedicine.com/medline/ebm/record/19718488/abstract/%5BSpice_drugs:_cannabinoid s_as_a_new_designer_drugs_%5D

 

Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.             (full – 2010)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2009.01419.x/pdf

 

Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)

http://jpet.aspetjournals.org/content/332/2/336.full?sid=af53ea87-ab4b-426e-9c7e-8f750e9c4a17

 

Regulation of nausea and vomiting by cannabinoids                (abst – 2010)  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-  5381.2010.01176.x/abstract;jsessionid=56CED9CE51B025C161AA2E821BEC94ED.d01t01

 

Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2                                                    (news – 2010)

http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-  Reveals-Significantly-Increased-Abuse-1356247.htm

 

The potential for clinical use of cannabinoids in treatment of cardiovascular diseases. (full – 2011)                                    http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5922.2010.00233.x/pdf

 

Beyond THC: The New Generation of Cannabinoid Designer Drugs.             (full – 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187647/?tool=pubmed

 

Investigating a not-so-natural high.               (full – 2011)

http://pubs.acs.org/doi/full/10.1021/ac900564u

 

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.                                                                 (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21886913

 

Regulation of nausea and vomiting by cannabinoids.                (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21175589/abstract/Regulation_of_nausea_and_vo miting_by_cannabinoids_

 

Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation                                                         (abst – 2011)  http://www.jimmunol.org/content/187/12/6508.abstract?sid=590f7819-f39b-4214-abca-07231b51da55

 

The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.                                           (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/20888328/abstract/The_effects_of_cannabinoid_dr  ugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesio   ned_rats_

 

Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: A small animal PET imaging study with (18)F-FDG.                                                             (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/22155282

 

Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior

 

 

 

 

 

 

 

 

(abst – 2012)  http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_differen  t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_

 

Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system.                                                       (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22435752

 

Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples.     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22576873

 

The spice in France: mixed herbs containing synthetic cannabinoids.                 (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22796613

 

Analgesic effects of cannabinoids on central pain syndrome                (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22359935

 

Synthetic Cannabinoid and Cathinone Use Among US Soldiers.             (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/23007932

 

The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids.                                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23063785

 

Activation of Cannabinoid Receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms. (abst – 2012) http://www.ncbi.nlm.nih.gov/pubmed/23139224

 

The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex.            (abst – 2012)                http://www.ncbi.nlm.nih.gov/pubmed/22671779

 

Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: a small animal PET imaging study with 18F-FDG.                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22155282

 

Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis.                                     (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23285225

 

Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system                                                         (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2605.2012.01259.x/abstract

 

Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. (abst – 2013)                                    http://www.ncbi.nlm.nih.gov/pubmed/23289830

 

Functional Residues Essential for the Activation of the CB1 Cannabinoid Receptor. (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23332708

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