EPILEPSY/ SEIZURES

 

Marijuana and Epilepsy  (anecdotal- undated)                        http://www.rxmarihuana.com/epilepsy.htm

 

Anti-epileptic Action of Marijuana-Active Substances                     (full – 1949)

http://www.onlinepot.org/medical/Dr_Tods_PDFs/s3_6.pdf

 

Anticonvulsant nature of marihuana smoking.                    (abst – 1975)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=39

 

Antiepileptic and prophylactic effects of tetrahydrocannabinols in amygdaloid kindled cats.        (abst – 1975)                            http://www.ncbi.nlm.nih.gov/pubmed/1183427

 

Anticonvulsant activity of four oxygenated cannabidiol derivatives.                    (abst – 1975)

http://www.ncbi.nlm.nih.gov/pubmed/1188178

 

Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9- tetrahydrocannabinol.  (abst – 1975)                                               http://www.ncbi.nlm.nih.gov/pubmed/1222370

 

Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs. (abst – 1976)                                            http://www.ncbi.nlm.nih.gov/pubmed/1253828

 

Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.  (full – 1977)  http://jpet.aspetjournals.org/content/201/1/26.abstract?ijkey=8457ace5313942358e64d156c12d04bd3c7d5f 21&keytype2=tf_ipsecsha

 

Anticonvulsant Action of Cannabis in the Rat: Role of Brain Monoamines. (abst – 1978)                                          http://www.ncbi.nlm.nih.gov/pubmed/104333

 

Chronic administration of cannabidiol to healthy volunteers and epileptic patients. (abst – 1980)   http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=42

 

Antiepileptic potential of cannabidiol analogs.                   (abst – 1981)

http://www.ncbi.nlm.nih.gov/pubmed/7298873

 

The cannabinoids as potential antiepileptics.                      (abst – 1981)

http://www.ncbi.nlm.nih.gov/pubmed/6975285

 

Hypnotic and Antiepileptic Effects of Cannabidiol                   (abst – 1981)

http://www.ncbi.nlm.nih.gov/pubmed/7028792

 

Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs.        (abst – 1982)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=7071126&dopt=abstract plus

 

 

 

 

 

 

 

 

Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.        (abst – 1982)                             http://www.ncbi.nlm.nih.gov/pubmed/6129147

 

ILLICIT DRUG USE AND THE RISK OF NEW-ONSET SEIZURES

(abst – 1990)

http://aje.oxfordjournals.org/content/132/1/47.abstract?sid=9fd403c4-2e6e-4df4-a57c-208434b8ad0a

 

Marijuana use and the risk of new onset seizures.              (full – 1992)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376682/?tool=pmcentrez

 

Treatment with CBD in oily solution of drug-resistant paediatric epilepsies. (full – 2001)

http://www.cannabis-  med.org/studies/ww_en_db_study_show.php?s_id=173&&search_pattern=EPILEPSY

 

Therapeutic Aspects of Cannabis and Cannabinoids            (full – 2001)

http://bjp.rcpsych.org/cgi/reprint/178/2/107.pdf

 

Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.           (abst – 2001)                       http://www.ncbi.nlm.nih.gov/pubmed/11442148

 

Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy. (abst – 2001)                                     http://www.ncbi.nlm.nih.gov/pubmed/11737161

 

The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy                                                        (full – 2003)  http://jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

 

Experiences with THC-treatment in children and adolescents                 (abst – 2003)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=80

 

On the application of cannabis in paediatrics and epileptology.                (abst – 2003)

http://www.ncbi.nlm.nih.gov/pubmed/15159680

 

Cannabis may help epileptics             (news – 2003)

http://www.medicalnewstoday.com/articles/4423.php

 

Cannabis ‘could help epileptics’   (news – 2003)              http://news.bbc.co.uk/2/hi/health/3162000.stm

 

Marijuana Use More Prevalent With Epilepsy  (needs free registration) (news – 2003)                                                 http://www.medscape.com/viewarticle/465891

 

Endocannabinoids and Their Implications for Epilepsy              (full – 2004)

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1176361&tool=pmcentrez

 

Cannabinoids: Defending the Epileptic Brain             (full – 2004)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez

 

 

 

 

 

 

 

 

Marijuana use and epilepsy – Prevalence in patients of a tertiary care epilepsy center (abst – 2004)

http://www.neurology.org/cgi/content/abstract/62/11/2095?maxtoshow=&hits=80&RESULTFORMAT=&f  ulltext=marihuana&searchid=1&FIRSTINDEX=1760&resourcetype=HWCIT

 

Epilepsy patients are smoking pot              (news – 2004)

http://www.safeaccessnow.org/article.php?id=1638

 

Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid. (abst – 2005)                                     http://www.ncbi.nlm.nih.gov/pubmed/15461672

 

Cannabinoids as potential anti-epileptic drugs.                (abst – 2005)  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=16044663&dopt=abstrac tplus

 

Not Too Excited? Thank Your Endocannabinoids              (full – 2006)

http://www.sciencedirect.com/science/article/pii/S0896627306005927

 

Forebrain-Specific Inactivation of Gq/G11 Family G Proteins Results in Age-Dependent Epilepsy and Impaired Endocannabinoid Formation                                                     (full – 2006)  http://mcb.asm.org/cgi/content/full/26/15/5888?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=can  nabinoid&searchid=1&FIRSTINDEX=1360&resourcetype=HWCIT

 

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus (full – 2006)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/?tool=pmcentrez

 

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy                                                               (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808496/?tool=pmcentrez

 

Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus        (full – 2006)  http://jpet.aspetjournals.org/content/317/3/1072.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext

=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#ref-list-1

 

Cannabinoids In Medicine: A Review Of Their Therapeutic Potential                  (full – 2006)

http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/CannabinoidsMedMetaAnalysis06.pdf

 

Arachidonyl-2′-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock- induced seizure model.     (abst – 2006)                                                                   http://www.ncbi.nlm.nih.gov/pubmed/16930590

 

Brain’s Cannabinoid System ‘Mellows’ Seizures               (news – 2006)

http://www.sciencedaily.com/releases/2006/08/060817103710.htm

 

Brain’s cannabinoid system fights seizures               (news – 2006)

http://www.physorg.com/news75053658.html

 

 

 

 

 

 

 

 

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus                                                              (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094113/?tool=pmcentrez

 

Endocannabinoids block status epilepticus in cultured hippocampal neurons (full – 2007)                                http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617750/?tool=pmcentrez

 

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus                                                   (full – 2007)  http://www.jneurosci.org/cgi/content/full/28/12/2976?maxtoshow=&hits=80&RESULTFORMAT=&fullte   xt=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetyp e=HWCIT

 

Marijuana: an effective antiepileptic treatment in partial epilepsy?              (abst – 2007)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=157

 

Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.                                    (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17870135

 

In Vitro Anticonvulsant Action of 2-Arachidonyl Glycerol                   (abst – 2007)  http://www.doaj.org/doaj?func=abstract&id=463469&q1=anandamide&f1=all&b1=and&q2=&f2=all&rec No=29&uiLanguage=en

 

Rimonabant: safety issues                (news – 2007)

http://www.xagena.it/news/medicinenews_net_news/09a11be6989d5a0e438dd9e589210a79.html

 

The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.                                                                           (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438968/?tool=pubmed

 

The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice                                                               (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18502613

 

The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.

(full – 2009)                http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full

 

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.       (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed

 

Effect of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.        (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19751793

 

 

 

 

 

 

 

 

Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.                                                 (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19223154

 

Medical Marijuana and Epilepsy              (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/79?ailment=epilepsy

 

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo (full – 2010)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/?tool=pmcentrez

 

Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.                                                        (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed

 

AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.                                               (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006205/?tool=pubmed

 

Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.   (abst – 2010)                                       http://www.ncbi.nlm.nih.gov/pubmed/20196794

 

Anticonvulsant effects of GWP42006 in vitro and in vivo in rat              (abst – 2010)

http://www.physoc.org/proceedings/abstract/Proc%20Physiol%20Soc%2019C117

 

Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.         (abst – 2010)                           http://www.ncbi.nlm.nih.gov/pubmed/20618415

 

Endocannabinoid system protects against cryptogenic seizures.              (full – 2011)

http://www.if-pan.krakow.pl/pjp/pdf/2011/1_165.pdf

 

Convulsions Associated with the Use of a Synthetic Cannabinoid Product.           (full – 2011)

http://www.springerlink.com/content/9651q2672027n38g/fulltext.html

 

Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy.                                              (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/21733658

 

Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.  (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21238473/abstract/Synthetic_cannabinoid_WIN_5  5212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maxima  l_electroshock_induced_seizures_in_mice_

 

Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy                                                         (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21469332/abstract/%5BProtective_effects_of_CB1

_receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lobe_epilepsy%5D_

 

 

 

 

 

 

 

 

L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure.                                                            (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21928146

 

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.                                              (abst – 2011)      http://www.ncbi.nlm.nih.gov/pubmed/22079489

 

In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.        (abst – 2011)                                         http://www.ncbi.nlm.nih.gov/pubmed/21303859

 

Marijuana, endocannabinoids, and epilepsy: Potential and challenges for improved therapeutic intervention.                                                     (abst – 2011)        http://www.ncbi.nlm.nih.gov/pubmed/22178327

 

Cannabis could help treat epilepsy                (news – 2011)

http://www.newkerala.com/news/world/fullnews-186693.html

 

Cannabis could be used to treat epilepsy               (news – 2011)

http://www.telegraph.co.uk/science/science-news/8440303/Cannabis-could-be-used-to-treat-epilepsy.html

 

New research provides hope for those with epilepsy             (news – 2011)

http://medicalxpress.com/news/2011-04-epilepsy.html

 

Cannabidivarin is anticonvulsant in mouse and rat in vitro and in seizure models. (full – 2012)                                 http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02207.x/full

 

Cannabidivarin is anticonvulsant in mouse and rat.               (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02207.x/pdf

 

Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy: Patent Application 20120004251                                                          (full – 2012)

http://www.freshpatents.com/-dt20120105ptan20120004251.php

 

Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.                                                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22019959

 

Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22270809

 

Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.  (abst – 2012)                                           http://www.ncbi.nlm.nih.gov/pubmed/22388975

 

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?                                              (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22625422

 

 

 

 

 

 

 

 

Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

(abst – 2012)               http://www.ncbi.nlm.nih.gov/pubmed/22509801

 

Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.           (abst – 2012)                    http://www.ncbi.nlm.nih.gov/pubmed/22520455

 

Internet Highs-Seizures After Consumption of Synthetic Cannabinoids Purchased Online. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22824736

 

Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.       (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22504215

 

Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. (abst – 2012)                                       http://www.ncbi.nlm.nih.gov/pubmed/22789660

 

First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.                                                  (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22936123

 

Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/23159379

 

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.                                                                (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23206503

 

Science/UK: Antiepileptic efficacy of cannabidivarin will be tested in clinical studies (news – 2012)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=382

 

‘Hammer Head’ ‘incense’ blamed for seizure of youth in Le Roy             (news – 2012)

http://thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983

 

How Medical Marijuana Is Giving a Six-Year-Old Boy New Life              (news – 2012)  http://thinkprogress.org/justice/2012/09/18/854811/how-medical-marijuana-is-giving-a-six-year-old-boy- new-life/?mobile=nc

 

Cannabis and other illicit drug use in epilepsy patients.               (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/23311572

 

Science/Animal: CBD inhibits the activity of a certain liver enzyme             (news – 2013)  http://www.cannabis-  med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=391&search_pattern=2013#10

 

Cannabis Anti-Convulsant Shakes up Epilepsy Treatment             (news – 2013)  http://www.thecompassionchronicles.com/2013/01/26/cannabis-anti-convulsant-shakes-up-epilepsy-  treatment/

 

 

 

 

 

 

 

 

 

New cannabis discovery could lead to better treatments for epilepsy                   (news – 2013)

http://www.reading.ac.uk/news-and-events/releases/PR464765.aspx

 

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