DIABETES

 

Cannabidiol Preserves Retinal Neurons and Reduces Vascular Permeability in Experimental Diabetes     (abst – 2004)  http://abstracts.iovs.org/cgi/content/abstract/45/5/860?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabinoid&searchid=1&FIRSTINDEX=1760&resourcetype=HWCIT

 

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats. (abst – 2004)                                          http://www.ncbi.nlm.nih.gov/pubmed/15519750

 

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice                     (full – 2005)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270485/?tool=pmcentrez

 

Activation of the Peripheral Endocannabinoid System in Human Obesity (full – 2005)                                       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228268/?tool=pmcentrez

 

Gpr40 Gene Expression in Human Pancreas and Insulinoma.                     (abst – 2005)

http://www.ncbi.nlm.nih.gov/pubmed/16289108

 

The Ffa Receptor Gpr40 Links Hyperinsulinemia, Hepatic Steatosis, and Impaired Glucose Homeostasis in Mouse.                                                                          (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/16054069

 

Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592672/?tool=pubmed

 

Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia                                                               (full – 2006)  http://jcem.endojournals.org/cgi/content/full/91/8/3171?ijkey=83a68cef202eafe129332eda53eee8eb613499 82

 

Weight Control in Individuals With Diabetes                       (full – 2006)  http://care.diabetesjournals.org/content/29/12/2749.full?maxtoshow=&hits=80&RESULTFORMAT=&full text=cannabis&searchid=1&FIRSTINDEX=2000&resourcetype=HWCIT

 

 

 

 

 

 

 

 

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.                                                         (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/17011761

 

Expression of the Gene for a Membrane-bound Fatty Acid Receptor in the Pancreas and Islet Cell Tumours in Humans: Evidence for Gpr40 Expression in Pancreatic Beta Cells and Implications for Insulin Secretion.                                                                              (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16525841

 

The Cannabinergic System as a Target for Anti-inflammatory Therapies

(abst – 2006)              http://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000013/art00008

 

Non-Psychoactive Cannabinoid Reduces Incidence Of Diabetes, Study Says (news – 2006)                                     http://www.norml.org/index.cfm?Group_ID=6909

 

Marijuana Compound May Help Stop Diabetic Retinopathy              (news – 2006)

http://www.sciencedaily.com/releases/2006/02/060227184647.htm

 

Cannabidiol, a marijuana compound, may help stop diabetic retinopathy             (news – 2006)

http://www.xagena.it/news/medicinenews_net_news/549d841c3704e2b6a273a258dd0b6f17.html

 

Marijuana Compound Offers Hope In Diabetic Retinopathy Prevention (news – 2006)  http://www.bio-medicine.org/medicine-news/Marijuana-Compound-Offers-Hope-In-Diabetic-Retinopathy-  Prevention-8121-1/

 

Cannabidiol reduces the development of diabetes in an animal study              (news – 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=219#3

 

Getting Eye On Cannabinoids              (news – 2006)

http://www.thehempire.com/index.php/cannabis/news/getting_eye_on_cannabinoids

 

Marijuana compound could prevent eye damage in diabetics               (news – 2006)  http://www.thehempire.com/index.php/cannabis/news/marijuana_compound_could_prevent_eye_damage_i   n_diabetics

 

Compound found in marijuana may defend against diabetic retinopathy            (news – 2006)

http://www.news-medical.net/news/2006/03/01/16284.aspx

 

Cannabidiol arrests onset of autoimmune diabetes in NOD mice               (full – 2007)

http://safeaccess.ca/research/pdf/WeissCBD_ArrestsDiabetesNeuropharmacology2007.pdf

 

Expression of Cannabinoid CB1 Receptors in Models of Diabetic Neuropathy (full – 2007)

http://jpet.aspetjournals.org/content/323/2/508.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

 

Cannabidiol attenuates high-induced endothelial cell inflammatory response and barrier disruption         (full – 2007)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2228254&tool=pmcentrez

 

 

 

 

 

 

 

 

 

US Patent Application 20070099987 – Treating or preventing diabetes with cannabidiol (full – 2007)                                    http://www.patentstorm.us/applications/20070099987/fulltext.html

 

Role of cannabinoid CB2 receptors in glucose homeostasis in rats             (abst – 2007)

http://www.sciencedirect.com/science/article/pii/S001429990700249X

 

The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells                                          (abst – 2007)  http://lib.bioinfo.pl/pmid:17604177

 

Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model             (abst – 2007)

http://marijuana.researchtoday.net/archive/4/4/736.htm

 

Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor                                                  (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588644/?tool=pmcentrez

 

The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids                                                                    (full – 2008)  http://diabetes.diabetesjournals.org/content/57/5/1262.full?sid=00769f3d-54ab-451b-b69e-4650931c5e25

 

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity        (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268073/?tool=pmcentrez

 

Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells.                                                              (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528830/?tool=pubmed

 

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet   (full – 2008)                         http://www.nature.com/oby/journal/v16/n3/full/oby2007106a.html

 

Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.        (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592995/?tool=pubmed

 

Endocannabinoids and the Control of Energy Homeostasis             (full – 2008)

http://www.jbc.org/content/283/48/33021.full?sid=931583b1-e797-43e0-8296-7fd75bb49403

 

Mediation of Cannabidiol Anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor                                                (full – 2008)  http://www.iovs.org/content/49/12/5526.full

 

Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats                                                              (abst – 2008)  http://www.doaj.org/doaj?func=abstract&id=859448&q1=anandamide&f1=all&b1=and&q2=&f2=all&rec No=25&uiLanguage=en

 

 

 

 

 

 

 

 

Presence of functional cannabinoid receptors in human endocrine pancreas. (abst – 2008)                                     http://www.ncbi.nlm.nih.gov/pubmed/18092149

 

Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development. (full – 2009)    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955420/?tool=pubmed

 

Cannabinoids as novel anti-inflammatory drugs.              (full – 2009)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/?tool=pubmed

 

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis                                                                  (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688760/?tool=pubmed

 

The endocanabinnoid system and diabetes – critical analyses of studies conducted with rimonabant         (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770455/?tool=pmcentrez

 

Biological effects of THC and a lipophilic cannabis extract on normal and insulin resistant 3T3-L1 adipocytes                                                          (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19345076/abstract/Biological_effects_of_THC_an  d_a_lipophilic_cannabis_extract_on_normal_and_insulin_resistant_3T3_L1_adipocytes_

 

Anti-inflammatory effect of palmitoylethanolamide on human adipocytes.            (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19131941

 

Beneficial effects of a Cannabis sativa extract on diabetes induced neuropathy and oxidative stress.       (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19441010/abstract/Beneficial_effects_of_a_Canna bis_sativa_extract_treatment_on_diabetes_induced_neuropathy_and_oxidative_stress_

 

Cannabis plant extracts could potentially form the basic ingredients for a market-leading diabetes drug   (news – 2009)  http://www.thefreelibrary.com/Cannabis+plant+extracts+could+potentially+form+the+basic+ingredients…-  a0202701009

 

Medical Marijuana and Diabetes, Adult Onset              (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/23?ailment=diabetes-adult-onset

 

Expression and function of cannabinoid receptors in mouse islets.              (full – 2010)

http://www.landesbioscience.com/journals/islets/LiISLETS2-5.pdf

 

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain                                                       (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845559/?tool=pmcentrez

 

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full – 2010)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005548/?tool=pubmed

 

 

 

 

 

 

 

 

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy       (full – 2010)  http://diabetes.diabetesjournals.org/content/59/4/1046.full?sid=0bc8e3fa-5275-4b19-8acc-4aec5dfac384

 

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.                                                                (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003779/

 

Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells          (full – 2010)  http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=320527       &Ausgabe=25   4555&ProduktNr=224332&filename=320527.pdf

 

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients                                                 (full – 2010)  http://www.lipidworld.com/content/9/1/43

 

Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. (full – 2010)                                    http://diabetes.diabetesjournals.org/content/59/11/2826.long#sec-25

 

Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes.        (full – 2010)                          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925907/?tool=pubmed

 

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy (full – 2010)         http://www.natap.org/2010/newsUpdates/marijuana.pdf

 

Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?                                                      (full – 2010)  http://www.jci.org/articles/view/44099?search[abstract_text]=&search[article_text]=cannabinoid&search[a   uthors_text]=&search[fpage]=&search[title_text]=&search[volume]=

 

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.                                                   (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868848/?tool=pubmed

 

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. (full– 2010)                                    http://www.wjgnet.com/1948-9358/full/v1/i1/12.htm

 

Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice.                                                                 (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20937249

 

AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes.                                                         (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20816753

 

 

 

 

 

 

 

 

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age.                                                                      (abst – 2010)  http://www.springerlink.com/content/g037q1lh40l15161/

 

Endocannabinoid (EC) Receptor, CB1, and EC Enzymes’ Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin           (abst – 2010)

http://www.degruyter.com/abstract/j/jpem.2010.23.issue-  10/jpem.2010.162/jpem.2010.162.xml?rskey=38kdx0&result=22&q=cannabinoid

 

G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population.                                                        (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20851297

 

GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders.  (abst – 2010)                              http://www.ncbi.nlm.nih.gov/pubmed/21094910

 

Pot Compound Mitigates Diabetic Cardiomyopathy               (news – 2010)

http://www.norml.org/index.cfm?Group_ID=8424

 

Cannabinoids inhibit and may prevent neuropathic pain in diabetes.               (news – 2010)

http://medigardens.blogspot.com/2010/04/march-2010-cannabinoids-inhibit-and-may.html

 

Lab Notes: Pot Has Benefits for Diabetic Hearts              (news – 2010)

http://www.medpagetoday.com/LabNotes/LabNotes/23853

 

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. (full – 2011)                                  http://joe.endocrinology-journals.org/content/211/2/177.long

 

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy.     (full – 2011)                                    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161308/

 

Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice             (full– 2011)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082575/?tool=pubmed

 

Role for cannabinoid receptors in human proximal tubular hypertrophy.              (full– 2011)

http://content.karger.com/produktedb/produkte.asp?DOI=000323997&typ=pdf

 

The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia.    (full – 2011)  http://www.rjme.ro/RJME/resources/files/520311791795.pdf

 

Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis        (abst – 2011)                   http://diabetes.diabetesjournals.org/content/60/4/1055.abstract

 

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells               (abst – 2011)  http://diabetes.diabetesjournals.org/content/60/4/1198.abstract?sid=0bc8e3fa-5275-4b19-8acc-  4aec5dfac384

 

 

 

 

 

 

 

 

Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice.                                                           (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21340622

 

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans.                                                             (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21564460/abstract/Cannabinoid_receptor_agonists

_and_antagonists_stimulate_insulin_secretion_from_isolated_human_islets_of_Langerhans_

 

Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes. (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21484568/abstract/Cannabinoids_and_Endocannab   inoids_in_Metabolic_Disorders_with_Focus_on_Diabetes_

 

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.                                               (abst – 2011)           http://www.ncbi.nlm.nih.gov/pubmed/21238581

 

Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression.                                                         (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21309057/abstract/Win_55212_2_reduces_cardiac

_ischaemia_reperfusion_injury_in_zucker_diabetic_fatty_rats:_role_of_cb2_receptors_and_cardiac_inos/e nos_expression_

 

GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms                                           (abst – 2011)  http://endo.endojournals.org/content/152/2/374.abstract?sid=c77be354-b90f-4368-9bb3-fea533824b24

 

Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.                                                           (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21633404

 

Cannabidiol Dampens Streptozotocin-Induced Retinal Inflammation by Targeting of Microglial Activation                                                  (abst – 2011)  http://abstracts.iovs.org/cgi/content/abstract/52/6/1002?maxtoshow=&hits=80&RESULTFORMAT=&fullt  ext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT

 

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.                                                 (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/22029844

 

The Endocannabinoid System: Plant-Derived Cannabinoids in Diabetes and Diabetic Complications.      (abst – 2011)                             http://www.ncbi.nlm.nih.gov/pubmed/22155112

 

TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats.                                                                                              (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21752941

 

Takeda moves potential first-in-class diabetes drug into phase III             (news – 2011)

http://www.inpharm.com/news/166980/takeda-diabetes-tak-875-phase-iii

 

 

 

 

 

 

 

 

 

Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III.                                                                   (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289985/

 

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.                                                    (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01755.x/full

 

The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. (full – 2012)                                      http://diabetes.diabetesjournals.org/content/61/2/281.long

 

Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012)                                      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409167/?tool=pubmed

 

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series                                                       (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/

 

Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids                                                                        (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493609/

 

Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice                                                          (full – 2012)  http://www.dmsjournal.com/content/4/1/35

 

Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant (full – 2012)                                      http://www.nutritionj.com/content/11/1/50

 

Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids.                                                         (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372498/

 

Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice                                                        (full – 2012)         http://www.lipidworld.com/content/11/1/98

 

Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol                                            (link to PDF – 2012)  http://www.scirp.org/journal/PaperInformation.aspx?paperID=17302

 

Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes.                                             (abst – 2012)           http://www.ncbi.nlm.nih.gov/pubmed/22609797

 

Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice.                                                   (abst – 2012)      http://www.ncbi.nlm.nih.gov/pubmed/22487302

 

 

 

 

 

 

 

 

Induction of Glucose Intolerance by Acute Administration of Rimonabant. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/22678147

 

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.                                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22374408

 

Stimulating beta cell replication and improving islet graft function by GPR119 agonists. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/21902730

 

A Randomized, Double-Blind, Placebo Controlled, Parallel Assignment, Flexible Dose, Efficacy Study of Nabilone as Adjuvant in the Treatment of Diabetic Peripheral Neuropathic Pain Using an Enriched Enrollment Randomized Withdrawal Design (S38.003)           (abst – 2012)

http://www.neurology.org/cgi/content/meeting_abstract/78/1_MeetingAbstracts/S38.003?maxtoshow=&hit   s=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=180&sortspec=date&reso  urcetype=HWCIT

 

The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (abst – 2012)

http://jpet.aspetjournals.org/content/342/1/188.abstract?sid=ae58f15a-06bb-4a81-b850-61bb89fd59f5

 

G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes.                                                           (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22138970

 

A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes.       (abst – 2012)                           http://www.ncbi.nlm.nih.gov/pubmed/22669289

 

Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.                                                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22490067

 

An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo- controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain.                                                                           (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22921260

 

The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity.                                             (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22943701

 

Reports of the death of CB1 antagonists have been greatly exaggerated: recent preclinical findings predict improved safety in the treatment of obesity.                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22743603

 

 

 

 

 

 

 

 

Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats. (abst – 2012)           http://www.ncbi.nlm.nih.gov/pubmed/22959964

 

New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance.                                                                             (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22674489

 

Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function.   (abst – 2012)                                  http://www.ncbi.nlm.nih.gov/pubmed/23078523

 

The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity                                                     (abst – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1467-789X.2012.01026.x/abstract

 

Synthetic cannabinoid could treat pain in diabetes patients                     (news – 2012)  http://www.medwirenews.com/57/102248/Diabetes/Synthetic_cannabinoid_could_treat_pain_in_diabetes_ patients_.html

 

Study: Synthetic THC Analogue Mitigates Diabetic Neuropathy, Is ‘Well Tolerated’ In Patients   (news – 2012)

http://norml.org/news/2012/09/20/study-synthetic-thc-analogue-mitigates-diabetic-neuropathy-is-well-  tolerated-in-patients

 

New drug offers novel pain management therapy for diabetics.                     (news – 2012)  http://www.thefreelibrary.com/New+drug+offers+novel+pain+management+therapy+for+diabetics.-  a0306899453

 

Drug offers new pain management therapy for diabetics                     (news – 2012)

http://medicalxpress.com/news/2012-10-drug-pain-therapy-diabetics.html

 

Is the cardiovascular system a therapeutic target for cannabidiol?                     (abst – 2013)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04351.x/abstract

 

Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids (abst – 2013)  http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3321.html

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