CP 55,940 – a synthetic cannabinoid-CB1, CB2 & GPR-55 agonist


Molecular cloning of a human cannabinoid receptor which is also expressed in testis (full – 1991)                                       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151556/


Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism.                                                            (full – 1992)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907498/?tool=pmcentrez&page=1


Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.                                                                 (full – 1993)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175863/?tool=pmcentrez&page=1


Cannabinoids enhance human B-cell growth at low nanomolar concentrations. (abst – 1995)                                            http://www.ncbi.nlm.nih.gov/pubmed/7544292


AM630, a competitive cannabinoid receptor antagonist.                  (abst  – 1995)



Involvement of Dynorphin B in the Antinociceptive Effects of the Cannabinoid CP55,940 in the Spinal Cord    (full – 1997)                                        http://jpet.aspetjournals.org/content/281/2/730.full










Cannabinoid Receptor Agonists Protect Cultured Rat Hippocampal Neurons from Excitotoxicity            (full – 1998)                            http://molpharm.aspetjournals.org/content/54/3/459.full


Potent Effects of a Selective Cannabinoid Receptor Agonist on Some Guinea Pig Medial Vestibular Nucleus Neurons.                                              (abst – 1998)      http://www.ncbi.nlm.nih.gov/pubmed/9650841


The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats (abst – 1999)                                 http://www.ncbi.nlm.nih.gov/pubmed/10611417


Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human                                                              (full – 2000)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571997/?tool=pmcentrez


Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation                                               (full – 2001)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572987/?tool=pmcentrez


Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. (abst – 2001)                                 http://www.ncbi.nlm.nih.gov/pubmed/11566149


The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.                                                     (full – 2002)  http://jpet.aspetjournals.org/content/300/1/34.long


Chronic Morphine Modulates the Contents of the Endocannabinoid, 2-Arachidonoyl Glycerol, in Rat Brain       (full – 2003)  http://www.nature.com/npp/journal/v28/n6/full/1300117a.html


Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea- pigs by cannabinoid (CB2) receptor activation.                                                (full – 2003)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574031/?tool=pubmed





Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala                                                       (full – 2005)  http://www.nature.com/npp/journal/v30/n3/full/1300535a.html


Avoidance of Abeta[(25-35)] / (H(2)O(2)) -induced apoptosis in lymphocytes by the cannabinoid agonists CP55,940 and JWH-015 via receptor-independent and PI3K- dependent mechanisms: role of NF-kappaB and p53.                                                                                                 (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/17017986


Effects of repeated administration with CP-55,940, a cannabinoid CB1 receptor agonist on the metabolism of the hepatic heme.                                                        (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/15896668










Endocannabinoids — The Brain’s Cannabis — Demonstrate Novel Modes Of Action To Stress      (news – 2005)                         http://www.sciencedaily.com/releases/2005/07/050720065810.htm


Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs                                                             (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075518/?tool=pubmed


Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.  (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189718/?tool=pubmed


The orphan receptor GPR55 is a novel cannabinoid receptor.               (full – 2007)



Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.                                                       (full – 2007)  http://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=2007&issue=04000&article=00021



Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells.     (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042924/?tool=pubmed


CB2 receptors in the brain: role in central immune function                  (full – 2007)



Cannabinoids enhance gastric X/A-like cells activity.                 (full – 2008)



Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                 (full – 2008)  http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block


Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells   (full – 2008)  http://www.jimmunol.org/cgi/content/full/181/9/6406?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson’s disease. (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18538428


Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder.          (abst – 2009)                http://www.ncbi.nlm.nih.gov/pubmed/19237169


Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects.                                                           (full – 2010)











Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor.                                                  (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846023/?tool=pubmed


Rimonabant-induced Delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs.                                                                (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/20375197/abstract/Rimonabant_induced_Delta9_te trahydrocannabinol_withdrawal_in_rhesus_monkeys:_discriminative_stimulus_effects_and_other_withdra wal_signs_


Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure.                                                             (abst – 2010)  http://www.ncbi.nlm.nih.gov/pubmed/20514518


Effects of cannabinoid CB(1) receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys. (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21029743


Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2011)



Cytotoxicity of synthetic cannabinoids found in “Spice” products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line. (abst – 2011)    http://www.ncbi.nlm.nih.gov/pubmed/21907772


Chronic Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys: differential tolerance and

cross-tolerance among cannabinoids.        (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21091643/abstract/Chronic_%CE%94%E2%81%B 9_tetrahydrocannabinol_treatment_in_rhesus_monkeys:_differential_tolerance_and_cross_tolerance_amon g_cannabinoids_


Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro (abst – 2011) http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01519.x/abstract


The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.    (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/20701826/abstract/The_schizophrenia_susceptibilit y_gene_neuregulin_1_modulates_tolerance_to_the_effects_of_cannabinoids_


A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells.          (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21492165/abstract/A_synthetic_cannabinoid_CP55  940_inhibits_lipopolysaccharide_induced_cytokine_mRNA_expression_in_a_cannabinoid_receptor_indep  endent_mechanism_in_rat_cerebellar_granule_cells_










Allosteric modulator ORG27569 induces a CB1 Cannabinoid receptor high affinity agonist binding state, receptor internalization and Gi-independent ERK1/2 activation. (full – 2012)                                  http://www.jbc.org/content/early/2012/02/16/jbc.M111.316463.long

GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                                   http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02019.x/full


Effects of CP 55,940–agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas.                                                        (full – 2012)  http://czasopisma.viamedica.pl/fhc/article/view/18705/14714


Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

(link to PDF – 2012)                     http://www.hindawi.com/isrn/pharmacology/2012/276902/


Cannabinoid Receptor Activity In The Tumour Necrosis Factor (tnf)−α-Induced Increased Contractility Of The Guinea-Pig Isolated Trachea                                                                 (abst – 2012)  http://ajrccm.atsjournals.org/cgi/reprint/185/1_MeetingAbstracts/A2154?maxtoshow=&hits=25&RESULT   FORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCI  T


Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.          (abst – 2008)                         http://www.ncbi.nlm.nih.gov/pubmed/18266975


International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                                             (full – 2010)  http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html


Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst – 2012)  http://www.unboundmedicine.com/medline/ebm/record/22772336/abstract/Contrasting_effects_of_differen t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_


Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat

(abst – 2012)



Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA(B) Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission.                                        (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22850737


Pharmacological effects of cannabinoids on the reference and working memory functions in mice.           (abst – 2012)                     http://www.ncbi.nlm.nih.gov/pubmed/22903389


Multitarget Cannabinoids as Novel Strategy for Alzheimer Disease.                  (abst – 2013)










Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.                                                                          (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23394117

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