CP 47,497 – a synthetic cannabinoid, CB1 & CB2 agonist


Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol (abst – 1982)

http://jpet.aspetjournals.org/content/223/2/516.abstract?maxtoshow=&hits=80&RESULTFORMAT=&fullt  ext=Hexahydrocannabinol&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT


The Conformational Properties of the Highly Selective Cannabinoid Receptor Ligand CP-55,940            (full – 1996)

http://www.jbc.org/content/271/18/10640.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=Hex ahydrocannabinol&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT


Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005)                                         http://www.sciencedirect.com/science/article/pii/S0028390805001668


Withdrawal Phenomena and Dependence Syndrome After the Consumption of “Spice Gold”       (full – 2009)                             http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719097/?tool=pmcentrez










Spice drugs: cannabinoids as a new designer drugs.              (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19718488/abstract/%5BSpice_drugs:_cannabinoid s_as_a_new_designer_drugs_%5D


Spice: a never ending story?             (abst – 2009)    http://www.ncbi.nlm.nih.gov/pubmed/19589652


Pharmacological properties and dependence liabilities of synthetic cannabinoids (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/20681249/abstract/%5BPharmacological_propertie  s_and_dependence_liabilities_of_synthetic_cannabinoids%5D_


Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds.                                                      (abst – 2010)      http://www.ncbi.nlm.nih.gov/pubmed/20857386


THIS ISN’T YOUR MOTHER’S SPICE               (news – 2010)



Now, There’s a Test for That — Norchem’s “Fake Marijuana” Test Reveals Significantly Increased Abuse of Spice/K2                                                (news – 2010)

http://www.marketwire.com/press-release/Now-Theres-Test-That-Norchems-Fake-Marijuana-Test-  Reveals-Significantly-Increased-Abuse-1356247.htm


College students and use of K2: an emerging drug of abuse in young persons (full – 2011)                                 http://www.substanceabusepolicy.com/content/6/1/16


Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? (full – 2011)                                http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139381/?tool=pubmed


Beyond THC: The New Generation of Cannabinoid Designer Drugs.            (full – 2011)



Investigating a not-so-natural high.                 (full – 2011)



CP47,497-C8 and JWH073, commonly found in ‘Spice’ herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists.                                          (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21333643


A method for CP 47, 497 a synthetic non-traditional cannabinoid in human urine using liquid chromatography tandem mass spectrometry.                                                   (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21233028


Synthetic cannabinoids in oral fluid.              (abst – 2011)



Cytotoxicity of synthetic cannabinoids found in “Spice” products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line.









(abst – 2011)                   http://www.ncbi.nlm.nih.gov/pubmed/21907772


Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in “herbal high” products.                                                                       (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/20529459


Effects of synthetic cannabinoids on electroencephalogram power spectra in rats. (abst – 2011)

http://www.unboundmedicine.com/medline/ebm/record/21640532/abstract/Effects_of_synthetic_cannabino   ids_on_electroencephalogram_power_spectra_in_rats_


The emergence and analysis of synthetic cannabinoids.                   (abst – 2011)



Chemicals Used in “Spice” and “K2” Type Products Now Under Federal Control and Regulation            (news – 2011)                           http://www.justice.gov/dea/pubs/pressrel/pr030111.html


Characterization of In Vitro Metabolites of CP 47,497, a Synthetic Cannabinoid, in Human Liver Microsomes by LC-MS/MS.                                                                      (full – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/j.1556-4029.2012.02261.x/full


Detection and quantification of new designer drugs in human blood: part 1 – synthetic cannabinoids.       (abst – 2012)                                  http://www.ncbi.nlm.nih.gov/pubmed/22593567


The spice in France: mixed herbs containing synthetic cannabinoids.                     (abst – 2012)



Acute toxicity due to the confirmed consumption of synthetic cannabinoids: Clinical and laboratory findings.                                                 (abst – 2012)     http://www.ncbi.nlm.nih.gov/pubmed/22971158


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