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Activated by l-α-lysophosphatidylinositol (LPI), and to a lesser extent possibly by THC, CBD,O-1602, PEA, 2-AG, Anandamide, Virodhamine


Cannabinoid Receptor Ligands                    (full – undated)


Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (abst – 1999)


Evolutionary Origins of the Endocannabinoid System.                    (abst – 2006)


GPR55: a new member of the cannabinoid receptor clan?                     (full – 2007)


The orphan receptor GPR55 is a novel cannabinoid receptor.   (full – 2007)


GPR55 and the vascular receptors for cannabinoids.                      (full – 2007)


The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects.                                                        (full – 2007)


GPR55 and the vascular receptors for cannabinoids.                    (full – 2007)


GPR55 is a novel cannabinoid receptor                   (full – 2007)


Novel cannabinoid receptors                     (full – 2007)


GPR55: signaling pathways and functions                    (abst – 2007)


GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current          (full – 2008)                      










Interactions of the G protein-coupled receptor-associated sorting proteins (GASP) 1 and 2 with the novel cannabinoid receptor GPR55                                        (abst – 2008)


The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo       (full – 2009)


Receptors for acylethanolamides-GPR55 and GPR119.              (full – 2009)


Endocannabinoid-mediated control of synaptic transmission.             (full – 2009)


The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation.                                              (full – 2009)


Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. (full – 2009)


Is GPR55 an anandamide receptor?             (abst – 2009)


Receptors for acylethanolamides-GPR55 and GPR119.               (full – 2009)


The enigmatic pharmacology of GPR55.              (abst – 2009)


International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                                             (full – 2010)


GPR55 ligands promote receptor coupling to multiple signalling pathways.   (full – 2010)


Pharmacological characterization of GPR55, a putative cannabinoid receptor. (abst – 2010)       ti  on_of_GPR55_a_putative_cannabinoid_receptor_


The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.                                                    (abst – 2010)


GPR55: Current Knowledge and Future Perspectives of a Purported “Type-3” Cannabinoid Receptor.    (abst – 2010)                                 


Cannabinoids and the gut: new developments and emerging concepts              (abst – 2010)







A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.                                                             (abst – 2010)


Cannabinoids and Bone: Friend or Foe?               (abst – 2010)


Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator. (abst – 2010)                                 


Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist.                                            (full – 2011)


Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.  (full – 2011)


Screening for Selective Ligands for GPR55.            (full – 2011)


New blood brothers: the GPR55 and CB2 partnership                (full – 2011)


A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. (full – 2011)                        


Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed- Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist                                                              (full – 201)


A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.                                                              (full – 2011)


L-α-lysophosphatidylinositol meets GPR55: a deadly relationship.                (abst – 2011)


What is the natural ligand of GPR55?                (abst – 2011)


Pharmacology, Signaling and Physiological Relevance of the G Protein-coupled Receptor

55.   (abst – 2011)    


GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. (abst – 2011)







The GPCR – associated sorting protein 1 regulates ligand-induced downregulation of GPR55.     (abst – 2011)                  


Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor.                                                 (abst – 2011)


The novel cannabinoid receptor GPR55, inhibits cholangiocarcinoma growth (abst – 2011)

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Modulation of the novel cannabinoid receptor – GPR55 – during rat fetoplacental development    (abst – 2011)                          


A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents.        (abst – 2011)           


The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.                                                   (abst – 2011)


The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.                                                     (abst – 2011)


Pharmacology, signaling and physiological relevance of the G protein-coupled receptor

55.               (abst – 2011)


Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. (abst – 2011)                           


The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation.       (abst – 2011)             


Off-Target Cannabinoid Effects Mediated by GPR55.               (full – 2012)


Role of cannabinoids in the regulation of bone remodeling  (full – 2012)


The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. (full – 2012)                            


The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.   (full – 2012)







The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain.                                                                     (abst – 2012)


The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55.                                                            (abst – 2012)


Effects of Palmitoylethanolamide on Aqueous Humor Outflow.                 (abst – 2012)


The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.      (abst – 2012)                                                        


Evidence for the Putative Cannabinoid Receptor (GPR55)-Mediated Inhibitory Effects on Intestinal Contractility in Mice.   (abst – 2012)                                             


GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors. (abst – 2012)                                


A potential role for GPR55 in gastrointestinal functions.                    (abst – 2012)


The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55                                                              (abst – 2012)


A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55.

(abst – 2012)         


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