CANCER – GLIOMA/ BRAIN CANCERS

 

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. (full – 1992)                                        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525583/

 

Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.                      (abst – 1998)

http://www.ncbi.nlm.nih.gov/pubmed/9771884

 

Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors                  (full – 2000)

http://www.jbc.org/content/275/41/31938.full

 

Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.                                                             (full – 2000)  http://depts.washington.edu/stellalb/images/Nature2000.pdf

 

Marijuana’s Active Ingredient Targets Deadly Brain Cancer                     (news – 2000)

http://www.webmd.com/news/20000228/marijuanas-active-ingredient-targets-deadly-brain-cancer

 

Pot Shrinks Tumors; Government Knew in ’74                    (news – 2000)

http://www.alternet.org/story/9257/?page=entire

 

Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor1           (full – 2001)                            http://cancerres.aacrjournals.org/cgi/reprint/61/15/5784.pdf

 

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full – 2001)         http://jpet.aspetjournals.org/content/299/3/951.full

 

Anti-Tumor Effects                   (news – 2001)      http://www.ukcia.org/research/AntiTumorEffects.htm

 

Inhibition of tumor angiogenesis by cannabinoids                   (full – 2003)

 

http://www.fasebj.org/cgi/reprint/02-  0795fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=20&sortspec=relevance&resourcetype=HWCIT

 

Cannabinoids: Potential Anticancer Agents              (full – 2003)

http://americanmarijuana.org/Guzman-Cancer.pdf

 

Anti-tumor effects of cannabidiol              (abst – 2003)

http://www.hempworld.com/HempPharm/articles/milanstudy.html

 

Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.  (abst – 2003)                                              http://www.ncbi.nlm.nih.gov/pubmed/12948856

 

Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells                                                       (full – 2004)  http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz%202004.pdf

 

Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas (full – 2004)                                 http://cancerres.aacrjournals.org/cgi/content/full/64/16/5617

 

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.     (full – 2004)                      http://science.iowamedicalmarijuana.org/pdfs/cancer/Massi%202004.pdf

 

Hypothesis: Cannabinoid Therapy for the Treatment of Gliomas?                 (abst – 2004)

http://www.ncbi.nlm.nih.gov/pubmed/15275820

 

Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. (abst – 2004)                                 http://www.ncbi.nlm.nih.gov/pubmed/15453094

 

Cannabis extract shrinks brain tumours               (news – 2004)  (may need registration)

http://www.newscientist.com/article/dn6283

 

‘Cannabis’ brain tumour drug hope                  (news – 2004)

http://news.bbc.co.uk/2/hi/health/3561686.stm

 

Marijuana May Stall Brain Tumor Growth               (news – 2004)

http://www.webmd.com/cancer/news/20040815/marijuana-stall-brain-tumor-growth

 

Marijuana Extract Fights Brain Cancer in Mice              (news – 2004)

http://www.scientificamerican.com/article.cfm?id=marijuana-extract-fights

 

Cancer Killer              (news – 2004)      http://www.november.org/stayinfo/breaking2/CancerKiller.html

 

Marijuana Ingredient Inhibits VEGF Pathway Required For Brain Tumor Blood Vessels (news – 2004)                                     http://www.sciencedaily.com/releases/2004/08/040816085401.htm

 

Cannabis extract makes brain tumors shrink, halts growth of blood vessels (news – 2004)                                       http://www.medicalnewstoday.com/articles/12088.php

 

 

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor- independent mechanism         (full – 2005)  http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1576089&tool=pmcentrez

 

Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue                                                        (full – 2005)  http://www.ukcia.org/research/EndocannabinoidMetabolismInHumanGlioblastomasAndMeningiomas.pdf

 

Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.                                                                 (abst – 2005)  http://www.ncbi.nlm.nih.gov/pubmed/16078104?dopt=Abstract

 

Effects on cell viability.             (abst – 2005)      http://www.ncbi.nlm.nih.gov/pubmed/16596790

 

A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.         (full – 2006)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=193

 

The non-psychoactive Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.                                                 (abst  – 2006)

http://www.ihop-net.org/UniPub/iHOP/pm/12214911.html?pmid=16909207

 

Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations.                                                           (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16899063

 

R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells.                                                              (abst – 2006)  http://www.springerlink.com/content/l403431l1728x733/

 

Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma.                                              (abst – 2006)     http://www.springerlink.com/content/75pu360830261968/

 

Preclinical studies of KM-233, a safe and effective classical cannabinoid chemotherapeutic for the treatment of high-grade glioma                                                                           (news – 2006)  http://www.aans.org/Media/Article.aspx?ArticleId=36969

 

Cannabinoids Curb Brain Tumor Growth, First-Ever Patient Trial Shows            (news – 2006)

http://www.norml.org/index.cfm?Group_ID=6947

 

THC tested against brain tumour in pilot clinical study               (news – 2006)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=222#1

 

Cannabinoids Induce Glioma Stem-like Cell Differentiation  and Inhibit Gliomagenesis (full – 2007)                                 http://www.jbc.org/content/282/9/6854.long

 

Expression of cannabinoid receptors and neurotrophins in human gliomas.            (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/18175076

 

 

Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue.   (abst – 2007)                                    http://www.ncbi.nlm.nih.gov/pubmed/17952648

 

Cannabinoids and gliomas.              (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17952650?dopt=Abstract

 

New Study: Marijuana Might Cure Brain Tumors              (news – 2007)

http://stopthedrugwar.org/speakeasy/2007/oct/18/new_study_marijuana_might_cure_b

 

Cannabinoids for Cancer Treatment: Progress and Promise               (full – 2008)

http://cancerres.aacrjournals.org/content/68/2/339.long

 

Cannabinoids as potential new therapy for the treatment of gliomas             (full – 2008)

http://safeaccess.ca/research/pdf/ParolaroCBasTherapyforGliomas2008.pdf

 

US Patent Application 20080262099 – Inhibition of Tumour Cell Migration (full – 2008)                                    http://www.patentstorm.us/applications/20080262099/fulltext.html

 

Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression  (full – 2008)  http://cancerres.aacrjournals.org/cgi/content/full/68/6/1945

 

Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.                                                      (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/17934890

 

Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?                                                        (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/17675107

 

5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid.                                             (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18028339

 

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. (abst – 2008)                                    http://www.ncbi.nlm.nih.gov/pubmed/18615640

 

Marijuana Kills Brain Cancer Cells                (news – 2008)

http://www.entheology.org/edoto/anmviewer.asp?a=375

 

Cannabinoid action induces autophagymediated cell death through stimulation of ER stress in human glioma cells.                                                               (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/?tool=pmcentrez

 

TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.              (full – 2009)

http://www.landesbioscience.com/journals/autophagy/SalazarAUTO5-7.pdf

 

Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis (abst – 2009)                                      http://www.ncbi.nlm.nih.gov/pubmed/19229996

 

THC initiates brain cancer cells to destroy themselves               (news – 2009)

http://www.worldhealth.net/news/thc_initiates_brain_cancer_cells_to_dest/

 

Active Ingredient in Marijuana Kills Brain Cancer Cells               (news – 2009)  http://health.usnews.com/health-news/family-health/cancer/articles/2009/04/01/active-ingredient-in-   marijuana-kills-brain-cancer.html

 

Marijuana Chemical May Fight Brain Cancer                 (news – 2009)

http://www.webmd.com/cancer/brain-cancer/news/20090401/marijuana-chemical-may-fight-brain-cancer

 

Active Component Of Marijuana Has Anti-Cancer Effects, Study Suggests (news – 2009)                                     http://www.sciencedaily.com/releases/2009/04/090401181217.htm

 

Anti-Cancer Effects In Active Component Of Marijuana              (news – 2009)

http://www.medicalnewstoday.com/releases/144770.php

 

Medical Marijuana and Brain Tumor, Malignant                (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/16?ailment=brain-tumor-malignant

 

Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival                                             (full – 2010)  http://www.letfreedomgrow.com/cmu/Brain_Cancer_Study.pdf

 

The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas.                                                          (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806825/?tool=pubmed

 

Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. (full – 2010)                                   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919281/?tool=pubmed

 

Anti-tumoural effects of cannabinoid combinations  – Patent TW201002315  (A) ― 2010-01-16            (full – 2010)

http://worldwide.espacenet.com/publicationDetails/description?CC=TW&NR=201002315A&KC=A&FT=  D&ND=3&date=20100116&DB=EPODOC&locale=en_EP

 

Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti- Inflammatory Agents            (full – 2010)

http://etd.uthsc.edu/WORLD-ACCESS/Gurley/2010-030-Gurley.pdf

 

Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas. (abst – 2010)                                    http://www.ncbi.nlm.nih.gov/pubmed/20307616

 

Science: Cannabidiol enhances the anti-cancer effects of THC on human brain cancer cells          (news – 2010)

http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=313#3

 

Cannabinoids inhibit glioma cell invasion in brain cancer studies               (news – 2010)  http://www.examiner.com/x-19678-Cannabis-Revolution-Examiner~y2010m3d11-Cannabinoids-inhibit-  glioma-cell-invasion-in-brain-cancer-studies

 

Cannabis Rx: Cutting Through the Misinformation : Dr. Andrew Weil               (news – 2010)

http://www.huffingtonpost.com/andrew-weil-md/can-cannabis-treat-cancer_b_701005.html

 

Cannabis Inhalation Associated With Spontaneous Tumor Regression (news – 2010)

http://blog.norml.org/2011/03/22/cannabis-inhalation-associated-with-spontaneous-tumor-regression-study-  says/

 

Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas-possible role of Cannabis inhalation.                                                              (full – 2011)

http://cannabisclinicians.org/wp-content/uploads/2011/12/Cannabis-Inhalation-and-Brain-Tumor-  Regression-2011.pdf

 

Phytocannabinoids for use in the treatment of cancer   – Patent  GB2478595  (A) ― 2011-09-14            (full – 2011)

http://worldwide.espacenet.com/publicationDetails/biblio?CC=GB&NR=2478595A&KC=A&FT=D&ND=

&date=20110914&DB=&locale=en_EP

 

Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress                                                       (link to PDF – 2011)

http://www.mdpi.com/2072-6694/2/2/1013/

 

A combined preclinical therapy of cannabinoids and temozolomide against glioma. (abst – 2011)                                    http://www.ncbi.nlm.nih.gov/pubmed/21220494

 

Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action.    (abst – 2011)                                    http://www.ncbi.nlm.nih.gov/pubmed/21233844

 

Tumors Regressing — Thanks to Cannabis?                 (news – 2011)

http://cannabisclinicians.org/2011/tumors-regressing-%E2%80%94-thanks-to-cannabis/

 

Marijuana Compound Induces Cell Death In Hard-To-Treat Brain Cancer (news – 2011)                                        http://www.norml.org/index.cfm?Group_ID=8459

 

Inhaled Cannabis May Keep Brain Cancer in Remission              (news – 2011)

http://www.freedomisgreen.com/inhaled-marijuana-may-keep-brain-cancer-in-remission/

 

Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-

233.            (full – 2012)          http://link.springer.com/article/10.1007/s11060-012-0958-5/fulltext.html

 

Alteration of endocannabinoid system in human gliomas.               (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22176552

 

Cannabidiol inhibits angiogenesis by multiple mechanisms. (abst – 2012)    http://www.ncbi.nlm.nih.gov/pubmed/22624859

 

 

Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells.                                                    (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22842590

 

Id-1 is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target.                                                       (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/23243024

 

The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients (abst – 2012)                                              http://link.springer.com/article/10.1007%2Fs12094-010-0604-7#page-1

 

Marijuana compound could stop aggressive cancer metastasis                         (news – 2012)

http://in.news.yahoo.com/marijuana-compound-could-stop-aggressive-cancer-metastasis-064950912.html

 

Can marijuana stop cancer?                     (news – 2012)

http://www.examiner.com/article/can-marijuana-stop-cancer

 

Cannabinoid May Treat Brain Cancer                   (news – 2012)

http://www.sciencedaily.com/releases/2012/09/120925142557.htm?utm_source=feedburner&utm_medium

=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29

 

Is Marijuana the Cancer Cure We’ve Waited For?                         (news – 2012)

http://www.empowher.com/cancer/content/marijuana-cancer-cure-we-ve-waited

 

Cannabis For Infant’s Brain Tumor, Doctor Calls Child “A Miracle Baby”  (news – 2012)

http://www.huffingtonpost.com/2012/12/01/cannabis-for-infants-brai_n_2224898.html

 

Clinical trial evaluates synthetic cannabinoid as brain cancer treatment                       (news – 2012)

http://medicalxpress.com/news/2012-09-clinical-trial-synthetic-cannabinoid-brain.html

 

Cannabinoid signaling in glioma cells.                       (abst – 2013)

http://www.ncbi.nlm.nih.gov/pubmed/22879071

 

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme.                                                        (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23349970

 

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