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BRAIN TRAUMA

BRAIN TRAUMA

 

A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat.                                             (abst – 1993)        http://www.ncbi.nlm.nih.gov/pubmed/8411215

 

Development of HU-211 as a neuroprotectant for ischemic brain damage.                  (abst – 1995)

http://www.ncbi.nlm.nih.gov/pubmed/7477742

 

45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211.                                                                     (abst – 1995)     http://www.ncbi.nlm.nih.gov/pubmed/7583233

 

Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant.                                                             (abst – 1997)  http://www.ncbi.nlm.nih.gov/pubmed/9042110

 

How hash became a smash in brain trauma research               (news – 1998)

http://www.maps.org/pipermail/maps_forum/1998-October/001231.html

 

Exogenous anandamide protects rat brain against acute neuronal injury in vivo. (full – 2001)                                  http://www.jneurosci.org/content/21/22/8765.long

 

Brain Injury Circumvented by Endocannabinoids              (abst – 2001)  http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2001/104/tw380?maxtoshow=&hits=80&RESULT   FORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=1680&resourcetype=HWCIT

 

An endogenous cannabinoid (2-AG) is neuroprotective after brain injury.             (abst – 2001)

http://www.ncbi.nlm.nih.gov/pubmed/11586361

 

Cannabinoids on the Brain             (full – 2002)

http://www.ukcia.org/research/CannabinoidsOnTheBrain.pdf

 

Cannabinoids and brain injury: therapeutic implications             (full – 2002)

http://www.ukcia.org/research/CannabinoidsAndBrainInjury.pdf

 

Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial.                                                              (abst – 2002)  http://www.ncbi.nlm.nih.gov/pubmed/11990913?dopt=Abstract

 

Neuroprotective and brain edema-reducing efficacy of the novel cannabinoid receptor agonist BAY 38-7271.                                                   (abst – 2003)

http://www.ncbi.nlm.nih.gov/pubmed/14519516

 

BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury.                                                (abst – 2003)  http://www.ncbi.nlm.nih.gov/pubmed/14647528

 

Cannabinoids As Neuroprotective Agents in Traumatic Brain Injury.               (abst – 2004)

http://www.benthamdirect.org/pages/content.php?CPD/2004/00000010/00000018/0007B.SGM

 

The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines.                                                           (abst – 2005)  http://lib.bioinfo.pl/pmid:16364651

 

The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration      (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/?tool=pmcentrez

 

The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines.                                                         (abst – 2006)  http://www.ncbi.nlm.nih.gov/pubmed/16364651

 

Anandamide, an endocannabinoid, protects neurons from inflammation after brain damage          (news – 2006)  http://www.xagena.it/news/medicinenews_net_news/9c25dc28b94e5226f1983330dc421cec.html

 

 

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis                                                              (full – 2007)    http://www.jbc.org/content/282/33/23892.full

 

Endocannabinoids and traumatic brain injury.              (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/17952651

 

The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling.       (full – 2008)                             http://www.fasebj.org/cgi/content/full/22/1/285

 

LSUHSC research reports new method to protect brain cells from diseases like Alzheimer’s         (news – 2008)

http://www.eurekalert.org/pub_releases/2008-08/lsuh-lrr082008.php

 

Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease

(full – 2009)                       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750822/?tool=pmcentrez

 

Breakthrough in treatment of Traumatic Brain Injury: KeyNeurotek’s clinical study reaches primary endpoint and shows significant increase in survival                                                                 (news – 2009)  http://www.drugs.com/clinical_trials/breakthrough-traumatic-brain-injury-keyneurotek-s-clinical-study-  reaches-primary-endpoint-shows-8667.html

 

Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality.                                                            (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848893/?tool=pubmed

 

Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage.

(abst – 2011)                  http://www.ncbi.nlm.nih.gov/pubmed/21315768

 

N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis      (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21505478/abstract/N_arachidonoyl_L_serine_is_n europrotective_after_traumatic_brain_injury_by_reducing_apoptosis_

 

Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a murine model of traumatic brain injury                                                          (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21315768/abstract/Pre__and_post_conditioning_tr

 

 

 

 

Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury.                                                      (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21332427/abstract/Acute_effects_of_a_selective_c annabinoid_2_receptor_agonist_on_neuroinflammation_in_a_murine_model_of_traumatic_brain_injury_

 

New metabolic pathway for controlling brain inflammation (news – 2011)  http://www.news-medical.net/news/20111021/New-metabolic-pathway-for-controlling-brain-  inflammation.aspx

 

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections.                                                                 (full – 2012)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310878/?tool=pubmed

 

Cannabis Responsive Head Injury Induced Mutiple Disabilities: A Case Report (link to PDF- 2012)                                                    http://www.scirp.org/journal/PaperInformation.aspx?paperID=16958

 

Cannabidiol for neurodegenerative disorders: important new clinical applications for this hytocannabinoids?                                                       (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22625422

 

Early Survival of Comatose Patients after Severe Traumatic Brain Injury with the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271: A Randomized, Double-Blind, Placebo-Controlled Phase II Trial.           (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22696266

 

A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury.                                                                    (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22903455

 

Type-1 (CB(1)) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells.                                                                            (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23372698

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