Sedative activity of cannabis in relation to its delta’-trans-tetrahydrocannabinol and cannabidiol content.            (full – 1981)


The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety (abst – 1981)



Single-dose study of nabilone in anxious volunteers.               (abst – 1981)  http://www.cannabis-,pressure


Antianxiety effect of cannabidiol in the elevated plus-maze.              (abst – 1990)


Anxiety with Depression Research Review                (full – 2000)


Therapeutic aspects of cannabis and cannabinoids.                (full – 2001)


Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. (abst – 2001)                         


Marijuana’s Distant Relative May Be The Next Prozac; Chemical Reduces Anxiety Using Novel Nerve System In Body                                                    (news – 2002)


Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice                                           (abst – 2004)  9568.2004.03293.x/abstract;jsessionid=15C92BB3498FAF0EE40394675E8B1800.d01t01


Marijuana Eyed for Treatment of Anxiety Disorders              (news – 2004)


Easing anxiety with anandamide               (news – 2004)


Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects                                                                  (full – 2005)


Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full – 2005)                           


Cannabidiol as an antipsychotic. A double-blind, controlled clinical trial on cannabidiol vs. amisulpride in acute schizophrenia.                                                        (abst – 2005)


High-dose cannabis stimulates growth of brain cells in rats                 (news – 2005)  growth-of-brain-cells-in-rats-510869.html


Marijuana might cause new cell growth in the brain              (news – 2005) (may need registration)                                           


Endocannabinoids — The Brain’s Cannabis — Demonstrate Novel Modes Of Action To Stress      (news – 2005)             


Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation-Like Processes (full – 2006)  xt=cannabinoid&searchid=1&FIRSTINDEX=400&resourcetype=HWCIT


Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia             (full – 2006)


Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug              (full – 2006)


Anxiolytic-like properties of the anandamide transport inhibitor AM404.              (full – 2006)


Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test.            (abst – 2006)


Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs                                                             (full – 2007)


Modulation of Fear and Anxiety by the Endogenous Cannabinoid System           (full – 2007)


Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans (full – 2008)   xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT


The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings                                                             (full – 2008)


Endocannabinoids: Stress, Anxiety, and Fear             (full – 2009)


Effects of {Delta}9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress.                                                             (abst – 2009)  rahydrocannabinol_on_reward_and_anxiety_in_rats_exposed_to_chronic_unpredictable_stress_


Modulation of effective connectivity during emotional processing by Delta9- tetrahydrocannabinol and cannabidiol.                                                                           (abst – 2009)   med_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.                                      (abst – 2009)



Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)- tetrahydrocannabinol in rats.                                                   (abst – 2009)


Medical Marijuana and Anxiety Disorders                (news – 2009)


Medical Marijuana and Panic Disorder               (news – 2009)


Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide Hydrolase Inhibition (full – 2010)


Brain CB2 Receptors: Implications for Neuropsychiatric Disorders (link to PDF– 2010)


Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.                                                             (abst – 2010)


Cannabinoids and anxiety.             (abst – 2010)


A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice.                                                               (abst – 2010) acute_and_chronic_Delta9_tetrahydrocannabinol_and_cannabidiol_in_C57BL/6JArc_mice_


Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors.                                                     (abst – 2010) ay_administration_of_cannabidiol_blocks_panic_like_response_by_activating_5_HT1A_receptors_


Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?                                                             (abst – 2010) ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_


Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.  (full – 2011)


Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)                        


Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.                                                   (abst – 2011)


Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.                                                              (abst – 2011)


Cannabinoids and emotionality: a neuroanatomical perspective.                (abst – 2011)


Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.                                                               (abst – 2011)


Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm.  (abst – 2011)


Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.                                                                 (abst – 2011)


Behavioral alterations in cystic fibrosis mice are prevented by cannabinoid treatment in infancy   (abst – 2011)  2/jbcpp.2011.005/jbcpp.2011.005.xml?rskey=wRYgJd&result=2&q=cannabinoid


Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.                                                  (abst – 2011)



Hemp Seed Oil for Anxiety                (news – 2011)


A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity                                                         (full – 2012)


Differences in Spontaneously Avoiding or Approaching Mice Reflect Differences in CB1-Mediated Signaling of Dorsal Striatal Transmission.                                                              (full – 2012)


Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.             (full – 2012)  44462012000500008&lng=en&nrm=iso&tlng=en


Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(full – 2012)         


Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response                                                              (link to PDF – 2012) cNo=4&uiLanguage=en


Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test.      (abst – 2012)                    


Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.                                                     (abst  – 2012)


Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.      (abst – 2012)                                    


Cannabinoid-related Agents in the Treatment of Anxiety Disorders: Current Knowledge and Future Perspectives.                                                     (abst – 2012)


Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it.     (abst – 2012)                


Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?                                               (abst – 2012)


Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors. (abst – 2012)                           


Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia.                                                      (abst – 2012)


Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.                                                                 (abst – 2012)


Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear.                                                            (abst – 2012)


Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.                                              (abst – 2012)


Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour.                                                       (abst – 2012)


Prevalence of Cannabis Use Disorder Diagnoses Among Veterans in 2002, 2008, and 2009.        (abst – 2012)            


Cannabinoid facilitation of fear extinction memory recall in humans.              (abst – 2012)


Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA(B) Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. (abst – 2012)


Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: Effects of the cannabinoid receptor 1 antagonist AM251.                                                                                            (abst – 2012)


Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors.                                                                         (abst – 2012)


Cannabinoid CB(1) receptor in the modulation of stress coping behaviour in mice: the role of serotonin and different forebrain neuronal subpopulations.                                                   (abst – 2012)


Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.      (abst – 2012)                                     


Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. (abst – 2012)


Cannabis Use Vulnerability Among Socially Anxious Users: Cannabis Craving During a Social Interaction.                                            (abst – 2012) 


Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.                                              (abst – 2012)


Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1. (abst – 2012)                         


CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning. (abst – 2012)                          


Cannabinoid Modulation of Midbrain Urocortin 1 Neurones During Acute and Chronic Stress    (abst – 2012)


Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.                                                                   (abst – 2012)


Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult                                            (abst – 2012)[]=citjournalarticl e_374483_1


The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone (abst – 2012)                          


Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans     (abst – 2012)                     


Endocannabinoid system and mood disorders: Priming a target for new therapies. (abst – 2012)                            


Brain altering drug calms fears also                (news – 2012)


Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)


Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms. (abst – 2013)


Cannabidiol enhances consolidation of explicit fear extinction in humans. (abst – 2013)                       


The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. (abst – 2013)


Neonatal lipopolysaccharide treatment has long term effects on monoaminergic and cannabinoid receptors in the rat.                                                              (abst – 2013)


Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.                                                                    (abst – 2013)

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