ANXIETY/ANXIOLYTICEFFECTS(anxiety reducing)

 

Sedative activity of cannabis in relation to its delta’-trans-tetrahydrocannabinol and cannabidiol content.            (full – 1981)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071638/?tool=pmcentrez

 

The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety (abst – 1981)

http://www.cannabis-  med.org/studies/ww_en_db_study_show.php?s_id=229&&search_pattern=ANXIOLYTIC.

 

Single-dose study of nabilone in anxious volunteers.               (abst – 1981)  http://www.cannabis-  med.org/studies/ww_en_db_study_show.php?s_id=236&&search_pattern=blood,pressure

 

Antianxiety effect of cannabidiol in the elevated plus-maze.              (abst – 1990)

http://www.ncbi.nlm.nih.gov/pubmed/1969666

 

Anxiety with Depression Research Review                (full – 2000)

http://www.ukcia.org/research/AnxietyWithDepressionResearchReview.pdf

 

Therapeutic aspects of cannabis and cannabinoids.                (full – 2001)

http://bjp.rcpsych.org/cgi/content/full/178/2/107

 

Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. (abst – 2001)                                   http://www.ncbi.nlm.nih.gov/pubmed/11566149

 

Marijuana’s Distant Relative May Be The Next Prozac; Chemical Reduces Anxiety Using Novel Nerve System In Body                                                    (news – 2002)  http://www.sciencedaily.com/releases/2002/12/021202071928.htm

 

Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice                                           (abst – 2004)

http://onlinelibrary.wiley.com/doi/10.1111/j.1460-  9568.2004.03293.x/abstract;jsessionid=15C92BB3498FAF0EE40394675E8B1800.d01t01

 

Marijuana Eyed for Treatment of Anxiety Disorders              (news – 2004)

http://www.drugfree.org/join-together/drugs/marijuana-eyed-for-treatment

 

Easing anxiety with anandamide               (news – 2004)

http://www.rsc.org/chemistryworld/Issues/2004/July/anandamide.asp

 

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects                                                                  (full – 2005)  http://www.jci.org/cgi/content/full/115/11/3104

 

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear (full – 2005)                                     http://www.nature.com/npp/journal/v30/n3/full/1300655a.html

 

Cannabidiol as an antipsychotic. A double-blind, controlled clinical trial on cannabidiol vs. amisulpride in acute schizophrenia.                                                        (abst – 2005)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=171

 

High-dose cannabis stimulates growth of brain cells in rats                 (news – 2005)  http://www.independent.co.uk/life-style/health-and-families/health-news/highdose-cannabis-stimulates-  growth-of-brain-cells-in-rats-510869.html

 

Marijuana might cause new cell growth in the brain              (news – 2005) (may need registration)                                                     http://www.newscientist.com/article/dn8155

 

Endocannabinoids — The Brain’s Cannabis — Demonstrate Novel Modes Of Action To Stress      (news – 2005)                       http://www.sciencedaily.com/releases/2005/07/050720065810.htm

 

Cannabinoid CB1 Receptor Mediates Fear Extinction via Habituation-Like Processes (full – 2006)  http://www.jneurosci.org/cgi/content/full/26/25/6677?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabinoid&searchid=1&FIRSTINDEX=400&resourcetype=HWCIT

 

Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia             (full – 2006)

http://science.iowamedicalmarijuana.org/pdfs/neuro/Walther%202006.pdf

 

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug              (full – 2006)

http://www.scielo.br/scielo.php?pid=S0100-879X2006000400001&script=sci_arttext#Text

 

Anxiolytic-like properties of the anandamide transport inhibitor AM404.              (full – 2006)

http://www.nature.com/npp/journal/v31/n12/full/1301061a.html

 

Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test.            (abst – 2006)

http://www.ncbi.nlm.nih.gov/pubmed/16876926

 

Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs                                                             (full – 2007)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075518/?tool=pubmed

 

Modulation of Fear and Anxiety by the Endogenous Cannabinoid System           (full – 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789283/?tool=pmcentrez

 

Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans (full – 2008)  http://www.jneurosci.org/cgi/content/full/28/10/2313?maxtoshow=&hits=80&RESULTFORMAT=&fullte   xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

 

The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings                                                             (full – 2008)  http://fampra.oxfordjournals.org/cgi/content/full/25/5/321

 

Endocannabinoids: Stress, Anxiety, and Fear             (full – 2009)

http://neuro.psychiatryonline.org/article.aspx?volume=21&page=iv

 

Effects of {Delta}9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress.                                                             (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19406854/abstract/Effects_of_%7BDelta%7D9_tet  rahydrocannabinol_on_reward_and_anxiety_in_rats_exposed_to_chronic_unpredictable_stress_

 

Modulation of effective connectivity during emotional processing by Delta9- tetrahydrocannabinol and cannabidiol.                                                                           (abst – 2009)  http://www.ncbi.nlm.nih.gov/pubmed/19775500?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pub   med_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.                                      (abst – 2009)  http://www.unboundmedicine.com/medline/ebm/record/19924114/full_citation/Opposite_Effects_of_Delta

_9_Tetrahydrocannabinol_and_Cannabidiol_on_Human_Brain_Function_and_Psychopathology_

 

Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)- tetrahydrocannabinol in rats.                                                   (abst – 2009)     http://www.ncbi.nlm.nih.gov/pubmed/19393686

 

Medical Marijuana and Anxiety Disorders                (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/11?ailment=anxiety-disorders

 

Medical Marijuana and Panic Disorder               (news – 2009)

https://www.marijuanadoctors.com/content/ailments/view/51?ailment=panic-disorder

 

Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide Hydrolase Inhibition (full – 2010)  http://molpharm.aspetjournals.org/content/78/2/260.long

 

Brain CB2 Receptors: Implications for Neuropsychiatric Disorders (link to PDF– 2010)   http://www.mdpi.com/1424-8247/3/8/2517

 

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.                                                             (abst – 2010)     http://www.ncbi.nlm.nih.gov/pubmed/20829306

 

Cannabinoids and anxiety.             (abst – 2010)        http://www.ncbi.nlm.nih.gov/pubmed/21309120

 

A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice.                                                               (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/19785914/abstract/A_behavioural_comparison_of_ acute_and_chronic_Delta9_tetrahydrocannabinol_and_cannabidiol_in_C57BL/6JArc_mice_

 

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors.                                                     (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/20457188/abstract/Intra_dorsal_periaqueductal_gr ay_administration_of_cannabidiol_blocks_panic_like_response_by_activating_5_HT1A_receptors_

 

Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?                                                             (abst – 2010)  http://www.unboundmedicine.com/medline/ebm/record/20512266/abstract/%5BPharmacological_exploitat ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_

 

Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.  (full – 2011)  http://www.nature.com/npp/journal/v37/n2/full/npp2011204a.html

 

Is lipid signaling through cannabinoid 2 receptors part of a protective system? (full – 2011)                                  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062638/

 

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.                                                   (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/21307846

 

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.                                                              (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21771609

 

Cannabinoids and emotionality: a neuroanatomical perspective.                (abst – 2011)

http://www.ncbi.nlm.nih.gov/pubmed/21827834

 

Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.                                                               (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21867717

 

Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm.  (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21918503

 

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.                                                                 (abst – 2011)

http://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=315

 

Behavioral alterations in cystic fibrosis mice are prevented by cannabinoid treatment in infancy   (abst – 2011)

http://www.degruyter.com/abstract/j/jbcpp.2011.22.issue-1-  2/jbcpp.2011.005/jbcpp.2011.005.xml?rskey=wRYgJd&result=2&q=cannabinoid

 

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.                                                  (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/21145341/abstract/Inhibition_of_endocannabinoid

_catabolic_enzymes_elicits_anxiolytic_like_effects_in_the_marble_burying_assay_

 

Hemp Seed Oil for Anxiety                (news – 2011)

http://www.livestrong.com/article/379150-hemp-seed-oil-for-anxiety/

 

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity                                                         (full – 2012)  http://link.springer.com/article/10.1007/s00213-012-2785-y/fulltext.html

 

Differences in Spontaneously Avoiding or Approaching Mice Reflect Differences in CB1-Mediated Signaling of Dorsal Striatal Transmission.                                                              (full – 2012)  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033260

 

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.             (full – 2012)  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-  44462012000500008&lng=en&nrm=iso&tlng=en

 

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(full – 2012)                   http://link.springer.com/article/10.1007/s12035-012-8299-0/fulltext.html

 

Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response                                                              (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152480&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=4&uiLanguage=en

 

Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test.      (abst – 2012)                              http://www.ncbi.nlm.nih.gov/pubmed/23127569

 

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.                                                     (abst  – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/23108553

 

Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.      (abst – 2012)                                              http://www.ncbi.nlm.nih.gov/pubmed/21937980

 

Cannabinoid-related Agents in the Treatment of Anxiety Disorders: Current Knowledge and Future Perspectives.                                                     (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22280339

 

Fear relief-toward a new conceptual frame work and what endocannabinoids gotta do with it.     (abst – 2012)                          http://www.ncbi.nlm.nih.gov/pubmed/22173015

 

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?                                               (abst – 2012)          http://www.ncbi.nlm.nih.gov/pubmed/22625422

 

Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors. (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/22623656

 

Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia.                                                      (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22716146

 

Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.                                                                 (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22579951

 

Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear.                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22534181

 

Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.                                              (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22280339

 

Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour.                                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/11982628

 

Prevalence of Cannabis Use Disorder Diagnoses Among Veterans in 2002, 2008, and 2009.        (abst – 2012)                      http://www.ncbi.nlm.nih.gov/pubmed/22564034

 

Cannabinoid facilitation of fear extinction memory recall in humans.              (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22796109

 

Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA(B) Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22850737

 

Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: Effects of the cannabinoid receptor 1 antagonist AM251.                                                                                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22959963

 

Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors.                                                                         (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22979992

 

Cannabinoid CB(1) receptor in the modulation of stress coping behaviour in mice: the role of serotonin and different forebrain neuronal subpopulations.                                                   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23000076

 

Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.      (abst – 2012)                                               http://www.ncbi.nlm.nih.gov/pubmed/22990678

 

Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23007604

 

Cannabis Use Vulnerability Among Socially Anxious Users: Cannabis Craving During a Social Interaction.                                            (abst – 2012)           http://www.ncbi.nlm.nih.gov/pubmed/23002698

 

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.                                              (abst – 2012)          http://www.ncbi.nlm.nih.gov/pubmed/23042808

 

Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1. (abst – 2012)                                   http://www.ncbi.nlm.nih.gov/pubmed/23010766

 

CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning. (abst – 2012)                                    http://www.ncbi.nlm.nih.gov/pubmed/23018128

 

Cannabinoid Modulation of Midbrain Urocortin 1 Neurones During Acute and Chronic Stress    (abst – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.2012.02355.x/abstract

 

Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.                                                                   (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23183218

 

Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult                                            (abst – 2012)  http://www.safetylit.org/citations/index.php?fuseaction=citations.viewdetails&citationIds[]=citjournalarticl e_374483_1

 

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone (abst – 2012)                                    http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01478.x/abstract

 

Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans     (abst – 2012)                               http://www.ncbi.nlm.nih.gov/pubmed/22763622

 

Endocannabinoid system and mood disorders: Priming a target for new therapies. (abst – 2012)                                      http://www.ncbi.nlm.nih.gov/pubmed/23261685

 

Brain altering drug calms fears also                (news – 2012)

http://in.news.yahoo.com/brain-altering-drug-calms-fears-071146308.html

 

Dissociation of the Pharmacological Effects of THC by mTOR Blockade.            (full – 2013)

http://www.nature.com/npp/journal/vaop/naam/pdf/npp201331a.pdf

 

Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms. (abst – 2013)   http://www.ncbi.nlm.nih.gov/pubmed/23178193

 

Cannabidiol enhances consolidation of explicit fear extinction in humans. (abst – 2013)                                 http://www.ncbi.nlm.nih.gov/pubmed/23307069

 

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. (abst – 2013) http://www.ncbi.nlm.nih.gov/pubmed/23298518

 

Neonatal lipopolysaccharide treatment has long term effects on monoaminergic and cannabinoid receptors in the rat.                                                              (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23389966

 

Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.                                                                    (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/2339411

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