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ANANDAMIDE/ AEA – endocannabinoid, CB 1 & 2 agonist

 ANANDAMIDE/ AEA – endocannabinoid, CB 1 & 2 agonist


Phytocannabinoids                      (news – undated)


Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor. (abst – 1992)                                


Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agentsCP 55,940, WIN 55,212-2 and anandamide.                                                           (full – 1993)


Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction                                                            (full – 1993)


Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.    (abst – 1993)                             


Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes    (full – 1994)                               


Formation and inactivation of endogenous cannabinoid anandamide in central neurons. (letter – 1994)                                   


Formation and inactivation of endogenous cannabinoid anandamide in central neurons (abst – 1994)                                 


Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization.           (full – 1995)                          


Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin (abst – 1995)  T=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=2320&resourcetype=HWCIT


Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide.      (abst – 1995)               


The CB1 cannabinoid receptor antagonist SR 141716A affects A9 dopamine neuronal activity in the rat.                                         (abst – 1995)


Marijuana and chocolate.             (abst – 1996)


Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.                                                               (full – 1997)


Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand            (full – 1997)  AG_%20FEBSLet.pdf


Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB1-Like Cannabinoid Receptors  (full – 1997)



Patent 5631297 – Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same

(full – 1997)           


Anandamide : The molecule of extreme pleasure              (report– 1997)


Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. (abst – 1997)                             


Brain Chemicals Mimic Marijuana (news – 1997)


Anandamide, an Endogenous Cannabinoid, Has a Very Low Physical Dependence Potential       (full – 1998)  cannabinoid&searchid=1&FIRSTINDEX=480&resourcetype=HWCIT


The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation (full – 1998)                            


Cardiovascular actions of cannabinoids and their generation during shock.            (abst – 1998)


Trick or treat from food endocannabinoids?             (abst – 1998)


Doped skin   (news – 1998)  (may need registration)


Pain modulation by release of the endogenous cannabinoid anandamide             (full – 1999)


Cannabis: Discrimination of “Internal Bliss”?              (abst – 1999)


Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors (abst – 1999)                            


Brain Releases Marijuana-Like Substance In Response To Pain, Study Finds (news – 1999)                            


Links found between marijuana and vision                (news – 1999)


UC Irvine Researchers Demonstrate How Marijuana-Like Chemicals Work In The Brain (news – 1999)                            


Why your brain is primed for a high             (news – 1999) (may need registration)


Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors           (full – 2000)


Endocannabinoids and Vascular Function             (full – 2000)


Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation (full – 2000)                         


Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human (full – 2000)


Cardiovascular effects of endocannabinoids–the plot thickens.              (abst – 2000)  tplus


Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.                                                          (abst – 2000)



Endogenous cannabinoids and appetite.                (abst – 2000)


Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets.

(full – 2001)     


Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation                                               (full – 2001)


Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts                                                        (full – 2001)  04975ba34325


Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full – 2001)


Exogenous anandamide protects rat brain against acute neuronal injury in vivo. (full – 2001)                        


Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats          (full – 2001)        


Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase  and enhances the anti-proliferative effect of anandamide in human breast  cancer cells (full – 2001)


Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries (full – 2001)                        


Endogenous cannabinoids mediate hypotension after experimental myocardial infarction (full – 2001)   ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT


Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints (full – 2001)                          


Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase                                                        (full – 2001)


Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated With Inflammation of the Urinary Bladder                                                  (full – 2001) ts_a.23.aspx


Leptin-regulated endocannabinoids are involved in maintaining food intake (letter – 2001)                         


The neurobiology and evolution of cannabinoid signalling                 (abst – 2001)  5ef27a702e9ba&keytype2=tf_ipsecsha


Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic  effects of epinephrine: role of CB(1) and CB(2) receptors.                                                             (abst – 2001) tplus


The Central Cannabinoid Receptor Inactivation Suppresses Endocrine Reproductive Functions.  (abst – 2001)                      


Quantification of anandamide content in animal cells and tissues: the normalization makes the difference            (full – 2002)                           


Endocannabinoid Degradation, Endotoxic Shock and Inflammation (link to PDF – 2002)                                      


Sourcing the Code: Searching for the Evolutionary Origins of Cannabinoid Receptors, Vanilloid Receptors, and Anandamide                                                          (full – 2002)


Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation        (full – 2002)


Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease            (full – 2002)   a7d081bcc2771d


A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding       (full – 2002) 862e8&keytype2=tf_ipsecsha


Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.                                                          (full – 2002)


Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate  (full – 2002)                                  


Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism.                                                      (abst – 2002) tplus


Endocannabinoids and related fatty acid derivatives in pain modulation.            (abst – 2002)


Anandamide and R-(+)-methanandamide prevent development of ischemic and reperfusion arrhythmia in rats by stimulation of CB2-receptors                                                                     (abst – 2002)


Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. (abst – 2002)                               


Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine.                                             (abst – 2002)


Role of Endogenous Cannabinoids in Synaptic Signaling                (full – 2003)   ltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon         (full – 2003)


CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full – 2003)                           


Endocannabinoid signalling in the blood of patients with schizophrenia (full – 2003)                                        


A new endothelial target for cannabinoids.             (full – 2003)


The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis                                                     (full – 2003)


Endocannabinoids protect the rat isolated heart against ischaemia              (full – 2003)


Cannabis and the brain.   (full – 2003)  


Chronic Morphine Modulates the Contents of the Endocannabinoid, 2-Arachidonoyl Glycerol, in Rat Brain       (full – 2003)


Manipulation of the endocannabinoid system by a general anaesthetic.             (full – 2003)


Cannabinoids inhibit neurodegeneration in models of multiple sclerosis               (full – 2003)  2989ba0


Therapeutic potential of cannabinoids in CNS disease.              (abst – 2003)


Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production. (abst – 2003)


Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. (abst – 2003)                                    


Therapeutic potential of cannabinoids in CNS disease.              (abst – 2003)


Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. (abst – 2003)                           


An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice.    (abst – 2003)           


Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study.                                              (abst – 2003)


The endocannabinoid system: a general view and latest additions             (full – 2004)


Endocannabinoids: Getting the message across             (full – 2004)  nabis&searchid=1&FIRSTINDEX=2880&resourcetype=HWCIT


Endocannabinoids and Their Implications for Epilepsy               (full – 2004)


Anandamide Is Able to Inhibit Trigeminal Neurons Using an in Vivo Model of Trigeminovascular-Mediated Nociception                                                                (full – 2004)



The complexities of the cardiovascular actions of cannabinoids                (full – 2004)


Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells                                                          (full – 2004)


Involvement of cannabinoid receptors in gut motility and visceral perception (full – 2004)                           


Plasma Levels of the Endocannabinoid Anandamide in Women—A Potential Role in Pregnancy Maintenance and Labor?                                                             (full – 2004) 8a5b


Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1                                                (full – 2004)


A Cyclooxygenase Metabolite of Anandamide Causes Inhibition of Interleukin-2 Secretion in Murine Splenocytes                                                                     (full – 2004)


Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.                                                          (full – 2004)


Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes.        (abst – 2004)                          


How our brains fend off madness, we produce a cannabis like substance           (news – 2004)


Easing anxiety with anandamide               (news – 2004)


Exercise activates the endocannabinoid system.              (abst – 2004)


Study links marijuana buzz to ‘runner’s high’                (news – 2004)


Runner’s High  (news – 2004)–1102-0%2C00.html


Prescription Chocolate              (news – 2004)


Cardiovascular Pharmacology of Cannabinoids                  (full – 2005)


The cardiovascular actions of anandamide: more targets?               (full – 2005)


Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects          (full – 2005)                                   


Antidepressant-like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis.                                                       (full – 2005)


Blood pressure regulation by endocannabinoids and their receptors               (full – 2005)


The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2                                                        (full – 2005)


The effects of Δ9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide                                                            (full – 2005)


Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia–reperfusion by a novel cannabinoid mechanism                                                         (full – 2005)


Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity                                              (full – 2005)


Antidepressant-like activity by blockade of anandamide hydrolysis             (full – 2005)


Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa.                                                       (full – 2005)


Analgesia through endogenous cannabinoids                 (full – 2005)  ocannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HW   CIT


Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors                                                         (full – 2005)


Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N- arachidonoyldopamine (NADA) in the rat isolated aorta.                                                                          (abst – 2005)


Targeted lipidomics: fatty acid amides and pain modulation.               (abst – 2005)


Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005)                          


Influence of Anandamide, the Endogenous Agonist of Cannabinoid Receptors on the Circulatory System                                             (abst – 2005)


Finding of endocannabinoids in human eye tissues: implications for glaucoma. (abst – 2005)                            


Chocolate and cannabis           (article – 2005)


A biosynthetic pathway for anandamide                (full – 2006)


Activation of G-proteins in brain by endogenous and exogenous cannabinoids. (full – 2006)                           


Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia                                                        (full – 2006) 82


Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P                                                                    (full – 2006)


Endocannabinoids, feeding and suckling – from our perspective               (full – 2006)


Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle  ( full – 2006)                                             


Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice                                                          (full – 2006)


Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.                                                    (full – 2006)


Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection          (full – 2006)


Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor- mediated excitotoxic damage                                                 (full – 2006)


Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors            (full – 2006)   text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT


Not Too Excited? Thank Your Endocannabinoids              (full – 2006)


Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice                                                        (full – 2006)


Effects of general anesthesia on anandamide blood levels in humans.              (full – 2006)  ide_Blood.12.aspx


Cannabinoids and the Endocannabinoid System              (full – 2006)


Is there a temperature-dependent uptake of anandamide into cells?            ( full – 2006)


A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. (full – 2006)                        


Anxiolytic-like properties of the anandamide transport inhibitor AM404.              (full – 2006)




The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.                                                                       (abst – 2006)


Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions.        (abst – 2006)                     


Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome.    (abst – 2006) tplus


Anandamide inhibits adhesion and migration of breast cancer cells.             (abst – 2006)


Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain                                                                           (abst – 2006)


Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations.                                                         (abst – 2006)


Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2- arachidonoylglycerol.                                              (abst – 2006)


Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels.                                                              (abst – 2006)


Release of anandamide from blood cells                (abst – 2006)  4/cclm.2006.065/cclm.2006.065.xml?rskey=jSEJyD&result=7&q=cannabinoid


UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington’s disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.                                                                                             (abst – 2006)


Metabolism of Anandamide an Endogenous Cannabinoid                 (chart – 2006)   n&ppage=1&pathway_id=cb1rpathway


Anandamide, an endocannabinoid, protects neurons from inflammation after brain damage          (news – 2006)


Anandamide Regulates Keratinocyte Differentiation by Inducing DNA Methylation in a CB1 Receptor-dependent Manner                                                      (full – 2007)


Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury (full – 2007)                        


Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain   (full – 2007)         


Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.    (full – 2007)


Anandamide Regulates Keratinocyte Differentiation by Inducing DNA Methylation in a CB1 Receptor-dependent Manner                                                          (full – 2007)


Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB1 and TRPV1 receptors                                                  (full – 2007)


Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances ‘liking’ of a sweet reward.                                                                          (full – 2007)


Identification of Endocannabinoids and Related Compounds in Human Fat Cells (full – 2007)                         


Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full – 2007)                         


Endocannabinoids and the haematological system               (full – 2007)


Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta           (full – 2007)        


GPR55 and the vascular receptors for cannabinoids.              (full – 2007)


The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis                                                               (full – 2007)


The orphan receptor GPR55 is a novel cannabinoid receptor.               (full – 2007)


Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs

(full – 2007)     


Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure–Induced Ischemia in Rats                                                             (full – 2007)  nabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT


Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation                                                                           (full – 2007)


Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth (full – 2007)                         


The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3′- carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. (full – 2007)                          


Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.                                                              (full – 2007)


Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher       (interview – 2007)



The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon.  (abst – 2007)


Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients (abst – 2007) spinal_fluid_of_first_episode_schizophrenic_patients:_Impact_of_cannabis_use


Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor- suppressor efficacy.                                                  (abst – 2007)


Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.                                                (abst – 2007)


Effect of Endocannabinoid System on the Neurogenic Function of Rat Corpus Cavernosum        (abst – 2007) q2=&f2=all&recNo=26&uiLanguage=en


Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.                                                    (abst – 2007)


The endocannabinoid system               (news – 2007)


Marijuana-Like Brain Chemicals Work As Antidepressant              (news – 2007)


Role seen for cannabis in helping to alleviate allergic skin disease                (news – 2007)


CB1 Cannabinoid Receptor Inhibition: Promising Approach for Heart Failure? (full – 2008)                        


N-arachidonylethanolamide-Induced Increase in Aqueous Humor Outflow Facility (full – 2008)                      


Expression of the Endocannabinoid System in Human First Trimester Placenta and Its Role in Trophoblast Proliferation                                                       (full – 2008)


Pharmacological Inhibition of CB1 Cannabinoid Receptor Protects Against Doxorubicin- Induced Cardiotoxicity                                                 (full – 2008)


Modulation of the Endocannabinoid System in Cardiovascular Disease            (full – 2008)


Cannabinoid receptors and the regulation of bone mass               (full – 2008)


Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats    (full – 2008)


‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.                                                                         (full – 2008)


Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                   (full – 2008) ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block


Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide.         (full – 2008)


Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages         (full – 2008)  4a971695b4fb


Endocannabinoids and the Control of Energy Homeostasis             (full – 2008)


Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion.                                          (full – 2008)


The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway                                                     (full – 2008)


The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway.                                                 (full – 2008)


Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling.                                                                      (full – 2008)


Role of cannabinoids and endocannabinoids in cerebral ischemia              (full – 2008)


Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet  (full – 2008)                 


Endocannabinoids and nutrition.               (full – 2008)


Mechanisms for Recycling and Biosynthesis of Endogenous Cannabinoids Anandamide and 2-Arachidonylglycerol                                                           (full – 2008)


Endocannabinoids and nutrition.             (full – 2008)


Role of endocannabinoids and their analogues in obesity and eating disorders. (abst – 2008)                           


Inhibition of anandamide hydrolysis by URB597 reverses abuse-related behavioral and neurochemical effects of nicotine in rats.                                                      (abst – 2008)


The endocannabinoid system: emotion, learning and addiction.              (abst – 2008)


Anandamide and neutrophil function in patients with fibromyalgia.             (abst – 2008)


Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.     (abst – 2008)               


Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. (abst – 2008)                          


Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats                                                              (abst – 2008)  No=25&uiLanguage=en


Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets.                                            (abst – 2008)


Understanding the effects of endogenous cannabinoids                 (news – 2008)


Marijuana-Inspired Painkiller? New Chemical Pathway Discovered                (news – 2008)


Endocannabinoids and the Heart              (full – 2009)


Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation             (full – 2009)


Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.                                                   (full – 2009)


Localisation and Function of the Endocannabinoid System in the Human Ovary (full – 2009)                                 


Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer          (full – 2009)


The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine                                             (full – 2009)


Endogenous cannabinoids induce fever through the activation of CB1 receptors. (full – 2009)                           


Neuropathic Pain and Endocannabinoid-Degradation Blockade               (full – 2009)


Biomarkers of Endocannabinoid System Activation in Severe Obesity             (full – 2009)


Endocannabinoids and Their Receptors as Targets for Obesity Therapy              (full – 2009)


The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.                                                                 (full – 2009)


Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development   (full – 2009)                          


Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. (full – 2009)                            


Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum (full – 2009)                 


The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways                                                      (full – 2009)


Characterization of the Endocannabinoid System in Human Neuronal Cells and Proteomic Analysis of Anandamide-induced Apoptosis                                                  (full – 2009)


Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner                                                  (full – 2009)


Endocannabinoid-mediated control of synaptic transmission.             (full – 2009)


Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. (full – 2009)                         


Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. (full – 2009)


Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain                                                                         (full – 2009)


The Endocannabinoid Anandamide: From Immunomodulation to Neuroprotection. Implications for Multiple Sclerosis                                                         (abst – 2009)


From endocannabinoid profiling to ‘endocannabinoid therapeutics’.              (abst – 2009)


Plasma endocannabinoid levels in multiple sclerosis.                (abst – 2009)


Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.                                                 (abst – 2009)


Receptors for acylethanolamides-GPR55 and GPR119.              (full – 2009)


Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.         (abst – 2009)             


Circulating endocannabinoid concentrations during orthostatic stress              (abst – 2009)


Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons                                                         (abst – 2009)  study.html#post14325992


A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis                                                       (abst – 2009)  ue_of_anandamide_Met_F_AEA_inhibits_human_thyroid_carcinoma_cell_lines_by_activation_of_apopto sis_


Is GPR55 an anandamide receptor?                   (abst – 2009)


N-acylethanolamines, anandamide and food intake.              (abst – 2009)


International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                                                 (full – 2010)


Recent advances in the regulation of cholangiocarcinoma growth               (full – 2010)


Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies           (full – 2010)                  


Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism (full – 2010)                          


Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.                                                           (full – 2010)


Endocannabinoids Prevent β-Amyloid-mediated Lysosomal Destabilization in Cultured Neurons            (full – 2010)          



Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls (full – 2010)                           


Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling.                                                                    (full – 2010)


A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats            (full – 2010)


Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality.                                                            (full – 2010)


Antitumorigenic Effects of Cannabinoids beyond Apoptosis             (full – 2010)


Endogenous cannabinoid signaling is essential for stress adaptation             (full – 2010)


Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide Hydrolase Inhibition (full – 2010)


Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients                                                   (full – 2010)


The endocannabinoid system as a target for the treatment of neurodegenerative disease (full – 2010)                            


Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. (full – 2010)                               


Effects of a Commonly Occurring Genetic Polymorphism of Human CYP3A4 (I118V) on the Metabolism of Anandamide                                                   (full – 2010)


Cyclooxygenase-2 Mediates Anandamide Metabolism in the Mouse Brain             (full – 2010)


Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.                                                 (full – 2010)


Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women     (full – 2010)                 


Energetic Metabolism and Human Sperm Motility: Impact of CB1 Receptor Activation (full – 2010)                          


Characterization of the Endocannabinoid System in Human Spermatozoa and Involvement of Transient Receptor Potential Vanilloid 1 Receptor in Their Fertilizing Ability   (full – 2010)


Maternal Dietary Fat Determines Metabolic Profile and the Magnitude of Endocannabinoid Inhibition of the Stress Response in Neonatal Rat Offspring (full – 2010)


Inactivation of Anandamide Signaling: A Continuing Debate             (link to PDF- 2010)


From Fertilisation to Implantation in Mammalian Pregnancy—Modulation of Early Human Reproduction by the Endocannabinoid System                                                             (link to PDF – 2010)


The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.                                                          (link to PDF – 2010)


Endocannabinoids and Human Sperm Cells              (link to PDF – 2010)


Endocannabinoids and Schizophrenia                 (link to PDF – 2010)


Effects of anandamide on polyamine levels and cell growth in human colon cancer cells (abst – 2010)                           


PP-014 Control of receptor expression in vagal afferent neurons by activation of cannabinoid 1 receptors                                                      (abst – 2010)  be57-57f444307138


Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis.                                                 (abst – 2010)


Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea– specific role of oleoylethanolamide.                                          (abst – 2010)



Endogenous cannabinoids in liver disease: Many darts for a single target (abst – 2010)                           


Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels.       (abst – 2010)

_for_endocannabinoids_plant_cannabinoids_and_synthetic_cannabimimetics:_focus_on_G_protein_couple d_receptors_and_transient_receptor_potential_channels_


The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.           (abst – 2010)                                    


Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?                                                             (abst – 2010) ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_


Anandamide extends platelets survival through CB(1)-dependent Akt signaling. (abst – 2010)                                         


Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery                                                                         (abst – 2010) de_and_sphingosine_1_phosphate_in_mediating_vasorelaxation_in_rat_coronary_artery_


Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity.                                                              (abst – 2010)


Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. (abst – 2010)                


Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain.     (abst – 2010)               


The endocannabinoid system modulates the valence of the emotion associated to food ingestion (abst – 2010)


Compound boosts marijuana-like chemical in the body to relieve pain at injury site (news – 2010)                             –cbm092010.php


Chocolate: The Good, the Bad and the Angry               (news – 2010)


Nutritional Facts on Raw Cacao Beans                (news – 2010)


Cocoa and the Search for Dietary Cannabinoids               (news – 2010)


Receptors triggered by pot may lessen hit from chronic stress               (news – 2010)


Increasing the body’s (but not brain’s) cannabinoids dulls pain                (news – 2010)


Painkilling System in Brain: Too Much of a Good Thing?                  (news – 2010)


Research Reaps Reefer Madness               (news – 2010)


A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development      (full – 2011)                          


Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.                                                                       (full – 2011)


A catalytically silent FAAH-1 variant drives anandamide transport in neurons. (full – 2011)                         


Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors.    (full – 2011)


Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. (full – 2011)                          


Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.     (full – 2011)          


Targeting the CB2 cannabinoid receptor in osteoporosis               (full – 2011)  529&searchHistoryKey=


Endocannabinoid system in cardiovascular disorders – new pharmacotherapeutic opportunities    (full – 2011)  7406;year=2011;volume=3;issue=3;spage=350;epage=360;aulast=Cunha


The endocannabinoid system and cancer: therapeutic implication            (full – 2011)


Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat                                                        (full – 2011)


Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism.                                                           (full – 2011)


Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice                                                           (full – 2011)


The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans

(full – 2011)      


Anandamide-loaded nanoparticles: preparation and characterization.               (abst – 2011)


Cannabinoid-2 Receptor Activation Protects against Infarct and Ischemia/Reperfusion Heart Injury.      (abst – 2011)               


Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver                                                            (abst  – 2011)  cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT


Cannabinoid applications in glaucoma.               (abst – 2011)  laucoma_


A cannabinoid ligand, anandamide, exacerbates endotoxin-induced uveitis in rabbits. (abst – 2011)                           


An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer’s disease                                                        (abst – 2011)         d

ependent_deficit_in_anandamide_mobilization_is_associated_with_cognitive_dysfunction_in_Alzheimer%  27s_disease_


Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. (abst – 2011)





Intracellular Cannabinoid Type 1 (CB1) Receptors Are Activated by Anandamide (abst – 2011)


Abnormal anandamide metabolism in celiac disease.              (abst – 2011)


Inhibition of cannabinoid metabolic enzymes reduces NSAID-induced gastric pathology (abst – 2011)  RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype



Pharmacological elevation of anandamide impairs short-term memory by altering the neurophysiology in the hippocampus.                                                      (abst – 2011)


The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.      (abst – 2011) e_inhibitor_URB_597:_interactions_with_anandamide_in_rhesus_monkeys_


Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? (abst – 2011)                           


Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011)                          


Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines.                                                      (abst – 2011)


Anandamide inhibits the growth of colorectal cancer cells through CB1 and lipid rafts (abst – 2011)                           


Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.                                                    (abst – 2011)



The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.

(abst – 2011)      


Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice.                                                            (abst – 2011)



Effects of exercise stress on the endocannabinoid system in humans under field conditions.         (abst – 2011)                     


Intense exercise increases circulating endocannabinoid and BDNF levels in humans— Possible implications for reward and depression                                                           (abst – 2011)


The endocannabinoid system in the cancer therapy: an overview.             (abst – 2011)


Effect of an Acute Consumption of a Moderate Amount of Ethanol on Plasma Endocannabinoid Levels in Humans                                                                                (abst – 2011)


Effect of capacitation on the endocannabinoid system of mouse sperm.             (abst – 2011)


Marijuana Compound Treats Multiple Health Issues               (news – 2011)


New Way to Boost Potency of Natural Pain Relief Chemical in Body              (news – 2011)


Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(full – 2012)         


Serum contents of endocannabinoids are correlated with blood pressure in depressed women.     (full – 2012)                


Endocannabinoids Stimulate Human Melanogenesis via Type-1 Cannabinoid Receptor (full – 2012)                            


Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver                                                          (full – 2012)


Role of cannabinoids in the regulation of bone remodeling                (full – 2012)


Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells       (full – 2012)


Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain         (full – 2012)                                            



Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012)                         


Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines.           (full – 2012)


Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.           (full – 2012)


Plasma Endocannabinoid Alterations in Individuals with Substance Use Disorder are Dependent on the “Mirror Effect” of Schizophrenia.                                                            (full – 2012)


A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity                                                           (full – 2012)


The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation (full – 2012)                          


Review article: Endocannabinoids in neuroendopsychology: multiphasic control of mitochondrial function         (full – 2012)  5e962e352fda


Cannabinoid modulation of neuroinflammatory disorders.             (full – 2012)


The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-beta and in the cortex of aged rats.                                                               (full – 2012)


Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery                                                (full – 2012)


Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. (full – 2012)                           


Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. (full – 2012)                        


Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice                                                          (full – 2012)


Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids                                                                        (full – 2012)


GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                         


So what do we call GPR18 now?               (full – 2012)


The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription (full – 2012)                            


Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats                                                          (full – 2012)


Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells                                                          (full – 2012)


Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response                                                              (link to PDF – 2012) cNo=4&uiLanguage=en


Endocannabinoids in stressed humans                (link to PDF – 2012) cNo=2&uiLanguage=en


Positron emission tomography offers new perspectives for evidence-based treatment development in PTSD                                                     (link to PDF – 2012)  l&recNo=2&uiLanguage=en


Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system  (abst – 2012)


Monoacylglycerol lipase – a target for drug development?               (abst – 2012)


Revisiting CB1 Receptor as Drug Target in Human Melanoma.                (abst – 2012)


Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade.


(abst – 2012)      


Dynamic changes to the endocannabinoid system in models of chronic pain (abst – 2012)                           


Effect of omega-3 polyunsaturated fatty acids on the endocannabinoid system in osteoblast-like cells and muscle                                                                  (abst – 2012)


Review article: The endocannabinoid system in normal and pathological brain ageing (abst – 2012)                           


Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.                                                           (abst – 2012)


Review article: Why do cannabinoid receptors have more than one endogenous ligand? (abst – 2012)                           


Endocannabinoids at the synapse a decade after the Dies Mirabilis (29 March 2001): what we still do not know.                                                        (abst – 2012)


Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.                                                       (abst – 2012)


Inhibitors of the Endocannabinoid-Degrading Enzymes, or how to Increase Endocannabinoid’s Activity by Preventing their Hydrolysis.                                                                   (abst – 2012)


Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.                                              (abst – 2012)


Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.      (abst – 2012)                   


Changes of Blood Endocannabinoids during Anaesthesia: a Special Case for Fatty Acid Amide Hydrolase Inhibition by Propofol?                                               (abst – 2012)


Effect of an Acute Consumption of a Moderate Amount of Ethanol on Plasma Endocannabinoid Levels in Humans.                                                                             (abst – 2012)


Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology. (abst – 2012)                            


Alteration of endocannabinoid system in human gliomas.                (abst – 2012)


The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55.                                                      (abst – 2012)


Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level. (abst – 2012)                            


Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system.                                                             (abst – 2012)


Circulating Endocannabinoid Concentrations and Sexual Arousal in Women. (abst – 2012)                                  


Essential fatty acids and lipid mediators. Endocannabinoids                 (abst – 2012)


Anandamide Induces Matrix Metalloproteinase-2 Production through Cannabinoid-1 Receptor and Transient Receptor Potential Vanilloid-1 in Human Dental Pulp Cells in Culture.      (abst – 2012)                     


Vascular metabolism of anandamide to arachidonic acid affects myogenic constriction in response to intraluminal pressure elevation.                                                       (abst – 2012)


Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.           (abst – 2012)               


Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.                                              (abst – 2012)


Inhibition Of Fatty Acid Amide Hydrolase Produces Anti-Tussive Effects In Guinea- Pigs: Evidence For Elevated Fatty Acid Amides Acting Via Cannabinoid Receptors On Airway Sensory Nerves          (abst – 2012)   FORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCI   T


Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour.                                                       (abst – 2012)




Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat.                                                                (abst – 2012)


The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models (abst – 2012)


Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB1 receptors  (abst – 2012)


Analgesic effects of cannabinoids on central pain syndrome               (abst – 2012)


Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. (abst – 2012)


Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor.

(abst – 2012)       


Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation.                                                                 (abst – 2012)


Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. (abst – 2012)                         


The Endocannabinoid System and the Brain.              (abst – 2012)


“Redundancy” of endocannabinoid inactivation: new challenges and opportunities for pain control.        (abst – 2012)               


Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS.                                             (abst – 2012)


Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure. (abst – 2012)


Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids.

(abst – 2012)      


The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity.                                                       (abst – 2012)


Anandamide Transforms Noncopulating Rats into Sexually Active Animals. (abst – 2012)                         


Modulation of sweet responses of taste receptor cells.               (abst – 2012)


Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry.

(abst – 2012)     


Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice.                                                    (abst – 2012)


The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity.                                           (abst – 2012)


Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats. (abst – 2012) 


Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells. (abst – 2012)


The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms.                                                          (abst – 2012)


Modulation of low-voltage-activated T-type Ca(2+) Channels.              (abst – 2012)


Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.      (abst – 2012)                                     


Anandamide enhances expression of heat shock protein 72 to protect against ischemia- reperfusion injury in rat heart.                                                    (abst – 2012)


Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. (abst – 2012)                           



Circulating anandamide and blood pressure in patients with obstructive sleep apnea. (abst – 2012)                               


A potential role for GPR55 in gastrointestinal functions.             (abst – 2012)


Differences in the endocannabinoid system of sperm from fertile and infertile men. (abst – 2012)                           


The Volitional Nature of Nicotine Exposure Alters Anandamide and Oleoylethanolamide Levels in the Ventral Tegmental Area.                                                      (abst – 2012)


Essential fatty acids and lipid mediators. Endocannabinoids                 (abst – 2012)


CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning. (abst – 2012)                          


Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.   (abst – 2012)                                   


The evolution and comparative neurobiology of endocannabinoid signaling (abst  – 2012)                              


The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity.                                                      (abst – 2012)


Multiple functions of endocannabinoid signaling in the brain.              (abst – 2012)


Optimized synthesis and characterization of N-acylethanolamines and O- acylethanolamines, important family of lipid-signalling molecules.                                                                                     (abst – 2012)


Anandamide regulates the expression of GnRH1, GnRH2, and GnRH-Rs in frog testis (abst – 2012)                              


Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes.                                                 (abst – 2012)


The role of endocannabinoids in gonadal function and fertility along the evolutionary axis.           (abst – 2012)            



Temporal changes in N-acylethanolamine content and metabolism throughout the peri- adolescent period                                         (abst – 2012)


The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1 and FAAH-independent mechanisms                                                         (abst – 2012)


The role of the endocannabinoid system in skeletal muscle and metabolic adaptations to exercise: potential implications for the treatment of obesity                                               (abst – 2012)


TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts.                                               (abst – 2012)


Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure (abst – 2012)


Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat                                                                        (abst – 2012)


Anandamide Induces Matrix Metalloproteinase-2 Production through Cannabinoid-1 Receptor and Transient Receptor Potential Vanilloid-1 in Human Dental Pulp Cells in Culture       (abst – 2012)             


Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans     (abst – 2012)                       


Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity                                                              (abst – 2012)


Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.                                                                   (abst – 2012)


The Contractile Effect of Anandamide in the Guinea-Pig Small Intestine is Mediated by Prostanoids but not TRPV1 Receptors or Capsaicin-Sensitive Nerves. (abst – 2012)


CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation                                                        (abst – 2012)


Acute reduction of anandamide-hydrolase (FAAH) activity is coupled with a reduction of nociceptive pathways facilitation in medication-overuse headache subjects after withdrawal treatment.   (abst – 2012)


β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors    (abst – 2012)


The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.                                                               (abst – 2012)


The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55                                                        (abst – 2012)


The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone (abst – 2012)                          


The endocannabinoid system: a key modulator of emotions and cognition             (abst – 2012)


Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.                                                                (abst – 2012)


Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells  (abst – 2012)


Revisiting CB1 receptor as drug target in human melanoma.                (abst – 2012)


Tumour epithelial expression levels of endocannabinoid markers modulates the value of endoglin-positive vascular density as a prognostic marker in prostate cancer.

(abst – 2012)      


Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos            (abst – 2012)          


Endocannabinoid system and mood disorders: Priming a target for new therapies. (abst – 2012)                            


‘Runner’s High’ may have played role in evolutionary history of humans              (news – 2012)



Do we know if marijuana or narcotics adversely affect sleep?                  (news – 2012)



Marijuana Compound Treats Schizophrenia with Few Side Effects: Clinical Trial (news – 2012)                               


Cannnabinoids, Breast Milk, and Development                  (news – 2012)


Cannabinoids for the Treatment of Neuropathic Pain               (news – 2012)


Metabolisms of endocannabinoids and related N-acylethanolamines: Canonical and alternate pathways  (full – 2013)                         


THE ENDOCANNABINOID SYSTEM PROVIDES AN AVENUE FOR EVIDENCE- BASED TREATMENT DEVELOPMENT FOR PTSD                                                          (1st page – 2013)


CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                                        (abst – 2013)


Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.           (abst – 2013)         


The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. (abst – 2013)


Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats.     (abst – 2013)                


Modulation by 17β-estradiol of anandamide vasorelaxation in normotensive and hypertensive rats: a role for TRPV1 but not fatty acid amide hydrolase.                                                                      (abst – 2013)


Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells.                                       (abst – 2013)


Type-1 (CB(1)) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells.                                                                      (abst – 2013)


Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity.    (abst – 2013)


Involvement of nitric oxide through endocannabinoids release in microglia activation during the course of CNS regeneration in the medicinal leech.                                                                     (abst – 2013)


The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.                                                                       (abst – 2013)


Drug design for neuropathic pain regulation from traditional chinese medicine. (abst – 2013)                              


Prostaglandin ethanolamides attenuate damage in a human explant colitis model (abst – 2013)                                  


Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats                                                                   (abst – 2013)


Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.  (abst – 2013)                          


Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle                                                          (abst – 2013)


Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain.                       (abst – 2013)


Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.                                                    (abst – 2013)

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