AM-281 synthetic, CB1 antagonist and inverse agonist


Design and Synthesis of the CB1 Selective Cannabinoid Antagonist AM281: A Potential Human SPECT Ligand                  (link to PDF – 1999)


[123I]AM281 single-photon emission computed tomography imaging of central cannabinoid CB1 receptors before and after Delta9-tetrahydrocannabinol therapy and whole-body scanning for assessment of radiation dose in tourette patients.                                                               (abst – 2004)


Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats                              (full – 2005)


CARDIOVASCULAR Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats (abst – 2005)                 


The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors                      (abst – 2005)


Effects of AM281, a cannabinoid antagonist, on circulatory deterioration and cytokine production in an endotoxin shock model: comparison with norepinephrine.

(abst – 2006) 


The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation.                                        (full – 2009)


GPR55 ligands promote receptor coupling to multiple signalling pathways.  (full – 2010)


Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype                            (full – 2010)


Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. (full – 2010)                     


Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.                                 (full – 2012)


Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery                        (full – 2012)


The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.       (full – 2012)


Regulation of endocannabinoid release by G proteins: A paracrine mechanism of G protein-coupled receptor action.   (abst – 2012)                                   


Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells.                                      (abst – 2012)


Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats. (abst – 2012)                


Cannabinoid Receptors as Therapeutic Targets for Dialysis-Induced Peritoneal Fibrosis. (abst – 2013)                 

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