AM-251– synthetic, GPR 55 agonist, CB1 antagonist/ inverse agonist

 

Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors

 

(full – 2001)             http://jpet.aspetjournals.org/content/299/3/951.full

 

Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats                                       (full – 2002)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573379/?tool=pmcentrez

 

CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full – 2003)                            http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573770/?tool=pmcentrez

 

Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery (full – 2003)                              http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573773/?tool=pmcentrez

 

Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN                                              (full – 2003)  http://www.jleukbio.org/cgi/content/full/75/3/453?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=  cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT

 

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors   (full – 2003)  http://journals.lww.com/anesthesiology/Fulltext/2003/10000/Inhibition_of_Inflammatory_Hyperalgesia_by

.31.aspx

 

Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats                                         (full – 2004)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575196/?tool=pmcentrez

 

Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells                                      (full – 2004)  http://science.iowamedicalmarijuana.org/pdfs/cancer/Hinz%202004.pdf

 

The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis.                                  (full – 2005)      https://www.jstage.jst.go.jp/article/tjem/207/2/207_2_99/_pdf

 

Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005)                             http://www.sciencedirect.com/science/article/pii/S0028390805001668

 

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy                             (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808496/?tool=pmcentrez

 

AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion                                     (full – 2006)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615836/?tool=pmcentrez

 

Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors (full – 2006)  http://ebm.rsmjournals.com/cgi/content/full/231/8/1421?maxtoshow=&hits=80&RESULTFORMAT=&full   text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT

 

Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury          (full – 2006)    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861843/?tool=pmcentrez

 

EFFECT OF CANNABINOIDS ON TESTICULAR ISCHEMIA-REPERFUSION INJURY IN RAT                                 (full – 2006)

http://journals.tums.ac.ir/upload_files/pdf/_/3279.pdf

 

Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor- independent mechanism.                            (abst – 2006)          http://www.ncbi.nlm.nih.gov/pubmed/16500647

 

Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full – 2007)                           http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190006/?tool=pmcentrez

 

CANNABINOID-INDUCED HYPERPHAGIA: CORRELATION WITH INHIBITION OF PROOPIOMELANOCORTIN NEURONS?              (full – 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720321/?tool=pmcentrez

 

Cannabinoid action in the olfactory epithelium         (full – 2007)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815290/?tool=pmcentrez

 

Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.                             (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17870135

 

The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors                             (abst – 2007)  http://www.sciencedirect.com/science/article/pii/S0014299907007935

 

Effect of Endocannabinoid System on the Neurogenic Function of Rat Corpus Cavernosum (abst – 2007)  http://www.doaj.org/doaj?func=abstract&id=1150200&q1=endocannabinoid%20system&f1=all&b1=and&   q2=&f2=all&recNo=26&uiLanguage=en

 

Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells        (full – 2008)  http://www.jimmunol.org/cgi/content/full/181/9/6406?maxtoshow=&hits=80&RESULTFORMAT=&fullte  xt=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT

 

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                  (full – 2008)  http://molpharm.aspetjournals.org/content/74/1/20.full?maxtoshow=&hits=80&RESULTFORMAT=&fullt ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block

 

Loss of cannabinoid receptor 1 accelerates intestinal tumor growth       (full – 2008)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561258/?tool=pubmed

 

Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats                                (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697765/?tool=pmcentrez

 

Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats                                      (full – 2008)  http://www.jneurosci.org/cgi/content/full/28/39/9702?maxtoshow=&hits=80&RESULTFORMAT=&fullte   xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

 

Feeding induced by cannabinoids is mediated independently of the melanocortin system. (full – 2008)                           http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386290/?tool=pubmed

 

Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion.                                   (full – 2008)

http://joe.endocrinology-journals.org/content/199/2/235.long

 

High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. (abst – 2008)                            http://www.ncbi.nlm.nih.gov/pubmed/18615640

 

Effect of biliary cirrhosis on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum: Role of nitric oxide pathway and endocannabinoid system

(abst – 2008)  http://www.doaj.org/doaj?func=abstract&id=859538&q1=anandamide&f1=all&b1=and&q2=&f2=all&rec No=24&uiLanguage=en

 

Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats                          (abst – 2008)  http://www.doaj.org/doaj?func=abstract&id=859448&q1=anandamide&f1=all&b1=and&q2=&f2=all&rec No=25&uiLanguage=en

 

Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo        (abst – 2008)           http://www.sciencedirect.com/science/article/pii/S0014299908002719

 

Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice                                      (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697695/?tool=pubmed

 

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory                    (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660732/?tool=pmcentrez

 

Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. (full – 2009)                             http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739820/?tool=pubmed

 

The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.                               (full – 2009)  http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full

 

Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats.                       (full – 2009)  http://www.if-pan.krakow.pl/pjp/pdf/2009/2_304.pdf

 

Cannabinoids and neurodegenerative diseases.      (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19839933

 

Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons                               (forum post/abst – 2009)  http://forum.grasscity.com/medical-marijuana-usage-applications/1029121-alzheimers-  study.html#post14325992

 

Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic                                        (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964781/?tool=pmcentrez

 

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                  (full – 2010)  http://pharmrev.aspetjournals.org/content/62/4/588.full.pdf+html

 

Cannabinoids excite circadian clock neurons.         (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927117/?tool=pubmed

 

GPR55 ligands promote receptor coupling to multiple signalling pathways.   (full – 2010)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931561/?tool=pubmed

 

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis                                     (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898685/?tool=pubmed

 

Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.                                    (full – 2010)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931557/?tool=pubmed

 

The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor Interaction  (full – 2010)  http://celljournal.org/library/upload/article/af_4334422Hashemi.pdf

 

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala                                (abst – 2010)  http://www.nature.com/npp/journal/v35/n9/abs/npp201070a.html

 

Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish.     (abst – 2010)        http://www.ncbi.nlm.nih.gov/pubmed/19800340

 

The endocannabinoid system modulates the valence of the emotion associated to food ingestion      (abst – 2010)

http://onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2010.00271.x/abstract

 

 

Pharmacological characterization of GPR55, a putative cannabinoid receptor. (abst – 2010)

http://www.unboundmedicine.com/medline/ebm/record/20298715/abstract/Pharmacological_characterizati  on_of_GPR55_a_putative_cannabinoid_receptor_

 

Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors (news – 2010)

http://cannabisclinicians.org/2011/cannabidiol-cbd-as-an-anti-arrhythmic-the-role-of-the-cb1-receptors/

 

AM251, cannabinoids receptors ligand, improves recognition memory in rats. (full – 2011)                            http://www.if-pan.krakow.pl/pjp/pdf/2011/3_670.pdf

 

A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats              (full – 2011)  http://www.hindawi.com/journals/sd/2011/178469/

 

Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.                                   (full – 2011)  http://www.nature.com/npp/journal/v37/n2/full/npp2011204a.html

 

α-Tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.                  (abst – 2011)         http://www.ncbi.nlm.nih.gov/pubmed/21843633

 

Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors.         (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/22116907/abstract/17_Cannabidiol_as_an_anti_arr  hythmic_the_role_of_the_CB1_receptors_

 

CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant). (abst – 2011)                             http://www.ncbi.nlm.nih.gov/pubmed/21740450

 

Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011)                             http://www.ncbi.nlm.nih.gov/pubmed/21773721

 

The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.                                     (abst – 2011)  http://www.unboundmedicine.com/medline/ebm/record/20888328/abstract/The_effects_of_cannabinoid_dr   ugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesio  ned_rats_

 

Pot and Pumpkin Pie: Endocannabinoid System Enhanced by Vitamin E    (news – 2011)  http://www.examiner.com/medical-marijuana-in-philadelphia/pot-and-pumpkin-pie-endocannabinoid-  system-enhanced-by-vitamin-e

 

Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells                                (full – 2012)  http://endo.endojournals.org/content/153/1/29.full

 

Differences in Spontaneously Avoiding or Approaching Mice Reflect Differences in CB1-Mediated Signaling of Dorsal Striatal Transmission.                                   (full – 2012)  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033260

 

A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion.           (full – 2012)                     http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265030/?tool=pubmed

 

The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.        (full – 2012)  http://www.jbc.org/content/early/2012/11/16/jbc.M112.364109.long

 

Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences                             (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152481&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=3&uiLanguage=en

 

Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response                                 (link to PDF – 2012)  http://www.doaj.org/doaj?func=abstract&id=1152480&q1=cannabinoid&f1=all&b1=and&q2=&f2=all&re cNo=4&uiLanguage=en

 

Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.          (abst – 2012)                                     http://www.ncbi.nlm.nih.gov/pubmed/21937980

 

The cannabinoid receptor CB₁ inverse agonist AM251 potentiates the anxiogenic activity

of urocortin I in the basolateral amygdala.      (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/21736884

 

Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                                http://www.ncbi.nlm.nih.gov/pubmed/22354705

 

Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.           (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22248639

 

WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway.                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22634229

 

Revisiting CB1 Receptor as Drug Target in Human Melanoma.         (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22447182

 

Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.                                    (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22728691

 

Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System      (abst – 2012)         http://journal.muq.ac.ir/en/index.php/jmuqen/article/view/29

 

 

The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.        (abst – 2012)                                                    http://www.ncbi.nlm.nih.gov/pubmed/22201038

 

Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB1 receptors                               (abst – 2012)  http://ajpregu.physiology.org/content/302/7/R876.abstract?sid=952e2125-0502-477c-b603-30f0f3e51b55

 

Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: Effects of the cannabinoid receptor 1 antagonist AM251.                                                                    (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22959963

 

Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression.                        (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22971846

 

Diet-dependent modulation of hippocampal expression of endocannabinoid signaling- related proteins in cannabinoid antagonist-treated obese rats.                                         (full – 2012)  http://onlinelibrary.wiley.com/doi/10.1111/ejn.12012/full

 

So what do we call GPR18 now?        (full – 2012)

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01731.x/full

 

Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.                            (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23183218

 

The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex.    (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22671779

 

Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat                                  (abst – 2012)  http://content.karger.com/produktedb/produkte.asp?doi=339113

 

Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.                                       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22940464

 

Revisiting CB1 receptor as drug target in human melanoma.         (abst – 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22447182

 

Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis.                              (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/23285225

 

Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.      (full – 2013)           http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537620/

 

CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                           (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23302980

 

Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats.                            (abst – 2013)       http://www.ncbi.nlm.nih.gov/pubmed/23291357

 

Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.       (abst – 2013)                       http://www.ncbi.nlm.nih.gov/pubmed/23386808

 

Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle                           (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23396229

 

Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst – 2013)                               http://www.ncbi.nlm.nih.gov/pubmed/23394450

 

Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.                            (abst – 2013)  http://www.ncbi.nlm.nih.gov/pubmed/23394117

 

 

 

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