AM-251– synthetic, GPR 55 agonist, CB1 antagonist/ inverse agonist


Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors


(full – 2001)   


Influence of the CB1 receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats                                       (full – 2002)


CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction (full – 2003)                  


Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery (full – 2003)                    


Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN                                              (full – 2003)  cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT


Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors   (full – 2003)



Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats                                         (full – 2004)


Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(_)-Methanandamide- Induced Apoptotic Death of Human Neuroglioma Cells                                      (full – 2004)


The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis.                                  (full – 2005)


Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus (abst – 2005)                   


Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy                             (full – 2006)


AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion                                     (full – 2006)


Inhibition of Salivary Secretion by Activation of Cannabinoid Receptors (full – 2006)   text=cannabinoid&searchid=1&FIRSTINDEX=880&resourcetype=HWCIT


Antinociceptive effect of cannabinoid agonist WIN 55,212–2 in rats with a spinal cord injury          (full – 2006)




Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor- independent mechanism.                            (abst – 2006)


Cardiovascular effects of cannabinoids in conscious spontaneously hypertensive rats (full – 2007)                 




Cannabinoid action in the olfactory epithelium         (full – 2007)


Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.                             (abst – 2007)


The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors                             (abst – 2007)


Effect of Endocannabinoid System on the Neurogenic Function of Rat Corpus Cavernosum (abst – 2007)   q2=&f2=all&recNo=26&uiLanguage=en


Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells        (full – 2008)  xt=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                  (full – 2008) ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block


Loss of cannabinoid receptor 1 accelerates intestinal tumor growth       (full – 2008)


Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats                                (full – 2008)


Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats                                      (full – 2008)   xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT


Feeding induced by cannabinoids is mediated independently of the melanocortin system. (full – 2008)                 


Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion.                                   (full – 2008)


High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. (abst – 2008)                  


Effect of biliary cirrhosis on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum: Role of nitric oxide pathway and endocannabinoid system

(abst – 2008) No=24&uiLanguage=en


Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats                          (abst – 2008) No=25&uiLanguage=en


Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo        (abst – 2008) 


Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice                                      (full – 2009)


Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory                    (full – 2009)


Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. (full – 2009)                   


The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.                               (full – 2009)


Effects of the cannabinoid CB1 receptor antagonist AM 251 on the reinstatement of nicotine-conditioned place preference by drug priming in rats.                       (full – 2009)


Cannabinoids and neurodegenerative diseases.      (abst – 2009)


Endocannabinoids prevent lysosomal membrane destabilisation evoked by treatment with β-amyloid in cultured rat cortical neurons                               (forum post/abst – 2009)  study.html#post14325992


Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic                                        (full – 2010)


International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                                  (full – 2010)


Cannabinoids excite circadian clock neurons.         (full – 2010)


GPR55 ligands promote receptor coupling to multiple signalling pathways.   (full – 2010)


Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis                                     (full – 2010)


Spinal and peripheral analgesic effects of the CB cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain.                                    (full – 2010)


The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor Interaction  (full – 2010)


The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala                                (abst – 2010)


Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish.     (abst – 2010)


The endocannabinoid system modulates the valence of the emotion associated to food ingestion      (abst – 2010)



Pharmacological characterization of GPR55, a putative cannabinoid receptor. (abst – 2010)  on_of_GPR55_a_putative_cannabinoid_receptor_


Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors (news – 2010)


AM251, cannabinoids receptors ligand, improves recognition memory in rats. (full – 2011)                  


A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats              (full – 2011)


Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress.                                   (full – 2011)


α-Tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.                  (abst – 2011)


Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors.         (abst – 2011)  hythmic_the_role_of_the_CB1_receptors_


CB(1) -independent mechanisms of Δ(9) -THCV, AM251 and SR141716 (rimonabant). (abst – 2011)                   


Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011)                   


The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.                                     (abst – 2011)   ugs_on_abnormal_involuntary_movements_in_dyskinetic_and_non_dyskinetic_6_hydroxydopamine_lesio  ned_rats_


Pot and Pumpkin Pie: Endocannabinoid System Enhanced by Vitamin E    (news – 2011)  system-enhanced-by-vitamin-e


Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells                                (full – 2012)


Differences in Spontaneously Avoiding or Approaching Mice Reflect Differences in CB1-Mediated Signaling of Dorsal Striatal Transmission.                                   (full – 2012)


A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion.           (full – 2012)           


The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55.        (full – 2012)


Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences                             (link to PDF – 2012) cNo=3&uiLanguage=en


Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response                                 (link to PDF – 2012) cNo=4&uiLanguage=en


Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.          (abst – 2012)                           


The cannabinoid receptor CB₁ inverse agonist AM251 potentiates the anxiogenic activity

of urocortin I in the basolateral amygdala.      (abst – 2012)


Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                      


Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor.           (abst – 2012)


WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway.                              (abst – 2012)


Revisiting CB1 Receptor as Drug Target in Human Melanoma.         (abst – 2012)


Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.                                    (abst – 2012)


Mechanism of the Interaction of Cannabinoid System in Central Amygdale with Opioid System      (abst – 2012)



The interaction between intrathecal administration of low doses of  palmitoylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-β expression in rats.        (abst – 2012)                                          


Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB1 receptors                               (abst – 2012)


Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: Effects of the cannabinoid receptor 1 antagonist AM251.                                                                    (abst – 2012)


Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression.                        (abst – 2012)


Diet-dependent modulation of hippocampal expression of endocannabinoid signaling- related proteins in cannabinoid antagonist-treated obese rats.                                         (full – 2012)


So what do we call GPR18 now?        (full – 2012)


Cannabinoid type 1 receptor ligands WIN 55,212-2 and AM 251 alter anxiety-like behaviors of marmoset monkeys in an open-field test.                            (abst – 2012)


The anti-nausea effects of CB(1) agonists are mediated by an action at the visceral insular cortex.    (abst – 2012)


Anti-Inflammatory Effect of the Endocannabinoid Anandamide in Experimental Periodontitis and Stress in the Rat                                  (abst – 2012)


Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.                                       (abst – 2012)


Revisiting CB1 receptor as drug target in human melanoma.         (abst – 2012)


Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis.                              (abst – 2012)


Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.      (full – 2013) 


CB1 and CB2 Cannabinoid Receptor Agonists Induce Peripheral Antinociception by Activation of the Endogenous Noradrenergic System.                           (abst – 2013)


Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats.                            (abst – 2013)


Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.       (abst – 2013)             


Signaling cross-talk between cannabinoid and muscarinic systems actives Rho-kinase and increases the contractile responses of the bovine ciliary muscle                           (abst – 2013)


Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst – 2013)                     


Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors.                            (abst – 2013)




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