AM-111/D-JNKI-1/ XG- 102 – synthetic

 

AM-111     (news – undated)     http://www.aurismedical.com/p/therapies/am_111.php?lg=en

 

A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.                    (full – 2003)  http://www.jneurosci.org/content/23/24/8596.long

 

 

Cochlear implantation trauma and noise-induced hearing loss: Apoptosis and therapeutic strategies.                     (full – 2006)       http://onlinelibrary.wiley.com/doi/10.1002/ar.a.20305/pdf

 

AM-111 reduces hearing loss in a guinea pig model of acute labyrinthitis.     (abst – 2007)

http://www.ncbi.nlm.nih.gov/pubmed/18322422

 

Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study                             (abst – 2007)  http://www.ncbi.nlm.nih.gov/pubmed/17712672

 

AM-111 protects against permanent hearing loss from impulse noise trauma. (abst – 2007)                            http://www.ncbi.nlm.nih.gov/pubmed/16839720

 

AM-111 prevents hearing loss from semicircular canal injury in otitis media. (full – 2009)                                http://onlinelibrary.wiley.com/doi/10.1002/lary.20759/pdf

 

Blocking pro-cell-death signal pathways to conserve hearing.         (abst – 2009)

http://www.ncbi.nlm.nih.gov/pubmed/19923808

 

CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS                           (full – 2010)

http://www.faqs.org/patents/app/20100016218

 

Otoprotective Effect of AM-111 Also Shown In Model of Cochlear Ischemia (news – 2010)                               http://www.biospace.com/news_story.aspx?StoryID=192710

 

Protection against ischemic cochlear damage by intratympanic administration of AM-

111.        (abst – 2011)          http://www.ncbi.nlm.nih.gov/pubmed/22089955

 

The JNK inhibitor XG-102 protects against TNBS-induced colitis.  (full – 2012)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302790/

 

Analysis: Drugmakers step up search for hearing loss medicines          (news – 2012)

http://news.yahoo.com/analysis-drugmakers-step-search-hearing-loss-medicines-084329944–finance.html

 

Molecular mechanisms involved in cochlear implantation trauma and the protection of hearing and auditory sensory cells by inhibition of c-Jun-N-terminal kinase signaling. (abst – 2013)                           http://www.ncbi.nlm.nih.gov/pubmed/23382052

 

 

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