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Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). (full – 1999)


The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU- 210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.     (abst – 2002)                                                 


In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats.                                                               (full – 2006)


Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.                                                                  (full – 2006)


Arachidonyl-2′-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock- induced seizure model.     (abst – 2006)                                               


Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence.                                                                  (full – 2007)


Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice.                                            (abst – 2007)


Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells                                                                        (full – 2008)  ext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#content-block


Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation. (full – 2008)                               


Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. (full – 2008)                               


Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha- mediated ceramide de novo synthesis in colon cancer cells.                                                            (full – 2008)


Additive Interaction of the Cannabinoid Receptor I Agonist Arachidonyl-2- chloroethylamide with Etomidate in a Sedation Model in Mice                                                                           (full – 2008)  ceptor_I.19.aspx


Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo   (abst – 2008)                  


Endogenous cannabinoids induce fever through the activation of CB1 receptors. (full – 2009)                          


The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.                                                         (full – 2009)


Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.                                                 (abst – 2009)


Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration.                                                                      (abst – 2009)


Effect of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.        (abst – 2009)


Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. (abst – 2009)                         


Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation    (full – 2010)


Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.                                                                       (abst – 2011)


The Effect of Hypoxia on G Protein Coupled (CB1) Receptor Gene Expression in Cortical B50 Neurons in Culture                                                                   (abst – 2011)


Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.                                                       (abst – 2011)


L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure.                                                          (abst – 2011)


Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.                                            (abst – 2011)


Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behavior (abst – 2012) t_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_


CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice.         (abst – 2012)                        


Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by Aβ neurotoxicity.                                                                      (abst – 2012)


CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones. (abst – 2012)                          


Opposing Roles for Cannabinoid Receptor Type-1 (CB(1)) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats.      (abst – 2012)                                  


Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.                                                           (abst – 2012)


Cannabinoids and muscular pain. Effectiveness of the local administration in rat. (abst – 2012)                         


Revisiting CB1 Receptor as Drug Target in Human Melanoma.              (abst – 2012)


Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters                                               (abst – 2012)


Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. (abst – 2012)                             


Evaluation of Anti-invasion Effect of Cannabinoids on Human Hepatocarcinoma Cells.


(abst – 2012)             


Distribution and function of the endocannabinoid system in the rat and human bladder. (abst – 2012)                                 


Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function.   (abst – 2012)                        


Revisiting CB1 receptor as drug target in human melanoma.                      (abst – 2012)


Anti-Cancer Effects In Human Liver Cancer Cells Produced By Cannabis Agonists (news – 2012)                                 


Type-1 (CB(1)) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells.                                                                            (abst – 2013)


Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. (abst – 2013)                                 


Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells (abst – 2013)                                   



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