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 2-AG/ 2-ARACHIDONOYLGLYCEROL endocannabinoid, CB1 & CB 2 agonist


Phytocannabinoids        (news – undated)


2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain (abst – 1995)                    


Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand                       (full – 1997)  AG_%20FEBSLet.pdf


A Second Endogenous Cannabinoid That Modulates Long-term Potentiation. (abst – 1997)                      


Brain Chemicals Mimic Marijuana         (news – 1997)



2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through Ca2.-dependent and -independent mechanisms                                                                    (full – 1998)  pdf


2-Arachidonoyl-glycerol as an “endocannabinoid”: limelight for a formerly neglected metabolite.     (abst – 1998)    


Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor (full – 1999)                 


Synthesis and Biological Activities of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, and Its Metabolically Stable Ether-linked Analogues (full – 2000)              


Endocannabinoids control spasticity in a multiple sclerosis model        (full – 2000)  0399fjev1?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=cannabis&andorexactfulltext=and&sear chid=1&FIRSTINDEX=10&sortspec=relevance&resourcetype=HWCIT


Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.                           (full – 2000)


Endocannabinoids and Vascular Function       (full – 2000)


2-Arachidonoylglycerol and the cannabinoid receptors.         (abst – 2000)


Cardiovascular effects of endocannabinoids–the plot thickens.        (abst – 2000) tplus


Endogenous cannabinoids and appetite.         (abst – 2000)


Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes. (full – 2001)                     


Endogenous cannabinoids mediate hypotension after experimental myocardial infarction (full – 2001)  ext=cannabinoid&searchid=1&FIRSTINDEX=560&resourcetype=HWCIT


Inhibition of Rat C6 Glioma Cell Proliferation by Endogenous and Synthetic Cannabinoids. Relative Involvement of Cannabinoid and Vanilloid Receptors (full – 2001)                   


Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation                                         (full – 2001)


2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor (full – 2001)                   


Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts                  (full – 2001)  04975ba34325


The neurobiology and evolution of cannabinoid signalling         (abst – 2001)  5ef27a702e9ba&keytype2=tf_ipsecsha


An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. (abst – 2001)                   


Sourcing the Code: Searching for the Evolutionary Origins of Cannabinoid Receptors, Vanilloid Receptors, and Anandamide                        (full – 2002)


Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2- AG) in immune cells                                         (full – 2002)  cannabis&andorexactfulltext=and&searchid=1&FIRSTINDEX=10&sortspec=relevance&resourcetype=H   WCIT


The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.                                (full – 2002)


Comparison of the enzymatic stability and intraocular pressure effects of 2- arachidonylglycerol and noladin ether, a novel putative endocannabinoid.                                                           (full – 2002)


Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol.                                            (full – 2002)


Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine.                                     (abst – 2002)


Endocannabinoids and related fatty acid derivatives in pain modulation.      (abst – 2002)


Endocannabinoids protect the rat isolated heart against ischaemia       (full – 2003)


Chronic Morphine Modulates the Contents of the Endocannabinoid, 2-Arachidonoyl Glycerol, in Rat Brain                                   (full – 2003)


Role of Endogenous Cannabinoids in Synaptic Signaling       (full – 2003)  ltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy                                           (full – 2003)  cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


Manipulation of the endocannabinoid system by a general anaesthetic.      (full – 2003)


Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. (abst – 2003)                  


Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain.                            (abst – 2003)


The endocannabinoid system: a general view and latest additions         (full – 2004)


New perspectives in the studies on endocannabinoid and cannabis: 2- arachidonoylglycerol as a possible novel mediator of inflammation                                                                (full – 2004)


2-Arachidonoylglycerol A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion                             (full – 2004)  f2b094


The endocannabinoid-CB receptor system: Importance for development and in pediatric disease.     (abst – 2004)


A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells (full – 2005)       


2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells (full – 2005)



Analgesia through endogenous cannabinoids      (full – 2005)  ocannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=date&resourcetype=HW   CIT


CB1 cannabinoid receptor-mediated modulation of food intake in mice     (full – 2005)


Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. (full – 2005)                 


Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders.                                  (full – 2005)


The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines.                                 (abst – 2005)


Finding of endocannabinoids in human eye tissues: implications for glaucoma. (abst – 2005)                 


Body’s Own Marijuana-Like Compounds Are Crucial For Stress-Induced Pain Relief (news – 2005)                     


Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia                                     (full – 2006) 82


Endocannabinoids, feeding and suckling – from our perspective      (full – 2006)


Not Too Excited? Thank Your Endocannabinoids         (full – 2006)


Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection                                    (full – 2006)


Weight Control in Individuals With Diabetes       (full – 2006) text=cannabis&searchid=1&FIRSTINDEX=2000&resourcetype=HWCIT


A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. (full – 2006)                   


Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2- Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice                                             (full – 2006)


Methods evaluating cannabinoid and endocannabinoid effects on gastrointestinal functions. (abst – 2006)     


Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2- arachidonoylglycerol.        (abst – 2006)


Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice.                        (abst – 2006)


Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.                                         (abst – 2006)


The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines.                                  (abst – 2006)


The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis                                  (full – 2007)


Endocannabinoids and the haematological system       (full – 2007)


Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon                              (full – 2007)


Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism                                        (full – 2007)


Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth : RECRUITMENT OF Fas AND Fas LIGAND TO LIPID RAFTS                                                 (full – 2007)


Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus.

(full – 2007)


Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury (full – 2007)                     


Endocannabinoids block status epilepticus in cultured hippocampal neurons (full – 2007)                  



Chronologically overlapping occurrences of nicotine-induced anxiety- and depression- related behavioral symptoms: effects of anxiolytic and cannabinoid drugs                                    (full – 2007)


2-AG + 2 new players = forecast for therapeutic advances.      (full – 2007)  4&_user=10&_coverDate=12%2F26%2F2007&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&

_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=       9ee  f728e35c89b5764ef2d27c0cdffe9&searchtype=a


CB2 receptors in the brain: role in central immune function      (full – 2007)


Opposing Actions of Endocannabinoids on Cholangiocarcinoma Growth    (full – 2007)


Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher                       (interview – 2007)



In Vitro Anticonvulsant Action of 2-Arachidonyl Glycerol            (abst – 2007) No=29&uiLanguage=en


Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. (abst – 2007)                     


The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon.                                         (abst – 2007)


The endocannabinoid system        (news – 2007)


The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling.                       (full – 2008)


Cannabinoids Inhibit HIV-1 Gp120-Mediated Insults in Brain Microvascular Endothelial Cells        (full – 2008)  xt=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT


Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling.                             (full – 2008)


Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages                                  (full – 2008)  4a971695b4fb


Endocannabinoid 2-Arachidonoylglycerol Protects Neurons by Limiting COX-2 Elevation   (full – 2008)     


Endocannabinoids and nutrition.         (full – 2008)


Activating Parabrachial Cannabinoid CB1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats                                         (full – 2008)   xt=cannabinoid&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT


Cannabinoid receptors and the regulation of bone mass       (full – 2008)


Pharmacological Inhibition of CB1 Cannabinoid Receptor Protects Against Doxorubicin- Induced Cardiotoxicity                     (full – 2008)


Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet                             (full – 2008)


Endocannabinoids and the Control of Energy Homeostasis        (full – 2008)


The influence of mast cell mediators on migration of SW756 cervical carcinoma cells. (full – 2008)                  


Endocannabinoids and nutrition.       (full – 2008)


Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.                              (full – 2008)


Mechanisms for Recycling and Biosynthesis of Endogenous Cannabinoids Anandamide and 2-Arachidonylglycerol                     (full – 2008)


Dysregulation of the endocannabinoid system in obesity.     (abst – 2008)


Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets.                                    (abst – 2008)


Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. (abst – 2008)                    


Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.                           (abst – 2008)


Understanding the effects of endogenous cannabinoids       (news – 2008)


Marijuana-Inspired Painkiller? New Chemical Pathway Discovered         (news – 2008)


LSUHSC research reports new method to protect brain cells from diseases like Alzheimer’s  (news – 2008)              


Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner                                             (full – 2009)


Changes in the Endocannabinoid System May Give Insight into new and Effective Treatments for Cancer                                 (full – 2009)


Endocannabinoids and Their Receptors as Targets for Obesity Therapy        (full – 2009)


Endocannabinoid-mediated control of synaptic transmission.       (full – 2009)


Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum      (full – 2009)


Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects    (full – 2009)                 


Neuropathic Pain and Endocannabinoid-Degradation Blockade        (full – 2009)


Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. (full – 2009)


Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.                                     (full – 2009)


Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain                                          (full – 2009)


From endocannabinoid profiling to ‘endocannabinoid therapeutics’.       (abst – 2009)


Circulating endocannabinoid concentrations during orthostatic stress      (abst – 2009)


The endocannabinoid 2-arachidonoylglycerol promotes sperm developement through activation of cannabinoid-2 receptors                              (abst – 2009)


Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats.                                        (abst – 2009)


International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2                             (full – 2010)


Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality.                                  (full – 2010)


Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.           (full – 2010)


Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.    (full – 2010)    


Antitumorigenic Effects of Cannabinoids beyond Apoptosis      (full – 2010)


Endocannabinoid Overload         (full – 2010)


Maternal Dietary Fat Determines Metabolic Profile and the Magnitude of Endocannabinoid Inhibition of the Stress Response in Neonatal Rat Offspring (full – 2010)


Cyclooxygenase-2 Mediates Anandamide Metabolism in the Mouse Brain      (full – 2010)


Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies    (full – 2010)           


Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients                              (full – 2010)


Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.                                  (full – 2010)


Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls (full – 2010)                   


Energetic Metabolism and Human Sperm Motility: Impact of CB1 Receptor Activation (full – 2010)                  


Endogenous cannabinoid signaling is essential for stress adaptation      (full – 2010)


Endocannabinoid signalling: has it got rhythm?        (full – 2010)


The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.                              (full – 2010)


Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients.                                (full – 2010)


The endocannabinoid system as a target for the treatment of neurodegenerative disease (full – 2010)                     


The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.                             (full – 2010)


A model of endocannabinoid 2-AG-mediated depolarization-induced suppression of inhibition                        (article – 2010)


From Fertilisation to Implantation in Mammalian Pregnancy—Modulation of Early Human Reproduction by the Endocannabinoid System                   (link to PDF – 2010)


Endocannabinoids and Schizophrenia      (link to PDF – 2010)


The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury.                                            (abst – 2010)


The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration.    (abst – 2010)                    


Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?                              (abst – 2010) ion_of_the_endocannabinoid_system:_new_perspectives_for_the_treatment_of_depression_and_anxiety_d isorders%5D_


The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors                              (abst – 2010)


Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis.                              (abst – 2010)


Endogenous cannabinoids in liver disease: Many darts for a single target       (abst – 2010)


Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea– specific role of oleoylethanolamide.                                  (abst – 2010)


Receptors triggered by pot may lessen hit from chronic stress        (news – 2010)


Painkilling System in Brain: Too Much of a Good Thing?          (news – 2010)


Drugs that reduce activity of ABDH6 enzyme can prevent brain damage: Study (news – 2010)  brain-damage-Study.aspx?page=2


Newly discovered mechanism controls levels and efficacy of a marijuana-like substance in the brain (news – 2010)


Anti-proliferative Effect of a Putative Endocannabinoid, 2-Arachidonylglyceryl Ether in Prostate Carcinoma Cells                                           (full – 2011)


The endocannabinoid system and cancer: therapeutic implication         (full – 2011)


Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.                                       (full – 2011)


Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice                                     (full – 2011)


The activity of the endocannabinoid metabolising enzyme fatty acid amide hydrolase in subcutaneous adipocytes correlates with BMI in metabolically healthy humans

(full – 2011)


Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects. (full – 2011)                


Targeting the CB2 cannabinoid receptor in osteoporosis        (full – 2011)  529&searchHistoryKey=


The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of

2‐arachidonoylglycerol signalling through cannabinoid receptors         (full – 2011)


Dual inhibition of alpha/beta hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.                           (full – 2011)


Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation.                       (full – 2011)


Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy.                             (full – 2011)


Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness (full – 2011)                


Endogenous Cannabinoid Production in the Rat Female Reproductive Tract Is Regulated by Changes in the Hormonal Milieu                                   (link to PDF – 2011)


The Endogenous Cannabinoid 2-Arachidonoylglycerol Is Intravenously Self- Administered by Squirrel Monkeys                                                    (abst – 2011)



Effect of capacitation on the endocannabinoid system of mouse sperm.      (abst – 2011)


Chemoenzymatic synthesis of 2-arachidonoylglycerol, an endogenous ligand for cannabinoid receptors                             (abst – 2011)


Administration of 2-arachidonoylglycerol ameliorates both acute and chronic Experimental Autoimmune Encephalomyelitis                                                       (abst – 2011)  oylglycerol_ameliorates_both_acute_and_chronic_Experimental_Autoimmune_Encephalomyelitis_


The Effect of Hypoxia on G Protein Coupled (CB1) Receptor Gene Expression in Cortical B50 Neurons in Culture                                (abst – 2011)


Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. (abst – 2011)  ylglycerol_protects_neurons_against_%CE%B2_amyloid_insults_


Alteration of the Endocannabinoid System In Mouse Brain During Prion Disease. (abst – 2011)  noid_System_In_Mouse_Brain_During_Prion_Disease_


Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.                                (abst – 2011)


The endocannabinoid system in the cancer therapy: an overview.         (abst – 2011)


Cannabinoid Receptor 2 Is Critical for the Homing and Retention of Marginal Zone B Lineage Cells and for Efficient T-Independent Immune Responses                                           (abst – 2011)


The major central endocannabinoid directly acts at GABA(A) receptors.      (abst – 2011)


2-Arachidonoylglycerol (2-AG) Induces Corneal Epithelial Cell Migration via Cannabinoid CB1 Receptors                                                        (abst – 2011) ext=cannabinoid&searchid=1&FIRSTINDEX=80&sortspec=date&resourcetype=HWCIT


Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals.                                   (abst – 2011)


Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors                                       (abst – 2011)  arachidonoylglycerol_induces_the_preference_for_a_high_fat_diet_via_activation_of_cannabinoid_1_rece  ptors_


Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin- induced activation of central adrenomedullary outflow in rats.                                      (abst – 2011)


Endocannabinoid CB1 receptors modulate visual output from the thalamus. (abst – 2011)                  


Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines.                                   (abst – 2011)


The endocannabinoid system in the cancer therapy: an overview.      (abst – 2011)


Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro (abst – 2011)                   


Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.                                          (abst – 2011)



Cannabinoid-2 Receptor Activation Protects against Infarct and Ischemia/Reperfusion Heart Injury.                            (abst – 2011)


Effect of an Acute Consumption of a Moderate Amount of Ethanol on Plasma Endocannabinoid Levels in Humans                                            (abst – 2011)


Intense exercise increases circulating endocannabinoid and BDNF levels in humans— Possible implications for reward and depression                          (abst – 2011)


New metabolic pathway for controlling brain inflammation           (news – 2011)  inflammation.aspx


Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(full – 2012) 


Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. (full – 2012)                     


Endocannabinoids in nervous system health and disease: the big picture in a nutshell (full – 2012)                 


Serum contents of endocannabinoids are correlated with blood pressure in depressed women.          (full – 2012)


Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells                                         (full – 2012)


The role of CB2 receptor ligands in human eosinophil function        (full – 2012)


Endocannabinoids Stimulate Human Melanogenesis via Type-1 Cannabinoid Receptor (full – 2012)                    


Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.                             (full – 2012)


Cannabinoid Receptor Type 1 (CB1) Activation Inhibits Small GTPase RhoA Activity and Regulates Motility of Prostate Carcinoma Cells                                (full – 2012)


Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity. (full – 2012)                   


Role of cannabinoids in the regulation of bone remodeling        (full – 2012)


Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.                                  (full – 2012)


Endocannabinoids measurement in human saliva as potential biomarker of obesity. (full – 2012)               


Plasma Endocannabinoid Alterations in Individuals with Substance Use Disorder are Dependent on the “Mirror Effect” of Schizophrenia.                                        (full – 2012)


Type 2 Diabetes Associated Changes in the Plasma Non-Esterified Fatty Acids, Oxylipins and Endocannabinoids                                   (full – 2012)


Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues                       (full – 2012)


Review article: Endocannabinoids in neuroendopsychology: multiphasic control of mitochondrial function                              (full – 2012)  5e962e352fda


The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting CB receptors.                                      (full – 2012)


Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery                        (full – 2012)


So what do we call GPR18 now?        (full – 2012)


Diet-dependent modulation of hippocampal expression of endocannabinoid signaling- related proteins in cannabinoid antagonist-treated obese rats.                                         (full – 2012)


GPR18 in microglia: implications for the CNS and endocannabinoid system signaling (full – 2012)                  


A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer’s Disease                                     (full – 2012)


Monoacylglycerol lipase is a new therapeutic target for Alzheimer’s disease (full – 2012)                   


The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription (full – 2012)                    


Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome      (full – 2012)   


Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3      (full – 2012)                        


Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat            (full – 2012)


Autocrine Endocannabinoid Signaling Through CB1 Receptors Potentiates OX1 Orexin Receptor Signaling.                          (full – 2012)


Bidirectional regulation of endocannabinoid signaling in the amygdala contributes to activation and adaptation of the stress response                                 (link to PDF – 2012) cNo=4&uiLanguage=en


Critical role of the endocannabinoid system in mediating rapid glucocorticoid effects on memory for emotionally arousing experiences                             (link to PDF – 2012) cNo=3&uiLanguage=en


Endocannabinoids in stressed humans         (link to PDF – 2012) cNo=2&uiLanguage=en


Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression                                   (abst – 2012)  0058.xml?rskey=jSEJyD&result=10&q=cannabinoid


Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice.            (abst – 2012)        


Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia. (abst – 2012)                   


Monoacylglycerol lipase – a target for drug development?        (abst – 2012)


Dynamic changes to the endocannabinoid system in models of chronic pain (abst – 2012)                


Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system          (abst – 2012)


Review article: Why do cannabinoid receptors have more than one endogenous ligand? (abst – 2012)                    


Review article: The endocannabinoid system in normal and pathological brain ageing (abst – 2012)                  


The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats.                                       (abst – 2012)


Endocannabinoids at the synapse a decade after the Dies Mirabilis (29 March 2001): what we still do not know.                                       (abst – 2012)


Inhibitors of the Endocannabinoid-Degrading Enzymes, or how to Increase Endocannabinoid’s Activity by Preventing their Hydrolysis.                                       (abst – 2012)


Effect of an Acute Consumption of a Moderate Amount of Ethanol on Plasma Endocannabinoid Levels in Humans.                                         (abst – 2012)


Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology. (abst – 2012)                   


Alteration of endocannabinoid system in human gliomas.          (abst – 2012)


Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.                                        (abst – 2012)


Regulation of endocannabinoid release by G proteins: A paracrine mechanism of G protein-coupled receptor action.                                           (abst – 2012)


Effect of omega-3 polyunsaturated fatty acids on the endocannabinoid system in osteoblast-like cells and muscle                                 (abst – 2012)


Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at Spinal Level. (abst – 2012)                     


Circulating Endocannabinoid Concentrations and Sexual Arousal in Women. (abst – 2012)                  


Essential fatty acids and lipid mediators. Endocannabinoids        (abst – 2012)


Stimulation of acumbens shell cannabinoid CB(1) receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in rats.                                    (abst – 2012)


Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.                  (abst – 2012)


Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids                                 (abst – 2012)  annabinoid&searchid=1&FIRSTINDEX=105&sortspec=date&resourcetype=HWCIT


THE CO-EXPRESSION OF THE ENDOCANNABINOID SYSTEM AND THE RANK/RANKL SIGNALLING PATHWAY IN HUMAN BONE AND OSTEOCLAST CULTURE           (abst – 2012)  B/SUPP_XVIII/7.abstract?maxtoshow=&hits=25&RESULTFORMAT=&fulltext=cannabinoid&searchid=  1&FIRSTINDEX=130&sortspec=date&resourcetype=HWCIT


Photoperiodic Changes in Endocannabinoid Levels and Energetic Responses to Altered Signalling at CB1 Receptors in Siberian Hamsters                                       (abst – 2012)


The endocannabinoid 2-arachidonoylglicerol decreases calcium induced cytochrome c release from liver mitochondria.                                       (abst – 2012)


2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism (abst – 2012)                      


The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models           (abst – 2012)


Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. (abst – 2012)                     


GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors. (abst – 2012)                     


Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation.                                       (abst – 2012)


The Endocannabinoid System and the Brain.       (abst – 2012)


“Redundancy” of endocannabinoid inactivation: new challenges and opportunities for pain control.  (abst – 2012)     


Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS.                                    (abst – 2012)


Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. (abst – 2012)                    


Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.                                         (abst – 2012)


Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids.

(abst – 2012)


Endocannabinoid system and mood disorders: Priming a target for new therapies. (abst – 2012)                    


The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity.                          (abst – 2012)


Modulation of sweet responses of taste receptor cells.        (abst – 2012)


Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. (abst – 2012)                    


Differences in the endocannabinoid system of sperm from fertile and infertile men. (abst – 2012)                 


The endocannabinoid system: a key modulator of emotions and cognition     (abst – 2012)


The Volitional Nature of Nicotine Exposure Alters Anandamide and Oleoylethanolamide Levels in the Ventral Tegmental Area.                                  (abst – 2012)


Essential fatty acids and lipid mediators. Endocannabinoids          (abst – 2012)


Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.        (abst – 2012)                            


2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.                                             (abst – 2012)


The evolution and comparative neurobiology of endocannabinoid signaling (abst  – 2012)                      


The role of endocannabinoids in gonadal function and fertility along the evolutionary axis.    (abst – 2012)     


The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity.                          (abst – 2012)


Multiple functions of endocannabinoid signaling in the brain.       (abst – 2012)


Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.                                 (abst – 2012)


The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1 and FAAH-independent mechanisms                                      (abst – 2012)


Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system                                    (abst – 2012)


Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans                                 (abst – 2012)


The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear- conditioned analgesia and controls fear expression in the presence of nociceptive tone (abst – 2012)                  


Marijuana cannabinoids found to help combat autism       (news – 2012)


Marijuana Compound Treats Schizophrenia with Few Side Effects: Clinical Trial (news – 2012)                        


Marijuana-like brain chemicals could be key to treating fragile X syndrome (news – 2012) syndrome?page=0,2


How the endocannabinoid 2-AG may reduce symptoms of ‘Fragile X’ autism (news – 2012)


Fragile X Model Reveals New Role for the Fragile X Mental Retardation Protein


(news – 2012)  


Boosting pot-like chemicals treats fragile X symptoms      (news – 2012)


Boosting natural marijuana-like brain chemicals treats fragile X syndrome symptoms (news – 2012)                  


Cannnabinoids, Breast Milk, and Development       (news – 2012)


Intrinsic Up-Regulation of 2-AG Favors an Area Specific Neuronal Survival in Different In Vitro Models of Neuronal Damage.                                           (full – 2013)


Metabolisms of endocannabinoids and related N-acylethanolamines: Canonical and alternate pathways                                     (full – 2013)




Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. (abst – 2013)                 


Involvement of nitric oxide through endocannabinoids release in microglia activation during the course of CNS regeneration in the medicinal leech.                                               (abst – 2013)


Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals.                                       (abst – 2013)


The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis.                                      (abst – 2013)


Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats                                       (abst – 2013)


Stimulatory and Inhibitory Roles of Brain 2-Arachidonoylglycerol in Bombesin-Induced Central Activation of Adrenomedullary Outflow in Rats.                                         (abst – 2013)

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